CHRM4 (cholinergic receptor muscarinic 4)

Gene

• Entrez ID: 1132
• Gene name: Cholinergic receptor muscarinic 4
• Gene symbol: CHRM4
• Synonyms: HM4, M4R
• Chromosome: 11
• Chromosome location: 11p11.2
• Summary: The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, pho

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004993	Function	G protein-coupled serotonin receptor activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	15518545
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0007165	Process	Signal transduction	TAS	9603968
GO:0007166	Process	Cell surface receptor signaling pathway	TAS	2739737
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007187	Process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA	21873635
GO:0007197	Process	Adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway	IBA	21873635
GO:0007213	Process	G protein-coupled acetylcholine receptor signaling pathway	TAS	3443095
GO:0007268	Process	Chemical synaptic transmission	IBA	21873635
GO:0016907	Function	G protein-coupled acetylcholine receptor activity	IBA	21873635
GO:0030425	Component	Dendrite	IBA	21873635
GO:0030594	Function	Neurotransmitter receptor activity	IBA	21873635
GO:0040012	Process	Regulation of locomotion	IEA
GO:0045202	Component	Synapse	IBA	21873635
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0098664	Process	G protein-coupled serotonin receptor signaling pathway	IEA

Other IDs

• MIM: 118495
• HGNC: 1953
• e!Ensembl: ENSG00000180720

Protein

• UniProt ID: P08173
• Protein name: Muscarinic acetylcholine receptor M4
• Protein function: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effec
• PDB: 5DSG, 6D9H, 6KP6, 7LD3, 7LD4, 7TRK, 7TRP, 7TRQ, 7TRS, 7V68, 7V69, 7V6A, 8E9X, 8FX5, 8IYH, 8IYW, 8JER, 8JHN
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00001	7tm_1	49 → 453	7 transmembrane receptor (rhodopsin family)	Family

• Sequence:

  MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVN
  RQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASV
  MNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTV
  PDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAK
  TLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGS
  ATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIV
  PATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMV
  LVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR

• Sequence length: 479

Pathways

KEGG:

Neuroactive ligand-receptor interaction
Cholinergic synapse
Regulation of actin cytoskeleton

Reactome:

Muscarinic acetylcholine receptors
G alpha (i) signalling events

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	21747397, 23490763

Unknown
Disease name	Disease term	dbSNP ID	References
Catatonia	Catatonia		15273762
Malignant catatonia	Catatonia, Malignant		15273762