CHRM2 (cholinergic receptor muscarinic 2)

Gene

• Entrez ID: 1129
• Gene name: Cholinergic receptor muscarinic 2
• Gene symbol: CHRM2
• Synonyms: HM2
• Chromosome: 7
• Chromosome location: 7q33
• Summary: The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cycl

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017560	hsa-miR-335-5p	Microarray	18185580
MIRT617798	hsa-miR-3140-3p	HITS-CLIP	23824327
MIRT617797	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT617796	hsa-miR-29b-2-5p	HITS-CLIP	23824327
MIRT617795	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT617794	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT617793	hsa-miR-659-3p	HITS-CLIP	23824327
MIRT617797	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT617796	hsa-miR-29b-2-5p	HITS-CLIP	23824327
MIRT617795	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT617794	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT617793	hsa-miR-659-3p	HITS-CLIP	23824327
MIRT617792	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT617798	hsa-miR-3140-3p	HITS-CLIP	23824327
MIRT617797	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT617796	hsa-miR-29b-2-5p	HITS-CLIP	23824327
MIRT617795	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT617794	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT617793	hsa-miR-659-3p	HITS-CLIP	23824327
MIRT617792	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT617791	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT735110	hsa-miR-17-5p	qRT-PCR	31776299
MIRT735112	hsa-miR-582-3p	qRT-PCR	31776299
MIRT735121	hsa-miR-378a-5p	qRT-PCR	31776299
MIRT617798	hsa-miR-3140-3p	HITS-CLIP	23824327
MIRT617797	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT617796	hsa-miR-29b-2-5p	HITS-CLIP	23824327
MIRT617795	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT617794	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT617793	hsa-miR-659-3p	HITS-CLIP	23824327
MIRT617797	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT617796	hsa-miR-29b-2-5p	HITS-CLIP	23824327
MIRT617795	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT617794	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT617793	hsa-miR-659-3p	HITS-CLIP	23824327
MIRT617792	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT617798	hsa-miR-3140-3p	HITS-CLIP	23824327
MIRT617797	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT617796	hsa-miR-29b-2-5p	HITS-CLIP	23824327
MIRT617795	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT617794	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT617793	hsa-miR-659-3p	HITS-CLIP	23824327
MIRT617792	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT617791	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT891626	hsa-miR-18a	CLIP-seq
MIRT891627	hsa-miR-18b	CLIP-seq
MIRT891628	hsa-miR-200b	CLIP-seq
MIRT891629	hsa-miR-200c	CLIP-seq
MIRT891630	hsa-miR-3140-5p	CLIP-seq
MIRT891631	hsa-miR-335	CLIP-seq
MIRT891632	hsa-miR-3660	CLIP-seq
MIRT891633	hsa-miR-378g	CLIP-seq
MIRT891634	hsa-miR-4268	CLIP-seq
MIRT891635	hsa-miR-429	CLIP-seq
MIRT891636	hsa-miR-4437	CLIP-seq
MIRT891637	hsa-miR-4448	CLIP-seq
MIRT891638	hsa-miR-450b-5p	CLIP-seq
MIRT891639	hsa-miR-4526	CLIP-seq
MIRT891640	hsa-miR-4645-3p	CLIP-seq
MIRT891641	hsa-miR-4674	CLIP-seq
MIRT891642	hsa-miR-4712-3p	CLIP-seq
MIRT891643	hsa-miR-4731-5p	CLIP-seq
MIRT891644	hsa-miR-4735-3p	CLIP-seq
MIRT891645	hsa-miR-4778-3p	CLIP-seq
MIRT891646	hsa-miR-507	CLIP-seq
MIRT891647	hsa-miR-539	CLIP-seq
MIRT891648	hsa-miR-557	CLIP-seq
MIRT891649	hsa-miR-592	CLIP-seq
MIRT891650	hsa-miR-595	CLIP-seq
MIRT891651	hsa-miR-597	CLIP-seq
MIRT891652	hsa-miR-668	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004993	Function	G protein-coupled serotonin receptor activity	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0005887	Component	Integral component of plasma membrane	IDA	24256733
GO:0006940	Process	Regulation of smooth muscle contraction	IBA	21873635
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007187	Process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA	21873635
GO:0007188	Process	Adenylate cyclase-modulating G protein-coupled receptor signaling pathway	TAS	8139539
GO:0007197	Process	Adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway	IBA	21873635
GO:0007207	Process	Phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway	TAS	2739737
GO:0007213	Process	G protein-coupled acetylcholine receptor signaling pathway	IDA	24256733
GO:0007268	Process	Chemical synaptic transmission	IBA	21873635
GO:0007399	Process	Nervous system development	TAS	2739737
GO:0008016	Process	Regulation of heart contraction	IEA
GO:0009615	Process	Response to virus	IEP	16548883
GO:0016021	Component	Integral component of membrane	IDA	11566136
GO:0016907	Function	G protein-coupled acetylcholine receptor activity	IBA	21873635
GO:0016907	Function	G protein-coupled acetylcholine receptor activity	IDA	24256733
GO:0030425	Component	Dendrite	IBA	21873635
GO:0030594	Function	Neurotransmitter receptor activity	IBA	21873635
GO:0030665	Component	Clathrin-coated vesicle membrane	TAS
GO:0045202	Component	Synapse	IBA	21873635
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0061024	Process	Membrane organization	TAS
GO:0098664	Process	G protein-coupled serotonin receptor signaling pathway	IEA
GO:1990763	Function	Arrestin family protein binding	IPI	11566136

Other IDs

• MIM: 118493
• HGNC: 1951
• e!Ensembl: ENSG00000181072

Protein

• UniProt ID: P08172
• Protein name: Muscarinic acetylcholine receptor M2
• Protein function: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effec
• PDB: 3UON, 4MQS, 4MQT, 5YC8, 5ZK3, 5ZK8, 5ZKB, 5ZKC, 6OIK, 6U1N, 7T8X, 7T90, 7T94, 7T96, 8J8R, 8J97, 8JAF
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00001	7tm_1	40 → 440	7 transmembrane receptor (rhodopsin family)	Family

• Sequence:

  MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY
  FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD
  RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF
  FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRI
  VKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDE
  ITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNI
  VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT
  VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR

• Sequence length: 466

Pathways

KEGG:

Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Cholinergic synapse
Regulation of actin cytoskeleton

Reactome:

Muscarinic acetylcholine receptors
G alpha (i) signalling events
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Diabetes mellitus	Diabetes Mellitus, Insulin-Dependent, Diabetes Mellitus, Ketosis-Prone, Diabetes Mellitus, Sudden-Onset	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs4402960, rs1362648752, rs3745368, rs3792267, rs3842570, rs5030952, rs2975760, rs119489103, rs7903146, rs12255372, rs11196205, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs137852740, rs137852786, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs80356663, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356666, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs387906779, rs141804752, rs182349376, rs184917682, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs61736969, rs587783673, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs797045623, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs1553638903, rs1553638909, rs948820149, rs371977235, rs1553784995, rs76474829, rs200998587, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs776793516, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	18603373
Epilepsy	Epilepsy, Epilepsy, Cryptogenic, Awakening Epilepsy	rs113994140, rs119454947, rs28937874, rs1589762127, rs104894166, rs28939075, rs2134001459, rs104894167, rs119488099, rs119488100, rs1805032, rs387906420, rs121917752, rs121918622, rs121434579, rs1581220270, rs281865564, rs387907313, rs397514564, rs397514670, rs768241563, rs587776973, rs587776974, rs587776975, rs879255234, rs587776976, rs587776977, rs121917993, rs398123588, rs13306758, rs587777363, rs587777364, rs587777458, rs587777459, rs541024038, rs797044545, rs730882240, rs786205703, rs794726859, rs796053126, rs796053035, rs796053216, rs796052839, rs869025201, rs797044999, rs797044998, rs797045045, rs794726762, rs869312971, rs869312972, rs879255652, rs886037938, rs886037958, rs886037959, rs886037960, rs886037961, rs886037962, rs886037965, rs886037966, rs886039245, rs886039246, rs886039251, rs886039252, rs772872014, rs886039253, rs886039256, rs757511744, rs886039261, rs886039263, rs578185749, rs886039266, rs886039268, rs886039269, rs886039273, rs368820286, rs1057518801, rs1057518688, rs1057519107, rs1057519273, rs752753379, rs767795673, rs1057519424, rs755946598, rs760609867, rs1057521066, rs1057524233, rs1060501488, rs1060501487, rs755127868, rs751533302, rs771373457, rs1475605360, rs1555401942, rs1553567864, rs200661329, rs766667249, rs1556607762, rs1555882921, rs1555882867, rs1555900914, rs1553546836, rs77216276, rs755595256, rs1554169267, rs747661902, rs2105890565, rs1021001959, rs1555441032, rs1555439541, rs1556526609, rs1315483224, rs759952667, rs1555885023, rs1553456695, rs1555942720, rs1569083500, rs1559127505, rs1206309859, rs1567139896, rs1567134495, rs1431914212, rs1569166925, rs1569255443, rs1568955379, rs1567152003, rs374158137, rs1567129567, rs1569523728, rs1568991466, rs1569186093, rs1569254004, rs1372605067, rs1569067939, rs1568963062, rs1563959514, rs1569012755, rs1559118914, rs1602338615, rs1596522356, rs1364913665, rs1596522300, rs1596526976, rs1229740428, rs1596385588, rs1596500172, rs1596505517, rs1601925213, rs1601970168, rs1602010382, rs1602903591, rs1603014297, rs1603014708, rs1601875057, rs1601970824, rs1601755632, rs1587393982, rs1592977444, rs1575562076, rs1570998206, rs1588057922, rs1596528731, rs1602349641, rs1587401875, rs2065899210, rs1596526915, rs2093486364, rs2056165149, rs2056100951, rs781482552, rs1899868619, rs1900088045, rs1898675878, rs1898686157, rs1898837245, rs1898844513, rs2082841677, rs2085727988, rs2092933941, rs2091657024, rs1899864955, rs1898844907, rs2083056830, rs2084070588, rs1899713412, rs2082695884, rs1977106116, rs1977105425, rs1443687532	18333967
Esophagus neoplasm	Malignant neoplasm of esophagus	rs28934578, rs121918714, rs1567556006, rs1575166666	21642993
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	20691427

Unknown
Disease name	Disease term	dbSNP ID	References
Asymmetric diabetic proximal motor neuropathy	Asymmetric Diabetic Proximal Motor Neuropathy		20624991
Autoimmune diabetes	Diabetes, Autoimmune		18603373
Bipolar disorder	Bipolar Disorder		20351719
Brittle diabetes mellitus	Brittle diabetes		18603373
Diabetic amyotrophy	Diabetic Amyotrophy		20624991
Diabetic asymmetric polyneuropathy	Diabetic Asymmetric Polyneuropathy		20624991
Diabetic autonomic neuropathy	Diabetic Autonomic Neuropathy		20624991
Diabetic mononeuropathy	Diabetic Mononeuropathy		20624991
Diabetic nephropathy	Diabetic Neuropathies		20624991
Diabetic neuralgia	Diabetic Neuralgia		20624991
Diabetic polyneuropathy	Diabetic Polyneuropathies		20624991
Mental depression	Mental Depression, Depressive disorder	rs587778876, rs587778877	20351719, 15229186, 12116189, 19181679, 15229186, 19181679, 20351719, 12116189
Mood disorder	Mood Disorders		16000316
Neurogenic urinary bladder	Neurogenic Urinary Bladder, Neurogenic Urinary Bladder, Uninhibited		20624991
Symmetric diabetic proximal motor neuropathy	Symmetric Diabetic Proximal Motor Neuropathy		20624991