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KLF12 (KLF transcription factor 12)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
11278
Gene nameGene Name - the full gene name approved by the HGNC.
KLF transcription factor 12
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
KLF12
SynonymsGene synonyms aliases
AP-2rep, AP2REP, HSPC122
ChromosomeChromosome number
13
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
13q22.1
SummarySummary of gene provided in NCBI Entrez Gene.
Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc f
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT027368 hsa-miR-101-3p Sequencing 20371350
MIRT050396 hsa-miR-23a-3p CLASH 23622248
MIRT536465 hsa-miR-6773-3p PAR-CLIP 20371350
MIRT536463 hsa-miR-215-3p PAR-CLIP 20371350
MIRT536461 hsa-miR-6888-3p PAR-CLIP 20371350
Transcription factors
Transcription factor Regulation Reference
TFAP2A Repression 10704285
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 10704285, 16615998
GO:0000785 Component Chromatin ISA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA 21873635
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA 10704285
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID Q9Y4X4
Protein name Krueppel-like factor 12 (Transcriptional repressor AP-2rep)
Protein function Confers strong transcriptional repression to the AP-2-alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00096 zf-C2H2
317 341
Zinc finger, C2H2 type
Domain
PF00096 zf-C2H2
347 371
Zinc finger, C2H2 type
Domain
PF00096 zf-C2H2
377 399
Zinc finger, C2H2 type
Domain
Sequence
MNIHMKRKTIKNINTFENRMLMLDGMPAVRVKTELLESEQGSPNVHNYPDMEAVPLLLNN
VKGEPPEDSLSVDHFQTQTEPVDLSINKARTSPTAVSSSPVSMTASASSPSSTSTSSSSS
SRLASSPTVITSVSSASSSSTVLTPGPLVASASGVGGQQFLHIIHPVPPSSPMNLQSNKL
SHVHRIPVVVQSVPVVYTAVRSPGNVNNTIVVPLLEDGRGHGKAQMDPRGLSPRQSKSDS
DDDDLPNVTLDSVNETGSTALSIARAVQEVHPSPVSRVRGNRMNNQKFPCSISPFSIEST
RRQRRSESPDSRKRRIHRCDFEGCNKVYTKSSHLKAHRRTHTGEKPYKCTWEGCTWKFAR
SDELTRHYRKH
TGVKPFKCADCDRSFSRSDHLALHRRRHMLV
Sequence length 402
Interactions View interactions
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Narcolepsy Narcolepsy rs104894574, rs387906655 19629137
Schizophrenia Schizophrenia rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 26198764, 21822266
Unknown
Disease name Disease term dbSNP ID References
Achoo syndrome Autosomal dominant compelling helio ophthalmic outburst syndrome 27182965
Mental depression Major Depressive Disorder rs587778876, rs587778877 29071344

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