FILIP1L (filamin A interacting protein 1 like)

Gene

• Entrez ID: 11259
• Gene name: Filamin A interacting protein 1 like
• Gene symbol: FILIP1L
• Synonyms: DOC-1, DOC1, GIP130, GIP90
• Chromosome: 3
• Chromosome location: 3q12.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018948	hsa-miR-335-5p	Microarray	18185580
MIRT031073	hsa-miR-21-5p	Microarray	20371350
MIRT031073	hsa-miR-21-5p	Microarray	18591254
MIRT996921	hsa-miR-1243	CLIP-seq
MIRT996922	hsa-miR-1255a	CLIP-seq
MIRT996923	hsa-miR-1255b	CLIP-seq
MIRT996924	hsa-miR-1269	CLIP-seq
MIRT996925	hsa-miR-1269b	CLIP-seq
MIRT996926	hsa-miR-1288	CLIP-seq
MIRT996927	hsa-miR-4515	CLIP-seq
MIRT996928	hsa-miR-4740-5p	CLIP-seq
MIRT996929	hsa-miR-4792	CLIP-seq
MIRT996930	hsa-miR-106a	CLIP-seq
MIRT996931	hsa-miR-106b	CLIP-seq
MIRT996932	hsa-miR-17	CLIP-seq
MIRT996933	hsa-miR-197	CLIP-seq
MIRT996934	hsa-miR-20a	CLIP-seq
MIRT996935	hsa-miR-20b	CLIP-seq
MIRT996936	hsa-miR-3174	CLIP-seq
MIRT996937	hsa-miR-3609	CLIP-seq
MIRT996938	hsa-miR-4424	CLIP-seq
MIRT996939	hsa-miR-4796-3p	CLIP-seq
MIRT996940	hsa-miR-5096	CLIP-seq
MIRT996941	hsa-miR-519d	CLIP-seq
MIRT996942	hsa-miR-548ah	CLIP-seq
MIRT996943	hsa-miR-93	CLIP-seq
MIRT2229626	hsa-miR-1206	CLIP-seq
MIRT2229627	hsa-miR-568	CLIP-seq
MIRT2229628	hsa-miR-643	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003674	Function	Molecular_function	ND
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0008150	Process	Biological_process	ND
GO:0016020	Component	Membrane	IEA

Other IDs

• MIM: 612993
• HGNC: 24589
• e!Ensembl: ENSG00000168386

Protein

• UniProt ID: Q4L180
• Protein name: Filamin A-interacting protein 1-like (130 kDa GPBP-interacting protein) (90 kDa GPBP-interacting protein) (Protein down-regulated in ovarian cancer 1) (DOC-1)
• Protein function: Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma growth When expressed in tu
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF09727	CortBP2	63 → 248	Cortactin-binding protein-2	Family

• Sequence:

  MRSRGSDTEGSAQKKFPRHTKGHSFQGPKNMKHRQQDKDSPSESDVILPCPKAEKPHSGN
  GHQAEDLSRDDLLFLLSILEGELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQ
  RDAFQAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKR
  KHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFAL
  MVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTT
  KFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISK
  GEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKL
  SKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLE
  KTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLI
  EETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEK
  DFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLE
  RRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVD
  ALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKS
  LRPSLNGRRISDPQVFSKEVQTEAVDNEPPDYKSLIPLERAVINGQLYEESENQDEDPND
  EGSVLSFKCSQSTPCPVNRKLWIPWMKSKEGHLQNGKMQTKPNANFVQPGDLVLSHTPGQ
  PLHIKVTPDHVQNTATLEITSPTTESPHSYTSTAVIPNCGTPKQRITILQNASITPVKSK
  TSTEDLMNLEQGMSPITMATFARAQTPESCGSLTPERTMSPIQVLAVTGSASSPEQGRSP
  EPTEISAKHAIFRVSPDRQSSWQFQRSNSNSSSVITTEDNKIHIHLGSPYMQAVASPVRP
  ASPSAPLQDNRTQGLINGALNKTTNKVTSSITITPTATPLPRQSQITVEPLLLPH

• Sequence length: 1135

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Breast carcinoma	Breast Carcinoma	rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451, rs397507859, rs80359709, rs80359742, rs80359205, rs80357627, rs80357004, rs80357571, rs80357767, rs80357653, rs80358086, rs80357608, rs28897696, rs41293465, rs146650273, rs63751017, rs63750617, rs63750726, rs63750199, rs63749848, rs398122618, rs398122653, rs397509211, rs80357791, rs121912666, rs587778541, rs121908698, rs536907995, rs587781302, rs140342925, rs587781506, rs587782652, rs587782849, rs587783057, rs10520699, rs11852999, rs139770721, rs374950566, rs786202800, rs863224451, rs377153250, rs747727055, rs876658804, rs780001540, rs760815829, rs878854926, rs775248597, rs886040658, rs886040192, rs786203523, rs886040319, rs397508006, rs587782011, rs1060502772, rs1555461727, rs1553333072, rs1114167702, rs1257401983, rs886040950, rs1060502759, rs774684620, rs142947311, rs1555580883, rs748513310, rs376170600, rs863224499, rs1593909229, rs748453607, rs1294578913, rs1574737047, rs1593909960, rs2081922847, rs2082559544, rs2053694038	29059683

Unknown
Disease name	Disease term	dbSNP ID	References
Coronary heart disease	Coronary heart disease	rs9289231, rs281864746	22751097