PTGDR2 (prostaglandin D2 receptor 2)

Gene

• Entrez ID: 11251
• Gene name: Prostaglandin D2 receptor 2
• Gene symbol: PTGDR2
• Synonyms: CD294, CRTH2, DL1R, DP2, GPR44
• Chromosome: 11
• Chromosome location: 11q12.2
• Summary: This gene encodes a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells. This protein is a prostaglandin D2 receptor that mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocyt

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT647268	hsa-miR-302c-3p	HITS-CLIP	23824327
MIRT647267	hsa-miR-520f-3p	HITS-CLIP	23824327
MIRT647266	hsa-miR-6715a-3p	HITS-CLIP	23824327
MIRT647265	hsa-miR-3183	HITS-CLIP	23824327
MIRT647264	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT647263	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT647262	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT647261	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT647260	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT647259	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT647258	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT647257	hsa-miR-5695	HITS-CLIP	23824327
MIRT647256	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT647255	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT647254	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT647253	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT647252	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT647251	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT647250	hsa-miR-103a-2-5p	HITS-CLIP	23824327
MIRT647249	hsa-miR-6715b-3p	HITS-CLIP	23824327
MIRT647248	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT647247	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT647246	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT647245	hsa-miR-513c-5p	HITS-CLIP	23824327
MIRT647244	hsa-miR-514b-5p	HITS-CLIP	23824327
MIRT647243	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT647242	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT647241	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT647240	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT647239	hsa-miR-1238-3p	HITS-CLIP	23824327
MIRT647268	hsa-miR-302c-3p	HITS-CLIP	23824327
MIRT647267	hsa-miR-520f-3p	HITS-CLIP	23824327
MIRT647266	hsa-miR-6715a-3p	HITS-CLIP	23824327
MIRT647265	hsa-miR-3183	HITS-CLIP	23824327
MIRT647264	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT647263	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT647262	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT647261	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT647260	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT647259	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT647258	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT647257	hsa-miR-5695	HITS-CLIP	23824327
MIRT647256	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT647255	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT647254	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT647253	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT647252	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT647251	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT647250	hsa-miR-103a-2-5p	HITS-CLIP	23824327
MIRT647249	hsa-miR-6715b-3p	HITS-CLIP	23824327
MIRT647248	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT647247	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT647246	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT647245	hsa-miR-513c-5p	HITS-CLIP	23824327
MIRT647244	hsa-miR-514b-5p	HITS-CLIP	23824327
MIRT647243	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT647242	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT647241	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT647240	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT647239	hsa-miR-1238-3p	HITS-CLIP	23824327

Transcription factors

Transcription factor	Regulation	Reference
TBX21	Repression	14500650

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001785	Function	Prostaglandin J receptor activity	IEA
GO:0004930	Function	G protein-coupled receptor activity	IBA	21873635
GO:0004930	Function	G protein-coupled receptor activity	IDA	11208866
GO:0004956	Function	Prostaglandin D receptor activity	IBA	21873635
GO:0004956	Function	Prostaglandin D receptor activity	IDA	11208866
GO:0004958	Function	Prostaglandin F receptor activity	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0006935	Process	Chemotaxis	IDA	11208866
GO:0006955	Process	Immune response	TAS	9973380
GO:0007186	Process	G protein-coupled receptor signaling pathway	IDA	11208866
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007193	Process	Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IEA
GO:0007218	Process	Neuropeptide signaling pathway	IBA	21873635
GO:0019722	Process	Calcium-mediated signaling	IDA	11208866
GO:0042277	Function	Peptide binding	IBA	21873635
GO:0042923	Function	Neuropeptide binding	IBA	21873635
GO:0043005	Component	Neuron projection	IBA	21873635
GO:0045745	Process	Positive regulation of G protein-coupled receptor signaling pathway	IEA
GO:2000255	Process	Negative regulation of male germ cell proliferation	IEA

Other IDs

• MIM: 604837
• HGNC: 4502
• e!Ensembl: ENSG00000183134

Protein

• UniProt ID: Q9Y5Y4
• Protein name: Prostaglandin D2 receptor 2 (Chemoattractant receptor-homologous molecule expressed on Th2 cells) (G-protein coupled receptor 44) (CD antigen CD294)
• Protein function: Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2
• PDB: 6D26, 6D27, 7M8W, 8XXU, 8XXV, 9IYB
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00001	7tm_1	49 → 304	7 transmembrane receptor (rhodopsin family)	Family

• Sequence:

  MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCR
  MRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGF
  LLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRI
  MCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRR
  PGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVAN
  PVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRP
  EEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS

• Sequence length: 395

Pathways

Reactome:

Prostanoid ligand receptors
G alpha (i) signalling events

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Asthma	Asthma, Asthma, Aspirin-Induced	rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283	27103662, 20485159