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PADI2 (peptidyl arginine deiminase 2)

Gene

11240

Peptidyl arginine deiminase 2

PADI2

PAD-H19, PAD2, PDI2

1p36.13

This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distin

Show/Hide all(254)

miRTarBase ID	miRNA	Experiments	Reference
MIRT655549	hsa-miR-5088-3p	HITS-CLIP	19536157
MIRT655548	hsa-miR-6734-3p	HITS-CLIP	19536157
MIRT655547	hsa-miR-3667-3p	HITS-CLIP	19536157
MIRT655544	hsa-miR-623	HITS-CLIP	19536157
MIRT655543	hsa-miR-204-5p	HITS-CLIP	19536157
MIRT655542	hsa-miR-211-5p	HITS-CLIP	19536157
MIRT655541	hsa-miR-4713-5p	HITS-CLIP	19536157
MIRT655540	hsa-miR-6867-3p	HITS-CLIP	19536157
MIRT655539	hsa-miR-4755-5p	HITS-CLIP	19536157
MIRT655537	hsa-miR-5006-3p	HITS-CLIP	19536157
MIRT655538	hsa-miR-629-3p	HITS-CLIP	19536157
MIRT655551	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT655550	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT655549	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT655548	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT655547	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT655546	hsa-miR-3128	HITS-CLIP	23824327
MIRT655545	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT655544	hsa-miR-623	HITS-CLIP	23824327
MIRT655543	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT655542	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT655541	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT655540	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT655539	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT655537	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT655538	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT625830	hsa-miR-8485	HITS-CLIP	23824327
MIRT625829	hsa-miR-4643	HITS-CLIP	23824327
MIRT625830	hsa-miR-8485	HITS-CLIP	23824327
MIRT625829	hsa-miR-4643	HITS-CLIP	23824327
MIRT498285	hsa-miR-4418	PAR-CLIP	22291592
MIRT498284	hsa-miR-509-3-5p	PAR-CLIP	22291592
MIRT498283	hsa-miR-509-5p	PAR-CLIP	22291592
MIRT498282	hsa-miR-3158-5p	PAR-CLIP	22291592
MIRT498281	hsa-miR-2467-3p	PAR-CLIP	22291592
MIRT498280	hsa-miR-3678-3p	PAR-CLIP	22291592
MIRT655549	hsa-miR-5088-3p	HITS-CLIP	19536157
MIRT655548	hsa-miR-6734-3p	HITS-CLIP	19536157
MIRT655547	hsa-miR-3667-3p	HITS-CLIP	19536157
MIRT655544	hsa-miR-623	HITS-CLIP	19536157
MIRT655543	hsa-miR-204-5p	HITS-CLIP	19536157
MIRT655542	hsa-miR-211-5p	HITS-CLIP	19536157
MIRT655541	hsa-miR-4713-5p	HITS-CLIP	19536157
MIRT655540	hsa-miR-6867-3p	HITS-CLIP	19536157
MIRT655539	hsa-miR-4755-5p	HITS-CLIP	19536157
MIRT655537	hsa-miR-5006-3p	HITS-CLIP	19536157
MIRT655538	hsa-miR-629-3p	HITS-CLIP	19536157
MIRT655551	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT655550	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT655549	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT655548	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT655547	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT655546	hsa-miR-3128	HITS-CLIP	23824327
MIRT655545	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT655544	hsa-miR-623	HITS-CLIP	23824327
MIRT655543	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT655542	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT655541	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT655540	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT655539	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT655537	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT655538	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT625830	hsa-miR-8485	HITS-CLIP	23824327
MIRT625829	hsa-miR-4643	HITS-CLIP	23824327
MIRT625830	hsa-miR-8485	HITS-CLIP	23824327
MIRT625829	hsa-miR-4643	HITS-CLIP	23824327
MIRT498285	hsa-miR-4418	PAR-CLIP	22291592
MIRT498284	hsa-miR-509-3-5p	PAR-CLIP	22291592
MIRT498283	hsa-miR-509-5p	PAR-CLIP	22291592
MIRT498282	hsa-miR-3158-5p	PAR-CLIP	22291592
MIRT498281	hsa-miR-2467-3p	PAR-CLIP	22291592
MIRT498280	hsa-miR-3678-3p	PAR-CLIP	22291592
MIRT1210193	hsa-miR-1276	CLIP-seq
MIRT1210194	hsa-miR-183	CLIP-seq
MIRT1210195	hsa-miR-3179	CLIP-seq
MIRT1210196	hsa-miR-3182	CLIP-seq
MIRT1210197	hsa-miR-374a	CLIP-seq
MIRT1210198	hsa-miR-374b	CLIP-seq
MIRT1210199	hsa-miR-4263	CLIP-seq
MIRT1210200	hsa-miR-4311	CLIP-seq
MIRT1210201	hsa-miR-4420	CLIP-seq
MIRT1210202	hsa-miR-4509	CLIP-seq
MIRT1210203	hsa-miR-4659a-3p	CLIP-seq
MIRT1210204	hsa-miR-4659b-3p	CLIP-seq
MIRT1210205	hsa-miR-4688	CLIP-seq
MIRT1210206	hsa-miR-4729	CLIP-seq
MIRT1210207	hsa-miR-4733-3p	CLIP-seq
MIRT1210208	hsa-miR-4744	CLIP-seq
MIRT1210209	hsa-miR-4760-3p	CLIP-seq
MIRT1210210	hsa-miR-4799-5p	CLIP-seq
MIRT1210211	hsa-miR-486-3p	CLIP-seq
MIRT1210212	hsa-miR-576-5p	CLIP-seq
MIRT1210213	hsa-miR-579	CLIP-seq
MIRT1210214	hsa-miR-583	CLIP-seq
MIRT1210215	hsa-miR-664	CLIP-seq
MIRT1210193	hsa-miR-1276	CLIP-seq
MIRT1210200	hsa-miR-4311	CLIP-seq
MIRT1210208	hsa-miR-4744	CLIP-seq
MIRT1210214	hsa-miR-583	CLIP-seq
MIRT2060261	hsa-miR-1182	CLIP-seq
MIRT2060262	hsa-miR-124	CLIP-seq
MIRT2060263	hsa-miR-1271	CLIP-seq
MIRT2060264	hsa-miR-135a	CLIP-seq
MIRT2060265	hsa-miR-135b	CLIP-seq
MIRT2060266	hsa-miR-182	CLIP-seq
MIRT2060267	hsa-miR-193a-5p	CLIP-seq
MIRT2060268	hsa-miR-2964a-5p	CLIP-seq
MIRT2060269	hsa-miR-3120-5p	CLIP-seq
MIRT2060270	hsa-miR-3123	CLIP-seq
MIRT2060271	hsa-miR-3130-3p	CLIP-seq
MIRT2060272	hsa-miR-3134	CLIP-seq
MIRT2060273	hsa-miR-3201	CLIP-seq
MIRT2060274	hsa-miR-346	CLIP-seq
MIRT2060275	hsa-miR-3919	CLIP-seq
MIRT2060276	hsa-miR-4270	CLIP-seq
MIRT2060277	hsa-miR-4288	CLIP-seq
MIRT2060278	hsa-miR-4299	CLIP-seq
MIRT2060279	hsa-miR-4426	CLIP-seq
MIRT2060280	hsa-miR-4441	CLIP-seq
MIRT2060281	hsa-miR-4470	CLIP-seq
MIRT2060282	hsa-miR-4502	CLIP-seq
MIRT2060283	hsa-miR-4647	CLIP-seq
MIRT2060284	hsa-miR-4662b	CLIP-seq
MIRT1210205	hsa-miR-4688	CLIP-seq
MIRT2060285	hsa-miR-4712-3p	CLIP-seq
MIRT2060286	hsa-miR-4791	CLIP-seq
MIRT2060287	hsa-miR-4793-3p	CLIP-seq
MIRT2060288	hsa-miR-506	CLIP-seq
MIRT2060289	hsa-miR-548an	CLIP-seq
MIRT2060290	hsa-miR-632	CLIP-seq
MIRT2060291	hsa-miR-9	CLIP-seq
MIRT2060292	hsa-miR-96	CLIP-seq
MIRT2060261	hsa-miR-1182	CLIP-seq
MIRT2288664	hsa-miR-1245b-5p	CLIP-seq
MIRT2288665	hsa-miR-1253	CLIP-seq
MIRT2288666	hsa-miR-1256	CLIP-seq
MIRT2288667	hsa-miR-1266	CLIP-seq
MIRT1210193	hsa-miR-1276	CLIP-seq
MIRT2288668	hsa-miR-1287	CLIP-seq
MIRT2288669	hsa-miR-1321	CLIP-seq
MIRT2288670	hsa-miR-1587	CLIP-seq
MIRT2288671	hsa-miR-185	CLIP-seq
MIRT2288672	hsa-miR-197	CLIP-seq
MIRT2288673	hsa-miR-203	CLIP-seq
MIRT738859	hsa-miR-214	CLIP-seq
MIRT2288674	hsa-miR-31	CLIP-seq
MIRT2060270	hsa-miR-3123	CLIP-seq
MIRT2288675	hsa-miR-3135b	CLIP-seq
MIRT2288676	hsa-miR-3142	CLIP-seq
MIRT2288677	hsa-miR-3147	CLIP-seq
MIRT2288678	hsa-miR-3150a-3p	CLIP-seq
MIRT2288679	hsa-miR-3164	CLIP-seq
MIRT2288680	hsa-miR-3173-3p	CLIP-seq
MIRT2288681	hsa-miR-3175	CLIP-seq
MIRT1210195	hsa-miR-3179	CLIP-seq
MIRT2288682	hsa-miR-3190	CLIP-seq
MIRT2288683	hsa-miR-326	CLIP-seq
MIRT2288684	hsa-miR-330-5p	CLIP-seq
MIRT2288685	hsa-miR-34a	CLIP-seq
MIRT2288686	hsa-miR-34c-5p	CLIP-seq
MIRT2288687	hsa-miR-3545-3p	CLIP-seq
MIRT2288688	hsa-miR-3612	CLIP-seq
MIRT738861	hsa-miR-3619-5p	CLIP-seq
MIRT2288689	hsa-miR-3652	CLIP-seq
MIRT2288690	hsa-miR-3664-3p	CLIP-seq
MIRT2288691	hsa-miR-3714	CLIP-seq
MIRT2060275	hsa-miR-3919	CLIP-seq
MIRT2288692	hsa-miR-3974	CLIP-seq
MIRT1210199	hsa-miR-4263	CLIP-seq
MIRT2060276	hsa-miR-4270	CLIP-seq
MIRT2288693	hsa-miR-4283	CLIP-seq
MIRT738863	hsa-miR-4291	CLIP-seq
MIRT2060278	hsa-miR-4299	CLIP-seq
MIRT2288694	hsa-miR-4306	CLIP-seq
MIRT1210200	hsa-miR-4311	CLIP-seq
MIRT1210201	hsa-miR-4420	CLIP-seq
MIRT2288695	hsa-miR-4425	CLIP-seq
MIRT2060279	hsa-miR-4426	CLIP-seq
MIRT2288696	hsa-miR-4430	CLIP-seq
MIRT2060280	hsa-miR-4441	CLIP-seq
MIRT2288697	hsa-miR-4457	CLIP-seq
MIRT2060281	hsa-miR-4470	CLIP-seq
MIRT2288698	hsa-miR-4476	CLIP-seq
MIRT2288699	hsa-miR-4489	CLIP-seq
MIRT2288700	hsa-miR-4492	CLIP-seq
MIRT2288701	hsa-miR-4498	CLIP-seq
MIRT2288702	hsa-miR-449a	CLIP-seq
MIRT2288703	hsa-miR-449b	CLIP-seq
MIRT2060282	hsa-miR-4502	CLIP-seq
MIRT1210202	hsa-miR-4509	CLIP-seq
MIRT2288704	hsa-miR-450b-5p	CLIP-seq
MIRT2288705	hsa-miR-4511	CLIP-seq
MIRT2288706	hsa-miR-4518	CLIP-seq
MIRT2288707	hsa-miR-4644	CLIP-seq
MIRT2288708	hsa-miR-4645-5p	CLIP-seq
MIRT2060283	hsa-miR-4647	CLIP-seq
MIRT2288709	hsa-miR-4656	CLIP-seq
MIRT2060284	hsa-miR-4662b	CLIP-seq
MIRT2288710	hsa-miR-4667-5p	CLIP-seq
MIRT2288711	hsa-miR-4673	CLIP-seq
MIRT2288712	hsa-miR-4674	CLIP-seq
MIRT2288713	hsa-miR-4675	CLIP-seq
MIRT2288714	hsa-miR-4680-5p	CLIP-seq
MIRT2288715	hsa-miR-4682	CLIP-seq
MIRT2288716	hsa-miR-4687-3p	CLIP-seq
MIRT1210205	hsa-miR-4688	CLIP-seq
MIRT2288717	hsa-miR-4695-5p	CLIP-seq
MIRT2288718	hsa-miR-4700-5p	CLIP-seq
MIRT2288719	hsa-miR-4709-5p	CLIP-seq
MIRT2288720	hsa-miR-4717-5p	CLIP-seq
MIRT2288721	hsa-miR-4720-5p	CLIP-seq
MIRT2288722	hsa-miR-4728-3p	CLIP-seq
MIRT1210206	hsa-miR-4729	CLIP-seq
MIRT2288723	hsa-miR-4739	CLIP-seq
MIRT2288724	hsa-miR-4741	CLIP-seq
MIRT2288725	hsa-miR-4742-5p	CLIP-seq
MIRT1210208	hsa-miR-4744	CLIP-seq
MIRT2288726	hsa-miR-4756-5p	CLIP-seq
MIRT2288727	hsa-miR-4757-5p	CLIP-seq
MIRT738858	hsa-miR-4797-5p	CLIP-seq
MIRT2288728	hsa-miR-4799-3p	CLIP-seq
MIRT1210210	hsa-miR-4799-5p	CLIP-seq
MIRT2288729	hsa-miR-485-5p	CLIP-seq
MIRT1210211	hsa-miR-486-3p	CLIP-seq
MIRT2288730	hsa-miR-493	CLIP-seq
MIRT2288731	hsa-miR-507	CLIP-seq
MIRT2288732	hsa-miR-5096	CLIP-seq
MIRT2288733	hsa-miR-513b	CLIP-seq
MIRT2060289	hsa-miR-548an	CLIP-seq
MIRT2288734	hsa-miR-548c-3p	CLIP-seq
MIRT2288735	hsa-miR-557	CLIP-seq
MIRT1210212	hsa-miR-576-5p	CLIP-seq
MIRT1210214	hsa-miR-583	CLIP-seq
MIRT2288736	hsa-miR-604	CLIP-seq
MIRT2288737	hsa-miR-630	CLIP-seq
MIRT2288738	hsa-miR-637	CLIP-seq
MIRT2288739	hsa-miR-645	CLIP-seq
MIRT2288740	hsa-miR-647	CLIP-seq
MIRT2288741	hsa-miR-650	CLIP-seq
MIRT2288742	hsa-miR-671-5p	CLIP-seq
MIRT2288743	hsa-miR-7	CLIP-seq
MIRT738860	hsa-miR-761	CLIP-seq
MIRT2288744	hsa-miR-762	CLIP-seq
MIRT2288745	hsa-miR-873	CLIP-seq
MIRT2288746	hsa-miR-892a	CLIP-seq
MIRT738862	hsa-miR-922	CLIP-seq
MIRT2288747	hsa-miR-924	CLIP-seq
MIRT2288748	hsa-miR-939	CLIP-seq
MIRT2288749	hsa-miR-940	CLIP-seq
MIRT2465794	hsa-miR-1264	CLIP-seq
MIRT2465795	hsa-miR-1324	CLIP-seq
MIRT2465796	hsa-miR-3925-3p	CLIP-seq
MIRT2465797	hsa-miR-618	CLIP-seq
MIRT2465798	hsa-miR-766	CLIP-seq

Show/Hide all(25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004668	Function	Protein-arginine deiminase activity	IBA	21873635
GO:0004668	Function	Protein-arginine deiminase activity	IDA	12392711, 15629448, 18645041, 22853951, 25621824
GO:0005509	Function	Calcium ion binding	IDA	25621824
GO:0005576	Component	Extracellular region	TAS
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	IDA	12392711
GO:0005829	Component	Cytosol	TAS
GO:0006325	Process	Chromatin organization	TAS
GO:0010848	Process	Regulation of chromatin disassembly	IDA	22853951
GO:0018101	Process	Protein citrullination	IDA	12392711, 15629448, 25621824
GO:0021762	Process	Substantia nigra development	HEP	22926577
GO:0030331	Function	Estrogen receptor binding	IPI	22853951
GO:0030520	Process	Intracellular estrogen receptor signaling pathway	IMP	22853951
GO:0035327	Component	Transcriptionally active chromatin	IDA	22853951
GO:0035578	Component	Azurophil granule lumen	TAS
GO:0036413	Process	Histone H3-R26 citrullination	IDA	22853951
GO:0036414	Process	Histone citrullination	IBA	21873635
GO:0042803	Function	Protein homodimerization activity	IDA	25621824
GO:0043312	Process	Neutrophil degranulation	TAS
GO:0048096	Process	Chromatin-mediated maintenance of transcription	IMP	22853951
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0070100	Process	Negative regulation of chemokine-mediated signaling pathway	IDA	18645041
GO:1901624	Process	Negative regulation of lymphocyte chemotaxis	IDA	18645041
GO:1990830	Process	Cellular response to leukemia inhibitory factor	IEA

MIM	HGNC	e!Ensembl
607935	18341	ENSG00000117115

Protein

UniProt ID

Q9Y2J8

Protein name

Protein-arginine deiminase type-2 (EC 3.5.3.15) (PAD-H19) (Peptidylarginine deiminase II) (Protein-arginine deiminase type II)

Protein function

Catalyzes the deimination of arginine residues of proteins.

PDB

4N20 , 4N22 , 4N24 , 4N25 , 4N26 , 4N28 , 4N2A , 4N2B , 4N2C , 4N2D , 4N2E , 4N2F , 4N2G , 4N2H , 4N2I , 4N2K , 4N2L , 4N2M , 4N2N , 9B96 , 9B97 , 9B98

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF08526	PAD_N	1 → 114	Protein-arginine deiminase (PAD) N-terminal domain	Domain
PF08527	PAD_M	116 → 274	Protein-arginine deiminase (PAD) middle domain	Domain
PF03068	PAD	284 → 662	Protein-arginine deiminase (PAD)	Family

Sequence

MLRERTVRLQYGSRVEAVYVLGTYLWTDVYSAAPAGAQTFSLKHSEHVWVEVVRDGEAEE
VATNGKQRWLLSPSTTLRVTMSQASTEASSDKVTVNYYDEEGSIPIDQAGLFLTAIEISL
DVDADRDGVVEKNNPKKASWTWGPEGQGAILLVNCDRETPWLPKEDCRDEKVYSKEDLKD
MSQMILRTKGPDRLPAGYEIVLYISMSDSDKVGVFYVENPFFGQRYIHILGRRKLYHVVK
YTGGSAELLFFVEGLCFPDEGFSGLVSIHVSLLEYMAQDIPLTPIFTDTVIFRIAPWIMT
PNILPPVSVFVCCMKDNYLFLKEVKNLVEKTNCELKVCFQYLNRGDRWIQDEIEFGYIEA
PHKGFPVVLDSPRDGNLKDFPVKELLGPDFGYVTREPLFESVTSLDSFGNLEVSPPVTVN
GKTYPLGRILIGSSFPLSGGRRMTKVVRDFLKAQQVQAPVELYSDWLTVGHVDEFMSFVP
IPGTKKFLLLMASTSACYKLFREKQKDGHGEAIMFKGLGGMSSKRITINKILSNESLVQE
NLYFQRCLDWNRDILKKELGLTEQDIIDLPALFKMDEDHRARAFFPNMVNMIVLDKDLGI
PKPFGPQVEEECCLEMHVRGLLEPLGLECTFIDDISAYHKFLGEVHCGTNVRRKPFTFKW
WHMVP

Sequence length

665

Interactions

View interactions

	Reactome
			Chromatin modifying enzymes Neutrophil degranulation

Associated diseases

Show/Hide Causal Diseases (1)

Causal
Disease name	Disease term	dbSNP ID	References
Rheumatoid arthritis	Rheumatoid Arthritis	rs3766379, rs3792876, rs2071592, rs3087456, rs587776843, rs1566328963, rs2240340, rs1557787212	30423114

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