CHN2 (chimerin 2)

Gene

• Entrez ID: 1124
• Gene name: Chimerin 2
• Gene symbol: CHN2
• Synonyms: ARHGAP3, BCH, CHN2-3, RHOGAP3
• Chromosome: 7
• Chromosome location: 7p14.3
• Summary: This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that contains a phorbol-ester/diacylglycerol (DAG)-type zinc finger, a Rho-GAP domain, and an SH2 domain. The encoded protein translocates from the cytosol to the Golgi apparatus membra

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT890926	hsa-miR-1184	CLIP-seq
MIRT890927	hsa-miR-1205	CLIP-seq
MIRT890928	hsa-miR-1290	CLIP-seq
MIRT890929	hsa-miR-1302	CLIP-seq
MIRT890930	hsa-miR-132	CLIP-seq
MIRT890931	hsa-miR-198	CLIP-seq
MIRT890932	hsa-miR-212	CLIP-seq
MIRT890933	hsa-miR-3122	CLIP-seq
MIRT890934	hsa-miR-3148	CLIP-seq
MIRT890935	hsa-miR-3158-5p	CLIP-seq
MIRT890936	hsa-miR-3167	CLIP-seq
MIRT890937	hsa-miR-3199	CLIP-seq
MIRT890938	hsa-miR-3913-5p	CLIP-seq
MIRT890939	hsa-miR-421	CLIP-seq
MIRT890940	hsa-miR-4298	CLIP-seq
MIRT890941	hsa-miR-455-3p	CLIP-seq
MIRT890942	hsa-miR-4704-3p	CLIP-seq
MIRT890943	hsa-miR-4709-5p	CLIP-seq
MIRT890944	hsa-miR-4778-3p	CLIP-seq
MIRT890945	hsa-miR-505	CLIP-seq
MIRT890946	hsa-miR-5096	CLIP-seq
MIRT890947	hsa-miR-511	CLIP-seq
MIRT890948	hsa-miR-520d-5p	CLIP-seq
MIRT890949	hsa-miR-524-5p	CLIP-seq
MIRT890950	hsa-miR-548c-3p	CLIP-seq
MIRT890951	hsa-miR-665	CLIP-seq
MIRT890952	hsa-miR-876-5p	CLIP-seq
MIRT890953	hsa-miR-3126-5p	CLIP-seq
MIRT890954	hsa-miR-4419a	CLIP-seq
MIRT890955	hsa-miR-4510	CLIP-seq
MIRT890956	hsa-miR-4672	CLIP-seq
MIRT890957	hsa-miR-624	CLIP-seq
MIRT1964121	hsa-miR-3941	CLIP-seq
MIRT2200277	hsa-miR-200b	CLIP-seq
MIRT2200278	hsa-miR-200c	CLIP-seq
MIRT2200279	hsa-miR-202	CLIP-seq
MIRT2200280	hsa-miR-2117	CLIP-seq
MIRT2200281	hsa-miR-217	CLIP-seq
MIRT2200282	hsa-miR-3120-3p	CLIP-seq
MIRT890953	hsa-miR-3126-5p	CLIP-seq
MIRT2200283	hsa-miR-3127-5p	CLIP-seq
MIRT2200284	hsa-miR-3150b-3p	CLIP-seq
MIRT2200285	hsa-miR-3662	CLIP-seq
MIRT2200286	hsa-miR-369-3p	CLIP-seq
MIRT2200287	hsa-miR-4257	CLIP-seq
MIRT2200288	hsa-miR-4273	CLIP-seq
MIRT2200289	hsa-miR-429	CLIP-seq
MIRT2200290	hsa-miR-4418	CLIP-seq
MIRT890954	hsa-miR-4419a	CLIP-seq
MIRT890955	hsa-miR-4510	CLIP-seq
MIRT2200291	hsa-miR-4666-3p	CLIP-seq
MIRT890956	hsa-miR-4672	CLIP-seq
MIRT2200292	hsa-miR-4689	CLIP-seq
MIRT2200293	hsa-miR-4698	CLIP-seq
MIRT2200294	hsa-miR-4784	CLIP-seq
MIRT2200295	hsa-miR-509-3-5p	CLIP-seq
MIRT2200296	hsa-miR-509-5p	CLIP-seq
MIRT2200297	hsa-miR-545	CLIP-seq
MIRT2200298	hsa-miR-548p	CLIP-seq
MIRT2200299	hsa-miR-597	CLIP-seq
MIRT890957	hsa-miR-624	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005096	Function	GTPase activator activity	IBA	21873635
GO:0005096	Function	GTPase activator activity	IDA	8175705
GO:0005515	Function	Protein binding	IPI	16628218, 32296183
GO:0005829	Component	Cytosol	TAS
GO:0016020	Component	Membrane	IEA
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0043087	Process	Regulation of GTPase activity	IBA	21873635
GO:0043547	Process	Positive regulation of GTPase activity	IEA
GO:0045202	Component	Synapse	IDA	8175705
GO:0046872	Function	Metal ion binding	IEA
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	TAS

Other IDs

• MIM: 602857
• HGNC: 1944
• e!Ensembl: ENSG00000106069

Protein

• UniProt ID: P52757
• Protein name: Beta-chimaerin (Beta-chimerin) (Rho GTPase-activating protein 3)
• Protein function: GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low-grade to high-grade tumors.
• PDB: 1XA6
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00017	SH2	60 → 129	SH2 domain	Domain
  PF00130	C1_1	215 → 267	Phorbol esters/diacylglycerol binding domain (C1 domain)	Domain
  PF00620	RhoGAP	291 → 444	RhoGAP domain	Domain

• Sequence:

  MAASSNSSLSGSSVSSDAEEYQPPIWKSYLYQLQQEAPRPKRIICPREVENRPKYYGREF
  HGIISREQADELLGGVEGAYILRESQRQPGCYTLALRFGNQTLNYRLFHDGKHFVGEKRF
  ESIHDLVTDGLITLYIETKAAEYISKMTTNPIYEHIGYATLLREKVSRRLSRSKNEPRKT
  NVTHEEHTAVEKISSLVRRAALTHNDNHFNYEKTHNFKVHTFRGPHWCEYCANFMWGLIA
  QGVRCSDCGLNVHKQCSKHVPNDCQPDLKRIKKVYCCDLTTLVKAHNTQRPMVVDICIRE
  IEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADISANVYPDINIITGALKLYFRDLP
  IPVITYDTYSKFIDAAKISNADERLEAVHEVLMLLPPAHYETLRYLMIHLKKVTMNEKDN
  FMNAENLGIVFGPTLMRPPEDSTLTTLHDMRYQKLIVQILIENEDVLF

• Sequence length: 468

Pathways

Reactome:

Rho GTPase cycle

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Alzheimer disease	Alzheimer`s Disease	rs63750215, rs28936379, rs63749851, rs63749884, rs28936380, rs63750048, rs63750579, rs63750264, rs63749964, rs63750671, rs281865161, rs63750066, rs63750399, rs63750734, rs63751039, rs63750973, rs63749810, rs63750643, rs193922916, rs63750306, rs63750590, rs63750526, rs63751235, rs661, rs63751037, rs63749885, rs63750231, rs63751229, rs63751272, rs63751223, rs63750391, rs63751163, rs281875357, rs63751141, rs63750082, rs121917807, rs63751399, rs63750265, rs63751144, rs63750886, rs63751068, rs121917808, rs63749891, rs63750083, rs63749824, rs63750577, rs267606983, rs63750218, rs63751287, rs63750900, rs145518263, rs63751475, rs63750450, rs63749805, rs63751278, rs63751106, rs63750004, rs63749806, rs63751024, rs63750248, rs63750779, rs63751139, rs63750219, rs63750298, rs63750687, rs63750851, rs1553268799, rs1561901881, rs1561905293, rs866101707, rs1566638673, rs63750009, rs1566656702, rs1566657804, rs1567885728, rs1568339995, rs1566630791, rs1555358260, rs63750964, rs1594998354, rs63751316	26830138
Leukemia	Leukemia, Myelocytic, Acute	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297, rs11978267, rs4132601	27903959

Unknown
Disease name	Disease term	dbSNP ID	References
Diabetic nephropathy	Diabetic Nephropathy		19252134
Liver neoplasms	Liver neoplasms		19233941
Liver cancer	Malignant neoplasm of liver		19233941
Psychosis	Psychotic Disorders		24132900
Reactive psychosis	Other and unspecified reactive psychosis		24132900