POLI (DNA polymerase iota)

Gene

• Entrez ID: 11201
• Gene name: DNA polymerase iota
• Gene symbol: POLI
• Synonyms: RAD30B, RAD3OB, eta2
• Chromosome: 18
• Chromosome location: 18q21.2
• Summary: The protein encoded by this gene is an error-prone DNA polymerase involved in DNA repair. The encoded protein promotes DNA synthesis across lesions in the template DNA, which other polymerases cannot do. The encoded polymerase inserts deoxynucleotides acr

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT049053	hsa-miR-92a-3p	CLASH	23622248
MIRT497086	hsa-miR-455-5p	PAR-CLIP	22291592
MIRT450749	hsa-miR-4786-5p	PAR-CLIP	22291592
MIRT450750	hsa-miR-769-5p	PAR-CLIP	22291592
MIRT450748	hsa-miR-548aj-5p	PAR-CLIP	22291592
MIRT450747	hsa-miR-548f-5p	PAR-CLIP	22291592
MIRT450746	hsa-miR-548g-5p	PAR-CLIP	22291592
MIRT450745	hsa-miR-548x-5p	PAR-CLIP	22291592
MIRT450744	hsa-miR-1468-3p	PAR-CLIP	22291592
MIRT290693	hsa-miR-19a-3p	PAR-CLIP	22291592
MIRT290694	hsa-miR-19b-3p	PAR-CLIP	22291592
MIRT497085	hsa-miR-376a-5p	PAR-CLIP	22291592
MIRT450743	hsa-miR-340-5p	PAR-CLIP	22291592
MIRT450742	hsa-miR-3672	PAR-CLIP	22291592
MIRT450741	hsa-miR-6864-3p	PAR-CLIP	22291592
MIRT290698	hsa-miR-548aw	PAR-CLIP	22291592
MIRT290697	hsa-miR-4760-5p	PAR-CLIP	22291592
MIRT290699	hsa-miR-8061	PAR-CLIP	22291592
MIRT450753	hsa-miR-142-3p	PAR-CLIP	22100165
MIRT450752	hsa-miR-1277-5p	PAR-CLIP	22100165
MIRT199034	hsa-miR-5197-3p	PAR-CLIP	22100165
MIRT199032	hsa-miR-4255	PAR-CLIP	22100165
MIRT199031	hsa-miR-27b-5p	PAR-CLIP	22100165
MIRT450751	hsa-miR-889-3p	PAR-CLIP	22100165
MIRT199033	hsa-miR-3591-5p	PAR-CLIP	22100165
MIRT450749	hsa-miR-4786-5p	PAR-CLIP	22100165
MIRT450750	hsa-miR-769-5p	PAR-CLIP	22100165
MIRT450748	hsa-miR-548aj-5p	PAR-CLIP	22100165
MIRT450747	hsa-miR-548f-5p	PAR-CLIP	22100165
MIRT450746	hsa-miR-548g-5p	PAR-CLIP	22100165
MIRT450745	hsa-miR-548x-5p	PAR-CLIP	22100165
MIRT450744	hsa-miR-1468-3p	PAR-CLIP	22100165
MIRT290693	hsa-miR-19a-3p	PAR-CLIP	22100165
MIRT290694	hsa-miR-19b-3p	PAR-CLIP	22100165
MIRT450743	hsa-miR-340-5p	PAR-CLIP	22100165
MIRT450742	hsa-miR-3672	PAR-CLIP	22100165
MIRT450741	hsa-miR-6864-3p	PAR-CLIP	22100165
MIRT290698	hsa-miR-548aw	PAR-CLIP	22100165
MIRT450749	hsa-miR-4786-5p	PAR-CLIP	27292025
MIRT497086	hsa-miR-455-5p	PAR-CLIP	22291592
MIRT450749	hsa-miR-4786-5p	PAR-CLIP	22291592
MIRT450750	hsa-miR-769-5p	PAR-CLIP	22291592
MIRT450748	hsa-miR-548aj-5p	PAR-CLIP	22291592
MIRT450747	hsa-miR-548f-5p	PAR-CLIP	22291592
MIRT450746	hsa-miR-548g-5p	PAR-CLIP	22291592
MIRT450745	hsa-miR-548x-5p	PAR-CLIP	22291592
MIRT450744	hsa-miR-1468-3p	PAR-CLIP	22291592
MIRT290693	hsa-miR-19a-3p	PAR-CLIP	22291592
MIRT290694	hsa-miR-19b-3p	PAR-CLIP	22291592
MIRT497085	hsa-miR-376a-5p	PAR-CLIP	22291592
MIRT450743	hsa-miR-340-5p	PAR-CLIP	22291592
MIRT450742	hsa-miR-3672	PAR-CLIP	22291592
MIRT450741	hsa-miR-6864-3p	PAR-CLIP	22291592
MIRT290698	hsa-miR-548aw	PAR-CLIP	22291592
MIRT290697	hsa-miR-4760-5p	PAR-CLIP	22291592
MIRT290699	hsa-miR-8061	PAR-CLIP	22291592
MIRT450753	hsa-miR-142-3p	PAR-CLIP	22100165
MIRT450752	hsa-miR-1277-5p	PAR-CLIP	22100165
MIRT199034	hsa-miR-5197-3p	PAR-CLIP	22100165
MIRT199032	hsa-miR-4255	PAR-CLIP	22100165
MIRT199031	hsa-miR-27b-5p	PAR-CLIP	22100165
MIRT450751	hsa-miR-889-3p	PAR-CLIP	22100165
MIRT199033	hsa-miR-3591-5p	PAR-CLIP	22100165
MIRT450749	hsa-miR-4786-5p	PAR-CLIP	22100165
MIRT450750	hsa-miR-769-5p	PAR-CLIP	22100165
MIRT450748	hsa-miR-548aj-5p	PAR-CLIP	22100165
MIRT450747	hsa-miR-548f-5p	PAR-CLIP	22100165
MIRT450746	hsa-miR-548g-5p	PAR-CLIP	22100165
MIRT450745	hsa-miR-548x-5p	PAR-CLIP	22100165
MIRT450744	hsa-miR-1468-3p	PAR-CLIP	22100165
MIRT290693	hsa-miR-19a-3p	PAR-CLIP	22100165
MIRT290694	hsa-miR-19b-3p	PAR-CLIP	22100165
MIRT450743	hsa-miR-340-5p	PAR-CLIP	22100165
MIRT450742	hsa-miR-3672	PAR-CLIP	22100165
MIRT450741	hsa-miR-6864-3p	PAR-CLIP	22100165
MIRT290698	hsa-miR-548aw	PAR-CLIP	22100165
MIRT1247913	hsa-miR-1271	CLIP-seq
MIRT1247914	hsa-miR-1273	CLIP-seq
MIRT1247915	hsa-miR-1273e	CLIP-seq
MIRT1247916	hsa-miR-1276	CLIP-seq
MIRT1247917	hsa-miR-1298	CLIP-seq
MIRT1247918	hsa-miR-139-5p	CLIP-seq
MIRT1247919	hsa-miR-1537	CLIP-seq
MIRT1247920	hsa-miR-181a	CLIP-seq
MIRT1247921	hsa-miR-181b	CLIP-seq
MIRT1247922	hsa-miR-181c	CLIP-seq
MIRT1247923	hsa-miR-181d	CLIP-seq
MIRT1247924	hsa-miR-182	CLIP-seq
MIRT1247925	hsa-miR-1827	CLIP-seq
MIRT1247926	hsa-miR-194	CLIP-seq
MIRT1247927	hsa-miR-224	CLIP-seq
MIRT1247928	hsa-miR-23a	CLIP-seq
MIRT1247929	hsa-miR-23b	CLIP-seq
MIRT1247930	hsa-miR-23c	CLIP-seq
MIRT1247931	hsa-miR-2964a-3p	CLIP-seq
MIRT1247932	hsa-miR-302f	CLIP-seq
MIRT1247933	hsa-miR-3120-5p	CLIP-seq
MIRT1247934	hsa-miR-3143	CLIP-seq
MIRT1247935	hsa-miR-3145-5p	CLIP-seq
MIRT1247936	hsa-miR-3160-3p	CLIP-seq
MIRT1247937	hsa-miR-3174	CLIP-seq
MIRT1247938	hsa-miR-3192	CLIP-seq
MIRT1247939	hsa-miR-3200-3p	CLIP-seq
MIRT1247940	hsa-miR-335	CLIP-seq
MIRT1247941	hsa-miR-3605-5p	CLIP-seq
MIRT1247942	hsa-miR-3620	CLIP-seq
MIRT1247943	hsa-miR-3664-5p	CLIP-seq
MIRT1247944	hsa-miR-3689a-3p	CLIP-seq
MIRT1247945	hsa-miR-3689c	CLIP-seq
MIRT1247946	hsa-miR-3929	CLIP-seq
MIRT1247947	hsa-miR-4252	CLIP-seq
MIRT1247948	hsa-miR-4262	CLIP-seq
MIRT1247949	hsa-miR-4292	CLIP-seq
MIRT1247950	hsa-miR-4311	CLIP-seq
MIRT1247951	hsa-miR-4419b	CLIP-seq
MIRT1247952	hsa-miR-4459	CLIP-seq
MIRT1247953	hsa-miR-4478	CLIP-seq
MIRT1247954	hsa-miR-4486	CLIP-seq
MIRT1247955	hsa-miR-4487	CLIP-seq
MIRT1247956	hsa-miR-4522	CLIP-seq
MIRT1247957	hsa-miR-4649-3p	CLIP-seq
MIRT1247958	hsa-miR-4649-5p	CLIP-seq
MIRT1247959	hsa-miR-4662a-5p	CLIP-seq
MIRT1247960	hsa-miR-4668-5p	CLIP-seq
MIRT1247961	hsa-miR-4695-5p	CLIP-seq
MIRT1247962	hsa-miR-4722-5p	CLIP-seq
MIRT1247963	hsa-miR-4728-5p	CLIP-seq
MIRT1247964	hsa-miR-4747-3p	CLIP-seq
MIRT1247965	hsa-miR-4768-3p	CLIP-seq
MIRT1247966	hsa-miR-4797-5p	CLIP-seq
MIRT1247967	hsa-miR-485-5p	CLIP-seq
MIRT1247968	hsa-miR-490-3p	CLIP-seq
MIRT1247969	hsa-miR-508-5p	CLIP-seq
MIRT1247970	hsa-miR-515-5p	CLIP-seq
MIRT1247971	hsa-miR-543	CLIP-seq
MIRT1247972	hsa-miR-558	CLIP-seq
MIRT1247973	hsa-miR-583	CLIP-seq
MIRT1247974	hsa-miR-658	CLIP-seq
MIRT1247975	hsa-miR-664	CLIP-seq
MIRT1247976	hsa-miR-888	CLIP-seq
MIRT1247977	hsa-miR-889	CLIP-seq
MIRT1247978	hsa-miR-921	CLIP-seq
MIRT1247979	hsa-miR-940	CLIP-seq
MIRT1247980	hsa-miR-96	CLIP-seq
MIRT1247915	hsa-miR-1273e	CLIP-seq
MIRT1247925	hsa-miR-1827	CLIP-seq
MIRT2073174	hsa-miR-190	CLIP-seq
MIRT2073175	hsa-miR-190b	CLIP-seq
MIRT1247931	hsa-miR-2964a-3p	CLIP-seq
MIRT1247932	hsa-miR-302f	CLIP-seq
MIRT1247936	hsa-miR-3160-3p	CLIP-seq
MIRT2073176	hsa-miR-3160-5p	CLIP-seq
MIRT1247937	hsa-miR-3174	CLIP-seq
MIRT1247938	hsa-miR-3192	CLIP-seq
MIRT2073177	hsa-miR-3664-3p	CLIP-seq
MIRT1247944	hsa-miR-3689a-3p	CLIP-seq
MIRT1247945	hsa-miR-3689c	CLIP-seq
MIRT1247946	hsa-miR-3929	CLIP-seq
MIRT1247951	hsa-miR-4419b	CLIP-seq
MIRT2073178	hsa-miR-4433	CLIP-seq
MIRT1247952	hsa-miR-4459	CLIP-seq
MIRT1247953	hsa-miR-4478	CLIP-seq
MIRT1247955	hsa-miR-4487	CLIP-seq
MIRT2073179	hsa-miR-4520a-3p	CLIP-seq
MIRT2073180	hsa-miR-4520b-3p	CLIP-seq
MIRT1247957	hsa-miR-4649-3p	CLIP-seq
MIRT1247961	hsa-miR-4695-5p	CLIP-seq
MIRT1247962	hsa-miR-4722-5p	CLIP-seq
MIRT1247963	hsa-miR-4728-5p	CLIP-seq
MIRT2073181	hsa-miR-4753-3p	CLIP-seq
MIRT1247965	hsa-miR-4768-3p	CLIP-seq
MIRT2073182	hsa-miR-4768-5p	CLIP-seq
MIRT1247967	hsa-miR-485-5p	CLIP-seq
MIRT1247968	hsa-miR-490-3p	CLIP-seq
MIRT2073183	hsa-miR-510	CLIP-seq
MIRT2073184	hsa-miR-512-5p	CLIP-seq
MIRT2073185	hsa-miR-526b	CLIP-seq
MIRT1247972	hsa-miR-558	CLIP-seq
MIRT2073186	hsa-miR-578	CLIP-seq
MIRT1247973	hsa-miR-583	CLIP-seq
MIRT1247974	hsa-miR-658	CLIP-seq
MIRT2073187	hsa-miR-890	CLIP-seq
MIRT1247978	hsa-miR-921	CLIP-seq
MIRT2073188	hsa-miR-935	CLIP-seq
MIRT1247979	hsa-miR-940	CLIP-seq
MIRT2300290	hsa-miR-1295	CLIP-seq
MIRT2300291	hsa-miR-1299	CLIP-seq
MIRT2300292	hsa-miR-1303	CLIP-seq
MIRT2300293	hsa-miR-15a	CLIP-seq
MIRT2300294	hsa-miR-15b	CLIP-seq
MIRT2300295	hsa-miR-16	CLIP-seq
MIRT1247925	hsa-miR-1827	CLIP-seq
MIRT2300296	hsa-miR-195	CLIP-seq
MIRT2300297	hsa-miR-3126-3p	CLIP-seq
MIRT2300298	hsa-miR-3140-3p	CLIP-seq
MIRT1247936	hsa-miR-3160-3p	CLIP-seq
MIRT1247937	hsa-miR-3174	CLIP-seq
MIRT1247938	hsa-miR-3192	CLIP-seq
MIRT1247944	hsa-miR-3689a-3p	CLIP-seq
MIRT1247945	hsa-miR-3689c	CLIP-seq
MIRT1247946	hsa-miR-3929	CLIP-seq
MIRT2300299	hsa-miR-424	CLIP-seq
MIRT2300300	hsa-miR-4253	CLIP-seq
MIRT2300301	hsa-miR-4279	CLIP-seq
MIRT1247951	hsa-miR-4419b	CLIP-seq
MIRT2300302	hsa-miR-4422	CLIP-seq
MIRT2073178	hsa-miR-4433	CLIP-seq
MIRT1247953	hsa-miR-4478	CLIP-seq
MIRT1247955	hsa-miR-4487	CLIP-seq
MIRT2300303	hsa-miR-451b	CLIP-seq
MIRT1247957	hsa-miR-4649-3p	CLIP-seq
MIRT2300304	hsa-miR-4661-5p	CLIP-seq
MIRT1247963	hsa-miR-4728-5p	CLIP-seq
MIRT1247964	hsa-miR-4747-3p	CLIP-seq
MIRT2300305	hsa-miR-4761-5p	CLIP-seq
MIRT1247965	hsa-miR-4768-3p	CLIP-seq
MIRT1247968	hsa-miR-490-3p	CLIP-seq
MIRT2300306	hsa-miR-497	CLIP-seq
MIRT2300307	hsa-miR-520f	CLIP-seq
MIRT1247972	hsa-miR-558	CLIP-seq
MIRT1247974	hsa-miR-658	CLIP-seq
MIRT2300308	hsa-miR-765	CLIP-seq
MIRT2300309	hsa-miR-875-3p	CLIP-seq
MIRT1247978	hsa-miR-921	CLIP-seq
MIRT2300310	hsa-miR-922	CLIP-seq
MIRT2456866	hsa-miR-3136-3p	CLIP-seq
MIRT2456867	hsa-miR-4637	CLIP-seq
MIRT2456868	hsa-miR-548aa	CLIP-seq
MIRT1247933	hsa-miR-3120-5p	CLIP-seq
MIRT1247943	hsa-miR-3664-5p	CLIP-seq
MIRT1247956	hsa-miR-4522	CLIP-seq
MIRT1247966	hsa-miR-4797-5p	CLIP-seq
MIRT1247970	hsa-miR-515-5p	CLIP-seq
MIRT2597058	hsa-miR-759	CLIP-seq
MIRT1247933	hsa-miR-3120-5p	CLIP-seq
MIRT2073177	hsa-miR-3664-3p	CLIP-seq
MIRT1247943	hsa-miR-3664-5p	CLIP-seq
MIRT2300300	hsa-miR-4253	CLIP-seq
MIRT2073178	hsa-miR-4433	CLIP-seq
MIRT1247952	hsa-miR-4459	CLIP-seq
MIRT1247956	hsa-miR-4522	CLIP-seq
MIRT1247961	hsa-miR-4695-5p	CLIP-seq
MIRT2688344	hsa-miR-4761-3p	CLIP-seq
MIRT1247965	hsa-miR-4768-3p	CLIP-seq
MIRT1247966	hsa-miR-4797-5p	CLIP-seq
MIRT2073183	hsa-miR-510	CLIP-seq
MIRT2073184	hsa-miR-512-5p	CLIP-seq
MIRT1247970	hsa-miR-515-5p	CLIP-seq
MIRT2597058	hsa-miR-759	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003684	Function	Damaged DNA binding	IEA
GO:0003887	Function	DNA-directed DNA polymerase activity	IBA	21873635
GO:0003887	Function	DNA-directed DNA polymerase activity	TAS
GO:0005515	Function	Protein binding	IPI	16189514, 16763556, 18923427, 19060904, 21516116, 25416956, 30659753, 32296183, 32814053
GO:0005654	Component	Nucleoplasm	TAS
GO:0006260	Process	DNA replication	IEA
GO:0006281	Process	DNA repair	TAS	10458907
GO:0016607	Component	Nuclear speck	IDA
GO:0019985	Process	Translesion synthesis	IBA	21873635
GO:0019985	Process	Translesion synthesis	TAS
GO:0036464	Component	Cytoplasmic ribonucleoprotein granule	IDA
GO:0042276	Process	Error-prone translesion synthesis	TAS
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 605252
• HGNC: 9182
• e!Ensembl: ENSG00000101751

Protein

• UniProt ID: Q9UNA4
• Protein name: DNA polymerase iota (EC 2.7.7.7) (Eta2) (RAD30 homolog B)
• Protein function: Error-prone DNA polymerase specifically involved in DNA repair (PubMed:11013228, PubMed:11387224). Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls (PubMed:1
• PDB: 1T3N, 1ZET, 2ALZ, 2DPI, 2DPJ, 2FLL, 2FLN, 2FLP, 2KHU, 2KHW, 2KTF, 2L0F, 2L0G, 2MBB, 3EPG, 3EPI, 3G6V, 3G6X, 3G6Y, 3GV5, 3GV7, 3GV8, 3H40, 3H4B, 3H4D, 3NGD, 3OSN, 3Q8P, 3Q8Q, 3Q8R, 3Q8S, 4EBC, 4EBD, 4EBE, 4EYH, 4EYI, 4FS1, 4FS2, 5KT2, 5KT3, 5KT4, 5KT5, 5KT6, 5KT7, 5ULW, 5ULX
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00817	IMS	58 → 236	impB/mucB/samB family	Family
  PF11799	IMS_C	320 → 446	impB/mucB/samB family C-terminal domain	Domain

• Sequence:

  MEKLGVEPEEEGGGDDDEEDAEAWAMELADVGAAASSQGVHDQVLPTPNASSRVIVHVDL
  DCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVN
  GEDLTRYREMSYKVTELLEEFSPVVERLGFDENFVDLTEMVEKRLQQLQSDELSAVTVSG
  HVYNNQSINLLDVLHIRLLVGSQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKP
  NQQTVLLPESCQHLIHSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGI
  SVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKCSSEVEAKNKIEELLASLLNRVCQD
  GRKPHTVRLIIRRYSSEKHYGRESRQCPIPSHVIQKLGTGNYDVMTPMVDILMKLFRNMV
  NVKMPFHLTLLSVCFCNLKALNTAKKGLIDYYLMPSLSTTSRSGKHSFKMKDTHMEDFPK
  DKETNRDFLPSGRIESTRTRESPLDTTNFSKEKDINEFPLCSLPEGVDQEVFKQLPVDIQ
  EEILSGKSREKFQGKGSVSCPLHASRGVLSFFSKKQMQDIPINPRDHLSSSKQVSSVSPC
  EPGTSGFNSSSSSYMSSQKDYSYYLDNRLKDERISQGPKEPQGFHFTNSNPAVSAFHSFP
  NLQSEQLFSRNHTTDSHKQTVATDSHEGLTENREPDSVDEKITFPSDIDPQVFYELPEAV
  QKELLAEWKRAGSDFHIGHK

• Sequence length: 740

Pathways

KEGG:

Fanconi anemia pathway

Reactome:

Translesion synthesis by POLI
Termination of translesion DNA synthesis

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Asthma	Asthma, Childhood asthma	rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283	30929738
Narcolepsy	Narcolepsy	rs104894574, rs387906655	19629137
Psoriasis	Psoriasis	rs281875215, rs587777763, rs281875213, rs281875212	23143594, 25903422, 25574825

Unknown
Disease name	Disease term	dbSNP ID	References
Eczema	Eczema		30595370