CEP250 (centrosomal protein 250)

Gene

• Entrez ID: 11190
• Gene name: Centrosomal protein 250
• Gene symbol: CEP250
• Synonyms: C-NAP1, CEP2, CNAP1, CRDHL2
• Chromosome: 20
• Chromosome location: 20q11.22
• Summary: This gene encodes a core centrosomal protein required for centriole-centriole cohesion during interphase of the cell cycle. The encoded protein dissociates from the centrosomes when parental centrioles separate at the beginning of mitosis. The protein ass

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs749314857	C>A,T	Pathogenic	Coding sequence variant, non coding transcript variant, stop gained, synonymous variant
rs774702094	C>G,T	Pathogenic	Non coding transcript variant, coding sequence variant, stop gained, missense variant
rs1341298773	C>T	Pathogenic	Genic upstream transcript variant, stop gained, coding sequence variant, non coding transcript variant, upstream transcript variant, 5 prime UTR variant
rs1369076411	C>T	Pathogenic	5 prime UTR variant, coding sequence variant, non coding transcript variant, genic upstream transcript variant, stop gained
rs1568820302	A>T	Pathogenic	Stop gained, non coding transcript variant, coding sequence variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT046692	hsa-miR-222-3p	CLASH	23622248
MIRT042169	hsa-miR-484	CLASH	23622248
MIRT040255	hsa-miR-615-3p	CLASH	23622248
MIRT1962756	hsa-miR-1252	CLIP-seq
MIRT1962757	hsa-miR-1253	CLIP-seq
MIRT1962758	hsa-miR-3173-3p	CLIP-seq
MIRT1962759	hsa-miR-3689d	CLIP-seq
MIRT1962760	hsa-miR-425	CLIP-seq
MIRT1962761	hsa-miR-4428	CLIP-seq
MIRT1962762	hsa-miR-4434	CLIP-seq
MIRT1962763	hsa-miR-4516	CLIP-seq
MIRT1962764	hsa-miR-642b	CLIP-seq
MIRT2199083	hsa-miR-105	CLIP-seq
MIRT2199084	hsa-miR-1236	CLIP-seq
MIRT2199085	hsa-miR-124	CLIP-seq
MIRT2199086	hsa-miR-125a-3p	CLIP-seq
MIRT2199087	hsa-miR-1262	CLIP-seq
MIRT2199088	hsa-miR-1292	CLIP-seq
MIRT2199089	hsa-miR-1321	CLIP-seq
MIRT2199090	hsa-miR-1343	CLIP-seq
MIRT2199091	hsa-miR-1915	CLIP-seq
MIRT2199092	hsa-miR-219-1-3p	CLIP-seq
MIRT2199093	hsa-miR-3152-5p	CLIP-seq
MIRT2199094	hsa-miR-3162-5p	CLIP-seq
MIRT2199095	hsa-miR-326	CLIP-seq
MIRT2199096	hsa-miR-330-5p	CLIP-seq
MIRT2199097	hsa-miR-3678-3p	CLIP-seq
MIRT2199098	hsa-miR-3682-5p	CLIP-seq
MIRT2199099	hsa-miR-4259	CLIP-seq
MIRT2199100	hsa-miR-4471	CLIP-seq
MIRT2199101	hsa-miR-4646-5p	CLIP-seq
MIRT2199102	hsa-miR-4699-3p	CLIP-seq
MIRT2199103	hsa-miR-4701-3p	CLIP-seq
MIRT2199104	hsa-miR-4708-3p	CLIP-seq
MIRT2199105	hsa-miR-4726-3p	CLIP-seq
MIRT2199106	hsa-miR-4739	CLIP-seq
MIRT2199107	hsa-miR-4756-5p	CLIP-seq
MIRT2199108	hsa-miR-4774-3p	CLIP-seq
MIRT2199109	hsa-miR-506	CLIP-seq
MIRT2199110	hsa-miR-571	CLIP-seq
MIRT2199111	hsa-miR-587	CLIP-seq
MIRT2199112	hsa-miR-629	CLIP-seq
MIRT2199090	hsa-miR-1343	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000086	Process	G2/M transition of mitotic cell cycle	TAS
GO:0000278	Process	Mitotic cell cycle	IDA	12140259
GO:0001750	Component	Photoreceptor outer segment	ISS
GO:0001917	Component	Photoreceptor inner segment	ISS
GO:0005515	Function	Protein binding	IPI	10880350, 20300119, 20708153, 32814053
GO:0005813	Component	Centrosome	IDA	9647649, 21399614, 31974111
GO:0005814	Component	Centriole	IDA	18851962, 24421332, 26337392, 27623382
GO:0005814	Component	Centriole	IDA	11076968
GO:0005815	Component	Microtubule organizing center	NAS	9647649
GO:0005829	Component	Cytosol	TAS
GO:0008022	Function	Protein C-terminus binding	IPI	18851962
GO:0008104	Process	Protein localization	IMP	18851962, 23213374
GO:0010389	Process	Regulation of G2/M transition of mitotic cell cycle	TAS
GO:0010457	Process	Centriole-centriole cohesion	IMP	11076968, 18851962, 23213374, 24554434
GO:0019901	Function	Protein kinase binding	IPI	9647649
GO:0019904	Function	Protein domain specific binding	IPI	24554434
GO:0030997	Process	Regulation of centriole-centriole cohesion	IDA	9647649
GO:0032991	Component	Protein-containing complex	IMP	10880350
GO:0033365	Process	Protein localization to organelle	IMP	24554434
GO:0036064	Component	Ciliary basal body	ISS
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0050908	Process	Detection of light stimulus involved in visual perception	ISS
GO:0060271	Process	Cilium assembly	IMP	28005958
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0097711	Process	Ciliary basal body-plasma membrane docking	TAS
GO:1904781	Process	Positive regulation of protein localization to centrosome	IMP	27623382
GO:1905515	Process	Non-motile cilium assembly	IMP	23789104

Other IDs

• MIM: 609689
• HGNC: 1859
• e!Ensembl: ENSG00000126001

Protein

• UniProt ID: Q9BV73
• Protein name: Centrosome-associated protein CEP250 (250 kDa centrosomal protein) (Cep250) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Centrosomal protein 2)
• Protein function: Plays an important role in centrosome cohesion during interphase (PubMed:30404835, PubMed:36282799). Recruits CCDC102B to the proximal ends of centrioles (PubMed:30404835). Maintains centrosome cohesion by forming intercentriolar linkages (PubMe
• PDB: 6OQA
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15035	Rootletin	39 → 215		Family

• Sequence:

  METRSPGLNNMKPQSLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQ
  AKVLQYRSWCQELEKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQL
  RLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSL
  WREVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDG
  REPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNE
  DYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIA
  QGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQ
  QQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLE
  VLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLS
  ELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVK
  LSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEK
  NTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQ
  EEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQN
  SVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEG
  KTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEA
  IQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKL
  KEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLV
  AQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQ
  ELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRA
  SLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESR
  PELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRD
  VLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHE
  TMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEED
  LRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETL
  RGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQERE
  QKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLAL
  ELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTV
  LARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKI
  LEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVEC
  QQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQS
  LQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGE
  LQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVE
  TRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGK
  EQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQL
  QQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQ
  LTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALR
  QTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRR
  ALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVA
  RLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRG
  QKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQ
  APEATVLEAETRRLDESLTQSLTSPGPVLLHPSPSTTQAASR

• Sequence length: 2442

Pathways

Reactome:

Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
AURKA Activation by TPX2

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Hearing loss	Sensorineural Hearing Loss (disorder)	rs267607135, rs267606855, rs779841884, rs267606854, rs28942097, rs121908073, rs121908076, rs74315289, rs121908144, rs111033313, rs74315437, rs121908348, rs121908349, rs121908350, rs397515359, rs180177151, rs180177154, rs180177153, rs35689081, rs35887622, rs80338944, rs104894396, rs104894398, rs80338947, rs80338948, rs80338942, rs104894402, rs104894403, rs80338945, rs28931594, rs80338940, rs80338941, rs80356590, rs80338950, rs387906706, rs387906707, rs387906708, rs398122848, rs387907016, rs587776894, rs387907088, rs397515411, rs370965183, rs398122930, rs199897298, rs111033187, rs111033448, rs199606180, rs111033284, rs397516413, rs111033305, rs111033220, rs111033256, rs111033297, rs111033253, rs104894408, rs111033295, rs397516874, rs76434661, rs111033335, rs397517323, rs111033247, rs367928692, rs374793617, rs143939430, rs397515605, rs80338939, rs200656442, rs779748859, rs587781261, rs587781262, rs143343083, rs200147906, rs730880338, rs797044491, rs146281367, rs756484720, rs869025593, rs201306709, rs540895576, rs777777359, rs879255246, rs1554358720, rs142498437, rs377145777, rs1057517519, rs779077039, rs952741388, rs1060499797, rs764139009, rs1060499590, rs1064794012, rs1064797115, rs756790858, rs775633137, rs1554952443, rs1554952193, rs782063761, rs1199012623, rs756147087, rs1555648043, rs1555661490, rs1553196233, rs781546107, rs111033190, rs775428246, rs782539587, rs537227442, rs148695069, rs1554835827, rs953422571, rs1554834186, rs1554834161, rs1554835103, rs1554577339, rs1554577402, rs768471577, rs782279338, rs781951909, rs998045226, rs375759781, rs755804651, rs1557458426, rs767797828, rs538027448, rs1559366084, rs367688416, rs1558480402, rs1558490542, rs1559870857, rs1560690591, rs1561299289, rs1562817224, rs1562817529, rs1562822565, rs1562835391, rs1564113368, rs1564554255, rs773851192, rs1564555240, rs761261855, rs1564805114, rs1565522273, rs1565127413, rs781790246, rs1565430886, rs1565469959, rs746667217, rs1565819402, rs1565855932, rs150529554, rs1567939793, rs201866631, rs754472294, rs1559372512, rs1558464965, rs1558488902, rs775062249, rs1226171550, rs1561590396, rs765574676, rs762876554, rs757327146, rs1564949059, rs1565519673, rs368050948, rs1565541888, rs781989117, rs1565402473, rs750358148, rs1386887007, rs1209665716, rs1567641234, rs1237955948, rs1569042782, rs752672077, rs146689036, rs1560070780, rs149712664, rs1564556995, rs762226905, rs773573968, rs1568528171, rs1198256157, rs377267777, rs370564476, rs1577876794, rs747787770, rs759432278, rs1043716893, rs1581138934, rs2033773650, rs1421964916, rs771766431, rs780917129, rs1895773215, rs1895769400, rs761543680, rs1565920060
Usher syndrome	Usher Syndrome	rs80338903, rs397518008, rs111033367, rs121912598, rs121912599, rs80338902, rs111033364, rs111033272, rs121912600, rs587776538, rs111033334, rs137852839, rs137852840, rs2133130286, rs104894651, rs730880268, rs397515345, rs587776546, rs104894652, rs121908140, rs121908141, rs1085307049, rs111033258, rs121908142, rs111033267, rs1553776036, rs121908347, rs111033270, rs727502931, rs121908349, rs121908350, rs111033271, rs121908351, rs796051861, rs121908354, rs1307471318, rs137853001, rs199469706, rs111033260, rs137853003, rs137853004, rs1480243085, rs397515359, rs55983148, rs151045328, rs1403777293, rs121908370, rs121909762, rs796051863, rs796051864, rs796051865, rs121909763, rs796051866, rs796051867, rs121965079, rs41298133, rs1555062984, rs28934610, rs121965080, rs121965081, rs121965082, rs121965083, rs35689081, rs121965085, rs1555102843, rs113624356, rs267606932, rs201539845, rs387906700, rs1554135663, rs775098953, rs786200928, rs786205115, rs786205116, rs587776894, rs1589229634, rs1306987034, rs778110397, rs111033415, rs111033206, rs111033180, rs111033201, rs111033290, rs397516295, rs111033233, rs199897298, rs397516303, rs111033178, rs397516304, rs111033347, rs111033403, rs111033187, rs397516308, rs397516315, rs111033174, rs111033448, rs111033182, rs397516317, rs368657015, rs397516321, rs397516322, rs111033215, rs199606180, rs397516323, rs111033192, rs111033232, rs397516326, rs111033198, rs111033486, rs111033283, rs397516330, rs397516332, rs111033284, rs111033285, rs397517329, rs397517342, rs183431253, rs367928692, rs397517350, rs370983472, rs397517353, rs397517367, rs371981035, rs397517451, rs397517452, rs202033121, rs397517925, rs397517932, rs374963432, rs397517964, rs369522997, rs111033379, rs111033264, rs202175091, rs111033265, rs111033418, rs111033382, rs397517973, rs397517974, rs397517976, rs397517977, rs397517978, rs151148854, rs111033526, rs111033518, rs397517981, rs397517983, rs397517984, rs111033385, rs397517988, rs397517989, rs397517990, rs397517994, rs111033273, rs397518003, rs397518010, rs397518011, rs397518012, rs397518013, rs397518014, rs397518015, rs375668376, rs397518021, rs397518022, rs397518023, rs111033386, rs111033268, rs397518029, rs111033280, rs397518036, rs397518039, rs397518041, rs397518043, rs41308425, rs397518048, rs73090721, rs111033263, rs267600727, rs398124618, rs398124619, rs137853923, rs483353055, rs483353056, rs527236132, rs527236131, rs527236133, rs527236139, rs527236138, rs527236137, rs527236124, rs527236135, rs527236136, rs727504551, rs727505116, rs727503731, rs146733615, rs727504867, rs727503715, rs727505343, rs727503723, rs727503725, rs730880349, rs727505337, rs727503736, rs727504893, rs727504301, rs727503329, rs373169422, rs730880367, rs376764423, rs377670513, rs797044491, rs797044492, rs797044510, rs782252317, rs797044511, rs797044516, rs797044518, rs746523071, rs786204428, rs748706627, rs750228923, rs794727408, rs794727579, rs201657446, rs372347027, rs148660051, rs779791079, rs753330544, rs794729204, rs797045113, rs368049814, rs863224941, rs876657624, rs886037762, rs869312182, rs869312180, rs869312179, rs869312178, rs754391973, rs869312181, rs876657415, rs1057519383, rs760225886, rs766590491, rs876657733, rs876657731, rs397517963, rs876657730, rs773404494, rs876657754, rs753886326, rs876657655, rs782255281, rs1555090368, rs878853233, rs775177930, rs368675850, rs878853407, rs878853413, rs878853405, rs878853404, rs765293412, rs878853410, rs878853378, rs751130485, rs886039450, rs886039449, rs748810737, rs886039867, rs886039893, rs886041502, rs750396156, rs371777049, rs773539640, rs886043626, rs1057517533, rs536593247, rs373208120, rs1057516687, rs1057517224, rs989521806, rs1057516560, rs1057516613, rs1057516351, rs1057516472, rs1057516821, rs758921360, rs1057516780, rs1057516268, rs770832663, rs1057516656, rs1057516974, rs1057517325, rs1057517284, rs758685587, rs1057516342, rs201328768, rs757027638, rs781148814, rs138983888, rs1057517261, rs1057517443, rs1057516474, rs1057517150, rs1057517251, rs1057516892, rs758947077, rs370261904, rs1057517048, rs1057516470, rs1057517182, rs1057517264, rs1057516992, rs1057516770, rs138138689, rs377145777, rs201892914, rs376535635, rs374536346, rs752179149, rs1057518826, rs1057519193, rs1057519225, rs369793306, rs759898765, rs397517979, rs199840367, rs1057520662, rs763797356, rs1057520709, rs1060499714, rs1060499716, rs1060499796, rs1060499800, rs1060499801, rs747656448, rs1064793289, rs200712760, rs1064795047, rs1064793745, rs137954284, rs750803248, rs1064795722, rs750358148, rs1064797134, rs1064797136, rs1064797138, rs1064797153, rs753886165, rs1553258031, rs539192853, rs749702843, rs1003869920, rs1553252388, rs762159022, rs1362058696, rs1553252528, rs1553257502, rs1288381992, rs1285853856, rs1388040238, rs751111524, rs1035024403, rs1553298240, rs746551311, rs1215540106, rs780308389, rs1338169194, rs772808534, rs1554090072, rs777309662, rs1554117973, rs749956288, rs1355262412, rs1555051390, rs116892396, rs782166819, rs782063761, rs1555078942, rs1171417339, rs1555090294, rs1199012623, rs1383147250, rs1555069238, rs1461319754, rs750880909, rs1264310782, rs1553299022, rs754768875, rs1555627787, rs1366496013, rs774573692, rs534534437, rs769838859, rs762551629, rs761469964, rs201730567, rs769348776, rs1553327452, rs1553320397, rs757696771, rs199679165, rs143344549, rs777465132, rs769215629, rs769433759, rs1555051455, rs782539587, rs751176116, rs1553268563, rs141672841, rs866435331, rs782077721, rs1553320542, rs1554857840, rs1554877007, rs936479651, rs148695069, rs1561416879, rs765476745, rs768161313, rs1553252499, rs1553248234, rs1553250192, rs1553252041, rs1177257719, rs200871041, rs1553248216, rs1553261478, rs757676723, rs747160949, rs764917754, rs1295968274, rs764182950, rs753505333, rs747063294, rs1553252052, rs367674026, rs779572631, rs1553257707, rs746447649, rs1553268562, rs1553271002, rs1431048303, rs749452910, rs1553273330, rs1553274448, rs779716464, rs1553257705, rs1485173724, rs1553261372, rs1553250050, rs1553285919, rs1553287118, rs1553250150, rs1553299079, rs1162305984, rs1553250184, rs199782530, rs370327669, rs944675223, rs199982344, rs1553313308, rs1553261479, rs988693758, rs760302201, rs1553313810, rs1414935620, rs749726310, rs1380261595, rs770383273, rs993185407, rs483353054, rs1553273412, rs1269642027, rs1553268582, rs762608746, rs780779563, rs1553287070, rs1553294144, rs772124060, rs1553258122, rs775293551, rs1553272201, rs754374132, rs1553300016, rs1553274424, rs1553300558, rs772100045, rs771051185, rs1553272176, rs1553273421, rs143521854, rs1553300340, rs745350407, rs756623509, rs764797292, rs1284826852, rs767078782, rs1342455785, rs1553320451, rs1177198729, rs372927796, rs1553250627, rs1394737087, rs748961218, rs771583281, rs1188025733, rs868562952, rs758571672, rs1553250952, rs1171672823, rs758303489, rs1553257761, rs1484339054, rs1553258097, rs1553258037, rs781223647, rs376155416, rs1553776061, rs1553776112, rs1553776052, rs1553776135, rs1553772595, rs1553776132, rs1554822897, rs1554823229, rs1554833242, rs1554836566, rs1402893508, rs1554882546, rs1554956088, rs1554806149, rs1554903842, rs1168400018, rs1555032952, rs903145299, rs1554934073, rs1554940316, rs1554822703, rs1554823231, rs1554824185, rs1328440878, rs1554833227, rs1554833314, rs1554872194, rs1554833699, rs1554822891, rs756692340, rs1554833249, rs1554852472, rs1554873550, rs1554883705, rs1554956023, rs1554816541, rs1554903979, rs143842048, rs1304228309, rs1555135419, rs147956944, rs1482487617, rs1207247951, rs1317951509, rs1385324903, rs782787126, rs782064437, rs782292032, rs1472566324, rs766641715, rs1555095933, rs1555099541, rs878864531, rs548172627, rs1555067667, rs755934966, rs1558151555, rs1560449207, rs1253419936, rs1564796487, rs1557720377, rs1564634581, rs767797828, rs201866631, rs1262416703, rs750647872, rs765574676, rs781989117, rs1568445893, rs727502919, rs1558111861, rs1561660434, rs1564794944, rs745571683, rs762226905, rs1558141330, rs758660532, rs41314534, rs1301139848, rs777629750, rs1039517349, rs1190307769, rs749314857, rs1564796673, rs1564808024, rs1561441451, rs1561543496, rs377650415, rs1561790371, rs1561843914, rs1316299165, rs1561805689, rs1559982739, rs1561740143, rs1571657875, rs1360258103, rs201863550, rs754970095, rs201205811, rs760858249, rs770329105, rs759187261, rs1200012430, rs1293202153, rs1591095476, rs1571801514, rs1230303971, rs1580905929, rs1581711527, rs1571949388, rs368770647, rs1571783742, rs1572020896, rs759433119, rs1572088481, rs1415484067, rs1415157305, rs1571703770, rs933370216, rs1439933768, rs1580845586, rs765376986, rs1581135405, rs1589950125, rs1590691343, rs1571703801, rs1386612395, rs1576651623, rs1580567084, rs1276890742, rs1591467894, rs1571876788, rs1580864592, rs764583867, rs1571945476, rs1571953449, rs1571686349, rs1571762632, rs1571941511, rs368687374, rs45555435, rs777701725, rs201625237, rs1576631624, rs1581041519, rs1581196586, rs750027965, rs1591286671, rs1591470904, rs1598584825, rs1656419435, rs754834155, rs1657799383, rs1657965422, rs1657996197, rs1662772955, rs1667316878, rs2030619513, rs2034849647, rs2034850724, rs2034948574, rs2036152207, rs1571701069, rs2038569132, rs2039616380, rs929034631, rs1767988429, rs1416386069, rs1841885880, rs1850678559, rs1850961650, rs1954240719, rs782396605, rs1956938352, rs1571947757, rs1358947010, rs1571701072, rs1571801788, rs1384677442, rs1292050472, rs1591286221, rs1555067598, rs1591369118, rs1296612982, rs760251968, rs1571929573, rs774677256, rs1571657777, rs376674482, rs746618021, rs201845656, rs1580624630, rs1591467918, rs750321557, rs1403618793, rs780036975, rs1424639717, rs1667314337, rs2032147505, rs201529124, rs2034899784, rs376591221, rs1364987785, rs2039614529, rs756193571, rs771766431, rs759981467, rs782281371, rs778934538, rs1359109336, rs767630412, rs1841212177, rs758482449, rs1656901821, rs1662771528, rs1665132445, rs769198746, rs2034852728, rs757154662, rs757525434, rs1758488956, rs1764301206, rs749747871, rs780609120, rs1235430504, rs2034951427, rs1661659605, rs1657036615, rs2034938852