PKP3 (plakophilin 3)

Gene

• Entrez ID: 11187
• Gene name: Plakophilin 3
• Gene symbol: PKP3
• Synonyms: -
• Chromosome: 11
• Chromosome location: 11p15.5
• Summary: This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1238145	hsa-miR-1470	CLIP-seq
MIRT1238146	hsa-miR-1913	CLIP-seq
MIRT1238147	hsa-miR-2355-5p	CLIP-seq
MIRT1238148	hsa-miR-296-5p	CLIP-seq
MIRT1238149	hsa-miR-3136-3p	CLIP-seq
MIRT1238150	hsa-miR-3184	CLIP-seq
MIRT1238151	hsa-miR-324-3p	CLIP-seq
MIRT1238152	hsa-miR-3667-5p	CLIP-seq
MIRT1238153	hsa-miR-3691-3p	CLIP-seq
MIRT1238154	hsa-miR-423-5p	CLIP-seq
MIRT1238155	hsa-miR-4456	CLIP-seq
MIRT1238156	hsa-miR-4480	CLIP-seq
MIRT1238157	hsa-miR-4667-3p	CLIP-seq
MIRT1238158	hsa-miR-4725-5p	CLIP-seq
MIRT1238159	hsa-miR-4749-3p	CLIP-seq
MIRT1238160	hsa-miR-4786-3p	CLIP-seq
MIRT1238161	hsa-miR-504	CLIP-seq
MIRT1238162	hsa-miR-663b	CLIP-seq
MIRT2070105	hsa-miR-1225-3p	CLIP-seq
MIRT2070106	hsa-miR-1233	CLIP-seq
MIRT2070107	hsa-miR-134	CLIP-seq
MIRT2070108	hsa-miR-1825	CLIP-seq
MIRT2070109	hsa-miR-197	CLIP-seq
MIRT2070110	hsa-miR-1972	CLIP-seq
MIRT2070111	hsa-miR-2278	CLIP-seq
MIRT2070112	hsa-miR-3118	CLIP-seq
MIRT2070113	hsa-miR-3164	CLIP-seq
MIRT2070114	hsa-miR-4501	CLIP-seq
MIRT2070115	hsa-miR-4717-5p	CLIP-seq
MIRT2070116	hsa-miR-4755-3p	CLIP-seq
MIRT2070117	hsa-miR-512-3p	CLIP-seq
MIRT2070110	hsa-miR-1972	CLIP-seq
MIRT1238147	hsa-miR-2355-5p	CLIP-seq
MIRT1238153	hsa-miR-3691-3p	CLIP-seq
MIRT1238156	hsa-miR-4480	CLIP-seq
MIRT2070115	hsa-miR-4717-5p	CLIP-seq
MIRT2070116	hsa-miR-4755-3p	CLIP-seq
MIRT1238160	hsa-miR-4786-3p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
ZEB1	Repression	17391671

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001533	Component	Cornified envelope	TAS
GO:0002159	Process	Desmosome assembly	IMP	20859650
GO:0003723	Function	RNA binding	IDA	25225333
GO:0005515	Function	Protein binding	IPI	25225333, 32296183, 32814053
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA	20859650
GO:0005886	Component	Plasma membrane	TAS
GO:0005911	Component	Cell-cell junction	TAS	10374265
GO:0005912	Component	Adherens junction	HDA	25468996
GO:0005912	Component	Adherens junction	IBA	21873635
GO:0006417	Process	Regulation of translation	IMP	25225333
GO:0007043	Process	Cell-cell junction assembly	IBA	21873635
GO:0010628	Process	Positive regulation of gene expression	IMP	25225333
GO:0019899	Function	Enzyme binding	IPI	25225333
GO:0030054	Component	Cell junction	IDA
GO:0030057	Component	Desmosome	IEA
GO:0031424	Process	Keratinization	TAS
GO:0045182	Function	Translation regulator activity	IMP	25225333
GO:0045294	Function	Alpha-catenin binding	IPI	23136403
GO:0045296	Function	Cadherin binding	IBA	21873635
GO:0050839	Function	Cell adhesion molecule binding	IPI	20859650
GO:0070268	Process	Cornification	TAS
GO:0072659	Process	Protein localization to plasma membrane	IMP	20859650
GO:0098609	Process	Cell-cell adhesion	IBA	21873635
GO:0098641	Function	Cadherin binding involved in cell-cell adhesion	HDA	25468996
GO:1902373	Process	Negative regulation of mRNA catabolic process	IMP	25225333
GO:1990124	Component	Messenger ribonucleoprotein complex	IDA	25225333

Other IDs

• MIM: 605561
• HGNC: 9025
• e!Ensembl: ENSG00000184363

Protein

• UniProt ID: Q9Y446
• Protein name: Plakophilin-3
• Protein function: A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:24124604). Required for the localization of DSG2, DSP and PKP2 to mature desmosome junctions (PubMed:20859650). May also play a
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00514	Arm	350 → 390	Armadillo/beta-catenin-like repeat	Repeat
  PF00514	Arm	392 → 432	Armadillo/beta-catenin-like repeat	Repeat

• Sequence:

  MQDGNFLLSALQPEAGVCSLALPSDLQLDRRGAEGPEAERLRAARVQEQVRARLLQLGQQ
  PRHNGAAEPEPEAETARGTSRGQYHTLQAGFSSRSQGLSGDKTSGFRPIAKPAYSPASWS
  SRSAVDLSCSRRLSSAHNGGSAFGAAGYGGAQPTPPMPTRPVSFHERGGVGSRADYDTLS
  LRSLRLGPGGLDDRYSLVSEQLEPAATSTYRAFAYERQASSSSSRAGGLDWPEATEVSPS
  RTIRAPAVRTLQRFQSSHRSRGVGGAVPGAVLEPVARAPSVRSLSLSLADSGHLPDVHGF
  NSYGSHRTLQRLSSGFDDIDLPSAVKYLMASDPNLQVLGAAYIQHKCYSDAAAKKQARSL
  QAVPRLVKLFNHANQEVQRHATGAMRNLIYDNADNKLALVEENGIFELLRTLREQDDELR
  KNVTGILWNLSSSDHLKDRLARDTLEQLTDLVLSPLSGAGGPPLIQQNASEAEIFYNATG
  FLRNLSSASQATRQKMRECHGLVDALVTSINHALDAGKCEDKSVENAVCVLRNLSYRLYD
  EMPPSALQRLEGRGRRDLAGAPPGEVVGCFTPQSRRLRELPLAADALTFAEVSKDPKGLE
  WLWSPQIVGLYNRLLQRCELNRHTTEAAAGALQNITAGDRRWAGVLSRLALEQERILNPL
  LDRVRTADHHQLRSLTGLIRNLSRNARNKDEMSTKVVSHLIEKLPGSVGEKSPPAEVLVN
  IIAVLNNLVVASPIAARDLLYFDGLRKLIFIKKKRDSPDSEKSSRAASSLLANLWQYNKL
  HRDFRAKGYRKEDFLGP

• Sequence length: 797

Pathways

Reactome:

Keratinization
Formation of the cornified envelope

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	17013881

Unknown
Disease name	Disease term	dbSNP ID	References
Prostatic neoplasms	Prostatic Neoplasms		17013881