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INMT (indolethylamine N-methyltransferase)

Gene

11185

Indolethylamine N-methyltransferase

INMT

TEMT

7p14.3

N-methylation of endogenous and xenobiotic compounds is a major method by which they are degraded. This gene encodes an enzyme that N-methylates indoles such as tryptamine. Alternative splicing results in multiple transcript variants. Read-through transcr

Show/Hide all(263)

miRTarBase ID	miRNA	Experiments	Reference
MIRT697177	hsa-miR-4761-5p	HITS-CLIP	23313552
MIRT697178	hsa-miR-1226-3p	HITS-CLIP	23313552
MIRT697175	hsa-miR-4733-3p	HITS-CLIP	23313552
MIRT697176	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT697174	hsa-miR-4459	HITS-CLIP	23313552
MIRT697173	hsa-miR-4433a-3p	HITS-CLIP	23313552
MIRT697172	hsa-miR-7106-5p	HITS-CLIP	23313552
MIRT697171	hsa-miR-149-3p	HITS-CLIP	23313552
MIRT697170	hsa-miR-4728-5p	HITS-CLIP	23313552
MIRT697169	hsa-miR-6785-5p	HITS-CLIP	23313552
MIRT697168	hsa-miR-6883-5p	HITS-CLIP	23313552
MIRT697167	hsa-miR-6799-5p	HITS-CLIP	23313552
MIRT697166	hsa-miR-363-5p	HITS-CLIP	23313552
MIRT697165	hsa-miR-6745	HITS-CLIP	23313552
MIRT697164	hsa-miR-6756-5p	HITS-CLIP	23313552
MIRT697163	hsa-miR-6766-5p	HITS-CLIP	23313552
MIRT697162	hsa-miR-1293	HITS-CLIP	23313552
MIRT697161	hsa-miR-4483	HITS-CLIP	23313552
MIRT697160	hsa-miR-3165	HITS-CLIP	23313552
MIRT697159	hsa-miR-6769a-5p	HITS-CLIP	23313552
MIRT697158	hsa-miR-6769b-5p	HITS-CLIP	23313552
MIRT697157	hsa-miR-6748-5p	HITS-CLIP	23313552
MIRT697156	hsa-miR-30c-1-3p	HITS-CLIP	23313552
MIRT697155	hsa-miR-30c-2-3p	HITS-CLIP	23313552
MIRT697154	hsa-miR-6788-5p	HITS-CLIP	23313552
MIRT697153	hsa-miR-1273h-5p	HITS-CLIP	23313552
MIRT697152	hsa-miR-30b-3p	HITS-CLIP	23313552
MIRT697151	hsa-miR-3689a-3p	HITS-CLIP	23313552
MIRT697150	hsa-miR-3689b-3p	HITS-CLIP	23313552
MIRT697149	hsa-miR-3689c	HITS-CLIP	23313552
MIRT697148	hsa-miR-6779-5p	HITS-CLIP	23313552
MIRT697147	hsa-miR-6780a-5p	HITS-CLIP	23313552
MIRT697146	hsa-miR-450a-1-3p	HITS-CLIP	23313552
MIRT697145	hsa-miR-3122	HITS-CLIP	23313552
MIRT697144	hsa-miR-3913-5p	HITS-CLIP	23313552
MIRT697143	hsa-miR-887-5p	HITS-CLIP	23313552
MIRT697142	hsa-miR-6513-5p	HITS-CLIP	23313552
MIRT673977	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT673976	hsa-miR-331-3p	HITS-CLIP	23824327
MIRT673975	hsa-miR-3064-5p	HITS-CLIP	23824327
MIRT673974	hsa-miR-6504-5p	HITS-CLIP	23824327
MIRT673973	hsa-miR-6776-5p	HITS-CLIP	23824327
MIRT673972	hsa-miR-4746-3p	HITS-CLIP	23824327
MIRT673971	hsa-miR-5589-5p	HITS-CLIP	23824327
MIRT673970	hsa-miR-4284	HITS-CLIP	23824327
MIRT673969	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT673968	hsa-miR-3652	HITS-CLIP	23824327
MIRT673967	hsa-miR-4430	HITS-CLIP	23824327
MIRT673966	hsa-miR-4505	HITS-CLIP	23824327
MIRT673965	hsa-miR-5787	HITS-CLIP	23824327
MIRT673964	hsa-miR-4466	HITS-CLIP	23824327
MIRT673963	hsa-miR-675-5p	HITS-CLIP	23824327
MIRT673962	hsa-miR-7977	HITS-CLIP	23824327
MIRT673961	hsa-miR-6842-3p	HITS-CLIP	23824327
MIRT673960	hsa-miR-6741-5p	HITS-CLIP	23824327
MIRT650948	hsa-miR-550b-3p	HITS-CLIP	23824327
MIRT650947	hsa-miR-6822-3p	HITS-CLIP	23824327
MIRT650946	hsa-miR-760	HITS-CLIP	23824327
MIRT650944	hsa-miR-8057	HITS-CLIP	23824327
MIRT650951	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT650950	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT650949	hsa-miR-4486	HITS-CLIP	23824327
MIRT650948	hsa-miR-550b-3p	HITS-CLIP	23824327
MIRT650947	hsa-miR-6822-3p	HITS-CLIP	23824327
MIRT650946	hsa-miR-760	HITS-CLIP	23824327
MIRT650945	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT650944	hsa-miR-8057	HITS-CLIP	23824327
MIRT697177	hsa-miR-4761-5p	HITS-CLIP	23313552
MIRT697178	hsa-miR-1226-3p	HITS-CLIP	23313552
MIRT697175	hsa-miR-4733-3p	HITS-CLIP	23313552
MIRT697176	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT697174	hsa-miR-4459	HITS-CLIP	23313552
MIRT697173	hsa-miR-4433a-3p	HITS-CLIP	23313552
MIRT697172	hsa-miR-7106-5p	HITS-CLIP	23313552
MIRT697171	hsa-miR-149-3p	HITS-CLIP	23313552
MIRT697170	hsa-miR-4728-5p	HITS-CLIP	23313552
MIRT697169	hsa-miR-6785-5p	HITS-CLIP	23313552
MIRT697168	hsa-miR-6883-5p	HITS-CLIP	23313552
MIRT697167	hsa-miR-6799-5p	HITS-CLIP	23313552
MIRT697166	hsa-miR-363-5p	HITS-CLIP	23313552
MIRT697165	hsa-miR-6745	HITS-CLIP	23313552
MIRT697164	hsa-miR-6756-5p	HITS-CLIP	23313552
MIRT697163	hsa-miR-6766-5p	HITS-CLIP	23313552
MIRT697162	hsa-miR-1293	HITS-CLIP	23313552
MIRT697161	hsa-miR-4483	HITS-CLIP	23313552
MIRT697160	hsa-miR-3165	HITS-CLIP	23313552
MIRT697159	hsa-miR-6769a-5p	HITS-CLIP	23313552
MIRT697158	hsa-miR-6769b-5p	HITS-CLIP	23313552
MIRT697157	hsa-miR-6748-5p	HITS-CLIP	23313552
MIRT697156	hsa-miR-30c-1-3p	HITS-CLIP	23313552
MIRT697155	hsa-miR-30c-2-3p	HITS-CLIP	23313552
MIRT697154	hsa-miR-6788-5p	HITS-CLIP	23313552
MIRT697153	hsa-miR-1273h-5p	HITS-CLIP	23313552
MIRT697152	hsa-miR-30b-3p	HITS-CLIP	23313552
MIRT697151	hsa-miR-3689a-3p	HITS-CLIP	23313552
MIRT697150	hsa-miR-3689b-3p	HITS-CLIP	23313552
MIRT697149	hsa-miR-3689c	HITS-CLIP	23313552
MIRT697148	hsa-miR-6779-5p	HITS-CLIP	23313552
MIRT697147	hsa-miR-6780a-5p	HITS-CLIP	23313552
MIRT697146	hsa-miR-450a-1-3p	HITS-CLIP	23313552
MIRT697145	hsa-miR-3122	HITS-CLIP	23313552
MIRT697144	hsa-miR-3913-5p	HITS-CLIP	23313552
MIRT697143	hsa-miR-887-5p	HITS-CLIP	23313552
MIRT697142	hsa-miR-6513-5p	HITS-CLIP	23313552
MIRT673977	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT673976	hsa-miR-331-3p	HITS-CLIP	23824327
MIRT673975	hsa-miR-3064-5p	HITS-CLIP	23824327
MIRT673974	hsa-miR-6504-5p	HITS-CLIP	23824327
MIRT673973	hsa-miR-6776-5p	HITS-CLIP	23824327
MIRT673972	hsa-miR-4746-3p	HITS-CLIP	23824327
MIRT673971	hsa-miR-5589-5p	HITS-CLIP	23824327
MIRT673970	hsa-miR-4284	HITS-CLIP	23824327
MIRT673969	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT673968	hsa-miR-3652	HITS-CLIP	23824327
MIRT673967	hsa-miR-4430	HITS-CLIP	23824327
MIRT673966	hsa-miR-4505	HITS-CLIP	23824327
MIRT673965	hsa-miR-5787	HITS-CLIP	23824327
MIRT673964	hsa-miR-4466	HITS-CLIP	23824327
MIRT673963	hsa-miR-675-5p	HITS-CLIP	23824327
MIRT673962	hsa-miR-7977	HITS-CLIP	23824327
MIRT673961	hsa-miR-6842-3p	HITS-CLIP	23824327
MIRT673960	hsa-miR-6741-5p	HITS-CLIP	23824327
MIRT650948	hsa-miR-550b-3p	HITS-CLIP	23824327
MIRT650947	hsa-miR-6822-3p	HITS-CLIP	23824327
MIRT650946	hsa-miR-760	HITS-CLIP	23824327
MIRT650944	hsa-miR-8057	HITS-CLIP	23824327
MIRT650951	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT650950	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT650949	hsa-miR-4486	HITS-CLIP	23824327
MIRT650948	hsa-miR-550b-3p	HITS-CLIP	23824327
MIRT650947	hsa-miR-6822-3p	HITS-CLIP	23824327
MIRT650946	hsa-miR-760	HITS-CLIP	23824327
MIRT650945	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT650944	hsa-miR-8057	HITS-CLIP	23824327
MIRT1066688	hsa-miR-1286	CLIP-seq
MIRT1066689	hsa-miR-1827	CLIP-seq
MIRT1066690	hsa-miR-2114	CLIP-seq
MIRT1066691	hsa-miR-24	CLIP-seq
MIRT1066692	hsa-miR-3174	CLIP-seq
MIRT1066693	hsa-miR-3679-3p	CLIP-seq
MIRT1066694	hsa-miR-3929	CLIP-seq
MIRT1066695	hsa-miR-4275	CLIP-seq
MIRT1066696	hsa-miR-4327	CLIP-seq
MIRT1066697	hsa-miR-4419b	CLIP-seq
MIRT1066698	hsa-miR-4436a	CLIP-seq
MIRT1066699	hsa-miR-4436b-5p	CLIP-seq
MIRT1066700	hsa-miR-4455	CLIP-seq
MIRT1066701	hsa-miR-4478	CLIP-seq
MIRT1066702	hsa-miR-4524	CLIP-seq
MIRT1066703	hsa-miR-4649-3p	CLIP-seq
MIRT1066704	hsa-miR-4661-3p	CLIP-seq
MIRT1066705	hsa-miR-4690-5p	CLIP-seq
MIRT1066706	hsa-miR-4722-5p	CLIP-seq
MIRT1066707	hsa-miR-4724-3p	CLIP-seq
MIRT1066708	hsa-miR-4773	CLIP-seq
MIRT1066709	hsa-miR-4785	CLIP-seq
MIRT1066710	hsa-miR-483-3p	CLIP-seq
MIRT1066711	hsa-miR-485-5p	CLIP-seq
MIRT1066712	hsa-miR-543	CLIP-seq
MIRT1066713	hsa-miR-550a	CLIP-seq
MIRT1066714	hsa-miR-602	CLIP-seq
MIRT1066715	hsa-miR-609	CLIP-seq
MIRT1066716	hsa-miR-675	CLIP-seq
MIRT1066717	hsa-miR-940	CLIP-seq
MIRT1066718	hsa-miR-1226	CLIP-seq
MIRT1066689	hsa-miR-1827	CLIP-seq
MIRT1066690	hsa-miR-2114	CLIP-seq
MIRT1066693	hsa-miR-3679-3p	CLIP-seq
MIRT1066694	hsa-miR-3929	CLIP-seq
MIRT1066697	hsa-miR-4419b	CLIP-seq
MIRT1066701	hsa-miR-4478	CLIP-seq
MIRT1066703	hsa-miR-4649-3p	CLIP-seq
MIRT1066706	hsa-miR-4722-5p	CLIP-seq
MIRT1066708	hsa-miR-4773	CLIP-seq
MIRT1066711	hsa-miR-485-5p	CLIP-seq
MIRT1066712	hsa-miR-543	CLIP-seq
MIRT1066713	hsa-miR-550a	CLIP-seq
MIRT1066714	hsa-miR-602	CLIP-seq
MIRT1066717	hsa-miR-940	CLIP-seq
MIRT1066692	hsa-miR-3174	CLIP-seq
MIRT1066696	hsa-miR-4327	CLIP-seq
MIRT1066709	hsa-miR-4785	CLIP-seq
MIRT1066718	hsa-miR-1226	CLIP-seq
MIRT1066689	hsa-miR-1827	CLIP-seq
MIRT1066691	hsa-miR-24	CLIP-seq
MIRT1066692	hsa-miR-3174	CLIP-seq
MIRT1066694	hsa-miR-3929	CLIP-seq
MIRT2015997	hsa-miR-4252	CLIP-seq
MIRT1066696	hsa-miR-4327	CLIP-seq
MIRT1066697	hsa-miR-4419b	CLIP-seq
MIRT1066701	hsa-miR-4478	CLIP-seq
MIRT1066703	hsa-miR-4649-3p	CLIP-seq
MIRT1066706	hsa-miR-4722-5p	CLIP-seq
MIRT1066709	hsa-miR-4785	CLIP-seq
MIRT2015998	hsa-miR-4793-3p	CLIP-seq
MIRT1066711	hsa-miR-485-5p	CLIP-seq
MIRT2015999	hsa-miR-508-5p	CLIP-seq
MIRT2016000	hsa-miR-766	CLIP-seq
MIRT1066717	hsa-miR-940	CLIP-seq
MIRT1066718	hsa-miR-1226	CLIP-seq
MIRT1066690	hsa-miR-2114	CLIP-seq
MIRT1066692	hsa-miR-3174	CLIP-seq
MIRT2248482	hsa-miR-3622b-5p	CLIP-seq
MIRT1066693	hsa-miR-3679-3p	CLIP-seq
MIRT2015997	hsa-miR-4252	CLIP-seq
MIRT2248483	hsa-miR-4253	CLIP-seq
MIRT2248484	hsa-miR-4634	CLIP-seq
MIRT1066708	hsa-miR-4773	CLIP-seq
MIRT1066709	hsa-miR-4785	CLIP-seq
MIRT1066712	hsa-miR-543	CLIP-seq
MIRT1066713	hsa-miR-550a	CLIP-seq
MIRT2248485	hsa-miR-661	CLIP-seq
MIRT2248482	hsa-miR-3622b-5p	CLIP-seq
MIRT2451869	hsa-miR-3675-3p	CLIP-seq
MIRT2248483	hsa-miR-4253	CLIP-seq
MIRT2248484	hsa-miR-4634	CLIP-seq
MIRT2451870	hsa-miR-4684-5p	CLIP-seq
MIRT2451871	hsa-miR-548c-3p	CLIP-seq
MIRT1066718	hsa-miR-1226	CLIP-seq
MIRT2552007	hsa-miR-1273	CLIP-seq
MIRT1066689	hsa-miR-1827	CLIP-seq
MIRT1066690	hsa-miR-2114	CLIP-seq
MIRT2552008	hsa-miR-2355-5p	CLIP-seq
MIRT2552009	hsa-miR-3613-3p	CLIP-seq
MIRT2248482	hsa-miR-3622b-5p	CLIP-seq
MIRT2552010	hsa-miR-3671	CLIP-seq
MIRT2451869	hsa-miR-3675-3p	CLIP-seq
MIRT2552011	hsa-miR-371-5p	CLIP-seq
MIRT2552012	hsa-miR-371b-5p	CLIP-seq
MIRT1066694	hsa-miR-3929	CLIP-seq
MIRT2015997	hsa-miR-4252	CLIP-seq
MIRT2248483	hsa-miR-4253	CLIP-seq
MIRT1066697	hsa-miR-4419b	CLIP-seq
MIRT1066701	hsa-miR-4478	CLIP-seq
MIRT2248484	hsa-miR-4634	CLIP-seq
MIRT2552013	hsa-miR-4649-5p	CLIP-seq
MIRT2451870	hsa-miR-4684-5p	CLIP-seq
MIRT2552014	hsa-miR-4693-3p	CLIP-seq
MIRT2552015	hsa-miR-4712-3p	CLIP-seq
MIRT1066706	hsa-miR-4722-5p	CLIP-seq
MIRT2015998	hsa-miR-4793-3p	CLIP-seq
MIRT1066711	hsa-miR-485-5p	CLIP-seq
MIRT2015999	hsa-miR-508-5p	CLIP-seq
MIRT2451871	hsa-miR-548c-3p	CLIP-seq
MIRT1066713	hsa-miR-550a	CLIP-seq
MIRT1066714	hsa-miR-602	CLIP-seq
MIRT2248485	hsa-miR-661	CLIP-seq
MIRT2016000	hsa-miR-766	CLIP-seq
MIRT1066717	hsa-miR-940	CLIP-seq
MIRT1066718	hsa-miR-1226	CLIP-seq
MIRT1066690	hsa-miR-2114	CLIP-seq
MIRT2248482	hsa-miR-3622b-5p	CLIP-seq
MIRT2451869	hsa-miR-3675-3p	CLIP-seq
MIRT2248483	hsa-miR-4253	CLIP-seq
MIRT2682840	hsa-miR-4433	CLIP-seq
MIRT2248484	hsa-miR-4634	CLIP-seq
MIRT2451870	hsa-miR-4684-5p	CLIP-seq
MIRT2682841	hsa-miR-4786-5p	CLIP-seq
MIRT2682842	hsa-miR-4793-5p	CLIP-seq
MIRT2682843	hsa-miR-4794	CLIP-seq
MIRT2451871	hsa-miR-548c-3p	CLIP-seq
MIRT1066713	hsa-miR-550a	CLIP-seq
MIRT1066714	hsa-miR-602	CLIP-seq

Show/Hide all(11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004790	Function	Thioether S-methyltransferase activity	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	IDA	10552930
GO:0008170	Function	N-methyltransferase activity	IBA	21873635
GO:0009308	Process	Amine metabolic process	IDA	10552930
GO:0009636	Process	Response to toxic substance	IEA
GO:0030748	Function	Amine N-methyltransferase activity	IBA	21873635
GO:0030748	Function	Amine N-methyltransferase activity	IDA	10552930
GO:0032259	Process	Methylation	IDA	10552930
GO:0102707	Function	S-adenosyl-L-methionine:beta-alanine N-methyltransferase activity	IEA

MIM	HGNC	e!Ensembl
604854	6069	ENSG00000241644

Protein

UniProt ID

O95050

Protein name

Indolethylamine N-methyltransferase (Indolamine N-methyltransferase) (EC 2.1.1.49) (EC 2.1.1.96) (Aromatic alkylamine N-methyltransferase) (Amine N-methyltransferase) (Arylamine N-methyltransferase) (Thioether S-methyltransferase) (TEMT)

Protein function

Functions as a thioether S-methyltransferase and is active with a variety of thioethers and the corresponding selenium and tellurium compounds, including 3-methylthiopropionaldehyde, dimethyl selenide, dimethyl telluride, 2-methylthioethylamine,

PDB

2A14

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01234	NNMT_PNMT_TEMT	1 → 259	NNMT/PNMT/TEMT family	Family

Sequence

MKGGFTGGDEYQKHFLPRDYLATYYSFDGSPSPEAEMLKFNLECLHKTFGPGGLQGDTLI
DIGSGPTIYQVLAACDSFQDITLSDFTDRNREELEKWLKKEPGAYDWTPAVKFACELEGN
SGRWEEKEEKLRAAVKRVLKCDVHLGNPLAPAVLPLADCVLTLLAMECACCSLDAYRAAL
CNLASLLKPGGHLVTTVTLRLPSYMVGKREFSCVALEKEEVEQAVLDAGFDIEQLLHSPQ
SYSVTNAANNGVCFIVARKKPGP

Sequence length

263

Interactions

View interactions

	KEGG
	Tryptophan metabolism Selenocompound metabolism Metabolic pathways

Associated diseases

Show/Hide Unknown Diseases (1)

Unknown
Disease name	Disease term	dbSNP ID	References
Liver carcinoma	Liver carcinoma		28284560

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