CHI3L1 (chitinase 3 like 1)

Gene

• Entrez ID: 1116
• Gene name: Chitinase 3 like 1
• Gene symbol: CHI3L1
• Synonyms: ASRT7, CGP-39, GP-39, GP39, HC-gp39, HCGP-3P, YK-40, YKL-40, YKL40, YYL-40, hCGP-39
• Chromosome: 1
• Chromosome location: 1q32.1
• Summary: Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein membe

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs4950928	G>A,C,T	Risk-factor	Upstream transcript variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT733139	hsa-miR-378g	Immunoprecipitaion (IP), Luciferase reporter assay, qRT-PCR, Western blotting	32021459
MIRT2436230	hsa-miR-125a-3p	CLIP-seq
MIRT2436231	hsa-miR-214	CLIP-seq
MIRT2436232	hsa-miR-24	CLIP-seq
MIRT2436233	hsa-miR-2467-5p	CLIP-seq
MIRT2436234	hsa-miR-3188	CLIP-seq
MIRT2436235	hsa-miR-3199	CLIP-seq
MIRT2436236	hsa-miR-3619-5p	CLIP-seq
MIRT2436237	hsa-miR-3665	CLIP-seq
MIRT2436238	hsa-miR-3975	CLIP-seq
MIRT2436239	hsa-miR-4291	CLIP-seq
MIRT2436240	hsa-miR-4436b-3p	CLIP-seq
MIRT2436241	hsa-miR-4736	CLIP-seq
MIRT2436242	hsa-miR-485-5p	CLIP-seq
MIRT2436243	hsa-miR-512-5p	CLIP-seq
MIRT2436244	hsa-miR-661	CLIP-seq
MIRT2436245	hsa-miR-761	CLIP-seq
MIRT2436246	hsa-miR-922	CLIP-seq
MIRT2502788	hsa-miR-1207-3p	CLIP-seq
MIRT2436230	hsa-miR-125a-3p	CLIP-seq
MIRT2436231	hsa-miR-214	CLIP-seq
MIRT2436232	hsa-miR-24	CLIP-seq
MIRT2436233	hsa-miR-2467-5p	CLIP-seq
MIRT2502789	hsa-miR-298	CLIP-seq
MIRT2502790	hsa-miR-3135b	CLIP-seq
MIRT2502791	hsa-miR-3155	CLIP-seq
MIRT2502792	hsa-miR-3155b	CLIP-seq
MIRT2436234	hsa-miR-3188	CLIP-seq
MIRT2502793	hsa-miR-3189-3p	CLIP-seq
MIRT2502794	hsa-miR-3191	CLIP-seq
MIRT2436235	hsa-miR-3199	CLIP-seq
MIRT2502795	hsa-miR-328	CLIP-seq
MIRT2436236	hsa-miR-3619-5p	CLIP-seq
MIRT2502796	hsa-miR-362-5p	CLIP-seq
MIRT2436237	hsa-miR-3665	CLIP-seq
MIRT2502797	hsa-miR-383	CLIP-seq
MIRT2502798	hsa-miR-3944-5p	CLIP-seq
MIRT2436238	hsa-miR-3975	CLIP-seq
MIRT2436239	hsa-miR-4291	CLIP-seq
MIRT2436240	hsa-miR-4436b-3p	CLIP-seq
MIRT2502799	hsa-miR-4716-3p	CLIP-seq
MIRT2436241	hsa-miR-4736	CLIP-seq
MIRT2502800	hsa-miR-4772-5p	CLIP-seq
MIRT2502801	hsa-miR-4773	CLIP-seq
MIRT2502802	hsa-miR-484	CLIP-seq
MIRT2436242	hsa-miR-485-5p	CLIP-seq
MIRT2502803	hsa-miR-500b	CLIP-seq
MIRT2436243	hsa-miR-512-5p	CLIP-seq
MIRT2436244	hsa-miR-661	CLIP-seq
MIRT2436245	hsa-miR-761	CLIP-seq
MIRT2436246	hsa-miR-922	CLIP-seq
MIRT2502788	hsa-miR-1207-3p	CLIP-seq
MIRT2436230	hsa-miR-125a-3p	CLIP-seq
MIRT2436231	hsa-miR-214	CLIP-seq
MIRT2436232	hsa-miR-24	CLIP-seq
MIRT2436233	hsa-miR-2467-5p	CLIP-seq
MIRT2502790	hsa-miR-3135b	CLIP-seq
MIRT2502791	hsa-miR-3155	CLIP-seq
MIRT2502792	hsa-miR-3155b	CLIP-seq
MIRT2436234	hsa-miR-3188	CLIP-seq
MIRT2502793	hsa-miR-3189-3p	CLIP-seq
MIRT2502794	hsa-miR-3191	CLIP-seq
MIRT2436235	hsa-miR-3199	CLIP-seq
MIRT2502795	hsa-miR-328	CLIP-seq
MIRT2436236	hsa-miR-3619-5p	CLIP-seq
MIRT2502796	hsa-miR-362-5p	CLIP-seq
MIRT2436237	hsa-miR-3665	CLIP-seq
MIRT2502797	hsa-miR-383	CLIP-seq
MIRT2436238	hsa-miR-3975	CLIP-seq
MIRT2436239	hsa-miR-4291	CLIP-seq
MIRT2436240	hsa-miR-4436b-3p	CLIP-seq
MIRT2502799	hsa-miR-4716-3p	CLIP-seq
MIRT2436241	hsa-miR-4736	CLIP-seq
MIRT2502800	hsa-miR-4772-5p	CLIP-seq
MIRT2502802	hsa-miR-484	CLIP-seq
MIRT2436242	hsa-miR-485-5p	CLIP-seq
MIRT2502803	hsa-miR-500b	CLIP-seq
MIRT2436243	hsa-miR-512-5p	CLIP-seq
MIRT2436244	hsa-miR-661	CLIP-seq
MIRT2436245	hsa-miR-761	CLIP-seq
MIRT2436246	hsa-miR-922	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
NFIX	Activation	21953450
SP1	Unknown	12933821
STAT3	Activation	21953450

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004568	Function	Chitinase activity	IBA	21873635
GO:0004568	Function	Chitinase activity	IDA	8245017, 9492324
GO:0005201	Function	Extracellular matrix structural constituent	NAS	8245017
GO:0005515	Function	Protein binding	IPI	23972995, 27629921, 28143526, 29427412
GO:0005576	Component	Extracellular region	IBA	21873635
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	HDA	16502470
GO:0005615	Component	Extracellular space	IDA	8245017, 9492324
GO:0005737	Component	Cytoplasm	ISS
GO:0005783	Component	Endoplasmic reticulum	ISS
GO:0005975	Process	Carbohydrate metabolic process	IEA
GO:0006032	Process	Chitin catabolic process	IBA	21873635
GO:0006915	Process	Apoptotic process	IEA
GO:0006954	Process	Inflammatory response	IEP	16234240
GO:0007250	Process	Activation of NF-kappaB-inducing kinase activity	ISS
GO:0008061	Function	Chitin binding	IBA	21873635
GO:0008061	Function	Chitin binding	IDA	9492324, 12775711
GO:0009612	Process	Response to mechanical stimulus	IEP	20650887
GO:0010800	Process	Positive regulation of peptidyl-threonine phosphorylation	ISS
GO:0030246	Function	Carbohydrate binding	IEA
GO:0030324	Process	Lung development	IMP	18403759
GO:0031012	Component	Extracellular matrix	NAS	8245017
GO:0032637	Process	Interleukin-8 production	ISS
GO:0034612	Process	Response to tumor necrosis factor	IEP	16234240
GO:0035580	Component	Specific granule lumen	TAS
GO:0043312	Process	Neutrophil degranulation	TAS
GO:0045766	Process	Positive regulation of angiogenesis	IMP	21385870
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0051216	Process	Cartilage development	NAS	8245017
GO:0051897	Process	Positive regulation of protein kinase B signaling	IMP	21385870
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IMP	21385870
GO:0070555	Process	Response to interleukin-1	IEP	16234240
GO:0070741	Process	Response to interleukin-6	IEP	21478032
GO:0071347	Process	Cellular response to interleukin-1	IEA
GO:0071356	Process	Cellular response to tumor necrosis factor	ISS

Other IDs

• MIM: 601525
• HGNC: 1932
• e!Ensembl: ENSG00000133048

Protein

• UniProt ID: P36222
• Protein name: Chitinase-3-like protein 1 (39 kDa synovial protein) (Cartilage glycoprotein 39) (CGP-39) (GP-39) (hCGP-39) (YKL-40)
• Protein function: Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2
• PDB: 1HJV, 1HJW, 1HJX, 1NWR, 1NWS, 1NWT, 1NWU, 7CJ2, 8DF1, 8R41, 8R42, 8R4X
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00704	Glyco_hydro_18	23 → 357	Glycosyl hydrolases family 18	Domain

• Sequence:

  MGVKASQTGFVVLVLLQCCSAYKLVCYYTSWSQYREGDGSCFPDALDRFLCTHIIYSFAN
  ISNDHIDTWEWNDVTLYGMLNTLKNRNPNLKTLLSVGGWNFGSQRFSKIASNTQSRRTFI
  KSVPPFLRTHGFDGLDLAWLYPGRRDKQHFTTLIKEMKAEFIKEAQPGKKQLLLSAALSA
  GKVTIDSSYDIAKISQHLDFISIMTYDFHGAWRGTTGHHSPLFRGQEDASPDRFSNTDYA
  VGYMLRLGAPASKLVMGIPTFGRSFTLASSETGVGAPISGPGIPGRFTKEAGTLAYYEIC
  DFLRGATVHRILGQQVPYATKGNQWVGYDDQESVKSKVQYLKDRQLAGAMVWALDLDDFQ
  GSFCGQDLRFPLTNAIKDALAAT

• Sequence length: 383

Pathways

Reactome:

Neutrophil degranulation

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Arthritis	Degenerative polyarthritis	rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470	18784066
Glioblastoma	Glioblastoma, Glioblastoma Multiforme	rs121913500, rs886042842, rs1555138291, rs1558518449, rs1567176006, rs1558650888	21029458
Glioma	Glioma, mixed gliomas, Malignant Glioma	rs121909219, rs121909224, rs587776667, rs587776671, rs121909239, rs121909241, rs28933368, rs121913500, rs55863639, rs786201995, rs786202517, rs786201044, rs398123317, rs1057518425, rs121913499, rs1060500122, rs781647403, rs1060500126, rs1554897889, rs1114167629, rs1114167656, rs587782603, rs1554893824, rs1554900615, rs1564568660, rs786204900, rs762518389, rs1339631701	20506295
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313

Unknown
Disease name	Disease term	dbSNP ID	References
Delusions	Delusions
Giant cell glioblastoma	Giant Cell Glioblastoma		21029458
Hallucinations	Hallucinations
Osteoarthrosis deformans	Osteoarthrosis Deformans		18784066