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CHGB (chromogranin B)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1114
Gene nameGene Name - the full gene name approved by the HGNC.
Chromogranin B
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
CHGB
SynonymsGene synonyms aliases
SCG1
ChromosomeChromosome number
20
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
20p12.3
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a tyrosine-sulfated secretory protein abundant in peptidergic endocrine cells and neurons. This protein may serve as a precursor for regulatory peptides. [provided by RefSeq, Jan 2009]
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT019922 hsa-miR-375 Microarray 20215506
MIRT889846 hsa-miR-1305 CLIP-seq
MIRT889847 hsa-miR-23a CLIP-seq
MIRT889848 hsa-miR-23b CLIP-seq
MIRT889849 hsa-miR-23c CLIP-seq
Transcription factors
Transcription factor Regulation Reference
REST Unknown 19118055
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005179 Function Hormone activity TAS 3608978
GO:0005515 Function Protein binding IPI 20195357, 22582013, 24510904, 24947832, 29513927
GO:0005615 Component Extracellular space IBA 21873635
GO:0005788 Component Endoplasmic reticulum lumen TAS
GO:0007165 Process Signal transduction IEA
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P05060
Protein name Secretogranin-1 (Chromogranin-B) (CgB) (Secretogranin I) (SgI) [Cleaved into: PE-11; GAWK peptide; CCB peptide]
Protein function Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01271 Granin
26 677
Granin (chromogranin or secretogranin)
Family
Sequence
Sequence length 677
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
Reactome
    Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Schizophrenia Schizophrenia, Chronic schizophrenia rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 17143778, 11959426, 15219467, 15219467

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