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ZWINT (ZW10 interacting kinetochore protein)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
11130
Gene nameGene Name - the full gene name approved by the HGNC.
ZW10 interacting kinetochore protein
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
ZWINT
SynonymsGene synonyms aliases
HZwint-1, KNTC2AP, SIP30, ZWINT1
ChromosomeChromosome number
10
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10q21.1
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a protein that is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein l
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT016569 hsa-miR-193b-3p Microarray 20304954
MIRT022987 hsa-miR-124-3p Microarray 18668037
MIRT029953 hsa-miR-26b-5p Microarray 19088304
MIRT049834 hsa-miR-92a-3p CLASH 23622248
MIRT045620 hsa-miR-149-5p CLASH 23622248
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000070 Process Mitotic sister chromatid segregation IBA 21873635
GO:0000070 Process Mitotic sister chromatid segregation IDA 15485811
GO:0000776 Component Kinetochore IBA 21873635
GO:0000776 Component Kinetochore IDA 11682612, 15485811
GO:0000777 Component Condensed chromosome kinetochore IEA
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID O95229
Protein name Outer kinetochore KNL1 complex subunit ZWINT (ZW10 interactor) (ZW10-interacting protein 1) (Zwint-1)
Protein function Acts as a component of the outer kinetochore KNL1 complex that serves as a docking point for spindle assembly checkpoint components and mediates microtubule-kinetochore interactions (PubMed:15094189, PubMed:15485811, PubMed:15824131, PubMed:1673
PDB 8PPR
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF15556 Zwint
29 277
ZW10 interactor
Family
Sequence
Sequence length 277
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
Reactome
    Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
EML4 and NUDC in mitotic spindle formation
Associated diseases
Unknown
Disease name Disease term dbSNP ID References
Liver carcinoma Liver carcinoma 28284560

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