KIF3A (kinesin family member 3A)
|
Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
11127 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
Kinesin family member 3A |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
KIF3A |
SynonymsGene synonyms aliases
|
FLA10, KLP-20 |
ChromosomeChromosome number
|
5 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
5q31.1 |
miRNAmiRNA information provided by mirtarbase database.
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|
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0003777 |
Function |
Microtubule motor activity |
IBA |
21873635 |
GO:0005515 |
Function |
Protein binding |
IPI |
16298999, 17043677, 19934039, 20643351, 22261744, 24338362, 24591568, 26496610, 27173435, 28514442, 31413325 |
GO:0005524 |
Function |
ATP binding |
IEA |
|
GO:0005813 |
Component |
Centrosome |
IDA |
16298999 |
GO:0005814 |
Component |
Centriole |
IDA |
23386061 |
GO:0005829 |
Component |
Cytosol |
TAS |
|
GO:0005871 |
Component |
Kinesin complex |
IBA |
21873635 |
GO:0005874 |
Component |
Microtubule |
IBA |
21873635 |
GO:0005876 |
Component |
Spindle microtubule |
IDA |
16298999 |
GO:0005929 |
Component |
Cilium |
ISS |
|
GO:0005929 |
Component |
Cilium |
TAS |
|
GO:0006890 |
Process |
Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum |
TAS |
|
GO:0006996 |
Process |
Organelle organization |
TAS |
1447303 |
GO:0007018 |
Process |
Microtubule-based movement |
IBA |
21873635 |
GO:0007018 |
Process |
Microtubule-based movement |
TAS |
|
GO:0008017 |
Function |
Microtubule binding |
IBA |
21873635 |
GO:0008089 |
Process |
Anterograde axonal transport |
IBA |
21873635 |
GO:0008574 |
Function |
ATP-dependent microtubule motor activity, plus-end-directed |
TAS |
16298999 |
GO:0010457 |
Process |
Centriole-centriole cohesion |
ISS |
|
GO:0015031 |
Process |
Protein transport |
IMP |
24338362 |
GO:0015630 |
Component |
Microtubule cytoskeleton |
IDA |
16298999 |
GO:0016887 |
Function |
ATPase activity |
IBA |
21873635 |
GO:0016939 |
Component |
Kinesin II complex |
IDA |
16298999 |
GO:0019886 |
Process |
Antigen processing and presentation of exogenous peptide antigen via MHC class II |
TAS |
|
GO:0019903 |
Function |
Protein phosphatase binding |
IPI |
24338362 |
GO:0030507 |
Function |
Spectrin binding |
IDA |
23704327 |
GO:0031267 |
Function |
Small GTPase binding |
IPI |
26021297 |
GO:0034454 |
Process |
Microtubule anchoring at centrosome |
ISS |
|
GO:0035735 |
Process |
Intraciliary transport involved in cilium assembly |
TAS |
|
GO:0060271 |
Process |
Cilium assembly |
IBA |
21873635 |
GO:0060271 |
Process |
Cilium assembly |
ISS |
|
GO:0070062 |
Component |
Extracellular exosome |
HDA |
19056867 |
GO:0072383 |
Process |
Plus-end-directed vesicle transport along microtubule |
TAS |
16298999 |
GO:0097542 |
Component |
Ciliary tip |
TAS |
|
GO:1902414 |
Process |
Protein localization to cell junction |
IMP |
24338362 |
GO:1904115 |
Component |
Axon cytoplasm |
IEA |
|
|
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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|
Protein
|
UniProt ID |
Q9Y496 |
Protein name |
Kinesin-like protein KIF3A (Microtubule plus end-directed kinesin motor 3A) |
Protein function |
Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation. Plays a role in centriole cohesion and subdistal appendage organization and f |
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00225 |
Kinesin |
20 → 345 |
Kinesin motor domain |
Domain |
|
Sequence |
|
Sequence length |
699 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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Associated diseases
|
Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Asthma |
Asthma, Childhood asthma |
rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283 |
31619474, 21912604, 29785011, 31036433, 31036433, 26542096 |
Dermatitis |
Dermatitis, Atopic |
rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174 |
26542096, 22197932, 26482879 |
Gastrointestinal stromal tumor |
Gastrointestinal Stromal Tumors, Gastrointestinal Stromal Sarcoma |
rs587776653, rs74315368, rs74315369, rs587776793, rs587776794, rs587776795, rs606231209, rs121908589, rs121913685, rs121913680, rs794726675, rs587776804, rs121913517, rs121913234, rs121913512, rs267607032, rs387906780, rs201286421, rs587778661, rs587781270, rs587782243, rs74315370, rs587782703, rs786203457, rs764575966, rs786203251, rs587782604, rs200245469, rs397516836, rs786202732, rs786201161, rs786201063, rs751000085, rs869025568, rs876660642, rs876658713, rs151170408, rs878854632, rs752360961, rs121913235, rs121913521, rs121913513, rs1057519708, rs1057519710, rs121913514, rs1057519713, rs778582853, rs1060503757, rs1060502521, rs1060502543, rs898854295, rs981049067, rs916516745, rs1553887262, rs1057520032, rs1553887960, rs775143272, rs1560395607, rs1560418178, rs751904543, rs1560420761, rs1560417385, rs1560417396, rs1560417427, rs1560417438, rs1560417535, rs1560417642, rs1560417666, rs1560417673, rs1577992594, rs1577995761, rs1578003055, rs1301704156, rs1734957331 |
27793025 |
Polydactyly |
Polydactyly |
rs1583729398, rs121917709, rs1583734240, rs121917714, rs397507422, rs398122899, rs587776959, rs386833752, rs1057518698, rs1060499558, rs755938967, rs1375768446, rs1309855392, rs1565601979, rs748321474, rs368652620, rs1562587032, rs760694987 |
17698054 |
|
Unknown |
Disease name |
Disease term |
dbSNP ID |
References |
Bone disease |
Bone Diseases, Developmental |
|
17698054 |
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