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RPP14 (ribonuclease P/MRP subunit p14)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
11102
Gene nameGene Name - the full gene name approved by the HGNC.
Ribonuclease P/MRP subunit p14
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
RPP14
SynonymsGene synonyms aliases
P14
ChromosomeChromosome number
3
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3p14.3
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a subunit of ribonuclease P and has 3` to 5` exoribonuclease activity. Transcripts for this gene are bicistronic and include a conserved downstream open reading frame for the hydroxyacyl-thioester dehydratase type 2 (HTD2) gene. [provide
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT028571 hsa-miR-30a-5p Proteomics 18668040
MIRT043625 hsa-miR-326 CLASH 23622248
MIRT708930 hsa-miR-6808-5p HITS-CLIP 19536157
MIRT708929 hsa-miR-6893-5p HITS-CLIP 19536157
MIRT708928 hsa-miR-940 HITS-CLIP 19536157
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001682 Process TRNA 5'-leader removal IDA 16723659, 30454648
GO:0001682 Process TRNA 5'-leader removal TAS
GO:0004526 Function Ribonuclease P activity IDA 16723659, 30454648
GO:0005515 Function Protein binding IPI 15096576, 28514442, 32296183
GO:0005654 Component Nucleoplasm TAS
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID O95059
Protein name Ribonuclease P protein subunit p14
Protein function Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.
PDB 6AHR , 6AHU
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01900 RNase_P_Rpp14
8 112
Rpp14/Pop5 family
Family
Sequence
Sequence length 124
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
Reactome
    tRNA processing in the nucleus
Major pathway of rRNA processing in the nucleolus and cytosol
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Rheumatoid arthritis Rheumatoid Arthritis rs3766379, rs3792876, rs2071592, rs3087456, rs587776843, rs1566328963, rs2240340, rs1557787212 24532676, 30423114, 24390342

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