ADAMTS8 (ADAM metallopeptidase with thrombospondin type 1 motif 8)

Gene

• Entrez ID: 11095
• Gene name: ADAM metallopeptidase with thrombospondin type 1 motif 8
• Gene symbol: ADAMTS8
• Synonyms: ADAM-TS8, METH2
• Chromosome: 11
• Chromosome location: 11q24.3
• Summary: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegri

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT650020	hsa-miR-4729	HITS-CLIP	23824327
MIRT650019	hsa-miR-5696	HITS-CLIP	23824327
MIRT650018	hsa-miR-579-3p	HITS-CLIP	23824327
MIRT650017	hsa-miR-664b-3p	HITS-CLIP	23824327
MIRT650016	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT495330	hsa-miR-4475	PAR-CLIP	22291592
MIRT495328	hsa-miR-190a-5p	PAR-CLIP	22291592
MIRT495327	hsa-miR-190b	PAR-CLIP	22291592
MIRT495326	hsa-miR-4312	PAR-CLIP	22291592
MIRT495325	hsa-miR-6882-3p	PAR-CLIP	22291592
MIRT495324	hsa-miR-3926	PAR-CLIP	22291592
MIRT495323	hsa-miR-548s	PAR-CLIP	22291592
MIRT495330	hsa-miR-4475	PAR-CLIP	23708386
MIRT495328	hsa-miR-190a-5p	PAR-CLIP	23708386
MIRT495327	hsa-miR-190b	PAR-CLIP	23708386
MIRT495326	hsa-miR-4312	PAR-CLIP	23708386
MIRT495325	hsa-miR-6882-3p	PAR-CLIP	23708386
MIRT495324	hsa-miR-3926	PAR-CLIP	23708386
MIRT495323	hsa-miR-548s	PAR-CLIP	23708386
MIRT650020	hsa-miR-4729	HITS-CLIP	23824327
MIRT650019	hsa-miR-5696	HITS-CLIP	23824327
MIRT650018	hsa-miR-579-3p	HITS-CLIP	23824327
MIRT650017	hsa-miR-664b-3p	HITS-CLIP	23824327
MIRT650016	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT495330	hsa-miR-4475	PAR-CLIP	22291592
MIRT495328	hsa-miR-190a-5p	PAR-CLIP	22291592
MIRT495327	hsa-miR-190b	PAR-CLIP	22291592
MIRT495326	hsa-miR-4312	PAR-CLIP	22291592
MIRT495325	hsa-miR-6882-3p	PAR-CLIP	22291592
MIRT495324	hsa-miR-3926	PAR-CLIP	22291592
MIRT495323	hsa-miR-548s	PAR-CLIP	22291592
MIRT495330	hsa-miR-4475	PAR-CLIP	23708386
MIRT495328	hsa-miR-190a-5p	PAR-CLIP	23708386
MIRT495327	hsa-miR-190b	PAR-CLIP	23708386
MIRT495326	hsa-miR-4312	PAR-CLIP	23708386
MIRT495325	hsa-miR-6882-3p	PAR-CLIP	23708386
MIRT495324	hsa-miR-3926	PAR-CLIP	23708386
MIRT495323	hsa-miR-548s	PAR-CLIP	23708386
MIRT766792	hsa-miR-181a	CLIP-seq
MIRT766793	hsa-miR-181b	CLIP-seq
MIRT766794	hsa-miR-181c	CLIP-seq
MIRT766795	hsa-miR-181d	CLIP-seq
MIRT766796	hsa-miR-197	CLIP-seq
MIRT766797	hsa-miR-4262	CLIP-seq
MIRT766798	hsa-miR-489	CLIP-seq
MIRT766799	hsa-miR-514	CLIP-seq
MIRT766800	hsa-miR-514b-3p	CLIP-seq
MIRT766801	hsa-miR-596	CLIP-seq
MIRT766792	hsa-miR-181a	CLIP-seq
MIRT766793	hsa-miR-181b	CLIP-seq
MIRT766794	hsa-miR-181c	CLIP-seq
MIRT766795	hsa-miR-181d	CLIP-seq
MIRT766796	hsa-miR-197	CLIP-seq
MIRT766797	hsa-miR-4262	CLIP-seq
MIRT1925889	hsa-miR-4540	CLIP-seq
MIRT766798	hsa-miR-489	CLIP-seq
MIRT766799	hsa-miR-514	CLIP-seq
MIRT766800	hsa-miR-514b-3p	CLIP-seq
MIRT1925890	hsa-miR-554	CLIP-seq
MIRT766801	hsa-miR-596	CLIP-seq
MIRT766792	hsa-miR-181a	CLIP-seq
MIRT766793	hsa-miR-181b	CLIP-seq
MIRT766794	hsa-miR-181c	CLIP-seq
MIRT766795	hsa-miR-181d	CLIP-seq
MIRT766796	hsa-miR-197	CLIP-seq
MIRT766797	hsa-miR-4262	CLIP-seq
MIRT766798	hsa-miR-489	CLIP-seq
MIRT766799	hsa-miR-514	CLIP-seq
MIRT766800	hsa-miR-514b-3p	CLIP-seq
MIRT766801	hsa-miR-596	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004222	Function	Metalloendopeptidase activity	IBA	21873635
GO:0005178	Function	Integrin binding	TAS	10438512
GO:0006508	Process	Proteolysis	IEA
GO:0008201	Function	Heparin binding	IEA
GO:0008237	Function	Metallopeptidase activity	TAS	10438512
GO:0008270	Function	Zinc ion binding	IEA
GO:0008285	Process	Negative regulation of cell population proliferation	TAS	10438512
GO:0009673	Function	Low-affinity phosphate transmembrane transporter activity	TAS	10610729
GO:0030198	Process	Extracellular matrix organization	IBA	21873635
GO:0031012	Component	Extracellular matrix	IBA	21873635
GO:0035435	Process	Phosphate ion transmembrane transport	IEA
GO:0062023	Component	Collagen-containing extracellular matrix	ISS	22261194

Other IDs

• MIM: 605175
• HGNC: 224
• e!Ensembl: ENSG00000134917

Protein

• UniProt ID: Q9UP79
• Protein name: A disintegrin and metalloproteinase with thrombospondin motifs 8 (ADAM-TS 8) (ADAM-TS8) (ADAMTS-8) (EC 3.4.24.-) (METH-2) (METH-8)
• Protein function: Has anti-angiogenic properties.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01562	Pep_M12B_propep	29 → 150	Reprolysin family propeptide	Family
  PF01421	Reprolysin	219 → 429	Reprolysin (M12B) family zinc metalloprotease	Domain
  PF17771	ADAM_CR_2	440 → 513	ADAM cysteine-rich domain	Domain
  PF00090	TSP_1	530 → 580	Thrombospondin type 1 domain	Domain
  PF05986	ADAM_spacer1	690 → 809	ADAM-TS Spacer 1	Family
  PF19030	TSP1_ADAMTS	836 → 887		Domain

• Sequence:

  MLPAPAAPRWPPLLLLLLLLLPLARGAPARPAAGGQASELVVPTRLPGSAGELALHLSAF
  GKGFVLRLAPDDSFLAPEFKIERLGGSGRATGGERGLRGCFFSGTVNGEPESLAAVSLCR
  GLSGSFLLDGEEFTIQPQGAGGSLAQPHRLQRWGPAGARPLPRGPEWEVETGEGQRQERG
  DHQEDSEEESQEEEAEGASEPPPPLGATSRTKRFVSEARFVETLLVADASMAAFYGADLQ
  NHILTLMSVAARIYKHPSIKNSINLMVVKVLIVEDEKWGPEVSDNGGLTLRNFCNWQRRF
  NQPSDRHPEHYDTAILLTRQNFCGQEGLCDTLGVADIGTICDPNKSCSVIEDEGLQAAHT
  LAHELGHVLSMPHDDSKPCTRLFGPMGKHHVMAPLFVHLNQTLPWSPCSAMYLTELLDGG
  HGDCLLDAPAAALPLPTGLPGRMALYQLDQQCRQIFGPDFRHCPNTSAQDVCAQLWCHTD
  GAEPLCHTKNGSLPWADGTPCGPGHLCSEGSCLPEEEVERPKPVADGGWAPWGPWGECSR
  TCGGGVQFSHRECKDPEPQNGGRYCLGRRAKYQSCHTEECPPDGKSFREQQCEKYNAYNY
  TDMDGNLLQWVPKYAGVSPRDRCKLFCRARGRSEFKVFEAKVIDGTLCGPETLAICVRGQ
  CVKAGCDHVVDSPRKLDKCGVCGGKGNSCRKVSGSLTPTNYGYNDIVTIPAGATNIDVKQ
  RSHPGVQNDGNYLALKTADGQYLLNGNLAISAIEQDILVKGTILKYSGSIATLERLQSFR
  PLPEPLTVQLLTVPGEVFPPKVKYTFFVPNDVDFSMQSSKERATTNIIQPLLHAQWVLGD
  WSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPCESQLCPL

• Sequence length: 889

Pathways

Reactome:

Defective B3GALTL causes Peters-plus syndrome (PpS)
O-glycosylation of TSR domain-containing proteins

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	29610475

Unknown
Disease name	Disease term	dbSNP ID	References
Corneal astigmatism	Regular astigmatism - corneal		30306274
Prostatic neoplasms	Prostatic Neoplasms		29610475