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DNAJB4 (DnaJ heat shock protein family (Hsp40) member B4)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
11080
Gene nameGene Name - the full gene name approved by the HGNC.
DnaJ heat shock protein family (Hsp40) member B4
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
DNAJB4
SynonymsGene synonyms aliases
CMYO21, CMYP21, DNAJW, DjB4, HLJ1
ChromosomeChromosome number
1
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p31.1
SummarySummary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a molecular chaperone, tumor suppressor, and member of the heat shock protein-40 family. The encoded protein binds the cell adhesion protein E-cadherin and targets it to the plasma membrane. This protein also binds inco
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT001471 hsa-miR-16-5p pSILAC 18668040
MIRT019300 hsa-miR-148b-3p Microarray 17612493
MIRT021629 hsa-miR-142-3p Microarray 17612493
MIRT024618 hsa-miR-215-5p Microarray 19074876
MIRT026002 hsa-miR-148a-3p Sequencing 20371350
Transcription factors
Transcription factor Regulation Reference
YY1 Activation 15782117;21345358
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001671 Function ATPase activator activity IDA 24318877
GO:0005515 Function Protein binding IPI 21255413, 32296183, 32814053
GO:0005654 Component Nucleoplasm IDA
GO:0005829 Component Cytosol IBA 21873635
GO:0005829 Component Cytosol IDA 21231916
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID Q9UDY4
Protein name DnaJ homolog subfamily B member 4 (Heat shock 40 kDa protein 1 homolog) (HSP40 homolog) (Heat shock protein 40 homolog) (Human liver DnaJ-like protein)
Protein function Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877).
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00226 DnaJ
4 65
DnaJ domain
Domain
PF01556 DnaJ_C
160 319
DnaJ C terminal domain
Domain
Sequence
Sequence length 337
Interactions View interactions
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Lung adenocarcinoma Adenocarcinoma of lung (disorder) rs28934576, rs121913530, rs397516975, rs587776805, rs121913469, rs121913364, rs121913351, rs121913366, rs397516896, rs397516977, rs397516981, rs397517127, rs121913344, rs727504233, rs121913370, rs760043106, rs1057519788, rs1131692238, rs1131692237, rs1554350382 28604730
Lung carcinoma Carcinoma of lung rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355, rs121912470, rs121913273, rs121913281, rs121913348, rs727503093, rs121913353, rs397516890, rs397516896, rs121913378, rs397516897, rs397516977, rs397516978, rs397516979, rs397516980, rs397516981, rs397516982, rs121913240, rs17851045, rs397517086, rs121913428, rs397517094, rs397517098, rs397517106, rs121913465, rs397517108, rs397517111, rs397517112, rs397517114, rs397517116, rs1554350366, rs397517127, rs397517200, rs397517202, rs121913283, rs121913370, rs121913357, rs727503106, rs121913238, rs727503108, rs397517040, rs397516976, rs1555618025, rs1057519729, rs1584238193 28604730
Psoriasis Psoriasis rs281875215, rs587777763, rs281875213, rs281875212 28537254
Schizophrenia Schizophrenia rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 31374203

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