TENT4A (terminal nucleotidyltransferase 4A)

Gene

• Entrez ID: 11044
• Gene name: Terminal nucleotidyltransferase 4A
• Gene symbol: TENT4A
• Synonyms: LAK-1, LAK1, PAPD7, POLK, POLS, TRF4, TRF4-1, TRF41, TUTASE5
• Chromosome: 5
• Chromosome location: 5p15.31
• Summary: The protein encoded by this gene is a DNA polymerase that is likely involved in DNA repair. In addition, the encoded protein may be required for sister chromatid adhesion. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jan 2010]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016682	hsa-miR-423-3p	Sequencing	20371350
MIRT024572	hsa-miR-215-5p	Microarray	19074876
MIRT026248	hsa-miR-192-5p	Microarray	19074876
MIRT028280	hsa-miR-32-5p	Sequencing, PAR-CLIP	20371350
MIRT028280	hsa-miR-32-5p	HITS-CLIP	22473208
MIRT028280	hsa-miR-32-5p	PAR-CLIP	23446348
MIRT028280	hsa-miR-32-5p	PAR-CLIP	22012620
MIRT028280	hsa-miR-32-5p	PAR-CLIP	21572407
MIRT038569	hsa-miR-106b-3p	CLASH	23622248
MIRT048855	hsa-miR-93-5p	CLASH	23622248
MIRT096931	hsa-miR-25-3p	PAR-CLIP	23446348
MIRT096931	hsa-miR-25-3p	PAR-CLIP	22012620
MIRT096931	hsa-miR-25-3p	PAR-CLIP	21572407
MIRT096931	hsa-miR-25-3p	PAR-CLIP	20371350
MIRT096932	hsa-miR-92a-3p	HITS-CLIP	22473208
MIRT096932	hsa-miR-92a-3p	PAR-CLIP	23446348
MIRT096932	hsa-miR-92a-3p	PAR-CLIP	22012620
MIRT096932	hsa-miR-92a-3p	PAR-CLIP	21572407
MIRT096932	hsa-miR-92a-3p	PAR-CLIP	20371350
MIRT096934	hsa-miR-363-3p	PAR-CLIP	23446348
MIRT096934	hsa-miR-363-3p	PAR-CLIP	22012620
MIRT096934	hsa-miR-363-3p	PAR-CLIP	21572407
MIRT096934	hsa-miR-363-3p	PAR-CLIP	20371350
MIRT096935	hsa-miR-367-3p	PAR-CLIP	23446348
MIRT096935	hsa-miR-367-3p	PAR-CLIP	22012620
MIRT096935	hsa-miR-367-3p	PAR-CLIP	21572407
MIRT096935	hsa-miR-367-3p	PAR-CLIP	20371350
MIRT096936	hsa-miR-92b-3p	HITS-CLIP	22473208
MIRT096936	hsa-miR-92b-3p	PAR-CLIP	23446348
MIRT096936	hsa-miR-92b-3p	PAR-CLIP	22012620
MIRT096936	hsa-miR-92b-3p	PAR-CLIP	21572407
MIRT096936	hsa-miR-92b-3p	PAR-CLIP	20371350
MIRT096938	hsa-miR-3200-5p	PAR-CLIP	23446348
MIRT096938	hsa-miR-3200-5p	PAR-CLIP	22012620
MIRT096938	hsa-miR-3200-5p	PAR-CLIP	21572407
MIRT096938	hsa-miR-3200-5p	PAR-CLIP	20371350
MIRT096940	hsa-miR-4424	PAR-CLIP	23446348
MIRT096940	hsa-miR-4424	PAR-CLIP	22012620
MIRT096940	hsa-miR-4424	PAR-CLIP	21572407
MIRT096940	hsa-miR-4424	PAR-CLIP	20371350
MIRT096941	hsa-miR-4682	PAR-CLIP	23446348
MIRT096941	hsa-miR-4682	PAR-CLIP	22012620
MIRT096941	hsa-miR-4682	PAR-CLIP	21572407
MIRT096941	hsa-miR-4682	PAR-CLIP	20371350
MIRT096942	hsa-miR-4719	PAR-CLIP	23446348
MIRT096942	hsa-miR-4719	PAR-CLIP	22012620
MIRT096942	hsa-miR-4719	PAR-CLIP	21572407
MIRT096942	hsa-miR-4719	PAR-CLIP	20371350
MIRT166742	hsa-miR-16-2-3p	PAR-CLIP	23446348
MIRT166742	hsa-miR-16-2-3p	PAR-CLIP	22012620
MIRT166742	hsa-miR-16-2-3p	PAR-CLIP	20371350
MIRT166745	hsa-miR-195-3p	PAR-CLIP	23446348
MIRT166745	hsa-miR-195-3p	PAR-CLIP	22012620
MIRT166745	hsa-miR-195-3p	PAR-CLIP	20371350
MIRT166749	hsa-miR-1305	PAR-CLIP	23446348
MIRT166749	hsa-miR-1305	PAR-CLIP	22012620
MIRT166749	hsa-miR-1305	PAR-CLIP	20371350
MIRT166752	hsa-miR-142-3p	HITS-CLIP	22473208
MIRT166755	hsa-miR-519d-5p	PAR-CLIP	20371350
MIRT166756	hsa-miR-510-5p	PAR-CLIP	21572407
MIRT166756	hsa-miR-510-5p	PAR-CLIP	20371350
MIRT166759	hsa-miR-940	PAR-CLIP	21572407
MIRT166759	hsa-miR-940	PAR-CLIP	20371350
MIRT166760	hsa-miR-548j-3p	PAR-CLIP	20371350
MIRT166763	hsa-miR-1266-5p	PAR-CLIP	21572407
MIRT166763	hsa-miR-1266-5p	PAR-CLIP	20371350
MIRT166767	hsa-miR-3134	PAR-CLIP	21572407
MIRT166767	hsa-miR-3134	PAR-CLIP	20371350
MIRT166770	hsa-miR-548x-3p	PAR-CLIP	20371350
MIRT166771	hsa-miR-4318	PAR-CLIP	20371350
MIRT166773	hsa-miR-3907	PAR-CLIP	20371350
MIRT166777	hsa-miR-548ae-3p	PAR-CLIP	20371350
MIRT166778	hsa-miR-548ah-3p	PAR-CLIP	20371350
MIRT166779	hsa-miR-548aj-3p	PAR-CLIP	20371350
MIRT166781	hsa-miR-2392	PAR-CLIP	21572407
MIRT166781	hsa-miR-2392	PAR-CLIP	20371350
MIRT166782	hsa-miR-4518	PAR-CLIP	21572407
MIRT166782	hsa-miR-4518	PAR-CLIP	20371350
MIRT166785	hsa-miR-548am-3p	PAR-CLIP	20371350
MIRT166794	hsa-miR-548aq-3p	PAR-CLIP	20371350
MIRT166796	hsa-miR-6074	PAR-CLIP	21572407
MIRT166796	hsa-miR-6074	PAR-CLIP	20371350
MIRT166797	hsa-miR-6808-5p	PAR-CLIP	21572407
MIRT166797	hsa-miR-6808-5p	PAR-CLIP	20371350
MIRT166798	hsa-miR-6823-5p	PAR-CLIP	21572407
MIRT166798	hsa-miR-6823-5p	PAR-CLIP	20371350
MIRT166803	hsa-miR-6893-5p	PAR-CLIP	21572407
MIRT166803	hsa-miR-6893-5p	PAR-CLIP	20371350
MIRT216334	hsa-miR-590-3p	HITS-CLIP	23824327
MIRT314017	hsa-miR-137	PAR-CLIP	23592263
MIRT314017	hsa-miR-137	PAR-CLIP	23446348
MIRT314017	hsa-miR-137	PAR-CLIP	21572407
MIRT314017	hsa-miR-137	PAR-CLIP	20371350
MIRT314018	hsa-miR-299-5p	PAR-CLIP	23592263
MIRT314019	hsa-miR-299-3p	PAR-CLIP	23592263
MIRT314020	hsa-miR-629-5p	PAR-CLIP	23592263
MIRT314026	hsa-miR-4639-5p	PAR-CLIP	23592263
MIRT314027	hsa-miR-6748-5p	PAR-CLIP	23592263
MIRT314028	hsa-miR-6759-5p	PAR-CLIP	23592263
MIRT314029	hsa-miR-6793-5p	PAR-CLIP	23592263
MIRT314032	hsa-miR-6839-3p	PAR-CLIP	23592263
MIRT358993	hsa-miR-578	PAR-CLIP	21572407
MIRT358993	hsa-miR-578	PAR-CLIP	20371350
MIRT440044	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT471628	hsa-miR-582-5p	PAR-CLIP	23592263
MIRT471629	hsa-miR-101-3p	PAR-CLIP	23592263
MIRT471630	hsa-miR-8066	PAR-CLIP	23592263
MIRT555842	hsa-miR-4423-3p	PAR-CLIP	21572407
MIRT555842	hsa-miR-4423-3p	PAR-CLIP	20371350
MIRT555843	hsa-miR-4791	PAR-CLIP	21572407
MIRT555843	hsa-miR-4791	PAR-CLIP	20371350
MIRT555844	hsa-miR-3201	PAR-CLIP	21572407
MIRT555844	hsa-miR-3201	PAR-CLIP	20371350
MIRT555845	hsa-miR-449c-5p	PAR-CLIP	21572407
MIRT555845	hsa-miR-449c-5p	PAR-CLIP	20371350
MIRT555846	hsa-miR-34b-5p	PAR-CLIP	21572407
MIRT555846	hsa-miR-34b-5p	PAR-CLIP	20371350
MIRT555847	hsa-miR-2682-5p	PAR-CLIP	21572407
MIRT555847	hsa-miR-2682-5p	PAR-CLIP	20371350
MIRT555848	hsa-miR-6511a-5p	PAR-CLIP	21572407
MIRT555848	hsa-miR-6511a-5p	PAR-CLIP	20371350
MIRT555849	hsa-miR-1910-3p	PAR-CLIP	21572407
MIRT555849	hsa-miR-1910-3p	PAR-CLIP	20371350
MIRT616229	hsa-miR-411-5p	HITS-CLIP	23824327
MIRT616230	hsa-miR-4775	HITS-CLIP	23824327
MIRT616231	hsa-miR-4735-5p	HITS-CLIP	23824327

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004652	Function	Polynucleotide adenylyltransferase activity	IBA	21873635
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IDA	10066793
GO:0005654	Component	Nucleoplasm	IDA
GO:0005730	Component	Nucleolus	IBA	21873635
GO:0005794	Component	Golgi apparatus	IDA
GO:0006302	Process	Double-strand break repair	NAS	10066793
GO:0006397	Process	MRNA processing	IEA
GO:0007062	Process	Sister chromatid cohesion	TAS	10066793
GO:0007076	Process	Mitotic chromosome condensation	NAS	10066793
GO:0031123	Process	RNA 3'-end processing	IBA	21873635
GO:0031499	Component	TRAMP complex	IBA	21873635
GO:0031965	Component	Nuclear membrane	IDA
GO:0042493	Process	Response to drug	IDA	10066793
GO:0043221	Function	SMC family protein binding	TAS	10066793
GO:0043631	Process	RNA polyadenylation	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0060212	Process	Negative regulation of nuclear-transcribed mRNA poly(A) tail shortening	IMP	30026317
GO:0070568	Function	Guanylyltransferase activity	IMP	30026317
GO:0071076	Process	RNA 3' uridylation	IMP	30026317
GO:1905870	Process	Positive regulation of 3'-UTR-mediated mRNA stabilization	IMP	30026317

Other IDs

• MIM: 605198
• HGNC: 16705
• e!Ensembl: ENSG00000112941

Protein

• UniProt ID: Q5XG87
• Protein name: Terminal nucleotidyltransferase 4A (DNA polymerase sigma) (LAK-1) (Non-canonical poly(A) RNA polymerase PAPD7) (EC 2.7.7.19) (PAP-associated domain-containing protein 7) (TRAMP-like complex polyadenylate polymerase) (Terminal guanylyltransferase) (EC 2.7.7.-) (Terminal uridylyltransferase 5) (TUTase 5) (Topoisomerase-related function protein 4-1) (TRF4-1)
• Protein function: Terminal nucleotidyltransferase that catalyzes preferentially the transfert of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation (PubMed:23376078, PubMed:30026317). Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Has no terminal uridylyltransferase activity, and does not play a role in replication-dependent histone mRNA degradation via uridylation (PubMed:23376078).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01909	NTP_transf_2	245 → 354	Nucleotidyltransferase domain	Family
  PF03828	PAP_assoc	408 → 468	Cid1 family poly A polymerase	Family

• Sequence:

  MQIWETSQGVGRGGSGFASYFCLNSPALDTAAAAGAAGRGSGGLGPALPAASPPPPGPTA
  PAALPPALLTALGPAAEGARRLHKSPSLSSSSSSSSSNAESGTESPGCSSSSSSSASLGR
  PGGGRGGAFFNFADGAPSAPGTANGHPGPRGPAPAGSPSQHQFHPGRRKRENKASTYGLN
  YLLSGSRAAALSGGGGPGAQAPRPGTPWKSRAYSPGIQGLHEEIIDFYNFMSPCPEEAAM
  RREVVKRIETVVKDLWPTADVQIFGSFSTGLYLPTSDIDLVVFGKWERPPLQLLEQALRK
  HNVAEPCSIKVLDKATVPIIKLTDQETEVKVDISFNMETGVRAAEFIKNYMKKYSLLPYL
  ILVLKQFLLQRDLNEVFTGGISSYSLILMAISFLQLHPRIDARRADENLGMLLVEFFELY
  GRNFNYLKTGIRIKEGGAYIAKEEIMKAMTSGYRPSMLCIEDPLLPGNDVGRSSYGAMQV
  KQVFDYAYIVLSHAVSPLARSYPNRDAESTLGRIIKVTQEVIDYRRWIKEKWGSKAHPSP
  GMDSRIKIKERIATCNGEQTQNREPESPYGQRLTLSLSSPQLLSSGSSASSVSSLSGSDV
  DSDTPPCTTPSVYQFSLQAPAPLMAGLPTALPMPSGKPQPTTSRTLIMTTNNQTRFTIPP
  PTLGVAPVPCRQAGVEGTASLKAVHHMSSPAIPSASPNPLSSPHLYHKQHNGMKLSMKGS
  HGHTQGGGYSSVGSGGVRPPVGNRGHHQYNRTGWRRKKHTHTRDSLPVSLSR

• Sequence length: 772

Pathways

KEGG:

RNA degradation

Reactome:

Signaling by BRAF and RAF fusions

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Coronary artery disease	Coronary Artery Disease	rs137852988, rs121918313, rs-1, rs121918529, rs121918531, rs137852340, rs405509, rs1555800701, rs1215189537	29212778