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KIF2C (kinesin family member 2C)

Gene

11004

Kinesin family member 2C

KIF2C

CT139, KNSL6, MCAK

1p34.1

This gene encodes a kinesin-like protein that functions as a microtubule-dependent molecular motor. The encoded protein can depolymerize microtubules at the plus end, thereby promoting mitotic chromosome segregation. Alternative splicing results in multip

Show/Hide all(185)

miRTarBase ID	miRNA	Experiments	Reference
MIRT016679	hsa-miR-423-3p	Sequencing	20371350
MIRT019473	hsa-miR-148b-3p	Microarray	17612493
MIRT023058	hsa-miR-124-3p	Proteomics;Microarray	18668037
MIRT024025	hsa-miR-1-3p	Proteomics	18668040
MIRT025335	hsa-miR-34a-5p	Proteomics	21566225
MIRT025335	hsa-miR-34a-5p	Proteomics	21566225
MIRT027317	hsa-miR-101-3p	Sequencing	20371350
MIRT031974	hsa-miR-16-5p	Proteomics	18668040
MIRT050506	hsa-miR-20a-5p	CLASH	23622248
MIRT049563	hsa-miR-92a-3p	CLASH	23622248
MIRT138452	hsa-miR-4484	PAR-CLIP	23592263
MIRT138427	hsa-miR-181a-5p	PAR-CLIP	23592263
MIRT138428	hsa-miR-181b-5p	PAR-CLIP	23592263
MIRT138429	hsa-miR-181c-5p	PAR-CLIP	23592263
MIRT138435	hsa-miR-181d-5p	PAR-CLIP	23592263
MIRT138449	hsa-miR-4262	PAR-CLIP	23592263
MIRT138447	hsa-miR-3154	PAR-CLIP	23592263
MIRT138463	hsa-miR-6858-3p	PAR-CLIP	23592263
MIRT138426	hsa-miR-148a-3p	PAR-CLIP	23592263
MIRT019473	hsa-miR-148b-3p	PAR-CLIP	23592263
MIRT138430	hsa-miR-152-3p	PAR-CLIP	23592263
MIRT138432	hsa-miR-186-3p	PAR-CLIP	23592263
MIRT138460	hsa-miR-6075	PAR-CLIP	23592263
MIRT016679	hsa-miR-423-3p	PAR-CLIP	23592263
MIRT138446	hsa-miR-3136-3p	PAR-CLIP	23592263
MIRT138464	hsa-miR-7155-3p	PAR-CLIP	23592263
MIRT455914	hsa-miR-4276	PAR-CLIP	23592263
MIRT455913	hsa-miR-1303	PAR-CLIP	23592263
MIRT138440	hsa-miR-583	PAR-CLIP	23592263
MIRT455912	hsa-miR-548a-5p	PAR-CLIP	23592263
MIRT455911	hsa-miR-548ab	PAR-CLIP	23592263
MIRT455910	hsa-miR-548ad-5p	PAR-CLIP	23592263
MIRT455909	hsa-miR-548ae-5p	PAR-CLIP	23592263
MIRT455908	hsa-miR-548ak	PAR-CLIP	23592263
MIRT455907	hsa-miR-548am-5p	PAR-CLIP	23592263
MIRT455906	hsa-miR-548ap-5p	PAR-CLIP	23592263
MIRT455905	hsa-miR-548aq-5p	PAR-CLIP	23592263
MIRT455904	hsa-miR-548ar-5p	PAR-CLIP	23592263
MIRT455903	hsa-miR-548as-5p	PAR-CLIP	23592263
MIRT455902	hsa-miR-548au-5p	PAR-CLIP	23592263
MIRT455901	hsa-miR-548ay-5p	PAR-CLIP	23592263
MIRT455900	hsa-miR-548b-5p	PAR-CLIP	23592263
MIRT455899	hsa-miR-548bb-5p	PAR-CLIP	23592263
MIRT455898	hsa-miR-548c-5p	PAR-CLIP	23592263
MIRT455897	hsa-miR-548d-5p	PAR-CLIP	23592263
MIRT455896	hsa-miR-548h-5p	PAR-CLIP	23592263
MIRT455895	hsa-miR-548i	PAR-CLIP	23592263
MIRT455894	hsa-miR-548j-5p	PAR-CLIP	23592263
MIRT455893	hsa-miR-548o-5p	PAR-CLIP	23592263
MIRT455892	hsa-miR-548w	PAR-CLIP	23592263
MIRT455891	hsa-miR-548y	PAR-CLIP	23592263
MIRT455890	hsa-miR-559	PAR-CLIP	23592263
MIRT138459	hsa-miR-548av-5p	PAR-CLIP	23592263
MIRT138444	hsa-miR-548k	PAR-CLIP	23592263
MIRT138465	hsa-miR-8054	PAR-CLIP	23592263
MIRT455889	hsa-miR-548l	PAR-CLIP	23592263
MIRT138462	hsa-miR-6760-5p	PAR-CLIP	23592263
MIRT455888	hsa-miR-1321	PAR-CLIP	23592263
MIRT455887	hsa-miR-4739	PAR-CLIP	23592263
MIRT455886	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT138451	hsa-miR-3675-3p	PAR-CLIP	23592263
MIRT138439	hsa-miR-545-5p	PAR-CLIP	23592263
MIRT455885	hsa-miR-4330	PAR-CLIP	23592263
MIRT455884	hsa-miR-517-5p	PAR-CLIP	23592263
MIRT455883	hsa-miR-1251-5p	PAR-CLIP	23592263
MIRT138434	hsa-miR-494-3p	PAR-CLIP	23592263
MIRT138455	hsa-miR-4645-3p	PAR-CLIP	23592263
MIRT138453	hsa-miR-4524a-3p	PAR-CLIP	23592263
MIRT138448	hsa-miR-3162-5p	PAR-CLIP	23592263
MIRT455882	hsa-miR-142-5p	PAR-CLIP	23592263
MIRT455881	hsa-miR-7113-5p	PAR-CLIP	23592263
MIRT138427	hsa-miR-181a-5p	HITS-CLIP	22473208
MIRT138428	hsa-miR-181b-5p	HITS-CLIP	22473208
MIRT138429	hsa-miR-181c-5p	HITS-CLIP	22473208
MIRT138435	hsa-miR-181d-5p	HITS-CLIP	22473208
MIRT138452	hsa-miR-4484	PAR-CLIP	23592263
MIRT138427	hsa-miR-181a-5p	PAR-CLIP	23592263
MIRT138428	hsa-miR-181b-5p	PAR-CLIP	23592263
MIRT138429	hsa-miR-181c-5p	PAR-CLIP	23592263
MIRT138435	hsa-miR-181d-5p	PAR-CLIP	23592263
MIRT138449	hsa-miR-4262	PAR-CLIP	23592263
MIRT138447	hsa-miR-3154	PAR-CLIP	23592263
MIRT138463	hsa-miR-6858-3p	PAR-CLIP	23592263
MIRT138426	hsa-miR-148a-3p	PAR-CLIP	23592263
MIRT019473	hsa-miR-148b-3p	PAR-CLIP	23592263
MIRT138430	hsa-miR-152-3p	PAR-CLIP	23592263
MIRT138432	hsa-miR-186-3p	PAR-CLIP	23592263
MIRT138460	hsa-miR-6075	PAR-CLIP	23592263
MIRT016679	hsa-miR-423-3p	PAR-CLIP	23592263
MIRT138446	hsa-miR-3136-3p	PAR-CLIP	23592263
MIRT138464	hsa-miR-7155-3p	PAR-CLIP	23592263
MIRT455914	hsa-miR-4276	PAR-CLIP	23592263
MIRT455913	hsa-miR-1303	PAR-CLIP	23592263
MIRT138440	hsa-miR-583	PAR-CLIP	23592263
MIRT455912	hsa-miR-548a-5p	PAR-CLIP	23592263
MIRT455911	hsa-miR-548ab	PAR-CLIP	23592263
MIRT455910	hsa-miR-548ad-5p	PAR-CLIP	23592263
MIRT455909	hsa-miR-548ae-5p	PAR-CLIP	23592263
MIRT455908	hsa-miR-548ak	PAR-CLIP	23592263
MIRT455907	hsa-miR-548am-5p	PAR-CLIP	23592263
MIRT455906	hsa-miR-548ap-5p	PAR-CLIP	23592263
MIRT455905	hsa-miR-548aq-5p	PAR-CLIP	23592263
MIRT455904	hsa-miR-548ar-5p	PAR-CLIP	23592263
MIRT455903	hsa-miR-548as-5p	PAR-CLIP	23592263
MIRT455902	hsa-miR-548au-5p	PAR-CLIP	23592263
MIRT455901	hsa-miR-548ay-5p	PAR-CLIP	23592263
MIRT455900	hsa-miR-548b-5p	PAR-CLIP	23592263
MIRT455899	hsa-miR-548bb-5p	PAR-CLIP	23592263
MIRT455898	hsa-miR-548c-5p	PAR-CLIP	23592263
MIRT455897	hsa-miR-548d-5p	PAR-CLIP	23592263
MIRT455896	hsa-miR-548h-5p	PAR-CLIP	23592263
MIRT455895	hsa-miR-548i	PAR-CLIP	23592263
MIRT455894	hsa-miR-548j-5p	PAR-CLIP	23592263
MIRT455893	hsa-miR-548o-5p	PAR-CLIP	23592263
MIRT455892	hsa-miR-548w	PAR-CLIP	23592263
MIRT455891	hsa-miR-548y	PAR-CLIP	23592263
MIRT455890	hsa-miR-559	PAR-CLIP	23592263
MIRT138459	hsa-miR-548av-5p	PAR-CLIP	23592263
MIRT138444	hsa-miR-548k	PAR-CLIP	23592263
MIRT138465	hsa-miR-8054	PAR-CLIP	23592263
MIRT455889	hsa-miR-548l	PAR-CLIP	23592263
MIRT138462	hsa-miR-6760-5p	PAR-CLIP	23592263
MIRT455888	hsa-miR-1321	PAR-CLIP	23592263
MIRT455887	hsa-miR-4739	PAR-CLIP	23592263
MIRT455886	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT138451	hsa-miR-3675-3p	PAR-CLIP	23592263
MIRT138439	hsa-miR-545-5p	PAR-CLIP	23592263
MIRT455885	hsa-miR-4330	PAR-CLIP	23592263
MIRT455884	hsa-miR-517-5p	PAR-CLIP	23592263
MIRT455883	hsa-miR-1251-5p	PAR-CLIP	23592263
MIRT138434	hsa-miR-494-3p	PAR-CLIP	23592263
MIRT138455	hsa-miR-4645-3p	PAR-CLIP	23592263
MIRT138453	hsa-miR-4524a-3p	PAR-CLIP	23592263
MIRT138448	hsa-miR-3162-5p	PAR-CLIP	23592263
MIRT455882	hsa-miR-142-5p	PAR-CLIP	23592263
MIRT455881	hsa-miR-7113-5p	PAR-CLIP	23592263
MIRT1094541	hsa-miR-136	CLIP-seq
MIRT1094542	hsa-miR-146b-3p	CLIP-seq
MIRT1094543	hsa-miR-1915	CLIP-seq
MIRT1094544	hsa-miR-22	CLIP-seq
MIRT1094545	hsa-miR-2355-5p	CLIP-seq
MIRT1094546	hsa-miR-296-5p	CLIP-seq
MIRT1094547	hsa-miR-3134	CLIP-seq
MIRT1094548	hsa-miR-3173-5p	CLIP-seq
MIRT1094549	hsa-miR-3688-3p	CLIP-seq
MIRT1094550	hsa-miR-3978	CLIP-seq
MIRT1094551	hsa-miR-4270	CLIP-seq
MIRT1094552	hsa-miR-4292	CLIP-seq
MIRT1094553	hsa-miR-4300	CLIP-seq
MIRT1094554	hsa-miR-4441	CLIP-seq
MIRT1094555	hsa-miR-4534	CLIP-seq
MIRT1094556	hsa-miR-4640-3p	CLIP-seq
MIRT1094557	hsa-miR-4780	CLIP-seq
MIRT1094558	hsa-miR-874	CLIP-seq
MIRT1094559	hsa-miR-885-5p	CLIP-seq
MIRT1094560	hsa-miR-920	CLIP-seq
MIRT2025322	hsa-miR-4728-3p	CLIP-seq
MIRT1094542	hsa-miR-146b-3p	CLIP-seq
MIRT2256591	hsa-miR-148a	CLIP-seq
MIRT2256592	hsa-miR-148b	CLIP-seq
MIRT2256593	hsa-miR-152	CLIP-seq
MIRT2256594	hsa-miR-181a	CLIP-seq
MIRT2256595	hsa-miR-181b	CLIP-seq
MIRT2256596	hsa-miR-181c	CLIP-seq
MIRT2256597	hsa-miR-181d	CLIP-seq
MIRT1094544	hsa-miR-22	CLIP-seq
MIRT1094545	hsa-miR-2355-5p	CLIP-seq
MIRT1094548	hsa-miR-3173-5p	CLIP-seq
MIRT2256598	hsa-miR-3617	CLIP-seq
MIRT2256599	hsa-miR-4256	CLIP-seq
MIRT2256600	hsa-miR-4514	CLIP-seq
MIRT2256601	hsa-miR-455-3p	CLIP-seq
MIRT2256602	hsa-miR-4639-3p	CLIP-seq
MIRT1094556	hsa-miR-4640-3p	CLIP-seq
MIRT2256603	hsa-miR-4676-5p	CLIP-seq
MIRT2256604	hsa-miR-4692	CLIP-seq
MIRT2256605	hsa-miR-4714-5p	CLIP-seq
MIRT2256606	hsa-miR-548h	CLIP-seq
MIRT2256607	hsa-miR-548j	CLIP-seq
MIRT2256608	hsa-miR-575	CLIP-seq
MIRT2256609	hsa-miR-641	CLIP-seq
MIRT2256610	hsa-miR-668	CLIP-seq
MIRT1094558	hsa-miR-874	CLIP-seq
MIRT1094559	hsa-miR-885-5p	CLIP-seq
MIRT2389869	hsa-miR-658	CLIP-seq

Transcription factors

Show/Hide all(3)

Transcription factor	Regulation	Reference
E2F1	Activation	23610368
E2F1	Repression	18440323
SP1	Activation	18440323

Show/Hide all(35)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000775	Component	Chromosome, centromeric region	IDA	14960279
GO:0000776	Component	Kinetochore	IDA	23891108
GO:0000776	Component	Kinetochore	IDA	14960279
GO:0000777	Component	Condensed chromosome kinetochore	IEA
GO:0003777	Function	Microtubule motor activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	11092768, 19543227, 19632184, 21820309, 26496610, 27173435
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005813	Component	Centrosome	IBA	21873635
GO:0005819	Component	Spindle	IBA	21873635
GO:0005829	Component	Cytosol	TAS
GO:0005871	Component	Kinesin complex	IBA	21873635
GO:0005874	Component	Microtubule	IBA	21873635
GO:0005881	Component	Cytoplasmic microtubule	ISS
GO:0006890	Process	Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	TAS
GO:0007018	Process	Microtubule-based movement	IBA	21873635
GO:0007018	Process	Microtubule-based movement	TAS
GO:0007019	Process	Microtubule depolymerization	IDA	21820309
GO:0007019	Process	Microtubule depolymerization	IMP	19060894
GO:0007019	Process	Microtubule depolymerization	TAS	26323690
GO:0007080	Process	Mitotic metaphase plate congression	IMP	15843429
GO:0008017	Function	Microtubule binding	IBA	21873635
GO:0015630	Component	Microtubule cytoskeleton	IDA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016887	Function	ATPase activity	IBA	21873635
GO:0019237	Function	Centromeric DNA binding	TAS	9434124
GO:0019886	Process	Antigen processing and presentation of exogenous peptide antigen via MHC class II	TAS
GO:0030951	Process	Establishment or maintenance of microtubule cytoskeleton polarity	IMP	14718566
GO:0035371	Component	Microtubule plus-end	IDA	21820309, 23891108
GO:0035371	Component	Microtubule plus-end	TAS	26323690
GO:0051010	Function	Microtubule plus-end binding	IDA	19632184
GO:0051301	Process	Cell division	IEA
GO:0051310	Process	Metaphase plate congression	IMP	23891108
GO:0051315	Process	Attachment of mitotic spindle microtubules to kinetochore	IMP	23891108
GO:0051983	Process	Regulation of chromosome segregation	IMP	19060894

MIM	HGNC	e!Ensembl
604538	6393	ENSG00000142945

Protein

UniProt ID

Q99661

Protein name

Kinesin-like protein KIF2C (Kinesin-like protein 6) (Mitotic centromere-associated kinesin) (MCAK)

Protein function

In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells (PubMed:21820309). Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis (PubM

PDB

2HEH , 4UBF , 4Y05 , 5MIO

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00225	Kinesin	264 → 588	Kinesin motor domain	Domain

Sequence

MAMDSSLQARLFPGLAIKIQRSNGLIHSANVRTVNLEKSCVSVEWAEGGATKGKEIDFDD
VAAINPELLQLLPLHPKDNLPLQENVTIQKQKRRSVNSKIPAPKESLRSRSTRMSTVSEL
RITAQENDMEVELPAAANSRKQFSVPPAPTRPSCPAVAEIPLRMVSEEMEEQVHSIRGSS
SANPVNSVRRKSCLVKEVEKMKNKREEKKAQNSEMRMKRAQEYDSSFPNWEFARMIKEFR
ATLECHPLTMTDPIEEHRICVCVRKRPLNKQELAKKEIDVISIPSKCLLLVHEPKLKVDL
TKYLENQAFCFDFAFDETASNEVVYRFTARPLVQTIFEGGKATCFAYGQTGSGKTHTMGG
DLSGKAQNASKGIYAMASRDVFLLKNQPCYRKLGLEVYVTFFEIYNGKLFDLLNKKAKLR
VLEDGKQQVQVVGLQEHLVNSADDVIKMIDMGSACRTSGQTFANSNSSRSHACFQIILRA
KGRMHGKFSLVDLAGNERGADTSSADRQTRMEGAEINKSLLALKECIRALGQNKAHTPFR
ESKLTQVLRDSFIGENSRTCMIATISPGISSCEYTLNTLRYADRVKELSPHSGPSGEQLI
QMETEEMEACSNGALIPGNLSKEEEELSSQMSSFNEAMTQIRELEEKAMEELKEIIQQGP
DWLELSEMTEQPDYDLETFVNKAESALAQQAKHFSALRDVIKALRLAMQLEEQASRQISS
KKRPQ

Sequence length

725

Interactions

View interactions

	KEGG		Reactome
	Motor proteins		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins COPI-dependent Golgi-to-ER retrograde traffic Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation Kinesins

Associated diseases

Show/Hide Causal Diseases (1)

Causal
Disease name	Disease term	dbSNP ID	References
Dermatitis	Contact Dermatitis	rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174	25724174

Show/Hide Unknown Diseases (1)

Unknown
Disease name	Disease term	dbSNP ID	References
Liver carcinoma	Liver carcinoma		28284560

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