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SLC27A4 (solute carrier family 27 member 4)

Gene

10999

Solute carrier family 27 member 4

SLC27A4

ACSVL4, ACSVL4 FATP4, FATP4, IPS

9q34.11

This gene encodes a member of a family of fatty acid transport proteins, which are involved in translocation of long-chain fatty acids cross the plasma membrane. This protein is expressed at high levels on the apical side of mature enterocytes in the smal

Show/Hide all(12)

SNP ID	Visualize variation	Clinical significance	Consequence
rs137853131	C>A,T	Pathogenic	Coding sequence variant, synonymous variant, stop gained
rs137853132	G>A	Pathogenic	Coding sequence variant, missense variant
rs137853133	T>C	Pathogenic	Coding sequence variant, missense variant
rs137853134	A>G	Pathogenic	Coding sequence variant, missense variant
rs137853135	G>A	Pathogenic	Coding sequence variant, missense variant
rs368207076	T>G	Pathogenic	Splice donor variant
rs758657421	AG>-	Pathogenic	Coding sequence variant, frameshift variant
rs764922350	A>G	Pathogenic	Splice acceptor variant
rs765311079	C>G,T	Likely-pathogenic	Coding sequence variant, missense variant
rs869312967	G>A	Pathogenic	Coding sequence variant, missense variant
rs1340721389	C>T	Likely-pathogenic	Coding sequence variant, stop gained
rs1588559786	G>A	Pathogenic	Splice acceptor variant

Show/Hide all(293)

miRTarBase ID	miRNA	Experiments	Reference
MIRT023551	hsa-miR-1-3p	Proteomics;Microarray	18668037
MIRT031405	hsa-miR-16-5p	Proteomics	18668040
MIRT050385	hsa-miR-23a-3p	CLASH	23622248
MIRT653664	hsa-miR-4798-3p	HITS-CLIP	23824327
MIRT653663	hsa-miR-3680-5p	HITS-CLIP	23824327
MIRT653662	hsa-miR-6729-3p	HITS-CLIP	23824327
MIRT653661	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT653660	hsa-miR-3183	HITS-CLIP	23824327
MIRT653659	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT653658	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT653657	hsa-miR-3121-5p	HITS-CLIP	23824327
MIRT653656	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT653655	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT653654	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT653653	hsa-miR-518c-5p	HITS-CLIP	23824327
MIRT653652	hsa-miR-326	HITS-CLIP	23824327
MIRT653651	hsa-miR-330-5p	HITS-CLIP	23824327
MIRT653650	hsa-miR-6764-3p	HITS-CLIP	23824327
MIRT653649	hsa-miR-6824-3p	HITS-CLIP	23824327
MIRT653648	hsa-miR-103a-2-5p	HITS-CLIP	23824327
MIRT653647	hsa-miR-3191-5p	HITS-CLIP	23824327
MIRT653646	hsa-miR-3977	HITS-CLIP	23824327
MIRT653645	hsa-miR-6885-3p	HITS-CLIP	23824327
MIRT518188	hsa-miR-552-3p	PAR-CLIP	23446348
MIRT518187	hsa-miR-764	PAR-CLIP	23446348
MIRT518186	hsa-miR-4740-3p	PAR-CLIP	23446348
MIRT518185	hsa-miR-7155-5p	PAR-CLIP	23446348
MIRT518184	hsa-miR-4731-5p	PAR-CLIP	23446348
MIRT518182	hsa-miR-193b-5p	PAR-CLIP	23446348
MIRT518183	hsa-miR-5095	PAR-CLIP	23446348
MIRT518181	hsa-miR-7151-3p	PAR-CLIP	23446348
MIRT518180	hsa-miR-3170	PAR-CLIP	23446348
MIRT518179	hsa-miR-6855-5p	PAR-CLIP	23446348
MIRT653664	hsa-miR-4798-3p	HITS-CLIP	23824327
MIRT653663	hsa-miR-3680-5p	HITS-CLIP	23824327
MIRT653662	hsa-miR-6729-3p	HITS-CLIP	23824327
MIRT653661	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT653660	hsa-miR-3183	HITS-CLIP	23824327
MIRT653659	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT653658	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT653657	hsa-miR-3121-5p	HITS-CLIP	23824327
MIRT653656	hsa-miR-6511a-3p	HITS-CLIP	23824327
MIRT653655	hsa-miR-6511b-3p	HITS-CLIP	23824327
MIRT653654	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT653653	hsa-miR-518c-5p	HITS-CLIP	23824327
MIRT653652	hsa-miR-326	HITS-CLIP	23824327
MIRT653651	hsa-miR-330-5p	HITS-CLIP	23824327
MIRT653650	hsa-miR-6764-3p	HITS-CLIP	23824327
MIRT653649	hsa-miR-6824-3p	HITS-CLIP	23824327
MIRT653648	hsa-miR-103a-2-5p	HITS-CLIP	23824327
MIRT653647	hsa-miR-3191-5p	HITS-CLIP	23824327
MIRT653646	hsa-miR-3977	HITS-CLIP	23824327
MIRT653645	hsa-miR-6885-3p	HITS-CLIP	23824327
MIRT518188	hsa-miR-552-3p	PAR-CLIP	23446348
MIRT518187	hsa-miR-764	PAR-CLIP	23446348
MIRT518186	hsa-miR-4740-3p	PAR-CLIP	23446348
MIRT518185	hsa-miR-7155-5p	PAR-CLIP	23446348
MIRT518184	hsa-miR-4731-5p	PAR-CLIP	23446348
MIRT518182	hsa-miR-193b-5p	PAR-CLIP	23446348
MIRT518183	hsa-miR-5095	PAR-CLIP	23446348
MIRT518181	hsa-miR-7151-3p	PAR-CLIP	23446348
MIRT518180	hsa-miR-3170	PAR-CLIP	23446348
MIRT518179	hsa-miR-6855-5p	PAR-CLIP	23446348
MIRT1358041	hsa-miR-1207-5p	CLIP-seq
MIRT1358042	hsa-miR-1268	CLIP-seq
MIRT1358043	hsa-miR-1268b	CLIP-seq
MIRT1358044	hsa-miR-1275	CLIP-seq
MIRT1358045	hsa-miR-1321	CLIP-seq
MIRT1358046	hsa-miR-1909	CLIP-seq
MIRT1358047	hsa-miR-1913	CLIP-seq
MIRT1358048	hsa-miR-1915	CLIP-seq
MIRT1358049	hsa-miR-1976	CLIP-seq
MIRT1358050	hsa-miR-2392	CLIP-seq
MIRT1358051	hsa-miR-3192	CLIP-seq
MIRT1358052	hsa-miR-3202	CLIP-seq
MIRT1358053	hsa-miR-324-3p	CLIP-seq
MIRT1358054	hsa-miR-3605-5p	CLIP-seq
MIRT1358055	hsa-miR-370	CLIP-seq
MIRT1358056	hsa-miR-4270	CLIP-seq
MIRT1358057	hsa-miR-4313	CLIP-seq
MIRT1358058	hsa-miR-4314	CLIP-seq
MIRT1358059	hsa-miR-4441	CLIP-seq
MIRT1358060	hsa-miR-4443	CLIP-seq
MIRT1358061	hsa-miR-4525	CLIP-seq
MIRT1358062	hsa-miR-4646-5p	CLIP-seq
MIRT1358063	hsa-miR-4665-5p	CLIP-seq
MIRT1358064	hsa-miR-4707-5p	CLIP-seq
MIRT1358065	hsa-miR-4711-5p	CLIP-seq
MIRT1358066	hsa-miR-4717-3p	CLIP-seq
MIRT1358067	hsa-miR-4718	CLIP-seq
MIRT1358068	hsa-miR-4723-5p	CLIP-seq
MIRT1358069	hsa-miR-4739	CLIP-seq
MIRT1358070	hsa-miR-4747-5p	CLIP-seq
MIRT1358071	hsa-miR-4756-5p	CLIP-seq
MIRT1358072	hsa-miR-4763-3p	CLIP-seq
MIRT1358073	hsa-miR-625	CLIP-seq
MIRT1358074	hsa-miR-634	CLIP-seq
MIRT1358075	hsa-miR-765	CLIP-seq
MIRT1358076	hsa-miR-940	CLIP-seq
MIRT2106052	hsa-miR-103b	CLIP-seq
MIRT2106053	hsa-miR-1193	CLIP-seq
MIRT2106054	hsa-miR-1225-3p	CLIP-seq
MIRT2106055	hsa-miR-1233	CLIP-seq
MIRT2106056	hsa-miR-1262	CLIP-seq
MIRT2106057	hsa-miR-1293	CLIP-seq
MIRT2106058	hsa-miR-150	CLIP-seq
MIRT1358050	hsa-miR-2392	CLIP-seq
MIRT2106059	hsa-miR-2861	CLIP-seq
MIRT2106060	hsa-miR-296-3p	CLIP-seq
MIRT2106061	hsa-miR-3065-3p	CLIP-seq
MIRT2106062	hsa-miR-3184	CLIP-seq
MIRT2106063	hsa-miR-3194-3p	CLIP-seq
MIRT1358052	hsa-miR-3202	CLIP-seq
MIRT2106064	hsa-miR-328	CLIP-seq
MIRT2106065	hsa-miR-34a	CLIP-seq
MIRT2106066	hsa-miR-34c-5p	CLIP-seq
MIRT2106067	hsa-miR-3614-5p	CLIP-seq
MIRT2106068	hsa-miR-3664-3p	CLIP-seq
MIRT2106069	hsa-miR-3689d	CLIP-seq
MIRT2106070	hsa-miR-3690	CLIP-seq
MIRT2106071	hsa-miR-3909	CLIP-seq
MIRT2106072	hsa-miR-3943	CLIP-seq
MIRT2106073	hsa-miR-423-5p	CLIP-seq
MIRT2106074	hsa-miR-4254	CLIP-seq
MIRT2106075	hsa-miR-4279	CLIP-seq
MIRT2106076	hsa-miR-4283	CLIP-seq
MIRT1358057	hsa-miR-4313	CLIP-seq
MIRT2106077	hsa-miR-4324	CLIP-seq
MIRT2106078	hsa-miR-4328	CLIP-seq
MIRT2106079	hsa-miR-4417	CLIP-seq
MIRT2106080	hsa-miR-4425	CLIP-seq
MIRT2106081	hsa-miR-4438	CLIP-seq
MIRT2106082	hsa-miR-4447	CLIP-seq
MIRT2106083	hsa-miR-4472	CLIP-seq
MIRT2106084	hsa-miR-4483	CLIP-seq
MIRT2106085	hsa-miR-449a	CLIP-seq
MIRT2106086	hsa-miR-449b	CLIP-seq
MIRT2106087	hsa-miR-4512	CLIP-seq
MIRT2106088	hsa-miR-4533	CLIP-seq
MIRT2106089	hsa-miR-4534	CLIP-seq
MIRT2106090	hsa-miR-4667-3p	CLIP-seq
MIRT2106091	hsa-miR-4667-5p	CLIP-seq
MIRT2106092	hsa-miR-4676-5p	CLIP-seq
MIRT2106093	hsa-miR-4688	CLIP-seq
MIRT2106094	hsa-miR-4690-3p	CLIP-seq
MIRT2106095	hsa-miR-4691-5p	CLIP-seq
MIRT2106096	hsa-miR-4700-5p	CLIP-seq
MIRT2106097	hsa-miR-4701-3p	CLIP-seq
MIRT1358065	hsa-miR-4711-5p	CLIP-seq
MIRT2106098	hsa-miR-4713-5p	CLIP-seq
MIRT2106099	hsa-miR-4729	CLIP-seq
MIRT1358070	hsa-miR-4747-5p	CLIP-seq
MIRT2106100	hsa-miR-4763-5p	CLIP-seq
MIRT2106101	hsa-miR-4802-5p	CLIP-seq
MIRT2106102	hsa-miR-486-3p	CLIP-seq
MIRT2106103	hsa-miR-507	CLIP-seq
MIRT2106104	hsa-miR-532-3p	CLIP-seq
MIRT2106105	hsa-miR-541	CLIP-seq
MIRT2106106	hsa-miR-544b	CLIP-seq
MIRT2106107	hsa-miR-557	CLIP-seq
MIRT2106108	hsa-miR-575	CLIP-seq
MIRT2106109	hsa-miR-617	CLIP-seq
MIRT2106110	hsa-miR-637	CLIP-seq
MIRT2106111	hsa-miR-654-5p	CLIP-seq
MIRT2106112	hsa-miR-767-3p	CLIP-seq
MIRT2106113	hsa-miR-876-3p	CLIP-seq
MIRT2106053	hsa-miR-1193	CLIP-seq
MIRT2330388	hsa-miR-1200	CLIP-seq
MIRT2330389	hsa-miR-1267	CLIP-seq
MIRT2330390	hsa-miR-1292	CLIP-seq
MIRT1358050	hsa-miR-2392	CLIP-seq
MIRT2106059	hsa-miR-2861	CLIP-seq
MIRT2106061	hsa-miR-3065-3p	CLIP-seq
MIRT2330391	hsa-miR-3144-5p	CLIP-seq
MIRT2106062	hsa-miR-3184	CLIP-seq
MIRT2330392	hsa-miR-3191	CLIP-seq
MIRT2106063	hsa-miR-3194-3p	CLIP-seq
MIRT2106065	hsa-miR-34a	CLIP-seq
MIRT2106066	hsa-miR-34c-5p	CLIP-seq
MIRT2106067	hsa-miR-3614-5p	CLIP-seq
MIRT2106068	hsa-miR-3664-3p	CLIP-seq
MIRT2330393	hsa-miR-3664-5p	CLIP-seq
MIRT2106071	hsa-miR-3909	CLIP-seq
MIRT2106073	hsa-miR-423-5p	CLIP-seq
MIRT2106077	hsa-miR-4324	CLIP-seq
MIRT2106078	hsa-miR-4328	CLIP-seq
MIRT2330394	hsa-miR-4471	CLIP-seq
MIRT2106085	hsa-miR-449a	CLIP-seq
MIRT2106086	hsa-miR-449b	CLIP-seq
MIRT2106087	hsa-miR-4512	CLIP-seq
MIRT2330395	hsa-miR-4520a-3p	CLIP-seq
MIRT2330396	hsa-miR-4520b-3p	CLIP-seq
MIRT2106089	hsa-miR-4534	CLIP-seq
MIRT1358062	hsa-miR-4646-5p	CLIP-seq
MIRT2330397	hsa-miR-4652-5p	CLIP-seq
MIRT2106091	hsa-miR-4667-5p	CLIP-seq
MIRT2106093	hsa-miR-4688	CLIP-seq
MIRT2106094	hsa-miR-4690-3p	CLIP-seq
MIRT2106096	hsa-miR-4700-5p	CLIP-seq
MIRT2106099	hsa-miR-4729	CLIP-seq
MIRT2106100	hsa-miR-4763-5p	CLIP-seq
MIRT2106101	hsa-miR-4802-5p	CLIP-seq
MIRT2106102	hsa-miR-486-3p	CLIP-seq
MIRT2106106	hsa-miR-544b	CLIP-seq
MIRT2106109	hsa-miR-617	CLIP-seq
MIRT2330398	hsa-miR-622	CLIP-seq
MIRT2330399	hsa-miR-627	CLIP-seq
MIRT2106110	hsa-miR-637	CLIP-seq
MIRT2330400	hsa-miR-661	CLIP-seq
MIRT2106112	hsa-miR-767-3p	CLIP-seq
MIRT2330401	hsa-miR-890	CLIP-seq
MIRT2330402	hsa-miR-924	CLIP-seq
MIRT2330388	hsa-miR-1200	CLIP-seq
MIRT1358042	hsa-miR-1268	CLIP-seq
MIRT1358043	hsa-miR-1268b	CLIP-seq
MIRT1358044	hsa-miR-1275	CLIP-seq
MIRT2624450	hsa-miR-1291	CLIP-seq
MIRT1358045	hsa-miR-1321	CLIP-seq
MIRT1358048	hsa-miR-1915	CLIP-seq
MIRT2624451	hsa-miR-2355-3p	CLIP-seq
MIRT1358050	hsa-miR-2392	CLIP-seq
MIRT2624452	hsa-miR-3126-5p	CLIP-seq
MIRT2624453	hsa-miR-3150a-3p	CLIP-seq
MIRT2624454	hsa-miR-3162-3p	CLIP-seq
MIRT2624455	hsa-miR-3169	CLIP-seq
MIRT2624456	hsa-miR-3173-5p	CLIP-seq
MIRT2624457	hsa-miR-3175	CLIP-seq
MIRT1358054	hsa-miR-3605-5p	CLIP-seq
MIRT2624458	hsa-miR-3617	CLIP-seq
MIRT2106071	hsa-miR-3909	CLIP-seq
MIRT2624459	hsa-miR-3913-3p	CLIP-seq
MIRT2624460	hsa-miR-4251	CLIP-seq
MIRT2624461	hsa-miR-4269	CLIP-seq
MIRT1358056	hsa-miR-4270	CLIP-seq
MIRT2624462	hsa-miR-4287	CLIP-seq
MIRT2106077	hsa-miR-4324	CLIP-seq
MIRT2624463	hsa-miR-4419a	CLIP-seq
MIRT1358059	hsa-miR-4441	CLIP-seq
MIRT2624464	hsa-miR-4457	CLIP-seq
MIRT2624465	hsa-miR-4469	CLIP-seq
MIRT2624466	hsa-miR-4481	CLIP-seq
MIRT2624467	hsa-miR-4510	CLIP-seq
MIRT2624468	hsa-miR-4514	CLIP-seq
MIRT1358061	hsa-miR-4525	CLIP-seq
MIRT1358063	hsa-miR-4665-5p	CLIP-seq
MIRT2624469	hsa-miR-4685-3p	CLIP-seq
MIRT2624470	hsa-miR-4691-3p	CLIP-seq
MIRT2624471	hsa-miR-4692	CLIP-seq
MIRT1358068	hsa-miR-4723-5p	CLIP-seq
MIRT1358069	hsa-miR-4739	CLIP-seq
MIRT2624472	hsa-miR-4740-5p	CLIP-seq
MIRT2624473	hsa-miR-4742-5p	CLIP-seq
MIRT2624474	hsa-miR-4745-5p	CLIP-seq
MIRT1358071	hsa-miR-4756-5p	CLIP-seq
MIRT2624475	hsa-miR-4793-5p	CLIP-seq
MIRT2624476	hsa-miR-491-5p	CLIP-seq
MIRT2624477	hsa-miR-539	CLIP-seq
MIRT2106106	hsa-miR-544b	CLIP-seq
MIRT1358073	hsa-miR-625	CLIP-seq
MIRT2624478	hsa-miR-641	CLIP-seq
MIRT2624479	hsa-miR-676	CLIP-seq
MIRT1358075	hsa-miR-765	CLIP-seq
MIRT2624480	hsa-miR-939	CLIP-seq
MIRT1358044	hsa-miR-1275	CLIP-seq
MIRT2624450	hsa-miR-1291	CLIP-seq
MIRT1358045	hsa-miR-1321	CLIP-seq
MIRT1358048	hsa-miR-1915	CLIP-seq
MIRT1358050	hsa-miR-2392	CLIP-seq
MIRT2624452	hsa-miR-3126-5p	CLIP-seq
MIRT2624455	hsa-miR-3169	CLIP-seq
MIRT2624456	hsa-miR-3173-5p	CLIP-seq
MIRT1358054	hsa-miR-3605-5p	CLIP-seq
MIRT2624461	hsa-miR-4269	CLIP-seq
MIRT1358056	hsa-miR-4270	CLIP-seq
MIRT2624463	hsa-miR-4419a	CLIP-seq
MIRT1358059	hsa-miR-4441	CLIP-seq
MIRT2624464	hsa-miR-4457	CLIP-seq
MIRT2624466	hsa-miR-4481	CLIP-seq
MIRT2624467	hsa-miR-4510	CLIP-seq
MIRT2624468	hsa-miR-4514	CLIP-seq
MIRT1358061	hsa-miR-4525	CLIP-seq
MIRT1358063	hsa-miR-4665-5p	CLIP-seq
MIRT2624470	hsa-miR-4691-3p	CLIP-seq
MIRT2624471	hsa-miR-4692	CLIP-seq
MIRT1358068	hsa-miR-4723-5p	CLIP-seq
MIRT1358069	hsa-miR-4739	CLIP-seq
MIRT2624472	hsa-miR-4740-5p	CLIP-seq
MIRT2624473	hsa-miR-4742-5p	CLIP-seq
MIRT2624474	hsa-miR-4745-5p	CLIP-seq
MIRT1358071	hsa-miR-4756-5p	CLIP-seq
MIRT2106106	hsa-miR-544b	CLIP-seq
MIRT1358073	hsa-miR-625	CLIP-seq
MIRT1358075	hsa-miR-765	CLIP-seq

Show/Hide all(39)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0001579	Process	Medium-chain fatty acid transport	IBA	21873635
GO:0001676	Process	Long-chain fatty acid metabolic process	IDA	22022213
GO:0004467	Function	Long-chain fatty acid-CoA ligase activity	IBA	21873635
GO:0004467	Function	Long-chain fatty acid-CoA ligase activity	IDA	22022213
GO:0005324	Function	Long-chain fatty acid transporter activity	IBA	21873635
GO:0005324	Function	Long-chain fatty acid transporter activity	IMP	21395585
GO:0005783	Component	Endoplasmic reticulum	IDA	32521232
GO:0005783	Component	Endoplasmic reticulum	ISS
GO:0005789	Component	Endoplasmic reticulum membrane	IBA	21873635
GO:0005789	Component	Endoplasmic reticulum membrane	IDA	22022213, 25603556
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	TAS
GO:0005902	Component	Microvillus	IBA	21873635
GO:0006631	Process	Fatty acid metabolic process	IDA	25603556
GO:0007584	Process	Response to nutrient	IBA	21873635
GO:0015908	Process	Fatty acid transport	IMP	32521232
GO:0015909	Process	Long-chain fatty acid transport	IMP	21395585
GO:0015909	Process	Long-chain fatty acid transport	TAS
GO:0016020	Component	Membrane	HDA	19946888
GO:0016021	Component	Integral component of membrane	IEA
GO:0031526	Component	Brush border membrane	IEA
GO:0031957	Function	Very long-chain fatty acid-CoA ligase activity	IEA
GO:0042760	Process	Very long-chain fatty acid catabolic process	IBA	21873635
GO:0043065	Process	Positive regulation of apoptotic process	IDA	25603556
GO:0043588	Process	Skin development	IEA
GO:0044381	Process	Glucose import in response to insulin stimulus	ISS
GO:0044539	Process	Long-chain fatty acid import into cell	IBA	21873635
GO:0044539	Process	Long-chain fatty acid import into cell	IDA	22022213
GO:0044539	Process	Long-chain fatty acid import into cell	ISS	24503477
GO:0046627	Process	Negative regulation of insulin receptor signaling pathway	IDA	25603556
GO:0047676	Function	Arachidonate-CoA ligase activity	IEA
GO:0062003	Process	Negative regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity	IEA
GO:0090433	Function	Palmitoyl-CoA ligase activity	IDA	25603556
GO:0090434	Function	Oleoyl-CoA ligase activity	IDA	25603556
GO:0090434	Function	Oleoyl-CoA ligase activity	ISS
GO:0090630	Process	Activation of GTPase activity	IDA	25603556
GO:0150104	Process	Transport across blood-brain barrier	NAS	26590417, 30280653
GO:1990379	Process	Lipid transport across blood-brain barrier	IMP	21395585

MIM	HGNC	e!Ensembl
604194	10998	ENSG00000167114

Protein

UniProt ID

Q6P1M0

Protein name

Long-chain fatty acid transport protein 4 (FATP-4) (Fatty acid transport protein 4) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Solute carrier family 27 member 4) (Very long-chain acyl-CoA synthetase 4) (ACSV

Protein function

Mediates the levels of long-chain fatty acids (LCFA) in the cell by facilitating their transport across cell membranes (PubMed:10518211, PubMed:12556534, PubMed:20448275, PubMed:21395585, PubMed:22022213). Appears to be the principal fatty acid

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00501	AMP-binding	80 → 512	AMP-binding enzyme	Family
PF13193	AMP-binding_C	520 → 595	AMP-binding enzyme C-terminal domain	Domain

Sequence

MLLGASLVGVLLFSKLVLKLPWTQVGFSLLFLYLGSGGWRFIRVFIKTIRRDIFGGLVLL
KVKAKVRQCLQERRTVPILFASTVRRHPDKTALIFEGTDTHWTFRQLDEYSSSVANFLQA
RGLASGDVAAIFMENRNEFVGLWLGMAKLGVEAALINTNLRRDALLHCLTTSRARALVFG
SEMASAICEVHASLDPSLSLFCSGSWEPGAVPPSTEHLDPLLKDAPKHLPSCPDKGFTDK
LFYIYTSGTTGLPKAAIVVHSRYYRMAALVYYGFRMRPNDIVYDCLPLYHSAGNIVGIGQ
CLLHGMTVVIRKKFSASRFWDDCIKYNCTIVQYIGELCRYLLNQPPREAENQHQVRMALG
NGLRQSIWTNFSSRFHIPQVAEFYGATECNCSLGNFDSQVGACGFNSRILSFVYPIRLVR
VNEDTMELIRGPDGVCIPCQPGEPGQLVGRIIQKDPLRRFDGYLNQGANNKKIAKDVFKK
GDQAYLTGDVLVMDELGYLYFRDRTGDTFRWKGENVSTTEVEGTLSRLLDMADVAVYGVE
VPGTEGRAGMAAVASPTGNCDLERFAQVLEKELPLYARPIFLRLLPELHKTGTYKFQKTE
LRKEGFDPAIVKDPLFYLDAQKGRYVPLDQEAYSRIQAGEEKL

Sequence length

643

Interactions

View interactions

	KEGG		Reactome
	PPAR signaling pathway Insulin resistance Fat digestion and absorption		Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS) Transport of fatty acids

Associated diseases

Show/Hide Causal Diseases (2)

Causal
Disease name	Disease term	dbSNP ID	References
Ichthyosis prematurity syndrome	ICHTHYOSIS PREMATURITY SYNDROME	rs137853131, rs1588559786, rs137853132, rs137853134, rs764922350, rs587776384, rs765311079, rs758657421, rs1340721389	19631310, 20815031
Ichthyosis	Ichthyoses	rs199766569, rs587776996, rs587777262, rs863223405, rs370031870, rs1569044747, rs200806519

Show/Hide Unknown Diseases (3)

Unknown
Disease name	Disease term	dbSNP ID	References
Congenital alveolar dysplasia	Respiratory Distress Syndrome, Newborn
Eosinophilia	Eosinophilia
Ichthyosis-prematurity syndrome	Ichthyosis-prematurity syndrome

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