STIP1 (stress induced phosphoprotein 1)

Gene

• Entrez ID: 10963
• Gene name: Stress induced phosphoprotein 1
• Gene symbol: STIP1
• Synonyms: HEL-S-94n, HOP, IEF-SSP-3521, P60, STI1, STI1L
• Chromosome: 11
• Chromosome location: 11q13.1
• Summary: STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substra

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT032016	hsa-miR-16-5p	Proteomics	18668040
MIRT051957	hsa-let-7b-5p	CLASH	23622248
MIRT047040	hsa-miR-183-5p	CLASH	23622248
MIRT044894	hsa-miR-193a-3p	CLASH	23622248
MIRT041679	hsa-miR-484	CLASH	23622248
MIRT035915	hsa-miR-1180-3p	CLASH	23622248
MIRT439523	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439523	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT1397117	hsa-miR-1270	CLIP-seq
MIRT1397118	hsa-miR-1827	CLIP-seq
MIRT1397119	hsa-miR-1909	CLIP-seq
MIRT1397120	hsa-miR-3616-3p	CLIP-seq
MIRT1397121	hsa-miR-3960	CLIP-seq
MIRT1397122	hsa-miR-410	CLIP-seq
MIRT1397123	hsa-miR-4434	CLIP-seq
MIRT1397124	hsa-miR-4436b-3p	CLIP-seq
MIRT1397125	hsa-miR-4516	CLIP-seq
MIRT1397126	hsa-miR-4531	CLIP-seq
MIRT1397127	hsa-miR-620	CLIP-seq
MIRT1397128	hsa-miR-885-3p	CLIP-seq
MIRT1397129	hsa-miR-892b	CLIP-seq
MIRT2118878	hsa-miR-1207-3p	CLIP-seq
MIRT1397117	hsa-miR-1270	CLIP-seq
MIRT2118879	hsa-miR-2467-5p	CLIP-seq
MIRT2118880	hsa-miR-3154	CLIP-seq
MIRT2118881	hsa-miR-3179	CLIP-seq
MIRT2118882	hsa-miR-3188	CLIP-seq
MIRT2118883	hsa-miR-3191	CLIP-seq
MIRT2118884	hsa-miR-3649	CLIP-seq
MIRT2118885	hsa-miR-3652	CLIP-seq
MIRT2118886	hsa-miR-3975	CLIP-seq
MIRT2118887	hsa-miR-4430	CLIP-seq
MIRT1397123	hsa-miR-4434	CLIP-seq
MIRT1397125	hsa-miR-4516	CLIP-seq
MIRT1397126	hsa-miR-4531	CLIP-seq
MIRT2118888	hsa-miR-4640-3p	CLIP-seq
MIRT2118889	hsa-miR-4649-3p	CLIP-seq
MIRT2118890	hsa-miR-485-5p	CLIP-seq
MIRT2118891	hsa-miR-492	CLIP-seq
MIRT2118892	hsa-miR-544b	CLIP-seq
MIRT2118893	hsa-miR-568	CLIP-seq
MIRT1397127	hsa-miR-620	CLIP-seq
MIRT2118894	hsa-miR-7	CLIP-seq
MIRT2118878	hsa-miR-1207-3p	CLIP-seq
MIRT1397118	hsa-miR-1827	CLIP-seq
MIRT1397119	hsa-miR-1909	CLIP-seq
MIRT2341250	hsa-miR-2278	CLIP-seq
MIRT2118879	hsa-miR-2467-5p	CLIP-seq
MIRT2341251	hsa-miR-3120-3p	CLIP-seq
MIRT2118882	hsa-miR-3188	CLIP-seq
MIRT2341252	hsa-miR-3192	CLIP-seq
MIRT1397120	hsa-miR-3616-3p	CLIP-seq
MIRT2118884	hsa-miR-3649	CLIP-seq
MIRT2118885	hsa-miR-3652	CLIP-seq
MIRT2341253	hsa-miR-3689a-3p	CLIP-seq
MIRT2341254	hsa-miR-3689c	CLIP-seq
MIRT2341255	hsa-miR-3924	CLIP-seq
MIRT1397121	hsa-miR-3960	CLIP-seq
MIRT2118886	hsa-miR-3975	CLIP-seq
MIRT2118887	hsa-miR-4430	CLIP-seq
MIRT1397124	hsa-miR-4436b-3p	CLIP-seq
MIRT2341256	hsa-miR-4532	CLIP-seq
MIRT2118888	hsa-miR-4640-3p	CLIP-seq
MIRT2118889	hsa-miR-4649-3p	CLIP-seq
MIRT2341257	hsa-miR-4707-5p	CLIP-seq
MIRT2341258	hsa-miR-4709-3p	CLIP-seq
MIRT2341259	hsa-miR-4711-3p	CLIP-seq
MIRT2341260	hsa-miR-4728-5p	CLIP-seq
MIRT2341261	hsa-miR-4731-5p	CLIP-seq
MIRT2341262	hsa-miR-4786-5p	CLIP-seq
MIRT2118890	hsa-miR-485-5p	CLIP-seq
MIRT2118891	hsa-miR-492	CLIP-seq
MIRT2118892	hsa-miR-544b	CLIP-seq
MIRT2341263	hsa-miR-548aa	CLIP-seq
MIRT2341264	hsa-miR-548ac	CLIP-seq
MIRT2341265	hsa-miR-548b-3p	CLIP-seq
MIRT2341266	hsa-miR-548d-3p	CLIP-seq
MIRT2341267	hsa-miR-548z	CLIP-seq
MIRT2118893	hsa-miR-568	CLIP-seq
MIRT2341268	hsa-miR-591	CLIP-seq
MIRT2341269	hsa-miR-593	CLIP-seq
MIRT2118894	hsa-miR-7	CLIP-seq
MIRT1397128	hsa-miR-885-3p	CLIP-seq
MIRT2118878	hsa-miR-1207-3p	CLIP-seq
MIRT2118879	hsa-miR-2467-5p	CLIP-seq
MIRT2118882	hsa-miR-3188	CLIP-seq
MIRT2118884	hsa-miR-3649	CLIP-seq
MIRT2118885	hsa-miR-3652	CLIP-seq
MIRT2118886	hsa-miR-3975	CLIP-seq
MIRT2118887	hsa-miR-4430	CLIP-seq
MIRT2118889	hsa-miR-4649-3p	CLIP-seq
MIRT2118890	hsa-miR-485-5p	CLIP-seq
MIRT2118891	hsa-miR-492	CLIP-seq
MIRT2118892	hsa-miR-544b	CLIP-seq
MIRT2341265	hsa-miR-548b-3p	CLIP-seq
MIRT2118894	hsa-miR-7	CLIP-seq
MIRT2118878	hsa-miR-1207-3p	CLIP-seq
MIRT1397118	hsa-miR-1827	CLIP-seq
MIRT1397119	hsa-miR-1909	CLIP-seq
MIRT2341250	hsa-miR-2278	CLIP-seq
MIRT2118879	hsa-miR-2467-5p	CLIP-seq
MIRT2341251	hsa-miR-3120-3p	CLIP-seq
MIRT2118882	hsa-miR-3188	CLIP-seq
MIRT2635141	hsa-miR-3189-5p	CLIP-seq
MIRT2341252	hsa-miR-3192	CLIP-seq
MIRT1397120	hsa-miR-3616-3p	CLIP-seq
MIRT2118884	hsa-miR-3649	CLIP-seq
MIRT2118885	hsa-miR-3652	CLIP-seq
MIRT2341253	hsa-miR-3689a-3p	CLIP-seq
MIRT2341254	hsa-miR-3689c	CLIP-seq
MIRT1397121	hsa-miR-3960	CLIP-seq
MIRT2118886	hsa-miR-3975	CLIP-seq
MIRT2118887	hsa-miR-4430	CLIP-seq
MIRT1397124	hsa-miR-4436b-3p	CLIP-seq
MIRT2118888	hsa-miR-4640-3p	CLIP-seq
MIRT2118889	hsa-miR-4649-3p	CLIP-seq
MIRT2341258	hsa-miR-4709-3p	CLIP-seq
MIRT2341260	hsa-miR-4728-5p	CLIP-seq
MIRT2341261	hsa-miR-4731-5p	CLIP-seq
MIRT2635142	hsa-miR-4758-3p	CLIP-seq
MIRT2341262	hsa-miR-4786-5p	CLIP-seq
MIRT2118890	hsa-miR-485-5p	CLIP-seq
MIRT2118891	hsa-miR-492	CLIP-seq
MIRT2118892	hsa-miR-544b	CLIP-seq
MIRT2341263	hsa-miR-548aa	CLIP-seq
MIRT2341264	hsa-miR-548ac	CLIP-seq
MIRT2341265	hsa-miR-548b-3p	CLIP-seq
MIRT2341266	hsa-miR-548d-3p	CLIP-seq
MIRT2341267	hsa-miR-548z	CLIP-seq
MIRT2341268	hsa-miR-591	CLIP-seq
MIRT2118894	hsa-miR-7	CLIP-seq
MIRT1397128	hsa-miR-885-3p	CLIP-seq
MIRT2118878	hsa-miR-1207-3p	CLIP-seq
MIRT1397118	hsa-miR-1827	CLIP-seq
MIRT1397119	hsa-miR-1909	CLIP-seq
MIRT2341250	hsa-miR-2278	CLIP-seq
MIRT2118879	hsa-miR-2467-5p	CLIP-seq
MIRT2341251	hsa-miR-3120-3p	CLIP-seq
MIRT2118882	hsa-miR-3188	CLIP-seq
MIRT2635141	hsa-miR-3189-5p	CLIP-seq
MIRT2341252	hsa-miR-3192	CLIP-seq
MIRT1397120	hsa-miR-3616-3p	CLIP-seq
MIRT2118884	hsa-miR-3649	CLIP-seq
MIRT2118885	hsa-miR-3652	CLIP-seq
MIRT2341253	hsa-miR-3689a-3p	CLIP-seq
MIRT2341254	hsa-miR-3689c	CLIP-seq
MIRT1397121	hsa-miR-3960	CLIP-seq
MIRT2118886	hsa-miR-3975	CLIP-seq
MIRT2118887	hsa-miR-4430	CLIP-seq
MIRT1397124	hsa-miR-4436b-3p	CLIP-seq
MIRT2118888	hsa-miR-4640-3p	CLIP-seq
MIRT2118889	hsa-miR-4649-3p	CLIP-seq
MIRT2341258	hsa-miR-4709-3p	CLIP-seq
MIRT2341260	hsa-miR-4728-5p	CLIP-seq
MIRT2341261	hsa-miR-4731-5p	CLIP-seq
MIRT2635142	hsa-miR-4758-3p	CLIP-seq
MIRT2341262	hsa-miR-4786-5p	CLIP-seq
MIRT2118890	hsa-miR-485-5p	CLIP-seq
MIRT2118891	hsa-miR-492	CLIP-seq
MIRT2118892	hsa-miR-544b	CLIP-seq
MIRT2341263	hsa-miR-548aa	CLIP-seq
MIRT2341264	hsa-miR-548ac	CLIP-seq
MIRT2341265	hsa-miR-548b-3p	CLIP-seq
MIRT2341266	hsa-miR-548d-3p	CLIP-seq
MIRT2341267	hsa-miR-548z	CLIP-seq
MIRT2341268	hsa-miR-591	CLIP-seq
MIRT2118894	hsa-miR-7	CLIP-seq
MIRT1397128	hsa-miR-885-3p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
HSF1	Unknown	20692357;22669480

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	HDA	22658674
GO:0005515	Function	Protein binding	IPI	20029029, 21044950, 21170051, 21360678, 23349634, 23431407, 24880080, 25036637, 27353360, 28330616, 28514442, 31980649, 32814053
GO:0005634	Component	Nucleus	TAS	16130169
GO:0005794	Component	Golgi apparatus	TAS	1569099
GO:0005829	Component	Cytosol	TAS
GO:0008022	Function	Protein C-terminus binding	IEA
GO:0030544	Function	Hsp70 protein binding	IEA
GO:0032991	Component	Protein-containing complex	IDA	23349634
GO:0051087	Function	Chaperone binding	IEA
GO:0051879	Function	Hsp90 protein binding	IBA	21873635
GO:0051879	Function	Hsp90 protein binding	IPI	29127155
GO:0098761	Process	Cellular response to interleukin-7	IEA
GO:0101031	Component	Chaperone complex	IDA	29127155

Other IDs

• MIM: 605063
• HGNC: 11387
• e!Ensembl: ENSG00000168439

Protein

• UniProt ID: P31948
• Protein name: Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop) (Renal carcinoma antigen NY-REN-11) (Transformation-sensitive protein IEF SSP 3521)
• Protein function: Acts as a co-chaperone for HSP90AA1 (PubMed:27353360). Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (By similarity).
• PDB: 1ELR, 1ELW, 2LNI, 2NC9, 3ESK, 3FWV, 7KW7
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF17830	STI1	130 → 184	STI1 domain	Domain
  PF13181	TPR_8	261 → 291	Tetratricopeptide repeat	Repeat
  PF00515	TPR_1	300 → 332	Tetratricopeptide repeat	Repeat
  PF00515	TPR_1	360 → 393	Tetratricopeptide repeat	Repeat
  PF00515	TPR_1	394 → 427	Tetratricopeptide repeat	Repeat
  PF17830	STI1	482 → 536	STI1 domain	Domain

• Sequence:

  MEQVNELKEKGNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYED
  GCKTVDLKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLKEGLQNMEARLA
  ERKFMNPFNMPNLYQKLESDPRTRTLLSDPTYRELIEQLRNKPSDLGTKLQDPRIMTTLS
  VLLGVDLGSMDEEEEIATPPPPPPPKKETKPEPMEEDLPENKKQALKEKELGNDAYKKKD
  FDTALKHYDKAKELDPTNMTYITNQAAVYFEKGDYNKCRELCEKAIEVGRENREDYRQIA
  KAYARIGNSYFKEEKYKDAIHFYNKSLAEHRTPDVLKKCQQAEKILKEQERLAYINPDLA
  LEEKNKGNECFQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQLALKDCEEC
  IQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDLDSSCKEAADGYQRCMMAQYNRHD
  SPEDVKRRAMADPEVQQIMSDPAMRLILEQMQKDPQALSEHLKNPVIAQKIQKLMDVGLI
  AIR

• Sequence length: 543

Pathways

KEGG:

Prion disease

Reactome:

HSP90 chaperone cycle for steroid hormone receptors (SHR)

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Melanoma	melanoma	rs121913315, rs121913323, rs137853080, rs137853081, rs121909232, rs121913388, rs104894094, rs1563902635, rs104894095, rs104894097, rs104894098, rs104894099, rs104894109, rs137854599, rs11547328, rs104894340, rs398123152, rs587780668, rs587782083, rs587782206, rs587782792, rs180177042, rs121913381, rs730881675, rs730881674, rs730881677, rs730881673, rs1800586, rs768966657, rs587778189, rs786204195, rs121913321, rs45476696, rs864622636, rs864622263, rs869025340, rs876660436, rs876658534, rs876658556, rs878853647, rs878853644, rs878853650, rs886041162, rs121913389, rs1057519852, rs121913384, rs121913387, rs1060501266, rs1060501263, rs1060501262, rs749714198, rs1060501265, rs559848002, rs1064794292, rs1131691187, rs1131691186, rs199907548, rs1554654052, rs1554656411, rs1554656624, rs1554653915, rs1554653956, rs1554656253, rs1554654224, rs754806883, rs1057520039, rs1563889584, rs1563889685, rs1287464120, rs1563888944, rs1563892715, rs1563889847, rs141798398, rs1587332338, rs1587340291, rs11552823, rs561034503, rs138677674, rs1819962958, rs1820531050	22535842

Unknown
Disease name	Disease term	dbSNP ID	References
Mental depression	Depressive disorder	rs587778876, rs587778877	20410598