ERP29 (endoplasmic reticulum protein 29)

Gene

• Entrez ID: 10961
• Gene name: Endoplasmic reticulum protein 29
• Gene symbol: ERP29
• Synonyms: C12orf8, ERp28, ERp31, HEL-S-107, PDI-DB, PDIA9
• Chromosome: 12
• Chromosome location: 12q24.13
• Summary: This gene encodes a protein which localizes to the lumen of the endoplasmic reticulum (ER). It is a member of the protein disulfide isomerase (PDI) protein family but lacks an active thioredoxin motif, suggesting that this protein does not function as a d

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT023299	hsa-miR-122-5p	Proteomics	21750653
MIRT037685	hsa-miR-744-5p	CLASH	23622248
MIRT737193	hsa-miR-205-5p	Luciferase reporter assay, Western blotting, RNA-seq, qRT-PCR	31602229
MIRT969859	hsa-miR-1266	CLIP-seq
MIRT969860	hsa-miR-1285	CLIP-seq
MIRT969861	hsa-miR-198	CLIP-seq
MIRT969862	hsa-miR-24	CLIP-seq
MIRT969863	hsa-miR-3127-5p	CLIP-seq
MIRT969864	hsa-miR-3187-5p	CLIP-seq
MIRT969865	hsa-miR-3661	CLIP-seq
MIRT969866	hsa-miR-3677-3p	CLIP-seq
MIRT969867	hsa-miR-3918	CLIP-seq
MIRT969868	hsa-miR-4437	CLIP-seq
MIRT969869	hsa-miR-4518	CLIP-seq
MIRT969870	hsa-miR-4645-5p	CLIP-seq
MIRT969871	hsa-miR-4673	CLIP-seq
MIRT969872	hsa-miR-483-3p	CLIP-seq
MIRT969873	hsa-miR-510	CLIP-seq
MIRT969874	hsa-miR-512-5p	CLIP-seq
MIRT969875	hsa-miR-612	CLIP-seq
MIRT969876	hsa-miR-631	CLIP-seq
MIRT969859	hsa-miR-1266	CLIP-seq
MIRT969861	hsa-miR-198	CLIP-seq
MIRT1987480	hsa-miR-214	CLIP-seq
MIRT969862	hsa-miR-24	CLIP-seq
MIRT969863	hsa-miR-3127-5p	CLIP-seq
MIRT1987481	hsa-miR-3162-3p	CLIP-seq
MIRT1987482	hsa-miR-3619-5p	CLIP-seq
MIRT969866	hsa-miR-3677-3p	CLIP-seq
MIRT969867	hsa-miR-3918	CLIP-seq
MIRT969868	hsa-miR-4437	CLIP-seq
MIRT969869	hsa-miR-4518	CLIP-seq
MIRT1987483	hsa-miR-4530	CLIP-seq
MIRT1987484	hsa-miR-4640-3p	CLIP-seq
MIRT969870	hsa-miR-4645-5p	CLIP-seq
MIRT969871	hsa-miR-4673	CLIP-seq
MIRT1987485	hsa-miR-4764-3p	CLIP-seq
MIRT969873	hsa-miR-510	CLIP-seq
MIRT969874	hsa-miR-512-5p	CLIP-seq
MIRT1987486	hsa-miR-618	CLIP-seq
MIRT1987487	hsa-miR-657	CLIP-seq
MIRT1987488	hsa-miR-761	CLIP-seq
MIRT2221874	hsa-miR-1237	CLIP-seq
MIRT2221875	hsa-miR-1248	CLIP-seq
MIRT2221876	hsa-miR-1260	CLIP-seq
MIRT2221877	hsa-miR-1260b	CLIP-seq
MIRT969860	hsa-miR-1285	CLIP-seq
MIRT2221878	hsa-miR-188-3p	CLIP-seq
MIRT1987480	hsa-miR-214	CLIP-seq
MIRT2221879	hsa-miR-3156-3p	CLIP-seq
MIRT1987481	hsa-miR-3162-3p	CLIP-seq
MIRT2221880	hsa-miR-3183	CLIP-seq
MIRT969864	hsa-miR-3187-5p	CLIP-seq
MIRT1987482	hsa-miR-3619-5p	CLIP-seq
MIRT969865	hsa-miR-3661	CLIP-seq
MIRT2221881	hsa-miR-3692	CLIP-seq
MIRT2221882	hsa-miR-4279	CLIP-seq
MIRT2221883	hsa-miR-4301	CLIP-seq
MIRT2221884	hsa-miR-4303	CLIP-seq
MIRT2221885	hsa-miR-4446-5p	CLIP-seq
MIRT2221886	hsa-miR-4457	CLIP-seq
MIRT2221887	hsa-miR-4475	CLIP-seq
MIRT1987483	hsa-miR-4530	CLIP-seq
MIRT1987484	hsa-miR-4640-3p	CLIP-seq
MIRT2221888	hsa-miR-4649-3p	CLIP-seq
MIRT2221889	hsa-miR-4723-3p	CLIP-seq
MIRT1987485	hsa-miR-4764-3p	CLIP-seq
MIRT969872	hsa-miR-483-3p	CLIP-seq
MIRT2221890	hsa-miR-580	CLIP-seq
MIRT969875	hsa-miR-612	CLIP-seq
MIRT2221891	hsa-miR-616	CLIP-seq
MIRT1987486	hsa-miR-618	CLIP-seq
MIRT969876	hsa-miR-631	CLIP-seq
MIRT1987487	hsa-miR-657	CLIP-seq
MIRT1987488	hsa-miR-761	CLIP-seq
MIRT2525503	hsa-miR-1226	CLIP-seq
MIRT2221874	hsa-miR-1237	CLIP-seq
MIRT2221875	hsa-miR-1248	CLIP-seq
MIRT969860	hsa-miR-1285	CLIP-seq
MIRT2525504	hsa-miR-1324	CLIP-seq
MIRT2525505	hsa-miR-197	CLIP-seq
MIRT1987480	hsa-miR-214	CLIP-seq
MIRT2525506	hsa-miR-2355-5p	CLIP-seq
MIRT2525507	hsa-miR-302a	CLIP-seq
MIRT2525508	hsa-miR-302b	CLIP-seq
MIRT2525509	hsa-miR-302c	CLIP-seq
MIRT2525510	hsa-miR-302d	CLIP-seq
MIRT2525511	hsa-miR-302e	CLIP-seq
MIRT2525512	hsa-miR-3148	CLIP-seq
MIRT1987481	hsa-miR-3162-3p	CLIP-seq
MIRT2221880	hsa-miR-3183	CLIP-seq
MIRT969864	hsa-miR-3187-5p	CLIP-seq
MIRT1987482	hsa-miR-3619-5p	CLIP-seq
MIRT2525513	hsa-miR-3622a-3p	CLIP-seq
MIRT2525514	hsa-miR-3622b-3p	CLIP-seq
MIRT969865	hsa-miR-3661	CLIP-seq
MIRT2525515	hsa-miR-372	CLIP-seq
MIRT2525516	hsa-miR-373	CLIP-seq
MIRT2525517	hsa-miR-4267	CLIP-seq
MIRT2221882	hsa-miR-4279	CLIP-seq
MIRT2221884	hsa-miR-4303	CLIP-seq
MIRT2525518	hsa-miR-4308	CLIP-seq
MIRT1987483	hsa-miR-4530	CLIP-seq
MIRT1987484	hsa-miR-4640-3p	CLIP-seq
MIRT2221888	hsa-miR-4649-3p	CLIP-seq
MIRT2525519	hsa-miR-4691-3p	CLIP-seq
MIRT2221889	hsa-miR-4723-3p	CLIP-seq
MIRT2525520	hsa-miR-4733-3p	CLIP-seq
MIRT2525521	hsa-miR-4738-3p	CLIP-seq
MIRT1987485	hsa-miR-4764-3p	CLIP-seq
MIRT969872	hsa-miR-483-3p	CLIP-seq
MIRT2525522	hsa-miR-5096	CLIP-seq
MIRT2525523	hsa-miR-519a	CLIP-seq
MIRT2525524	hsa-miR-519b-3p	CLIP-seq
MIRT2525525	hsa-miR-519c-3p	CLIP-seq
MIRT2525526	hsa-miR-520a-3p	CLIP-seq
MIRT2525527	hsa-miR-520b	CLIP-seq
MIRT2525528	hsa-miR-520c-3p	CLIP-seq
MIRT2525529	hsa-miR-520d-3p	CLIP-seq
MIRT2525530	hsa-miR-520e	CLIP-seq
MIRT2221890	hsa-miR-580	CLIP-seq
MIRT969875	hsa-miR-612	CLIP-seq
MIRT2221891	hsa-miR-616	CLIP-seq
MIRT1987486	hsa-miR-618	CLIP-seq
MIRT969876	hsa-miR-631	CLIP-seq
MIRT1987487	hsa-miR-657	CLIP-seq
MIRT1987488	hsa-miR-761	CLIP-seq
MIRT2525531	hsa-miR-766	CLIP-seq
MIRT2525532	hsa-miR-875-3p	CLIP-seq
MIRT2525503	hsa-miR-1226	CLIP-seq
MIRT2221874	hsa-miR-1237	CLIP-seq
MIRT2221875	hsa-miR-1248	CLIP-seq
MIRT2221876	hsa-miR-1260	CLIP-seq
MIRT2221877	hsa-miR-1260b	CLIP-seq
MIRT969859	hsa-miR-1266	CLIP-seq
MIRT969860	hsa-miR-1285	CLIP-seq
MIRT2525504	hsa-miR-1324	CLIP-seq
MIRT2221878	hsa-miR-188-3p	CLIP-seq
MIRT2525505	hsa-miR-197	CLIP-seq
MIRT969861	hsa-miR-198	CLIP-seq
MIRT1987480	hsa-miR-214	CLIP-seq
MIRT2525506	hsa-miR-2355-5p	CLIP-seq
MIRT969862	hsa-miR-24	CLIP-seq
MIRT2525507	hsa-miR-302a	CLIP-seq
MIRT2525508	hsa-miR-302b	CLIP-seq
MIRT2525509	hsa-miR-302c	CLIP-seq
MIRT2525510	hsa-miR-302d	CLIP-seq
MIRT2525511	hsa-miR-302e	CLIP-seq
MIRT969863	hsa-miR-3127-5p	CLIP-seq
MIRT2525512	hsa-miR-3148	CLIP-seq
MIRT2221879	hsa-miR-3156-3p	CLIP-seq
MIRT1987481	hsa-miR-3162-3p	CLIP-seq
MIRT2221880	hsa-miR-3183	CLIP-seq
MIRT969864	hsa-miR-3187-5p	CLIP-seq
MIRT1987482	hsa-miR-3619-5p	CLIP-seq
MIRT2525513	hsa-miR-3622a-3p	CLIP-seq
MIRT2525514	hsa-miR-3622b-3p	CLIP-seq
MIRT969865	hsa-miR-3661	CLIP-seq
MIRT969866	hsa-miR-3677-3p	CLIP-seq
MIRT2525515	hsa-miR-372	CLIP-seq
MIRT2525516	hsa-miR-373	CLIP-seq
MIRT969867	hsa-miR-3918	CLIP-seq
MIRT2525517	hsa-miR-4267	CLIP-seq
MIRT2221882	hsa-miR-4279	CLIP-seq
MIRT2221883	hsa-miR-4301	CLIP-seq
MIRT2221884	hsa-miR-4303	CLIP-seq
MIRT2525518	hsa-miR-4308	CLIP-seq
MIRT969868	hsa-miR-4437	CLIP-seq
MIRT2221885	hsa-miR-4446-5p	CLIP-seq
MIRT969869	hsa-miR-4518	CLIP-seq
MIRT1987483	hsa-miR-4530	CLIP-seq
MIRT1987484	hsa-miR-4640-3p	CLIP-seq
MIRT969870	hsa-miR-4645-5p	CLIP-seq
MIRT2221888	hsa-miR-4649-3p	CLIP-seq
MIRT969871	hsa-miR-4673	CLIP-seq
MIRT2525519	hsa-miR-4691-3p	CLIP-seq
MIRT2221889	hsa-miR-4723-3p	CLIP-seq
MIRT2525520	hsa-miR-4733-3p	CLIP-seq
MIRT2680285	hsa-miR-4733-5p	CLIP-seq
MIRT2525521	hsa-miR-4738-3p	CLIP-seq
MIRT1987485	hsa-miR-4764-3p	CLIP-seq
MIRT969872	hsa-miR-483-3p	CLIP-seq
MIRT2525522	hsa-miR-5096	CLIP-seq
MIRT969873	hsa-miR-510	CLIP-seq
MIRT969874	hsa-miR-512-5p	CLIP-seq
MIRT2525523	hsa-miR-519a	CLIP-seq
MIRT2525524	hsa-miR-519b-3p	CLIP-seq
MIRT2525525	hsa-miR-519c-3p	CLIP-seq
MIRT2525526	hsa-miR-520a-3p	CLIP-seq
MIRT2525527	hsa-miR-520b	CLIP-seq
MIRT2525528	hsa-miR-520c-3p	CLIP-seq
MIRT2525529	hsa-miR-520d-3p	CLIP-seq
MIRT2525530	hsa-miR-520e	CLIP-seq
MIRT2221890	hsa-miR-580	CLIP-seq
MIRT969875	hsa-miR-612	CLIP-seq
MIRT2221891	hsa-miR-616	CLIP-seq
MIRT1987486	hsa-miR-618	CLIP-seq
MIRT969876	hsa-miR-631	CLIP-seq
MIRT1987487	hsa-miR-657	CLIP-seq
MIRT1987488	hsa-miR-761	CLIP-seq
MIRT2525531	hsa-miR-766	CLIP-seq
MIRT2525532	hsa-miR-875-3p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
XBP1	Repression	19265690

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000187	Process	Activation of MAPK activity	IDA	22064321
GO:0001934	Process	Positive regulation of protein phosphorylation	IDA	22064321
GO:0003756	Function	Protein disulfide isomerase activity	IKR	9738895
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005783	Component	Endoplasmic reticulum	IBA	21873635
GO:0005783	Component	Endoplasmic reticulum	IDA	9738895
GO:0005788	Component	Endoplasmic reticulum lumen	NAS	22064321
GO:0005790	Component	Smooth endoplasmic reticulum	ISS
GO:0006457	Process	Protein folding	NAS	9738895
GO:0006886	Process	Intracellular protein transport	NAS	9738895
GO:0009306	Process	Protein secretion	IEA
GO:0009986	Component	Cell surface	IDA	19995400
GO:0010628	Process	Positive regulation of gene expression	IDA	22064321
GO:0010629	Process	Negative regulation of gene expression	IDA	22064321
GO:0016020	Component	Membrane	HDA	19946888
GO:0018215	Process	Protein phosphopantetheinylation	IEA
GO:0030133	Component	Transport vesicle	ISS
GO:0042470	Component	Melanosome	IEA
GO:0042803	Function	Protein homodimerization activity	ISS
GO:0043335	Process	Protein unfolding	NAS	22064321
GO:0050709	Process	Negative regulation of protein secretion	IDA	22064321
GO:0051087	Function	Chaperone binding	ISS
GO:1902235	Process	Regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IEA

Other IDs

• MIM: 602287
• HGNC: 13799
• e!Ensembl: ENSG00000089248

Protein

• UniProt ID: P30040
• Protein name: Endoplasmic reticulum resident protein 29 (ERp29) (Endoplasmic reticulum resident protein 28) (ERp28) (Endoplasmic reticulum resident protein 31) (ERp31)
• Protein function: Does not seem to be a disulfide isomerase. Plays an important role in the processing of secretory proteins within the endoplasmic reticulum (ER), possibly by participating in the folding of proteins in the ER.
• PDB: 2QC7, 5V8Z, 5V90
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07912	ERp29_N	33 → 155	ERp29, N-terminal domain	Domain
  PF07749	ERp29	156 → 251	Endoplasmic reticulum protein ERp29, C-terminal domain	Domain

• Sequence:

  MAAAVPRAAFLSPLLPLLLGFLLLSAPHGGSGLHTKGALPLDTVTFYKVIPKSKFVLVKF
  DTQYPYGEKQDEFKRLAENSASSDDLLVAEVGISDYGDKLNMELSEKYKLDKESYPVFYL
  FRDGDFENPVPYTGAVKVGAIQRWLKGQGVYLGMPGCLPVYDALAGEFIRASGVEARQAL
  LKQGQDNLSSVKETQKKWAEQYLKIMGKILDQGEDFPASEMTRIARLIEKNKMSDGKKEE
  LQKSLNILTAFQKKGAEKEEL

• Sequence length: 261

Pathways

KEGG:

Protein processing in endoplasmic reticulum

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Lung adenocarcinoma	Adenocarcinoma of lung (disorder)	rs28934576, rs121913530, rs397516975, rs587776805, rs121913469, rs121913364, rs121913351, rs121913366, rs397516896, rs397516977, rs397516981, rs397517127, rs121913344, rs727504233, rs121913370, rs760043106, rs1057519788, rs1131692238, rs1131692237, rs1554350382	19381893
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	17013881

Unknown
Disease name	Disease term	dbSNP ID	References
Liver carcinoma	Liver carcinoma		21472284
Prostatic neoplasms	Prostatic Neoplasms		17013881