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CBX1 (chromobox 1)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10951
Gene nameGene Name - the full gene name approved by the HGNC.
Chromobox 1
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
CBX1
SynonymsGene synonyms aliases
CBX, HP1-BETA, HP1Hs-beta, HP1Hsbeta, Hp1beta, M31, MOD1, p25beta
ChromosomeChromosome number
17
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17q21.32
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can b
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT003170 hsa-miR-210-3p immunoprecipitaion, Microarray, qRT-PCR 19826008
MIRT003170 hsa-miR-210-3p immunoprecipitaion, Microarray, qRT-PCR 19826008
MIRT016166 hsa-miR-590-3p Sequencing 20371350
MIRT016475 hsa-miR-193b-3p Microarray 20304954
MIRT021150 hsa-miR-186-5p Sequencing 20371350
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000775 Component Chromosome, centromeric region IDA 8287692
GO:0000781 Component Chromosome, telomeric region HDA 19135898
GO:0000781 Component Chromosome, telomeric region IDA 24270157
GO:0000785 Component Chromatin IDA 11101528
GO:0000792 Component Heterochromatin TAS 9169582
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P83916
Protein name Chromobox protein homolog 1 (HP1Hsbeta) (Heterochromatin protein 1 homolog beta) (HP1 beta) (Heterochromatin protein p25) (M31) (Modifier 1 protein) (p25beta)
Protein function Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear
PDB 2FMM , 3F2U , 3Q6S , 5T1G , 6D07 , 6D08
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00385 Chromo
21 70
Chromo (CHRromatin Organisation MOdifier) domain
Domain
PF01393 Chromo_shadow
118 170
Chromo shadow domain
Domain
Sequence
MGKKQNKKKVEEVLEEEEEEYVVEKVLDRRVVKGKVEYLLKWKGFSDEDNTWEPEENLDC
PDLIAEFLQS
QKTAHETDKSEGGKRKADSDSEDKGEESKPKKKKEESEKPRGFARGLEPE
RIIGATDSSGELMFLMKWKNSDEADLVPAKEANVKCPQVVISFYEERLTW
HSYPSEDDDK
KDDKN
Sequence length 185
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
Reactome
    HCMV Early Events
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Prostate cancer Malignant neoplasm of prostate rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 17199135
Unknown
Disease name Disease term dbSNP ID References
Prostatic neoplasms Prostatic Neoplasms 17199135

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