Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
10951 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
Chromobox 1 |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
CBX1 |
SynonymsGene synonyms aliases
|
CBX, HP1-BETA, HP1Hs-beta, HP1Hsbeta, Hp1beta, M31, MOD1, p25beta |
ChromosomeChromosome number
|
17 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
17q21.32 |
SummarySummary of gene provided in NCBI Entrez Gene.
|
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can b |
miRNAmiRNA information provided by mirtarbase database.
|
|
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0000775 |
Component |
Chromosome, centromeric region |
IDA |
8287692 |
GO:0000781 |
Component |
Chromosome, telomeric region |
HDA |
19135898 |
GO:0000781 |
Component |
Chromosome, telomeric region |
IDA |
24270157 |
GO:0000785 |
Component |
Chromatin |
IDA |
11101528 |
GO:0000792 |
Component |
Heterochromatin |
TAS |
9169582 |
GO:0001939 |
Component |
Female pronucleus |
IEA |
|
GO:0001940 |
Component |
Male pronucleus |
IEA |
|
GO:0003682 |
Function |
Chromatin binding |
TAS |
9169582 |
GO:0005515 |
Function |
Protein binding |
IPI |
9636146, 16169070, 16415788, 16615912, 20195357, 20850016, 20871592, 21346195, 21383955, 21888893, 23542155, 24981860, 27248496, 27705803, 29568061, 32296183, 32814053 |
GO:0005634 |
Component |
Nucleus |
IDA |
21383955 |
GO:0005654 |
Component |
Nucleoplasm |
TAS |
9169582 |
GO:0005721 |
Component |
Pericentric heterochromatin |
IEA |
|
GO:0005819 |
Component |
Spindle |
IDA |
11101528 |
GO:0006974 |
Process |
Cellular response to DNA damage stimulus |
IMP |
27248496 |
GO:0010369 |
Component |
Chromocenter |
IEA |
|
GO:0019899 |
Function |
Enzyme binding |
IPI |
19486527 |
GO:0042802 |
Function |
Identical protein binding |
IEA |
|
GO:0045892 |
Process |
Negative regulation of transcription, DNA-templated |
IEA |
|
GO:0090734 |
Component |
Site of DNA damage |
IMP |
27248496 |
GO:1990226 |
Function |
Histone methyltransferase binding |
IPI |
19486527 |
|
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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|
Protein
|
UniProt ID |
P83916 |
Protein name |
Chromobox protein homolog 1 (HP1Hsbeta) (Heterochromatin protein 1 homolog beta) (HP1 beta) (Heterochromatin protein p25) (M31) (Modifier 1 protein) (p25beta) |
Protein function |
Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear |
PDB |
2FMM
,
3F2U
,
3Q6S
,
5T1G
,
6D07
,
6D08
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00385 |
Chromo |
21 → 70 |
Chromo (CHRromatin Organisation MOdifier) domain |
Domain |
PF01393 |
Chromo_shadow |
118 → 170 |
Chromo shadow domain |
Domain |
|
Sequence |
|
Sequence length |
185 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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|
Associated diseases
|
Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Prostate cancer |
Malignant neoplasm of prostate |
rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 |
17199135 |
|
Unknown |
Disease name |
Disease term |
dbSNP ID |
References |
Prostatic neoplasms |
Prostatic Neoplasms |
|
17199135 |
|