STARD3 (StAR related lipid transfer domain containing 3)

Gene

• Entrez ID: 10948
• Gene name: StAR related lipid transfer domain containing 3
• Gene symbol: STARD3
• Synonyms: CAB1, MLN64, es64
• Chromosome: 17
• Chromosome location: 17q12
• Summary: This gene encodes a member of a subfamily of lipid trafficking proteins that are characterized by a C-terminal steroidogenic acute regulatory domain and an N-terminal metastatic lymph node 64 domain. The encoded protein localizes to the membranes of late

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT489075	hsa-miR-3714	PAR-CLIP	23592263
MIRT489074	hsa-miR-4476	PAR-CLIP	23592263
MIRT489073	hsa-miR-6876-5p	PAR-CLIP	23592263
MIRT489071	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT489072	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT489070	hsa-miR-940	PAR-CLIP	23592263
MIRT489069	hsa-miR-1321	PAR-CLIP	23592263
MIRT489068	hsa-miR-4739	PAR-CLIP	23592263
MIRT489067	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT489066	hsa-miR-605-3p	PAR-CLIP	23592263
MIRT489065	hsa-miR-4419a	PAR-CLIP	23592263
MIRT489064	hsa-miR-4510	PAR-CLIP	23592263
MIRT489063	hsa-miR-6127	PAR-CLIP	23592263
MIRT489062	hsa-miR-6129	PAR-CLIP	23592263
MIRT489061	hsa-miR-6130	PAR-CLIP	23592263
MIRT489059	hsa-miR-6133	PAR-CLIP	23592263
MIRT489060	hsa-miR-3194-5p	PAR-CLIP	23592263
MIRT489058	hsa-miR-766-5p	PAR-CLIP	23592263
MIRT489057	hsa-miR-765	PAR-CLIP	23592263
MIRT489056	hsa-miR-1249-5p	PAR-CLIP	23592263
MIRT489055	hsa-miR-6797-5p	PAR-CLIP	23592263
MIRT489054	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT489053	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT489052	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT489051	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT489050	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT489075	hsa-miR-3714	PAR-CLIP	23592263
MIRT489074	hsa-miR-4476	PAR-CLIP	23592263
MIRT489073	hsa-miR-6876-5p	PAR-CLIP	23592263
MIRT489071	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT489072	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT489070	hsa-miR-940	PAR-CLIP	23592263
MIRT489069	hsa-miR-1321	PAR-CLIP	23592263
MIRT489068	hsa-miR-4739	PAR-CLIP	23592263
MIRT489067	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT489066	hsa-miR-605-3p	PAR-CLIP	23592263
MIRT489065	hsa-miR-4419a	PAR-CLIP	23592263
MIRT489064	hsa-miR-4510	PAR-CLIP	23592263
MIRT489063	hsa-miR-6127	PAR-CLIP	23592263
MIRT489062	hsa-miR-6129	PAR-CLIP	23592263
MIRT489061	hsa-miR-6130	PAR-CLIP	23592263
MIRT489059	hsa-miR-6133	PAR-CLIP	23592263
MIRT489060	hsa-miR-3194-5p	PAR-CLIP	23592263
MIRT489058	hsa-miR-766-5p	PAR-CLIP	23592263
MIRT489057	hsa-miR-765	PAR-CLIP	23592263
MIRT489056	hsa-miR-1249-5p	PAR-CLIP	23592263
MIRT489055	hsa-miR-6797-5p	PAR-CLIP	23592263
MIRT489054	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT489053	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT489052	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT489051	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT489050	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT1395289	hsa-miR-1291	CLIP-seq
MIRT1395290	hsa-miR-1827	CLIP-seq
MIRT1395291	hsa-miR-3192	CLIP-seq
MIRT1395292	hsa-miR-361-3p	CLIP-seq
MIRT1395293	hsa-miR-3689a-3p	CLIP-seq
MIRT1395294	hsa-miR-3689c	CLIP-seq
MIRT1395295	hsa-miR-374c	CLIP-seq
MIRT1395296	hsa-miR-4292	CLIP-seq
MIRT1395297	hsa-miR-4307	CLIP-seq
MIRT1395298	hsa-miR-4459	CLIP-seq
MIRT1395299	hsa-miR-4695-5p	CLIP-seq
MIRT1395300	hsa-miR-4716-3p	CLIP-seq
MIRT1395301	hsa-miR-4756-3p	CLIP-seq
MIRT1395302	hsa-miR-4760-3p	CLIP-seq
MIRT1395303	hsa-miR-4779	CLIP-seq
MIRT1395304	hsa-miR-520d-5p	CLIP-seq
MIRT1395305	hsa-miR-524-5p	CLIP-seq
MIRT1395306	hsa-miR-655	CLIP-seq
MIRT1395307	hsa-miR-661	CLIP-seq
MIRT1395308	hsa-miR-665	CLIP-seq
MIRT2118566	hsa-miR-4645-5p	CLIP-seq
MIRT2118567	hsa-miR-4673	CLIP-seq
MIRT2340691	hsa-let-7a	CLIP-seq
MIRT2340692	hsa-let-7b	CLIP-seq
MIRT2340693	hsa-let-7c	CLIP-seq
MIRT2340694	hsa-let-7d	CLIP-seq
MIRT2340695	hsa-let-7e	CLIP-seq
MIRT2340696	hsa-let-7f	CLIP-seq
MIRT2340697	hsa-let-7g	CLIP-seq
MIRT2340698	hsa-let-7i	CLIP-seq
MIRT2340699	hsa-miR-106a	CLIP-seq
MIRT2340700	hsa-miR-106b	CLIP-seq
MIRT2340701	hsa-miR-10a	CLIP-seq
MIRT2340702	hsa-miR-10b	CLIP-seq
MIRT2340703	hsa-miR-1207-5p	CLIP-seq
MIRT2340704	hsa-miR-1224-3p	CLIP-seq
MIRT2340705	hsa-miR-1225-3p	CLIP-seq
MIRT2340706	hsa-miR-1228	CLIP-seq
MIRT2340707	hsa-miR-1245b-3p	CLIP-seq
MIRT2340708	hsa-miR-1273	CLIP-seq
MIRT2340709	hsa-miR-1286	CLIP-seq
MIRT2340710	hsa-miR-1289	CLIP-seq
MIRT1395289	hsa-miR-1291	CLIP-seq
MIRT2340711	hsa-miR-1299	CLIP-seq
MIRT2340712	hsa-miR-142-5p	CLIP-seq
MIRT2340713	hsa-miR-146b-3p	CLIP-seq
MIRT2340714	hsa-miR-149	CLIP-seq
MIRT2340715	hsa-miR-1538	CLIP-seq
MIRT2340716	hsa-miR-17	CLIP-seq
MIRT2340717	hsa-miR-1825	CLIP-seq
MIRT1395290	hsa-miR-1827	CLIP-seq
MIRT2340718	hsa-miR-1908	CLIP-seq
MIRT2340719	hsa-miR-1909	CLIP-seq
MIRT2340720	hsa-miR-1910	CLIP-seq
MIRT2340721	hsa-miR-1915	CLIP-seq
MIRT2340722	hsa-miR-1972	CLIP-seq
MIRT2340723	hsa-miR-199a-5p	CLIP-seq
MIRT2340724	hsa-miR-199b-5p	CLIP-seq
MIRT2340725	hsa-miR-205	CLIP-seq
MIRT2340726	hsa-miR-20a	CLIP-seq
MIRT2340727	hsa-miR-20b	CLIP-seq
MIRT2340728	hsa-miR-216a	CLIP-seq
MIRT2340729	hsa-miR-216b	CLIP-seq
MIRT2340730	hsa-miR-2277-3p	CLIP-seq
MIRT2340731	hsa-miR-2355-5p	CLIP-seq
MIRT2340732	hsa-miR-2682	CLIP-seq
MIRT2340733	hsa-miR-296-5p	CLIP-seq
MIRT2340734	hsa-miR-298	CLIP-seq
MIRT2340735	hsa-miR-299-3p	CLIP-seq
MIRT2340736	hsa-miR-3064-5p	CLIP-seq
MIRT2340737	hsa-miR-30a	CLIP-seq
MIRT2340738	hsa-miR-30b	CLIP-seq
MIRT2340739	hsa-miR-30c	CLIP-seq
MIRT2340740	hsa-miR-30d	CLIP-seq
MIRT2340741	hsa-miR-30e	CLIP-seq
MIRT2340742	hsa-miR-31	CLIP-seq
MIRT2340743	hsa-miR-3127-3p	CLIP-seq
MIRT2340744	hsa-miR-3128	CLIP-seq
MIRT2340745	hsa-miR-3151	CLIP-seq
MIRT2340746	hsa-miR-3173-5p	CLIP-seq
MIRT2340747	hsa-miR-3180	CLIP-seq
MIRT2340748	hsa-miR-3180-3p	CLIP-seq
MIRT2340749	hsa-miR-3189-5p	CLIP-seq
MIRT1395291	hsa-miR-3192	CLIP-seq
MIRT2340750	hsa-miR-3196	CLIP-seq
MIRT2340751	hsa-miR-329	CLIP-seq
MIRT2340752	hsa-miR-34a	CLIP-seq
MIRT2340753	hsa-miR-34c-5p	CLIP-seq
MIRT2340754	hsa-miR-3609	CLIP-seq
MIRT2340755	hsa-miR-3612	CLIP-seq
MIRT2340756	hsa-miR-362-3p	CLIP-seq
MIRT2340757	hsa-miR-3663-5p	CLIP-seq
MIRT1395293	hsa-miR-3689a-3p	CLIP-seq
MIRT1395294	hsa-miR-3689c	CLIP-seq
MIRT2340758	hsa-miR-3691-3p	CLIP-seq
MIRT2340759	hsa-miR-377	CLIP-seq
MIRT2340760	hsa-miR-3913-3p	CLIP-seq
MIRT2340761	hsa-miR-3918	CLIP-seq
MIRT2340762	hsa-miR-3922-5p	CLIP-seq
MIRT2340763	hsa-miR-3925-3p	CLIP-seq
MIRT2340764	hsa-miR-3927	CLIP-seq
MIRT2340765	hsa-miR-412	CLIP-seq
MIRT2340766	hsa-miR-421	CLIP-seq
MIRT2340767	hsa-miR-423-3p	CLIP-seq
MIRT2340768	hsa-miR-4253	CLIP-seq
MIRT2340769	hsa-miR-4256	CLIP-seq
MIRT2340770	hsa-miR-4265	CLIP-seq
MIRT2340771	hsa-miR-4269	CLIP-seq
MIRT2340772	hsa-miR-4286	CLIP-seq
MIRT1395296	hsa-miR-4292	CLIP-seq
MIRT2340773	hsa-miR-4296	CLIP-seq
MIRT2340774	hsa-miR-4322	CLIP-seq
MIRT2340775	hsa-miR-4417	CLIP-seq
MIRT2340776	hsa-miR-4435	CLIP-seq
MIRT2340777	hsa-miR-4438	CLIP-seq
MIRT2340778	hsa-miR-4458	CLIP-seq
MIRT1395298	hsa-miR-4459	CLIP-seq
MIRT2340779	hsa-miR-4480	CLIP-seq
MIRT2340780	hsa-miR-4488	CLIP-seq
MIRT2340781	hsa-miR-4495	CLIP-seq
MIRT2340782	hsa-miR-449a	CLIP-seq
MIRT2340783	hsa-miR-449b	CLIP-seq
MIRT2340784	hsa-miR-449c	CLIP-seq
MIRT2340785	hsa-miR-4500	CLIP-seq
MIRT2340786	hsa-miR-4504	CLIP-seq
MIRT2340787	hsa-miR-4514	CLIP-seq
MIRT2340788	hsa-miR-4520a-5p	CLIP-seq
MIRT2340789	hsa-miR-4520b-5p	CLIP-seq
MIRT2340790	hsa-miR-4530	CLIP-seq
MIRT2340791	hsa-miR-455-3p	CLIP-seq
MIRT2340792	hsa-miR-4640-5p	CLIP-seq
MIRT2118566	hsa-miR-4645-5p	CLIP-seq
MIRT2118567	hsa-miR-4673	CLIP-seq
MIRT2340793	hsa-miR-4676-5p	CLIP-seq
MIRT2340794	hsa-miR-4685-5p	CLIP-seq
MIRT2340795	hsa-miR-4686	CLIP-seq
MIRT2340796	hsa-miR-4690-3p	CLIP-seq
MIRT2340797	hsa-miR-4691-5p	CLIP-seq
MIRT2340798	hsa-miR-4692	CLIP-seq
MIRT1395299	hsa-miR-4695-5p	CLIP-seq
MIRT2340799	hsa-miR-4697-5p	CLIP-seq
MIRT2340800	hsa-miR-4700-3p	CLIP-seq
MIRT2340801	hsa-miR-4704-3p	CLIP-seq
MIRT2340802	hsa-miR-4709-3p	CLIP-seq
MIRT2340803	hsa-miR-4709-5p	CLIP-seq
MIRT2340804	hsa-miR-4715-3p	CLIP-seq
MIRT1395300	hsa-miR-4716-3p	CLIP-seq
MIRT2340805	hsa-miR-4717-5p	CLIP-seq
MIRT2340806	hsa-miR-4722-3p	CLIP-seq
MIRT2340807	hsa-miR-4725-5p	CLIP-seq
MIRT2340808	hsa-miR-4726-5p	CLIP-seq
MIRT2340809	hsa-miR-4736	CLIP-seq
MIRT2340810	hsa-miR-4745-3p	CLIP-seq
MIRT2340811	hsa-miR-4747-5p	CLIP-seq
MIRT1395301	hsa-miR-4756-3p	CLIP-seq
MIRT2340812	hsa-miR-4761-5p	CLIP-seq
MIRT2340813	hsa-miR-4762-3p	CLIP-seq
MIRT2340814	hsa-miR-4763-3p	CLIP-seq
MIRT1395303	hsa-miR-4779	CLIP-seq
MIRT2340815	hsa-miR-4794	CLIP-seq
MIRT2340816	hsa-miR-4795-5p	CLIP-seq
MIRT2340817	hsa-miR-4796-3p	CLIP-seq
MIRT2340818	hsa-miR-486-3p	CLIP-seq
MIRT2340819	hsa-miR-489	CLIP-seq
MIRT2340820	hsa-miR-504	CLIP-seq
MIRT2340821	hsa-miR-508-5p	CLIP-seq
MIRT2340822	hsa-miR-519d	CLIP-seq
MIRT2340823	hsa-miR-542-3p	CLIP-seq
MIRT2340824	hsa-miR-548ac	CLIP-seq
MIRT2340825	hsa-miR-548ah	CLIP-seq
MIRT2340826	hsa-miR-548d-3p	CLIP-seq
MIRT2340827	hsa-miR-548z	CLIP-seq
MIRT2340828	hsa-miR-575	CLIP-seq
MIRT2340829	hsa-miR-602	CLIP-seq
MIRT2340830	hsa-miR-625	CLIP-seq
MIRT2340831	hsa-miR-650	CLIP-seq
MIRT1395307	hsa-miR-661	CLIP-seq
MIRT2340832	hsa-miR-663	CLIP-seq
MIRT1395308	hsa-miR-665	CLIP-seq
MIRT2340833	hsa-miR-744	CLIP-seq
MIRT2340834	hsa-miR-760	CLIP-seq
MIRT2340835	hsa-miR-764	CLIP-seq
MIRT2340836	hsa-miR-766	CLIP-seq
MIRT2340837	hsa-miR-767-3p	CLIP-seq
MIRT2340838	hsa-miR-874	CLIP-seq
MIRT2340839	hsa-miR-875-3p	CLIP-seq
MIRT2340840	hsa-miR-93	CLIP-seq
MIRT2340841	hsa-miR-98	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
SP1	Activation	12802284

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	15718238, 24105263, 25416956, 28377464, 29858488, 32296183
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	TAS	9139840
GO:0005765	Component	Lysosomal membrane	HDA	17897319
GO:0005768	Component	Endosome	IDA	29858488
GO:0005789	Component	Endoplasmic reticulum membrane	IDA	24105263, 28377464
GO:0005829	Component	Cytosol	TAS
GO:0006629	Process	Lipid metabolic process	TAS	7490069
GO:0006700	Process	C21-steroid hormone biosynthetic process	TAS
GO:0006839	Process	Mitochondrial transport	TAS	9270027
GO:0008202	Process	Steroid metabolic process	TAS	9139840
GO:0008203	Process	Cholesterol metabolic process	TAS	9270027
GO:0015485	Function	Cholesterol binding	IDA	12011453, 15718238, 28377464
GO:0016021	Component	Integral component of membrane	IEA
GO:0030301	Process	Cholesterol transport	IDA	28377464
GO:0031902	Component	Late endosome membrane	IDA	24105263, 28377464
GO:0042803	Function	Protein homodimerization activity	IDA	15718238
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA
GO:0044232	Component	Organelle membrane contact site	IDA	24105263, 28377464, 29858488
GO:0099044	Process	Vesicle tethering to endoplasmic reticulum	IDA	24105263, 28377464
GO:0120009	Process	Intermembrane lipid transfer	IEA
GO:0120020	Function	Cholesterol transfer activity	IEA
GO:0140284	Component	Endoplasmic reticulum-endosome membrane contact site	IDA	24105263

Other IDs

• MIM: 607048
• HGNC: 17579
• e!Ensembl: ENSG00000131748

Protein

• UniProt ID: Q14849
• Protein name: StAR-related lipid transfer protein 3 (Metastatic lymph node gene 64 protein) (MLN 64) (Protein CAB1) (START domain-containing protein 3) (StARD3)
• Protein function: Sterol-binding protein that mediates cholesterol transport from the endoplasmic reticulum to endosomes (PubMed:11053434, PubMed:15930133, PubMed:22514632, PubMed:28377464, PubMed:33124732). The sterol transport mechanism is triggered by phosphor
• PDB: 1EM2, 5I9J, 6TQR, 6TQU
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF10457	MENTAL	47 → 213	Cholesterol-capturing domain	Domain
  PF01852	START	239 → 444	START domain	Domain

• Sequence:

  MSKLPRELTRDLERSLPAVASLGSSLSHSQSLSSHLLPPPEKRRAISDVRRTFCLFVTFD
  LLFISLLWIIELNTNTGIRKNLEQEIIQYNFKTSFFDIFVLAFFRFSGLLLGYAVLRLRH
  WWVIAVTTLVSSAFLIVKVILSELLSKGAFGYLLPIVSFVLAWLETWFLDFKVLPQEAEE
  ERWYLAAQVAVARGPLLFSGALSEGQFYSPPESFAGSDNESDEEVAGKKSFSAQEREYIR
  QGKEATAVVDQILAQEENWKFEKNNEYGDTVYTIEVPFHGKTFILKTFLPCPAELVYQEV
  ILQPERMVLWNKTVTACQILQRVEDNTLISYDVSAGAAGGVVSPRDFVNVRRIERRRDRY
  LSSGIATSHSAKPPTHKYVRGENGPGGFIVLKSASNPRVCTFVWILNTDLKGRLPRYLIH
  QSLAATMFEFAFHLRQRISELGARA

• Sequence length: 445

Pathways

KEGG:

Cholesterol metabolism

Reactome:

Pregnenolone biosynthesis

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	17013881, 17592021

Unknown
Disease name	Disease term	dbSNP ID	References
Prostatic neoplasms	Prostatic Neoplasms		17013881, 17592021