Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
10928 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
RalA binding protein 1 |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
RALBP1 |
SynonymsGene synonyms aliases
|
RIP1, RLIP1, RLIP76 |
ChromosomeChromosome number
|
18 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
18p11.22 |
SummarySummary of gene provided in NCBI Entrez Gene.
|
RALBP1 plays a role in receptor-mediated endocytosis and is a downstream effector of the small GTP-binding protein RAL (see RALA; MIM 179550). Small G proteins, such as RAL, have GDP-bound inactive and GTP-bound active forms, which shift from the inactive |
miRNAmiRNA information provided by mirtarbase database.
|
|
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0005096 |
Function |
GTPase activator activity |
IBA |
21873635 |
GO:0005096 |
Function |
GTPase activator activity |
IDA |
7673236 |
GO:0005515 |
Function |
Protein binding |
IPI |
9422736, 16189514, 17703191, 18239685, 20709745, 21516116, 23414517, 24550280, 25241761, 25416956, 25910212, 28514442, 28580172, 28851898, 29892012, 30126976, 31515488, 31980649, 32203420, 32296183, 32814053 |
GO:0005829 |
Component |
Cytosol |
TAS |
|
GO:0006897 |
Process |
Endocytosis |
IBA |
21873635 |
GO:0006935 |
Process |
Chemotaxis |
TAS |
10848592 |
GO:0007264 |
Process |
Small GTPase mediated signal transduction |
IBA |
21873635 |
GO:0007264 |
Process |
Small GTPase mediated signal transduction |
IPI |
7673236 |
GO:0016020 |
Component |
Membrane |
IBA |
21873635 |
GO:0016020 |
Component |
Membrane |
IDA |
10924126, 11437348 |
GO:0022857 |
Function |
Transmembrane transporter activity |
IDA |
10924126, 11437348 |
GO:0031267 |
Function |
Small GTPase binding |
IPI |
7673236, 9753634, 24056301 |
GO:0042626 |
Function |
ATPase-coupled transmembrane transporter activity |
IDA |
10924126 |
GO:0042626 |
Function |
ATPase-coupled transmembrane transporter activity |
TAS |
11437348 |
GO:0042910 |
Function |
Xenobiotic transmembrane transporter activity |
IDA |
10924126 |
GO:0043087 |
Process |
Regulation of GTPase activity |
IDA |
7673236 |
GO:0043547 |
Process |
Positive regulation of GTPase activity |
IBA |
21873635 |
GO:0043547 |
Process |
Positive regulation of GTPase activity |
IDA |
7673236 |
GO:0051056 |
Process |
Regulation of small GTPase mediated signal transduction |
TAS |
|
GO:0055085 |
Process |
Transmembrane transport |
IDA |
10924126, 11437348 |
GO:1900753 |
Process |
Doxorubicin transport |
IDA |
10924126 |
GO:1990961 |
Process |
Xenobiotic detoxification by transmembrane export across the plasma membrane |
IDA |
10924126 |
|
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
|
|
Protein
|
UniProt ID |
Q15311 |
Protein name |
RalA-binding protein 1 (RalBP1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase) (EC 7.6.2.2, EC 7.6.2.3) (Ral-interacting protein 1) |
Protein function |
Multifunctional protein that functions as a downstream effector of RALA and RALB (PubMed:7673236). As a GTPase-activating protein/GAP can inactivate CDC42 and RAC1 by stimulating their GTPase activity (PubMed:7673236). As part of the Ral signali |
PDB |
2KWH
,
2KWI
,
2MBG
,
6ZQT
,
6ZRN
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00620 |
RhoGAP |
210 → 355 |
RhoGAP domain |
Domain |
|
Sequence |
|
Sequence length |
655 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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|
Associated diseases
|
Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Hypertension |
Hypertensive disease |
rs13306026, rs13333226 |
23821548 |
Prostate cancer |
Malignant neoplasm of prostate |
rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 |
17013881 |
|
Unknown |
Disease name |
Disease term |
dbSNP ID |
References |
Myocardial ischemia |
Myocardial Ischemia |
|
16214533 |
Prostatic neoplasms |
Prostatic Neoplasms |
|
17013881 |
|