Gene
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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10914 |
Gene nameGene Name - the full gene name approved by the HGNC.
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Poly(A) polymerase alpha |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
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PAPOLA |
SynonymsGene synonyms aliases
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PAP, PAP-alpha |
ChromosomeChromosome number
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14 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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14q32.2 |
SummarySummary of gene provided in NCBI Entrez Gene.
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The protein encoded by this gene belongs to the poly(A) polymerase family. It is required for the addition of adenosine residues for the creation of the 3`-poly(A) tail of mRNAs. Alternatively spliced transcript variants encoding different isoforms have b |
SNPsSNP information provided by dbSNP.
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SNP ID |
Visualize variation |
Clinical significance |
Consequence |
rs483352759 |
A>G |
Conflicting-interpretations-of-pathogenicity |
Synonymous variant, coding sequence variant, genic downstream transcript variant |
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miRNAmiRNA information provided by mirtarbase database.
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Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
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UniProt ID |
P51003 |
Protein name |
Poly(A) polymerase alpha (PAP-alpha) (EC 2.7.7.19) (Polynucleotide adenylyltransferase alpha) |
Protein function |
Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor |
PDB |
8R8R
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Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF04928 |
PAP_central |
21 → 364 |
Poly(A) polymerase central domain |
Domain |
PF01909 |
NTP_transf_2 |
79 → 175 |
Nucleotidyltransferase domain |
Family |
PF04926 |
PAP_RNA-bind |
366 → 435 |
Poly(A) polymerase predicted RNA binding domain |
Domain |
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Sequence |
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Sequence length |
745 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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Associated diseases
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