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LYVE1 (lymphatic vessel endothelial hyaluronan receptor 1)

Gene

10894

Lymphatic vessel endothelial hyaluronan receptor 1

LYVE1

CRSBP-1, HAR, LYVE-1, XLKD1

11p15.4

This gene encodes a type I integral membrane glycoprotein. The encoded protein acts as a receptor and binds to both soluble and immobilized hyaluronan. This protein may function in lymphatic hyaluronan transport and have a role in tumor metastasis. [provi

Show/Hide all(109)

miRTarBase ID	miRNA	Experiments	Reference
MIRT023074	hsa-miR-124-3p	Microarray	18668037
MIRT532074	hsa-miR-551b-5p	HITS-CLIP	23824327
MIRT650047	hsa-miR-34a-3p	HITS-CLIP	23824327
MIRT634561	hsa-miR-6858-3p	HITS-CLIP	23824327
MIRT634560	hsa-miR-4691-3p	HITS-CLIP	23824327
MIRT634559	hsa-miR-4690-3p	HITS-CLIP	23824327
MIRT634558	hsa-miR-5685	HITS-CLIP	23824327
MIRT634557	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT634556	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT634555	hsa-miR-3194-5p	HITS-CLIP	23824327
MIRT634554	hsa-miR-3157-5p	HITS-CLIP	23824327
MIRT634552	hsa-miR-587	HITS-CLIP	23824327
MIRT532074	hsa-miR-551b-5p	HITS-CLIP	23824327
MIRT650047	hsa-miR-34a-3p	HITS-CLIP	23824327
MIRT634561	hsa-miR-6858-3p	HITS-CLIP	23824327
MIRT634560	hsa-miR-4691-3p	HITS-CLIP	23824327
MIRT634559	hsa-miR-4690-3p	HITS-CLIP	23824327
MIRT634558	hsa-miR-5685	HITS-CLIP	23824327
MIRT634557	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT634556	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT634555	hsa-miR-3194-5p	HITS-CLIP	23824327
MIRT634554	hsa-miR-3157-5p	HITS-CLIP	23824327
MIRT634553	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT634552	hsa-miR-587	HITS-CLIP	23824327
MIRT634561	hsa-miR-6858-3p	HITS-CLIP	23824327
MIRT634560	hsa-miR-4691-3p	HITS-CLIP	23824327
MIRT634559	hsa-miR-4690-3p	HITS-CLIP	23824327
MIRT634558	hsa-miR-5685	HITS-CLIP	23824327
MIRT634557	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT634556	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT634555	hsa-miR-3194-5p	HITS-CLIP	23824327
MIRT634554	hsa-miR-3157-5p	HITS-CLIP	23824327
MIRT634553	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT634552	hsa-miR-587	HITS-CLIP	23824327
MIRT532074	hsa-miR-551b-5p	PAR-CLIP	22012620
MIRT532073	hsa-miR-6861-5p	PAR-CLIP	22012620
MIRT532072	hsa-miR-503-3p	PAR-CLIP	22012620
MIRT532071	hsa-miR-340-5p	PAR-CLIP	22012620
MIRT532074	hsa-miR-551b-5p	HITS-CLIP	23824327
MIRT650047	hsa-miR-34a-3p	HITS-CLIP	23824327
MIRT634561	hsa-miR-6858-3p	HITS-CLIP	23824327
MIRT634560	hsa-miR-4691-3p	HITS-CLIP	23824327
MIRT634559	hsa-miR-4690-3p	HITS-CLIP	23824327
MIRT634558	hsa-miR-5685	HITS-CLIP	23824327
MIRT634557	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT634556	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT634555	hsa-miR-3194-5p	HITS-CLIP	23824327
MIRT634554	hsa-miR-3157-5p	HITS-CLIP	23824327
MIRT634552	hsa-miR-587	HITS-CLIP	23824327
MIRT532074	hsa-miR-551b-5p	HITS-CLIP	23824327
MIRT650047	hsa-miR-34a-3p	HITS-CLIP	23824327
MIRT634561	hsa-miR-6858-3p	HITS-CLIP	23824327
MIRT634560	hsa-miR-4691-3p	HITS-CLIP	23824327
MIRT634559	hsa-miR-4690-3p	HITS-CLIP	23824327
MIRT634558	hsa-miR-5685	HITS-CLIP	23824327
MIRT634557	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT634556	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT634555	hsa-miR-3194-5p	HITS-CLIP	23824327
MIRT634554	hsa-miR-3157-5p	HITS-CLIP	23824327
MIRT634553	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT634552	hsa-miR-587	HITS-CLIP	23824327
MIRT634561	hsa-miR-6858-3p	HITS-CLIP	23824327
MIRT634560	hsa-miR-4691-3p	HITS-CLIP	23824327
MIRT634559	hsa-miR-4690-3p	HITS-CLIP	23824327
MIRT634558	hsa-miR-5685	HITS-CLIP	23824327
MIRT634557	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT634556	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT634555	hsa-miR-3194-5p	HITS-CLIP	23824327
MIRT634554	hsa-miR-3157-5p	HITS-CLIP	23824327
MIRT634553	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT634552	hsa-miR-587	HITS-CLIP	23824327
MIRT532074	hsa-miR-551b-5p	PAR-CLIP	22012620
MIRT532073	hsa-miR-6861-5p	PAR-CLIP	22012620
MIRT532072	hsa-miR-503-3p	PAR-CLIP	22012620
MIRT532071	hsa-miR-340-5p	PAR-CLIP	22012620
MIRT1124297	hsa-miR-1245b-5p	CLIP-seq
MIRT1124298	hsa-miR-1324	CLIP-seq
MIRT1124299	hsa-miR-199a-3p	CLIP-seq
MIRT1124300	hsa-miR-199b-3p	CLIP-seq
MIRT1124301	hsa-miR-2053	CLIP-seq
MIRT1124302	hsa-miR-3123	CLIP-seq
MIRT1124303	hsa-miR-3129-5p	CLIP-seq
MIRT1124304	hsa-miR-3142	CLIP-seq
MIRT1124305	hsa-miR-3160-3p	CLIP-seq
MIRT1124306	hsa-miR-3925-5p	CLIP-seq
MIRT1124307	hsa-miR-4291	CLIP-seq
MIRT1124308	hsa-miR-4303	CLIP-seq
MIRT1124309	hsa-miR-4452	CLIP-seq
MIRT1124310	hsa-miR-4459	CLIP-seq
MIRT1124311	hsa-miR-4487	CLIP-seq
MIRT1124312	hsa-miR-4695-5p	CLIP-seq
MIRT1124313	hsa-miR-545	CLIP-seq
MIRT1124314	hsa-miR-558	CLIP-seq
MIRT1124315	hsa-miR-567	CLIP-seq
MIRT1124316	hsa-miR-569	CLIP-seq
MIRT1124317	hsa-miR-653	CLIP-seq
MIRT1124318	hsa-miR-665	CLIP-seq
MIRT1124319	hsa-miR-936	CLIP-seq
MIRT2035140	hsa-miR-544	CLIP-seq
MIRT2265546	hsa-miR-1207-3p	CLIP-seq
MIRT2265547	hsa-miR-1207-5p	CLIP-seq
MIRT2265548	hsa-miR-2054	CLIP-seq
MIRT2265549	hsa-miR-3173-3p	CLIP-seq
MIRT2265550	hsa-miR-4428	CLIP-seq
MIRT2265551	hsa-miR-4719	CLIP-seq
MIRT2265552	hsa-miR-4731-5p	CLIP-seq
MIRT2265553	hsa-miR-4763-3p	CLIP-seq
MIRT2265554	hsa-miR-486-3p	CLIP-seq
MIRT2265555	hsa-miR-555	CLIP-seq

Show/Hide all(13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004888	Function	Transmembrane signaling receptor activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005540	Function	Hyaluronic acid binding	IBA	21873635
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	TAS	10037799
GO:0007160	Process	Cell-matrix adhesion	TAS	10037799
GO:0009611	Process	Response to wounding	TAS	10037799
GO:0009653	Process	Anatomical structure morphogenesis	TAS	10037799
GO:0016020	Component	Membrane	TAS	10037799
GO:0030214	Process	Hyaluronan catabolic process	TAS
GO:0038023	Function	Signaling receptor activity	TAS	10037799
GO:0070062	Component	Extracellular exosome	HDA	23533145

MIM	HGNC	e!Ensembl
605702	14687	ENSG00000133800

Protein

UniProt ID

Q9Y5Y7

Protein name

Lymphatic vessel endothelial hyaluronic acid receptor 1 (LYVE-1) (Cell surface retention sequence-binding protein 1) (CRSBP-1) (Extracellular link domain-containing protein 1) (Hyaluronic acid receptor)

Protein function

Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). M

PDB

8OS2 , 8OXD

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00193	Xlink	41 → 129	Extracellular link domain	Domain

Sequence

MARCFSLVLLLTSIWTTRLLVQGSLRAEELSIQVSCRIMGITLVSKKANQQLNFTEAKEA
CRLLGLSLAGKDQVETALKASFETCSYGWVGDGFVVISRISPNPKCGKNGVGVLIWKVPV
SRQFAAYCYNSSDTWTNSCIPEIITTKDPIFNTQTATQTTEFIVSDSTYSVASPYSTIPA
PTTTPPAPASTSIPRRKKLICVTEVFMETSTMSTETEPFVENKAAFKNEAAGFGGVPTAL
LVLALLFFGAAAGLGFCYVKRYVKAFPFTNKNQQKEMIETKVVKEEKANDSNPNEESKKT
DKNPEESKSPSKTTVRCLEAEV

Sequence length

322

Interactions

View interactions

	Reactome
			Hyaluronan uptake and degradation

Associated diseases

Show/Hide Unknown Diseases (1)

Unknown
Disease name	Disease term	dbSNP ID	References
Liver carcinoma	Liver carcinoma		28284560

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