FGL2 (fibrinogen like 2)

Gene

• Entrez ID: 10875
• Gene name: Fibrinogen like 2
• Gene symbol: FGL2
• Synonyms: T49, pT49
• Chromosome: 7
• Chromosome location: 7q11.23
• Summary: The protein encoded by this gene is a secreted protein that is similar to the beta- and gamma-chains of fibrinogen. The carboxyl-terminus of the encoded protein consists of the fibrinogen-related domains (FRED). The encoded protein forms a tetrameric comp

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018781	hsa-miR-335-5p	Microarray	18185580
MIRT030088	hsa-miR-26b-5p	Microarray	19088304
MIRT440643	hsa-miR-155-5p	HITS-CLIP	22473208
MIRT440643	hsa-miR-155-5p	HITS-CLIP	22473208
MIRT996284	hsa-miR-1267	CLIP-seq
MIRT996285	hsa-miR-132	CLIP-seq
MIRT996286	hsa-miR-212	CLIP-seq
MIRT996287	hsa-miR-296-3p	CLIP-seq
MIRT996288	hsa-miR-30a	CLIP-seq
MIRT996289	hsa-miR-30b	CLIP-seq
MIRT996290	hsa-miR-30c	CLIP-seq
MIRT996291	hsa-miR-30d	CLIP-seq
MIRT996292	hsa-miR-30e	CLIP-seq
MIRT996293	hsa-miR-3120-3p	CLIP-seq
MIRT996294	hsa-miR-3143	CLIP-seq
MIRT996295	hsa-miR-33a	CLIP-seq
MIRT996296	hsa-miR-33b	CLIP-seq
MIRT996297	hsa-miR-3973	CLIP-seq
MIRT996298	hsa-miR-409-3p	CLIP-seq
MIRT996299	hsa-miR-4273	CLIP-seq
MIRT996300	hsa-miR-4652-3p	CLIP-seq
MIRT996301	hsa-miR-4677-5p	CLIP-seq
MIRT996302	hsa-miR-4684-3p	CLIP-seq
MIRT996303	hsa-miR-4699-3p	CLIP-seq
MIRT996304	hsa-miR-4753-3p	CLIP-seq
MIRT996305	hsa-miR-4768-5p	CLIP-seq
MIRT996306	hsa-miR-513a-5p	CLIP-seq
MIRT996307	hsa-miR-518a-5p	CLIP-seq
MIRT996308	hsa-miR-527	CLIP-seq
MIRT996309	hsa-miR-543	CLIP-seq
MIRT996310	hsa-miR-548a-5p	CLIP-seq
MIRT996311	hsa-miR-548ab	CLIP-seq
MIRT996312	hsa-miR-548ak	CLIP-seq
MIRT996313	hsa-miR-548b-5p	CLIP-seq
MIRT996314	hsa-miR-548c-5p	CLIP-seq
MIRT996315	hsa-miR-548d-5p	CLIP-seq
MIRT996316	hsa-miR-548h	CLIP-seq
MIRT996317	hsa-miR-548i	CLIP-seq
MIRT996318	hsa-miR-548j	CLIP-seq
MIRT996319	hsa-miR-548w	CLIP-seq
MIRT996320	hsa-miR-548y	CLIP-seq
MIRT996321	hsa-miR-559	CLIP-seq
MIRT996322	hsa-miR-619	CLIP-seq
MIRT1995381	hsa-miR-122	CLIP-seq
MIRT1995382	hsa-miR-1287	CLIP-seq
MIRT1995383	hsa-miR-150	CLIP-seq
MIRT1995384	hsa-miR-24	CLIP-seq
MIRT1995385	hsa-miR-3135b	CLIP-seq
MIRT1995386	hsa-miR-3159	CLIP-seq
MIRT1995387	hsa-miR-4264	CLIP-seq
MIRT1995388	hsa-miR-4284	CLIP-seq
MIRT1995389	hsa-miR-4328	CLIP-seq
MIRT1995390	hsa-miR-4438	CLIP-seq
MIRT996305	hsa-miR-4768-5p	CLIP-seq
MIRT1995391	hsa-miR-4772-3p	CLIP-seq
MIRT1995392	hsa-miR-5095	CLIP-seq
MIRT1995393	hsa-miR-562	CLIP-seq
MIRT1995394	hsa-miR-576-3p	CLIP-seq
MIRT1995395	hsa-miR-622	CLIP-seq
MIRT1995396	hsa-miR-944	CLIP-seq
MIRT1995381	hsa-miR-122	CLIP-seq
MIRT2229453	hsa-miR-1236	CLIP-seq
MIRT2229454	hsa-miR-1305	CLIP-seq
MIRT1995383	hsa-miR-150	CLIP-seq
MIRT2229455	hsa-miR-1976	CLIP-seq
MIRT1995384	hsa-miR-24	CLIP-seq
MIRT1995386	hsa-miR-3159	CLIP-seq
MIRT2229456	hsa-miR-3187-3p	CLIP-seq
MIRT2229457	hsa-miR-3617	CLIP-seq
MIRT2229458	hsa-miR-3663-5p	CLIP-seq
MIRT2229459	hsa-miR-371-5p	CLIP-seq
MIRT2229460	hsa-miR-371b-5p	CLIP-seq
MIRT1995387	hsa-miR-4264	CLIP-seq
MIRT2229461	hsa-miR-4279	CLIP-seq
MIRT1995388	hsa-miR-4284	CLIP-seq
MIRT1995389	hsa-miR-4328	CLIP-seq
MIRT2229462	hsa-miR-4435	CLIP-seq
MIRT1995390	hsa-miR-4438	CLIP-seq
MIRT2229463	hsa-miR-4701-5p	CLIP-seq
MIRT2229464	hsa-miR-4722-3p	CLIP-seq
MIRT2229465	hsa-miR-4755-3p	CLIP-seq
MIRT996305	hsa-miR-4768-5p	CLIP-seq
MIRT1995391	hsa-miR-4772-3p	CLIP-seq
MIRT2229466	hsa-miR-494	CLIP-seq
MIRT1995392	hsa-miR-5095	CLIP-seq
MIRT2229467	hsa-miR-548s	CLIP-seq
MIRT1995393	hsa-miR-562	CLIP-seq
MIRT2229468	hsa-miR-588	CLIP-seq
MIRT1995395	hsa-miR-622	CLIP-seq
MIRT2229469	hsa-miR-641	CLIP-seq
MIRT1995392	hsa-miR-5095	CLIP-seq
MIRT2428937	hsa-miR-3144-3p	CLIP-seq
MIRT2428938	hsa-miR-556-5p	CLIP-seq
MIRT2428939	hsa-miR-875-5p	CLIP-seq
MIRT2428937	hsa-miR-3144-3p	CLIP-seq
MIRT2428938	hsa-miR-556-5p	CLIP-seq
MIRT2428939	hsa-miR-875-5p	CLIP-seq
MIRT2449685	hsa-miR-4735-5p	CLIP-seq
MIRT2449686	hsa-miR-4775	CLIP-seq
MIRT2449687	hsa-miR-590-3p	CLIP-seq
MIRT1995381	hsa-miR-122	CLIP-seq
MIRT1995382	hsa-miR-1287	CLIP-seq
MIRT1995384	hsa-miR-24	CLIP-seq
MIRT2533356	hsa-miR-3065-5p	CLIP-seq
MIRT1995385	hsa-miR-3135b	CLIP-seq
MIRT1995387	hsa-miR-4264	CLIP-seq
MIRT1995388	hsa-miR-4284	CLIP-seq
MIRT1995390	hsa-miR-4438	CLIP-seq
MIRT2449685	hsa-miR-4735-5p	CLIP-seq
MIRT1995391	hsa-miR-4772-3p	CLIP-seq
MIRT2449686	hsa-miR-4775	CLIP-seq
MIRT1995392	hsa-miR-5095	CLIP-seq
MIRT2449687	hsa-miR-590-3p	CLIP-seq
MIRT1995395	hsa-miR-622	CLIP-seq
MIRT1995381	hsa-miR-122	CLIP-seq
MIRT1995382	hsa-miR-1287	CLIP-seq
MIRT1995384	hsa-miR-24	CLIP-seq
MIRT2533356	hsa-miR-3065-5p	CLIP-seq
MIRT1995385	hsa-miR-3135b	CLIP-seq
MIRT1995388	hsa-miR-4284	CLIP-seq
MIRT1995390	hsa-miR-4438	CLIP-seq
MIRT1995392	hsa-miR-5095	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
SP1	Unknown	11170750

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002291	Process	T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	IEA
GO:0002605	Process	Negative regulation of dendritic cell antigen processing and presentation	IEA
GO:0002617	Process	Negative regulation of macrophage antigen processing and presentation	IEA
GO:0005102	Function	Signaling receptor binding	IBA	21873635
GO:0005201	Function	Extracellular matrix structural constituent	RCA	28327460
GO:0005576	Component	Extracellular region	TAS
GO:0005577	Component	Fibrinogen complex	TAS	7642106
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0006508	Process	Proteolysis	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0043312	Process	Neutrophil degranulation	TAS
GO:0043381	Process	Negative regulation of memory T cell differentiation	IEA
GO:0050687	Process	Negative regulation of defense response to virus	IEA
GO:0062023	Component	Collagen-containing extracellular matrix	HDA	28327460
GO:0062023	Component	Collagen-containing extracellular matrix	IBA	21873635
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145
GO:1904813	Component	Ficolin-1-rich granule lumen	TAS

Other IDs

• MIM: 605351
• HGNC: 3696
• e!Ensembl: ENSG00000127951

Protein

• UniProt ID: Q14314
• Protein name: Fibroleukin (Fibrinogen-like protein 2) (pT49)
• Protein function: May play a role in physiologic lymphocyte functions at mucosal sites.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00147	Fibrinogen_C	209 → 435	Fibrinogen beta and gamma chains, C-terminal globular domain	Domain

• Sequence:

  MKLANWYWLSSAVLATYGFLVVANNETEEIKDERAKDVCPVRLESRGKCEEAGECPYQVS
  LPPLTIQLPKQFSRIEEVFKEVQNLKEIVNSLKKSCQDCKLQADDNGDPGRNGLLLPSTG
  APGEVGDNRVRELESEVNKLSSELKNAKEEINVLHGRLEKLNLVNMNNIENYVDSKVANL
  TFVVNSLDGKCSKCPSQEQIQSRPVQHLIYKDCSDYYAIGKRSSETYRVTPDPKNSSFEV
  YCDMETMGGGWTVLQARLDGSTNFTRTWQDYKAGFGNLRREFWLGNDKIHLLTKSKEMIL
  RIDLEDFNGVELYALYDQFYVANEFLKYRLHVGNYNGTAGDALRFNKHYNHDLKFFTTPD
  KDNDRYPSGNCGLYYSSGWWFDACLSANLNGKYYHQKYRGVRNGIFWGTWPGVSEAHPGG
  YKSSFKEAKMMIRPKHFKP

• Sequence length: 439

Pathways

Reactome:

Neutrophil degranulation

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Dermatitis	Dermatitis, Allergic Contact	rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174	17374397