ADAM28 (ADAM metallopeptidase domain 28)

Gene

• Entrez ID: 10863
• Gene name: ADAM metallopeptidase domain 28
• Gene symbol: ADAM28
• Synonyms: ADAM 28, MDC-L, MDCL, eMDC II, eMDCII
• Chromosome: 8
• Chromosome location: 8p21.2
• Summary: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT531705	hsa-miR-3914	PAR-CLIP	22012620
MIRT531704	hsa-miR-4717-3p	PAR-CLIP	22012620
MIRT531703	hsa-miR-3913-3p	PAR-CLIP	22012620
MIRT531702	hsa-miR-130a-5p	PAR-CLIP	22012620
MIRT531701	hsa-miR-23a-3p	PAR-CLIP	22012620
MIRT531700	hsa-miR-23b-3p	PAR-CLIP	22012620
MIRT531699	hsa-miR-23c	PAR-CLIP	22012620
MIRT531698	hsa-miR-489-3p	PAR-CLIP	22012620
MIRT531697	hsa-miR-6511b-5p	PAR-CLIP	22012620
MIRT531696	hsa-miR-6811-5p	PAR-CLIP	22012620
MIRT531695	hsa-miR-651-5p	PAR-CLIP	22012620
MIRT531705	hsa-miR-3914	PAR-CLIP	22012620
MIRT531704	hsa-miR-4717-3p	PAR-CLIP	22012620
MIRT531703	hsa-miR-3913-3p	PAR-CLIP	22012620
MIRT531702	hsa-miR-130a-5p	PAR-CLIP	22012620
MIRT531701	hsa-miR-23a-3p	PAR-CLIP	22012620
MIRT531700	hsa-miR-23b-3p	PAR-CLIP	22012620
MIRT531699	hsa-miR-23c	PAR-CLIP	22012620
MIRT531698	hsa-miR-489-3p	PAR-CLIP	22012620
MIRT531697	hsa-miR-6511b-5p	PAR-CLIP	22012620
MIRT531696	hsa-miR-6811-5p	PAR-CLIP	22012620
MIRT531695	hsa-miR-651-5p	PAR-CLIP	22012620
MIRT766144	hsa-miR-329	CLIP-seq
MIRT766145	hsa-miR-362-3p	CLIP-seq
MIRT766146	hsa-miR-4762-5p	CLIP-seq
MIRT766147	hsa-miR-548aa	CLIP-seq
MIRT1925769	hsa-miR-3942-3p	CLIP-seq
MIRT1925770	hsa-miR-4452	CLIP-seq
MIRT1925771	hsa-miR-4775	CLIP-seq
MIRT766144	hsa-miR-329	CLIP-seq
MIRT766145	hsa-miR-362-3p	CLIP-seq
MIRT766144	hsa-miR-329	CLIP-seq
MIRT766145	hsa-miR-362-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004175	Function	Endopeptidase activity	IBA	21873635
GO:0004222	Function	Metalloendopeptidase activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005576	Component	Extracellular region	IEA
GO:0005739	Component	Mitochondrion	IDA
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA
GO:0006508	Process	Proteolysis	IEA
GO:0007283	Process	Spermatogenesis	TAS	10587367
GO:0008237	Function	Metallopeptidase activity	IBA	21873635
GO:0008237	Function	Metallopeptidase activity	IDA	12777399
GO:0016021	Component	Integral component of membrane	IEA
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 606188
• HGNC: 206
• e!Ensembl: ENSG00000042980

Protein

• UniProt ID: Q9UKQ2
• Protein name: Disintegrin and metalloproteinase domain-containing protein 28 (ADAM 28) (EC 3.4.24.-) (Epididymal metalloproteinase-like, disintegrin-like, and cysteine-rich protein II) (eMDC II) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein L) (M
• Protein function: May play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L. May be involved in sperm maturation.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01562	Pep_M12B_propep	29 → 156	Reprolysin family propeptide	Family
  PF01421	Reprolysin	204 → 399	Reprolysin (M12B) family zinc metalloprotease	Domain
  PF00200	Disintegrin	416 → 488	Disintegrin	Domain
  PF08516	ADAM_CR	493 → 591	ADAM cysteine-rich	Family

• Sequence:

  MLQGLLPVSLLLSVAVSAIKELPGVKKYEVVYPIRLHPLHKREAKEPEQQEQFETELKYK
  MTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKVSDAS
  ISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDSTCGMDGVLWAHDL
  QQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANYVNM
  LYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKRHDIAQLITATE
  LAGTTVGLAFMSTMCSPYSVGVVQDHSDNLLRVAGTMAHEMGHNFGMFHDDYSCKCPSTI
  CVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPTDIISTPICGNQLVEMGED
  CDCGTSEECTNICCDAKTCKIKATFQCALGECCEKCQFKKAGMVCRPAKDECDLPEMCNG
  KSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWGPGTEVADKSCYNRNEGGSK
  YGYCRRVDDTLIPCKANDTMCGKLFCQGGSDNLPWKGRIVTFLTCKTFDPEDTSQEIGMV
  ANGTKCGDNKVCINAECVDIEKAYKSTNCSSKCKGHAVCDHELQCQCEEGWIPPDCDDSS
  VVFHFSIVVGVLFPMAVIFVVVAMVIRHQSSREKQKKDQRPLSTTGTRPHKQKRKPQMVK
  AVQPQEMSQMKPHVYDLPVEGNEPPASFHKDTNALPPTVFKDNPVSTPKDSNPKA

• Sequence length: 775

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Lung cancer	Malignant neoplasm of lung	rs121913530, rs121913529, rs878855122, rs1057519784, rs770315135	20544843
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	29662167

Unknown
Disease name	Disease term	dbSNP ID	References
Lung neoplasms	Lung Neoplasms		20544843
Prostatic neoplasms	Prostatic Neoplasms		29662167
Skin melanoma	Stage IV Skin Melanoma