LILRB1 (leukocyte immunoglobulin like receptor B1)
|
Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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10859 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
Leukocyte immunoglobulin like receptor B1 |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
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LILRB1 |
SynonymsGene synonyms aliases
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CD85J, ILT-2, ILT2, LIR-1, LIR1, MIR-7, MIR7, PIR-B, PIRB |
ChromosomeChromosome number
|
19 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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19q13.42 |
SummarySummary of gene provided in NCBI Entrez Gene.
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This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular |
miRNAmiRNA information provided by mirtarbase database.
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Transcription factors
|
Transcription factor |
Regulation |
Reference |
TRERF1 |
Repression |
18652845 |
|
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0001540 |
Function |
Amyloid-beta binding |
IDA |
24052308 |
GO:0001915 |
Process |
Negative regulation of T cell mediated cytotoxicity |
IDA |
21213105 |
GO:0002230 |
Process |
Positive regulation of defense response to virus by host |
IDA |
18398485 |
GO:0002250 |
Process |
Adaptive immune response |
IEA |
|
GO:0002309 |
Process |
T cell proliferation involved in immune response |
IDA |
18094328 |
GO:0002719 |
Process |
Negative regulation of cytokine production involved in immune response |
IDA |
18094328 |
GO:0002767 |
Process |
Immune response-inhibiting cell surface receptor signaling pathway |
NAS |
18550825 |
GO:0002774 |
Process |
Fc receptor mediated inhibitory signaling pathway |
IDA |
9842885 |
GO:0005515 |
Function |
Protein binding |
IPI |
11169396, 12853576, 12874224, 16455647, 18802077, 19583775, 28636952 |
GO:0005576 |
Component |
Extracellular region |
IEA |
|
GO:0005737 |
Component |
Cytoplasm |
IDA |
15585844 |
GO:0005886 |
Component |
Plasma membrane |
TAS |
|
GO:0007165 |
Process |
Signal transduction |
IDA |
18802077 |
GO:0008157 |
Function |
Protein phosphatase 1 binding |
IPI |
9285411, 9842885, 11907092, 18802077 |
GO:0009615 |
Process |
Response to virus |
IDA |
9285411, 17869268, 18094328 |
GO:0009897 |
Component |
External side of plasma membrane |
IDA |
9285411, 15585844, 17869268, 18094328, 18684926, 21233315, 21551166 |
GO:0010628 |
Process |
Positive regulation of gene expression |
IDA |
18094328 |
GO:0014063 |
Process |
Negative regulation of serotonin secretion |
IDA |
11907092 |
GO:0016021 |
Component |
Integral component of membrane |
IEA |
|
GO:0023025 |
Function |
MHC class Ib protein complex binding |
IDA |
17056715, 28636952 |
GO:0023029 |
Function |
MHC class Ib protein binding |
IDA |
11169396 |
GO:0030107 |
Function |
HLA-A specific inhibitory MHC class I receptor activity |
IDA |
18684926 |
GO:0030109 |
Function |
HLA-B specific inhibitory MHC class I receptor activity |
IDA |
11907092 |
GO:0031623 |
Process |
Receptor internalization |
TAS |
17869268 |
GO:0032393 |
Function |
MHC class I receptor activity |
IDA |
9285411, 9842885, 17869268, 18094328, 18398485, 18802077, 21213105, 21233315 |
GO:0032394 |
Function |
MHC class Ib receptor activity |
IDA |
24453251 |
GO:0032609 |
Process |
Interferon-gamma production |
IDA |
11907092, 15585844 |
GO:0032688 |
Process |
Negative regulation of interferon-beta production |
IDA |
21213105 |
GO:0032689 |
Process |
Negative regulation of interferon-gamma production |
IDA |
17869268, 18684926 |
GO:0032693 |
Process |
Negative regulation of interleukin-10 production |
IDA |
18094328 |
GO:0032695 |
Process |
Negative regulation of interleukin-12 production |
IDA |
18094328 |
GO:0032720 |
Process |
Negative regulation of tumor necrosis factor production |
IDA |
18684926 |
GO:0032945 |
Process |
Negative regulation of mononuclear cell proliferation |
IDA |
21551166 |
GO:0042130 |
Process |
Negative regulation of T cell proliferation |
IDA |
15585844 |
GO:0042169 |
Function |
SH2 domain binding |
IDA |
11907092 |
GO:0042288 |
Function |
MHC class I protein binding |
IDA |
9842885, 18094328, 18802077, 21213105 |
GO:0042288 |
Function |
MHC class I protein binding |
IMP |
18398485, 21233315 |
GO:0042288 |
Function |
MHC class I protein binding |
IPI |
9285411, 17869268, 18094328, 19124746, 20702625 |
GO:0042803 |
Function |
Protein homodimerization activity |
IPI |
21213105 |
GO:0043065 |
Process |
Positive regulation of apoptotic process |
IDA |
21551166 |
GO:0045786 |
Process |
Negative regulation of cell cycle |
IDA |
21551166 |
GO:0045806 |
Process |
Negative regulation of endocytosis |
IDA |
18094328 |
GO:0045944 |
Process |
Positive regulation of transcription by RNA polymerase II |
NAS |
18550825 |
GO:0045953 |
Process |
Negative regulation of natural killer cell mediated cytotoxicity |
IDA |
12874224, 18398485 |
GO:0046636 |
Process |
Negative regulation of alpha-beta T cell activation |
IDA |
21213105 |
GO:0050776 |
Process |
Regulation of immune response |
TAS |
|
GO:0051607 |
Process |
Defense response to virus |
IDA |
15585844 |
GO:0051926 |
Process |
Negative regulation of calcium ion transport |
IDA |
9842885 |
GO:0060907 |
Process |
Positive regulation of macrophage cytokine production |
IDA |
19304799 |
GO:0071222 |
Process |
Cellular response to lipopolysaccharide |
IEP |
18094328 |
GO:0071635 |
Process |
Negative regulation of transforming growth factor beta production |
IDA |
18094328 |
GO:0097028 |
Process |
Dendritic cell differentiation |
IEP |
18094328 |
GO:2000669 |
Process |
Negative regulation of dendritic cell apoptotic process |
IDA |
18094328 |
GO:2001186 |
Process |
Negative regulation of CD8-positive, alpha-beta T cell activation |
IDA |
21213105 |
GO:2001189 |
Process |
Negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell |
IDA |
18094328 |
GO:2001193 |
Process |
Positive regulation of gamma-delta T cell activation involved in immune response |
IDA |
21233315 |
GO:2001199 |
Process |
Negative regulation of dendritic cell differentiation |
IMP |
18684926 |
GO:2001205 |
Process |
Negative regulation of osteoclast development |
IDA |
18802077 |
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Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
|
UniProt ID |
Q8NHL6 |
Protein name |
Leukocyte immunoglobulin-like receptor subfamily B member 1 (LIR-1) (Leukocyte immunoglobulin-like receptor 1) (CD85 antigen-like family member J) (Immunoglobulin-like transcript 2) (ILT-2) (Monocyte/macrophage immunoglobulin-like receptor 7) (MIR-7) (CD |
Protein function |
Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles (PubMed:16455647, PubMed:28636952). Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inh |
PDB |
1G0X
,
1P7Q
,
1UFU
,
1UGN
,
1VDG
,
3D2U
,
4LL9
,
4NO0
,
5KNM
,
6AEE
,
6EWA
,
6EWC
,
6EWO
,
6K60
,
6ZDX
,
7KFK
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF13895 |
Ig_2 |
28 → 118 |
Immunoglobulin domain |
Domain |
PF00047 |
ig |
329 → 410 |
Immunoglobulin domain |
Domain |
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Sequence |
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Sequence length |
650 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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Associated diseases
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Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Schizophrenia |
Schizophrenia |
rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 |
25656957 |
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