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LILRB1 (leukocyte immunoglobulin like receptor B1)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10859
Gene nameGene Name - the full gene name approved by the HGNC.
Leukocyte immunoglobulin like receptor B1
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
LILRB1
SynonymsGene synonyms aliases
CD85J, ILT-2, ILT2, LIR-1, LIR1, MIR-7, MIR7, PIR-B, PIRB
ChromosomeChromosome number
19
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19q13.42
SummarySummary of gene provided in NCBI Entrez Gene.
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT609970 hsa-miR-8485 HITS-CLIP 21572407
MIRT609969 hsa-miR-329-3p HITS-CLIP 21572407
MIRT609968 hsa-miR-362-3p HITS-CLIP 21572407
MIRT609967 hsa-miR-603 HITS-CLIP 21572407
MIRT625538 hsa-miR-4789-3p HITS-CLIP 21572407
Transcription factors
Transcription factor Regulation Reference
TRERF1 Repression 18652845
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001540 Function Amyloid-beta binding IDA 24052308
GO:0001915 Process Negative regulation of T cell mediated cytotoxicity IDA 21213105
GO:0002230 Process Positive regulation of defense response to virus by host IDA 18398485
GO:0002250 Process Adaptive immune response IEA
GO:0002309 Process T cell proliferation involved in immune response IDA 18094328
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID Q8NHL6
Protein name Leukocyte immunoglobulin-like receptor subfamily B member 1 (LIR-1) (Leukocyte immunoglobulin-like receptor 1) (CD85 antigen-like family member J) (Immunoglobulin-like transcript 2) (ILT-2) (Monocyte/macrophage immunoglobulin-like receptor 7) (MIR-7) (CD
Protein function Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles (PubMed:16455647, PubMed:28636952). Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inh
PDB 1G0X , 1P7Q , 1UFU , 1UGN , 1VDG , 3D2U , 4LL9 , 4NO0 , 5KNM , 6AEE , 6EWA , 6EWC , 6EWO , 6K60 , 6ZDX , 7KFK
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13895 Ig_2
28 118
Immunoglobulin domain
Domain
PF00047 ig
329 410
Immunoglobulin domain
Domain
Sequence
MTPILTVLICLGLSLGPRTHVQAGHLPKPTLWAEPGSVITQGSPVTLRCQGGQETQEYRL
YREKKTALWITRIPQELVKKGQFPIPSITWEHAGRYRCYYGSDTAGRSESSDPLELVV
TG
AYIKPTLSAQPSPVVNSGGNVILQCDSQVAFDGFSLCKEGEDEHPQCLNSQPHARGSSRA
IFSVGPVSPSRRWWYRCYAYDSNSPYEWSLPSDLLELLVLGVSKKPSLSVQPGPIVAPEE
TLTLQCGSDAGYNRFVLYKDGERDFLQLAGAQPQAGLSQANFTLGPVSRSYGGQYRCYGA
HNLSSEWSAPSDPLDILIAGQFYDRVSLSVQPGPTVASGENVTLLCQSQGWMQTFLLTKE
GAADDPWRLRSTYQSQKYQAEFPMGPVTSAHAGTYRCYGSQSSKPYLLTH
PSDPLELVVS
GPSGGPSSPTTGPTSTSGPEDQPLTPTGSDPQSGLGRHLGVVIGILVAVILLLLLLLLLF
LILRHRRQGKHWTSTQRKADFQHPAGAVGPEPTDRGLQWRSSPAADAQEENLYAAVKHTQ
PEDGVEMDTRSPHDEDPQAVTYAEVKHSRPRREMASPPSPLSGEFLDTKDRQAEEDRQMD
TEAAASEAPQDVTYAQLHSLTLRREATEPPPSQEGPSPAVPSIYATLAIH
Sequence length 650
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
Reactome
  Osteoclast differentiation
B cell receptor signaling pathway
  Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Schizophrenia Schizophrenia rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 25656957

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