CPLX2 (complexin 2)

Gene

• Entrez ID: 10814
• Gene name: Complexin 2
• Gene symbol: CPLX2
• Synonyms: 921-L, CPX-2, CPX2, Hfb1
• Chromosome: 5
• Chromosome location: 5q35.2
• Summary: Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and di

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT713799	hsa-miR-574-3p	HITS-CLIP	19536157
MIRT713798	hsa-miR-1306-5p	HITS-CLIP	19536157
MIRT713797	hsa-miR-3622a-3p	HITS-CLIP	19536157
MIRT713796	hsa-miR-3622b-3p	HITS-CLIP	19536157
MIRT713795	hsa-miR-6765-3p	HITS-CLIP	19536157
MIRT713799	hsa-miR-574-3p	HITS-CLIP	19536157
MIRT713798	hsa-miR-1306-5p	HITS-CLIP	19536157
MIRT713797	hsa-miR-3622a-3p	HITS-CLIP	19536157
MIRT713796	hsa-miR-3622b-3p	HITS-CLIP	19536157
MIRT713795	hsa-miR-6765-3p	HITS-CLIP	19536157
MIRT906274	hsa-miR-1197	CLIP-seq
MIRT906275	hsa-miR-1200	CLIP-seq
MIRT906276	hsa-miR-1224-3p	CLIP-seq
MIRT906277	hsa-miR-1225-3p	CLIP-seq
MIRT906278	hsa-miR-1237	CLIP-seq
MIRT906279	hsa-miR-1260	CLIP-seq
MIRT906280	hsa-miR-1260b	CLIP-seq
MIRT906281	hsa-miR-1280	CLIP-seq
MIRT906282	hsa-miR-148a	CLIP-seq
MIRT906283	hsa-miR-148b	CLIP-seq
MIRT906284	hsa-miR-152	CLIP-seq
MIRT906285	hsa-miR-1825	CLIP-seq
MIRT906286	hsa-miR-1909	CLIP-seq
MIRT906287	hsa-miR-1912	CLIP-seq
MIRT906288	hsa-miR-194	CLIP-seq
MIRT906289	hsa-miR-1972	CLIP-seq
MIRT906290	hsa-miR-214	CLIP-seq
MIRT906291	hsa-miR-2355-5p	CLIP-seq
MIRT906292	hsa-miR-2467-3p	CLIP-seq
MIRT906293	hsa-miR-296-5p	CLIP-seq
MIRT906294	hsa-miR-3138	CLIP-seq
MIRT906295	hsa-miR-3184	CLIP-seq
MIRT906296	hsa-miR-3192	CLIP-seq
MIRT906297	hsa-miR-3199	CLIP-seq
MIRT906298	hsa-miR-3607-3p	CLIP-seq
MIRT906299	hsa-miR-3616-3p	CLIP-seq
MIRT906300	hsa-miR-3619-5p	CLIP-seq
MIRT906301	hsa-miR-3678-3p	CLIP-seq
MIRT906302	hsa-miR-3686	CLIP-seq
MIRT906303	hsa-miR-3690	CLIP-seq
MIRT906304	hsa-miR-376c	CLIP-seq
MIRT906305	hsa-miR-3909	CLIP-seq
MIRT906306	hsa-miR-423-5p	CLIP-seq
MIRT906307	hsa-miR-4254	CLIP-seq
MIRT906308	hsa-miR-4323	CLIP-seq
MIRT906309	hsa-miR-4324	CLIP-seq
MIRT906310	hsa-miR-4436b-3p	CLIP-seq
MIRT906311	hsa-miR-4477b	CLIP-seq
MIRT906312	hsa-miR-4515	CLIP-seq
MIRT906313	hsa-miR-4520a-3p	CLIP-seq
MIRT906314	hsa-miR-4527	CLIP-seq
MIRT906315	hsa-miR-4650-5p	CLIP-seq
MIRT906316	hsa-miR-4651	CLIP-seq
MIRT906317	hsa-miR-4711-5p	CLIP-seq
MIRT906318	hsa-miR-4713-5p	CLIP-seq
MIRT906319	hsa-miR-4731-3p	CLIP-seq
MIRT906320	hsa-miR-4786-5p	CLIP-seq
MIRT906321	hsa-miR-4789-3p	CLIP-seq
MIRT906322	hsa-miR-4793-5p	CLIP-seq
MIRT906323	hsa-miR-4801	CLIP-seq
MIRT906324	hsa-miR-516a-3p	CLIP-seq
MIRT906325	hsa-miR-532-3p	CLIP-seq
MIRT906326	hsa-miR-541	CLIP-seq
MIRT906327	hsa-miR-544b	CLIP-seq
MIRT906328	hsa-miR-608	CLIP-seq
MIRT906329	hsa-miR-654-5p	CLIP-seq
MIRT906330	hsa-miR-661	CLIP-seq
MIRT906331	hsa-miR-761	CLIP-seq
MIRT906332	hsa-miR-3154	CLIP-seq
MIRT906297	hsa-miR-3199	CLIP-seq
MIRT906333	hsa-miR-342-5p	CLIP-seq
MIRT906334	hsa-miR-4433	CLIP-seq
MIRT906335	hsa-miR-4475	CLIP-seq
MIRT906336	hsa-miR-4481	CLIP-seq
MIRT906312	hsa-miR-4515	CLIP-seq
MIRT906337	hsa-miR-4648	CLIP-seq
MIRT906316	hsa-miR-4651	CLIP-seq
MIRT906338	hsa-miR-4652-5p	CLIP-seq
MIRT906339	hsa-miR-4664-5p	CLIP-seq
MIRT906340	hsa-miR-4745-5p	CLIP-seq
MIRT906341	hsa-miR-542-3p	CLIP-seq
MIRT906328	hsa-miR-608	CLIP-seq
MIRT1968615	hsa-miR-4313	CLIP-seq
MIRT906316	hsa-miR-4651	CLIP-seq
MIRT906328	hsa-miR-608	CLIP-seq
MIRT1968616	hsa-miR-1291	CLIP-seq
MIRT1968617	hsa-miR-1343	CLIP-seq
MIRT1968618	hsa-miR-3127-3p	CLIP-seq
MIRT1968619	hsa-miR-3144-5p	CLIP-seq
MIRT1968620	hsa-miR-3191	CLIP-seq
MIRT906333	hsa-miR-342-5p	CLIP-seq
MIRT1968621	hsa-miR-3652	CLIP-seq
MIRT1968622	hsa-miR-3679-3p	CLIP-seq
MIRT1968623	hsa-miR-4260	CLIP-seq
MIRT1968624	hsa-miR-4283	CLIP-seq
MIRT1968625	hsa-miR-4287	CLIP-seq
MIRT1968626	hsa-miR-4430	CLIP-seq
MIRT1968627	hsa-miR-4446-5p	CLIP-seq
MIRT1968628	hsa-miR-4447	CLIP-seq
MIRT1968629	hsa-miR-4472	CLIP-seq
MIRT1968630	hsa-miR-4489	CLIP-seq
MIRT906338	hsa-miR-4652-5p	CLIP-seq
MIRT906339	hsa-miR-4664-5p	CLIP-seq
MIRT1968631	hsa-miR-4667-5p	CLIP-seq
MIRT1968632	hsa-miR-4685-3p	CLIP-seq
MIRT1968633	hsa-miR-4700-5p	CLIP-seq
MIRT1968634	hsa-miR-593	CLIP-seq
MIRT1968635	hsa-miR-939	CLIP-seq
MIRT2204687	hsa-miR-1	CLIP-seq
MIRT906276	hsa-miR-1224-3p	CLIP-seq
MIRT906279	hsa-miR-1260	CLIP-seq
MIRT906280	hsa-miR-1260b	CLIP-seq
MIRT906281	hsa-miR-1280	CLIP-seq
MIRT2204688	hsa-miR-1915	CLIP-seq
MIRT2204689	hsa-miR-206	CLIP-seq
MIRT2204690	hsa-miR-3064-5p	CLIP-seq
MIRT1968619	hsa-miR-3144-5p	CLIP-seq
MIRT2204691	hsa-miR-3187-3p	CLIP-seq
MIRT1968620	hsa-miR-3191	CLIP-seq
MIRT906297	hsa-miR-3199	CLIP-seq
MIRT2204692	hsa-miR-329	CLIP-seq
MIRT2204693	hsa-miR-331-3p	CLIP-seq
MIRT906333	hsa-miR-342-5p	CLIP-seq
MIRT2204694	hsa-miR-3545-5p	CLIP-seq
MIRT2204695	hsa-miR-362-3p	CLIP-seq
MIRT1968621	hsa-miR-3652	CLIP-seq
MIRT2204696	hsa-miR-3918	CLIP-seq
MIRT2204697	hsa-miR-3941	CLIP-seq
MIRT2204698	hsa-miR-4269	CLIP-seq
MIRT1968626	hsa-miR-4430	CLIP-seq
MIRT906334	hsa-miR-4433	CLIP-seq
MIRT2204699	hsa-miR-4435	CLIP-seq
MIRT2204700	hsa-miR-4446-3p	CLIP-seq
MIRT1968628	hsa-miR-4447	CLIP-seq
MIRT2204701	hsa-miR-4453	CLIP-seq
MIRT1968629	hsa-miR-4472	CLIP-seq
MIRT906336	hsa-miR-4481	CLIP-seq
MIRT2204702	hsa-miR-4488	CLIP-seq
MIRT2204703	hsa-miR-4492	CLIP-seq
MIRT2204704	hsa-miR-4498	CLIP-seq
MIRT2204705	hsa-miR-4505	CLIP-seq
MIRT906312	hsa-miR-4515	CLIP-seq
MIRT2204706	hsa-miR-4538	CLIP-seq
MIRT2204707	hsa-miR-4640-5p	CLIP-seq
MIRT906337	hsa-miR-4648	CLIP-seq
MIRT906316	hsa-miR-4651	CLIP-seq
MIRT906338	hsa-miR-4652-5p	CLIP-seq
MIRT906339	hsa-miR-4664-5p	CLIP-seq
MIRT1968631	hsa-miR-4667-5p	CLIP-seq
MIRT2204708	hsa-miR-4685-5p	CLIP-seq
MIRT2204709	hsa-miR-4697-5p	CLIP-seq
MIRT1968633	hsa-miR-4700-5p	CLIP-seq
MIRT2204710	hsa-miR-4701-5p	CLIP-seq
MIRT2204711	hsa-miR-4726-5p	CLIP-seq
MIRT2204712	hsa-miR-4731-5p	CLIP-seq
MIRT906340	hsa-miR-4745-5p	CLIP-seq
MIRT2204713	hsa-miR-486-3p	CLIP-seq
MIRT906325	hsa-miR-532-3p	CLIP-seq
MIRT906326	hsa-miR-541	CLIP-seq
MIRT906341	hsa-miR-542-3p	CLIP-seq
MIRT2204714	hsa-miR-548s	CLIP-seq
MIRT2204715	hsa-miR-588	CLIP-seq
MIRT2204716	hsa-miR-592	CLIP-seq
MIRT2204717	hsa-miR-597	CLIP-seq
MIRT906328	hsa-miR-608	CLIP-seq
MIRT2204718	hsa-miR-613	CLIP-seq
MIRT2204719	hsa-miR-647	CLIP-seq
MIRT906329	hsa-miR-654-5p	CLIP-seq
MIRT2204720	hsa-miR-762	CLIP-seq
MIRT2204721	hsa-miR-766	CLIP-seq
MIRT906316	hsa-miR-4651	CLIP-seq
MIRT906328	hsa-miR-608	CLIP-seq
MIRT2386403	hsa-miR-3170	CLIP-seq
MIRT2386404	hsa-miR-4326	CLIP-seq
MIRT906314	hsa-miR-4527	CLIP-seq
MIRT2386405	hsa-miR-4691-5p	CLIP-seq
MIRT906317	hsa-miR-4711-5p	CLIP-seq
MIRT2386406	hsa-miR-4719	CLIP-seq
MIRT2386407	hsa-miR-619	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000149	Function	SNARE binding	IBA	21873635
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IEA
GO:0005829	Component	Cytosol	IEA
GO:0006904	Process	Vesicle docking involved in exocytosis	TAS	7553862
GO:0007399	Process	Nervous system development	IEA
GO:0016079	Process	Synaptic vesicle exocytosis	IBA	21873635
GO:0017075	Function	Syntaxin-1 binding	IBA	21873635
GO:0017157	Process	Regulation of exocytosis	TAS	15217342
GO:0030154	Process	Cell differentiation	IEA
GO:0030425	Component	Dendrite	IEA
GO:0031201	Component	SNARE complex	IBA	21873635
GO:0031630	Process	Regulation of synaptic vesicle fusion to presynaptic active zone membrane	IEA
GO:0031915	Process	Positive regulation of synaptic plasticity	ISS
GO:0043195	Component	Terminal bouton	IBA	21873635
GO:0043204	Component	Perikaryon	IEA
GO:0043303	Process	Mast cell degranulation	IEA
GO:0044305	Component	Calyx of Held	IEA
GO:0046928	Process	Regulation of neurotransmitter secretion	IBA	21873635
GO:0048306	Function	Calcium-dependent protein binding	IEA
GO:0070033	Component	Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex	IEA
GO:0070554	Component	Synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex	TAS	15217342
GO:0098794	Component	Postsynapse	IEA
GO:0098978	Component	Glutamatergic synapse	IEA

Other IDs

• MIM: 605033
• HGNC: 2310
• e!Ensembl: ENSG00000145920

Protein

• UniProt ID: Q6PUV4
• Protein name: Complexin-2 (Complexin II) (CPX II) (Synaphin-1)
• Protein function: Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and ot
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05835	Synaphin	1 → 133	Synaphin protein	Family

• Sequence:

  MDFVMKQALGGATKDMGKMLGGEEEKDPDAQKKEEERQEALRQQEEERKAKHARMEAERE
  KVRQQIRDKYGLKKKEEKEAEEKAALEQPCEGSLTRPKKAIPAGCGDEEEEEEESILDTV
  LKYLPGPLQDMFKK

• Sequence length: 134

Pathways

KEGG:

Synaptic vesicle cycle

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Attention deficit hyperactivity disorder	Attention deficit hyperactivity disorder	rs120074176, rs786205019	23527680
Myocardial infarction	Myocardial Infarction	rs12316150, rs41303970, rs909253, rs7291467, rs2234693	21211798
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	14708030, 11483314

Unknown
Disease name	Disease term	dbSNP ID	References
Bipolar disorder	Bipolar Disorder, Depression, Bipolar		14708030
Manic disorder	Manic, Manic Disorder		14708030
Mental depression	Mental Depression, Depressive disorder	rs587778876, rs587778877	20584925
Psychosis	Psychosis, Brief Reactive, Psychotic Disorders		14708030
Schizoaffective disorder	Schizoaffective Disorder		14708030
Schizophreniform disorders	Schizophreniform Disorders		14708030