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CYSLTR1 (cysteinyl leukotriene receptor 1)
Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10800
Gene nameGene Name - the full gene name approved by the HGNC.
Cysteinyl leukotriene receptor 1
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
CYSLTR1
SynonymsGene synonyms aliases
CYSLT1, CYSLT1R, CYSLTR, HMTMF81
ChromosomeChromosome number
X
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
Xq21.1
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for cysteinyl leukotrienes, and is involved in mediating bronchoconstriction via activation of a phosphatidylinositol-calcium second messenger system.
miRNAmiRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
miRTarBase ID miRNA Experiments Reference
MIRT017591 hsa-miR-335-5p Microarray 18185580
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Transcription factor Regulation Reference
STAT6 Unknown 16210619
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
GO ID Ontology Definition Evidence Reference
GO:0001631 Function Cysteinyl leukotriene receptor activity IBA 21873635
GO:0002437 Process Inflammatory response to antigenic stimulus IEA
GO:0004974 Function Leukotriene receptor activity TAS 10391245
GO:0005515 Function Protein binding IPI 21203429
GO:0005886 Component Plasma membrane TAS
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM
HGNC
e!Ensembl
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q9Y271
Protein name Cysteinyl leukotriene receptor 1 (CysLTR1) (Cysteinyl leukotriene D4 receptor) (LTD4 receptor) (G-protein coupled receptor HG55) (HMTMF81)
Protein function Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus laye
PDB 6RZ4 , 6RZ5
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1
40 → 295
7 transmembrane receptor (rhodopsin family)
 Family
Sequence
Sequence length 337
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
 
KEGG
  
Reactome
  Calcium signaling pathway
Neuroactive ligand-receptor interaction 		  Leukotriene receptors
G alpha (q) signalling events
LTC4-CYSLTR mediated IL4 production
Associated diseases
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Causal
Disease name Disease term dbSNP ID References
Asthma Asthma, Aspirin-Induced rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283 20485159, 16502481, 17641958

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