IQGAP2 (IQ motif containing GTPase activating protein 2)

Gene

• Entrez ID: 10788
• Gene name: IQ motif containing GTPase activating protein 2
• Gene symbol: IQGAP2
• Synonyms: -
• Chromosome: 5
• Chromosome location: 5q13.3
• Summary: This gene encodes a member of the IQGAP family. The encoded protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. This protein interacts with components of the cytoskeleton, with cell adhesion molecules, an

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT442395	hsa-miR-548e-5p	PAR-CLIP	22100165
MIRT442394	hsa-miR-3617-5p	PAR-CLIP	22100165
MIRT442393	hsa-miR-641	PAR-CLIP	22100165
MIRT442392	hsa-miR-549a	PAR-CLIP	22100165
MIRT442391	hsa-miR-208a-3p	PAR-CLIP	22100165
MIRT442390	hsa-miR-208b-3p	PAR-CLIP	22100165
MIRT442389	hsa-miR-499a-5p	PAR-CLIP	22100165
MIRT442395	hsa-miR-548e-5p	PAR-CLIP	22100165
MIRT442394	hsa-miR-3617-5p	PAR-CLIP	22100165
MIRT442393	hsa-miR-641	PAR-CLIP	22100165
MIRT442392	hsa-miR-549a	PAR-CLIP	22100165
MIRT442391	hsa-miR-208a-3p	PAR-CLIP	22100165
MIRT442390	hsa-miR-208b-3p	PAR-CLIP	22100165
MIRT442389	hsa-miR-499a-5p	PAR-CLIP	22100165
MIRT442395	hsa-miR-548e-5p	PAR-CLIP	22100165
MIRT442394	hsa-miR-3617-5p	PAR-CLIP	22100165
MIRT442393	hsa-miR-641	PAR-CLIP	22100165
MIRT442392	hsa-miR-549a	PAR-CLIP	22100165
MIRT442391	hsa-miR-208a-3p	PAR-CLIP	22100165
MIRT442390	hsa-miR-208b-3p	PAR-CLIP	22100165
MIRT442389	hsa-miR-499a-5p	PAR-CLIP	22100165
MIRT442395	hsa-miR-548e-5p	PAR-CLIP	22100165
MIRT442394	hsa-miR-3617-5p	PAR-CLIP	22100165
MIRT442393	hsa-miR-641	PAR-CLIP	22100165
MIRT442392	hsa-miR-549a	PAR-CLIP	22100165
MIRT442391	hsa-miR-208a-3p	PAR-CLIP	22100165
MIRT442390	hsa-miR-208b-3p	PAR-CLIP	22100165
MIRT442389	hsa-miR-499a-5p	PAR-CLIP	22100165
MIRT1070047	hsa-miR-101	CLIP-seq
MIRT1070048	hsa-miR-128	CLIP-seq
MIRT1070049	hsa-miR-133a	CLIP-seq
MIRT1070050	hsa-miR-133b	CLIP-seq
MIRT1070051	hsa-miR-27a	CLIP-seq
MIRT1070052	hsa-miR-27b	CLIP-seq
MIRT1070053	hsa-miR-3074-3p	CLIP-seq
MIRT1070054	hsa-miR-3616-5p	CLIP-seq
MIRT1070055	hsa-miR-3647-5p	CLIP-seq
MIRT1070056	hsa-miR-3671	CLIP-seq
MIRT1070057	hsa-miR-3691-5p	CLIP-seq
MIRT1070058	hsa-miR-3911	CLIP-seq
MIRT1070059	hsa-miR-4272	CLIP-seq
MIRT1070060	hsa-miR-4302	CLIP-seq
MIRT1070061	hsa-miR-4326	CLIP-seq
MIRT1070062	hsa-miR-4328	CLIP-seq
MIRT1070063	hsa-miR-4752	CLIP-seq
MIRT1070064	hsa-miR-4773	CLIP-seq
MIRT1070065	hsa-miR-4781-3p	CLIP-seq
MIRT1070066	hsa-miR-573	CLIP-seq
MIRT1070067	hsa-miR-607	CLIP-seq
MIRT2017192	hsa-miR-1225-5p	CLIP-seq
MIRT2017193	hsa-miR-181a	CLIP-seq
MIRT2017194	hsa-miR-181b	CLIP-seq
MIRT2017195	hsa-miR-181c	CLIP-seq
MIRT2017196	hsa-miR-181d	CLIP-seq
MIRT2017197	hsa-miR-4262	CLIP-seq
MIRT1070047	hsa-miR-101	CLIP-seq
MIRT1070048	hsa-miR-128	CLIP-seq
MIRT2249128	hsa-miR-190	CLIP-seq
MIRT2249129	hsa-miR-190b	CLIP-seq
MIRT2249130	hsa-miR-1911	CLIP-seq
MIRT1070051	hsa-miR-27a	CLIP-seq
MIRT1070052	hsa-miR-27b	CLIP-seq
MIRT1070053	hsa-miR-3074-3p	CLIP-seq
MIRT2249131	hsa-miR-3201	CLIP-seq
MIRT1070057	hsa-miR-3691-5p	CLIP-seq
MIRT1070058	hsa-miR-3911	CLIP-seq
MIRT1070060	hsa-miR-4302	CLIP-seq
MIRT2249132	hsa-miR-4307	CLIP-seq
MIRT1070063	hsa-miR-4752	CLIP-seq
MIRT2249133	hsa-miR-4760-3p	CLIP-seq
MIRT2249134	hsa-miR-4791	CLIP-seq
MIRT2249135	hsa-miR-513a-5p	CLIP-seq
MIRT2249136	hsa-miR-587	CLIP-seq
MIRT2249137	hsa-miR-664	CLIP-seq
MIRT2249138	hsa-miR-759	CLIP-seq
MIRT2249139	hsa-miR-885-5p	CLIP-seq
MIRT2389459	hsa-miR-579	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003779	Function	Actin binding	TAS	8756646
GO:0005095	Function	GTPase inhibitor activity	TAS	8756646
GO:0005096	Function	GTPase activator activity	IBA	21873635
GO:0005516	Function	Calmodulin binding	IBA	21873635
GO:0005516	Function	Calmodulin binding	IPI	21299499
GO:0005547	Function	Phosphatidylinositol-3,4,5-trisphosphate binding	IDA	22493426
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	IDA	12515716
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	TAS
GO:0005902	Component	Microvillus	IEA
GO:0007165	Process	Signal transduction	TAS	8756646
GO:0009986	Component	Cell surface	IDA	12515716
GO:0015629	Component	Actin cytoskeleton	TAS	8756646
GO:0030027	Component	Lamellipodium	IDA	12515716
GO:0030175	Component	Filopodium	IDA	12515716
GO:0030667	Component	Secretory granule membrane	TAS
GO:0031267	Function	Small GTPase binding	IDA	12515716
GO:0032956	Process	Regulation of actin cytoskeleton organization	IBA	21873635
GO:0034260	Process	Negative regulation of GTPase activity	IEA
GO:0034314	Process	Arp2/3 complex-mediated actin nucleation	IDA	12515716
GO:0043312	Process	Neutrophil degranulation	TAS
GO:0043547	Process	Positive regulation of GTPase activity	IEA
GO:0051015	Function	Actin filament binding	IBA	21873635
GO:0051015	Function	Actin filament binding	IDA	12515716
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0070493	Process	Thrombin-activated receptor signaling pathway	IDA	12515716
GO:0071933	Function	Arp2/3 complex binding	IDA	12515716
GO:2000249	Process	Regulation of actin cytoskeleton reorganization	IDA	12515716

Other IDs

• MIM: 605401
• HGNC: 6111
• e!Ensembl: ENSG00000145703

Protein

• UniProt ID: Q13576
• Protein name: Ras GTPase-activating-like protein IQGAP2
• Protein function: Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin.
• PDB: 3IEZ, 4EZA, 5CJP
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00307	CH	41 → 158	Calponin homology (CH) domain	Domain
  PF00612	IQ	691 → 711	IQ calmodulin-binding motif	Motif
  PF00612	IQ	721 → 741	IQ calmodulin-binding motif	Motif
  PF00616	RasGAP	938 → 1150	GTPase-activator protein for Ras-like GTPase	Family
  PF03836	RasGAP_C	1367 → 1498	RasGAP C-terminus	Family

• Sequence:

  MPHEELPSLQRPRYGSIVDDERLSAEEMDERRRQNIAYEYLCHLEEAKRWMEVCLVEELP
  PTTELEEGLRNGVYLAKLAKFFAPKMVSEKKIYDVEQTRYKKSGLHFRHTDNTVQWLRAM
  ESIGLPKIFYPETTDVYDRKNIPRMIYCIHALSLYLFKLGIAPQIQDLLGKVDFTEEEIS
  NMRKELEKYGIQMPSFSKIGGILANELSVDEAALHAAVIAINEAVEKGIAEQTVVTLRNP
  NAVLTLVDDNLAPEYQKELWDAKKKKEENARLKNSCISEEERDAYEELLTQAEIQGNINK
  VNRQAAVDHINAVIPEGDPENTLLALKKPEAQLPAVYPFAAAMYQNELFNLQKQNTMNYL
  AHEELLIAVEMLSAVALLNQALESNDLVSVQNQLRSPAIGLNNLDKAYVERYANTLLSVK
  LEVLSQGQDNLSWNEIQNCIDMVNAQIQEENDRVVAVGYINEAIDEGNPLRTLETLLLPT
  ANISDVDPAHAQHYQDVLYHAKSQKLGDSESVSKVLWLDEIQQAVDDANVDKDRAKQWVT
  LVVDVNQCLEGKKSSDILSVLKSSTSNANDIIPECADKYYDALVKAKELKSERVSSDGSW
  LKLNLHKKYDYYYNTDSKESSWVTPESCLYKESWLTGKEIEDIIEEVTVGYIRENIWSAS
  EELLLRFQATSSGPILREEFEARKSFLHEQEENVVKIQAFWKGYKQRKEYMHRRQTFIDN
  TDSIVKIQSWFRMATARKSYLSRLQYFRDHNNEIVKIQSLLRANKARDDYKTLVGSENPP
  LTVIRKFVYLLDQSDLDFQEELEVARLREEVVTKIRANQQLEKDLNLMDIKIGLLVKNRI
  TLEDVISHSKKLNKKKGGEMEILNNTDNQGIKSLSKERRKTLETYQQLFYLLQTNPLYLA
  KLIFQMPQNKSTKFMDTVIFTLYNYASNQREEYLLLKLFKTALEEEIKSKVDQVQDIVTG
  NPTVIKMVVSFNRGARGQNTLRQLLAPVVKEIIDDKSLIINTNPVEVYKAWVNQLETQTG
  EASKLPYDVTTEQALTYPEVKNKLEASIENLRRVTDKVLNSIISSLDLLPYGLRYIAKVL
  KNSIHEKFPDATEDELLKIVGNLLYYRYMNPAIVAPDGFDIIDMTAGGQINSDQRRNLGS
  VAKVLQHAASNKLFEGENEHLSSMNNYLSETYQEFRKYFKEACNVPEPEEKFNMDKYTDL
  VTVSKPVIYISIEEIISTHSLLLEHQDAIAPEKNDLLSELLGSLGEVPTVESFLGEGAVD
  PNDPNKANTLSQLSKTEISLVLTSKYDIEDGEAIDSRSLMIKTKKLIIDVIRNQPGNTLT
  EILETPATAQQEVDHATDMVSRAMIDSRTPEEMKHSQSMIEDAQLPLEQKKRKIQRNLRT
  LEQTGHVSSENKYQDILNEIAKDIRNQRIYRKLRKAELAKLQQTLNALNKKAAFYEEQIN
  YYDTYIKTCLDNLKRKNTRRSIKLDGKGEPKGAKRAKPVKYTAAKLHEKGVLLDIDDLQT
  NQFKNVTFDIIATEDVGIFDVRSKFLGVEMEKVQLNIQDLLQMQYEGVAVMKMFDKVKVN
  VNLLIYLLNKKFYGK

• Sequence length: 1575

Pathways

KEGG:

Regulation of actin cytoskeleton

Reactome:

RHO GTPases activate IQGAPs
Neutrophil degranulation

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	27846195

Unknown
Disease name	Disease term	dbSNP ID	References
Brain neoplasms	Brain Neoplasms, Malignant neoplasm of brain, Benign neoplasm of brain, unspecified, Brain Tumor, Primary, Recurrent Brain Neoplasm, Primary malignant neoplasm of brain	rs1800720, rs587781720	27935819
Intracranial neoplasm	Neoplasms, Intracranial		27935819
Liver carcinoma	Liver carcinoma		20977743