CORIN (corin, serine peptidase)

Gene

• Entrez ID: 10699
• Gene name: Corin, serine peptidase
• Gene symbol: CORIN
• Synonyms: ATC2, CMH30, CRN, Lrp4, PEE5, TMPRSS10
• Chromosome: 4
• Chromosome location: 4p12
• Summary: This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologi

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs387906894	T>C	Pathogenic	Coding sequence variant, missense variant
rs387906895	T>C	Pathogenic	Coding sequence variant, missense variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT904547	hsa-miR-1224-5p	CLIP-seq
MIRT904548	hsa-miR-1305	CLIP-seq
MIRT904549	hsa-miR-141	CLIP-seq
MIRT904550	hsa-miR-183	CLIP-seq
MIRT904551	hsa-miR-200a	CLIP-seq
MIRT904552	hsa-miR-3065-3p	CLIP-seq
MIRT904553	hsa-miR-3129-3p	CLIP-seq
MIRT904554	hsa-miR-3168	CLIP-seq
MIRT904555	hsa-miR-329	CLIP-seq
MIRT904556	hsa-miR-362-3p	CLIP-seq
MIRT904557	hsa-miR-380	CLIP-seq
MIRT904558	hsa-miR-382	CLIP-seq
MIRT904559	hsa-miR-3941	CLIP-seq
MIRT904560	hsa-miR-3976	CLIP-seq
MIRT904561	hsa-miR-4277	CLIP-seq
MIRT904562	hsa-miR-4291	CLIP-seq
MIRT904563	hsa-miR-4307	CLIP-seq
MIRT904564	hsa-miR-4420	CLIP-seq
MIRT904565	hsa-miR-4495	CLIP-seq
MIRT904566	hsa-miR-466	CLIP-seq
MIRT904567	hsa-miR-4672	CLIP-seq
MIRT904568	hsa-miR-4694-3p	CLIP-seq
MIRT904569	hsa-miR-4698	CLIP-seq
MIRT904570	hsa-miR-4751	CLIP-seq
MIRT904571	hsa-miR-490-3p	CLIP-seq
MIRT904572	hsa-miR-515-5p	CLIP-seq
MIRT904573	hsa-miR-603	CLIP-seq
MIRT904574	hsa-miR-649	CLIP-seq
MIRT904550	hsa-miR-183	CLIP-seq
MIRT904552	hsa-miR-3065-3p	CLIP-seq
MIRT904553	hsa-miR-3129-3p	CLIP-seq
MIRT904557	hsa-miR-380	CLIP-seq
MIRT904562	hsa-miR-4291	CLIP-seq
MIRT904565	hsa-miR-4495	CLIP-seq
MIRT904571	hsa-miR-490-3p	CLIP-seq
MIRT904574	hsa-miR-649	CLIP-seq
MIRT904550	hsa-miR-183	CLIP-seq
MIRT904552	hsa-miR-3065-3p	CLIP-seq
MIRT904553	hsa-miR-3129-3p	CLIP-seq
MIRT904557	hsa-miR-380	CLIP-seq
MIRT904562	hsa-miR-4291	CLIP-seq
MIRT904565	hsa-miR-4495	CLIP-seq
MIRT904571	hsa-miR-490-3p	CLIP-seq
MIRT904574	hsa-miR-649	CLIP-seq
MIRT2386370	hsa-miR-1184	CLIP-seq
MIRT2386371	hsa-miR-1205	CLIP-seq
MIRT904550	hsa-miR-183	CLIP-seq
MIRT904552	hsa-miR-3065-3p	CLIP-seq
MIRT904553	hsa-miR-3129-3p	CLIP-seq
MIRT2386372	hsa-miR-3158-5p	CLIP-seq
MIRT904557	hsa-miR-380	CLIP-seq
MIRT904565	hsa-miR-4495	CLIP-seq
MIRT904571	hsa-miR-490-3p	CLIP-seq
MIRT904574	hsa-miR-649	CLIP-seq
MIRT904550	hsa-miR-183	CLIP-seq
MIRT2386370	hsa-miR-1184	CLIP-seq
MIRT2386371	hsa-miR-1205	CLIP-seq
MIRT2447458	hsa-miR-128	CLIP-seq
MIRT2447459	hsa-miR-27a	CLIP-seq
MIRT2447460	hsa-miR-27b	CLIP-seq
MIRT904553	hsa-miR-3129-3p	CLIP-seq
MIRT2386372	hsa-miR-3158-5p	CLIP-seq
MIRT904557	hsa-miR-380	CLIP-seq
MIRT2447461	hsa-miR-412	CLIP-seq
MIRT904565	hsa-miR-4495	CLIP-seq
MIRT2447462	hsa-miR-4514	CLIP-seq
MIRT2447463	hsa-miR-4660	CLIP-seq
MIRT2447464	hsa-miR-4692	CLIP-seq
MIRT904571	hsa-miR-490-3p	CLIP-seq
MIRT2447465	hsa-miR-513a-5p	CLIP-seq
MIRT904574	hsa-miR-649	CLIP-seq
MIRT904553	hsa-miR-3129-3p	CLIP-seq
MIRT904557	hsa-miR-380	CLIP-seq
MIRT904565	hsa-miR-4495	CLIP-seq
MIRT904571	hsa-miR-490-3p	CLIP-seq
MIRT904574	hsa-miR-649	CLIP-seq
MIRT904550	hsa-miR-183	CLIP-seq
MIRT2507511	hsa-miR-218	CLIP-seq
MIRT904553	hsa-miR-3129-3p	CLIP-seq
MIRT904557	hsa-miR-380	CLIP-seq
MIRT904565	hsa-miR-4495	CLIP-seq
MIRT904571	hsa-miR-490-3p	CLIP-seq
MIRT904574	hsa-miR-649	CLIP-seq
MIRT2678485	hsa-miR-2053	CLIP-seq
MIRT2507511	hsa-miR-218	CLIP-seq
MIRT904553	hsa-miR-3129-3p	CLIP-seq
MIRT2678486	hsa-miR-323b-3p	CLIP-seq
MIRT904557	hsa-miR-380	CLIP-seq
MIRT904565	hsa-miR-4495	CLIP-seq
MIRT904571	hsa-miR-490-3p	CLIP-seq
MIRT2678487	hsa-miR-569	CLIP-seq
MIRT904574	hsa-miR-649	CLIP-seq
MIRT2678488	hsa-miR-889	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003050	Process	Regulation of systemic arterial blood pressure by atrial natriuretic peptide	IMP	22437503
GO:0003050	Process	Regulation of systemic arterial blood pressure by atrial natriuretic peptide	ISS
GO:0004175	Function	Endopeptidase activity	IMP	20489134
GO:0004252	Function	Serine-type endopeptidase activity	IDA	10880574, 21763278
GO:0004252	Function	Serine-type endopeptidase activity	TAS
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005576	Component	Extracellular region	IEA
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	TAS
GO:0007565	Process	Female pregnancy	IMP	22437503
GO:0008217	Process	Regulation of blood pressure	ISS
GO:0009986	Component	Cell surface	IEA
GO:0015629	Component	Actin cytoskeleton	IDA
GO:0016021	Component	Integral component of membrane	IEA
GO:0016486	Process	Peptide hormone processing	IDA	10880574
GO:0016604	Component	Nuclear body	IDA
GO:0035813	Process	Regulation of renal sodium excretion	ISS
GO:1903779	Process	Regulation of cardiac conduction	TAS

Other IDs

• MIM: 605236
• HGNC: 19012
• e!Ensembl: ENSG00000145244

Protein

• UniProt ID: Q9Y5Q5
• Protein name: Atrial natriuretic peptide-converting enzyme (EC 3.4.21.-) (Corin) (Heart-specific serine proteinase ATC2) (Pro-ANP-converting enzyme) (Transmembrane protease serine 10) [Cleaved into: Atrial natriuretic peptide-converting enzyme, N-terminal propeptide; A
• Protein function: Serine-type endopeptidase involved in atrial natriuretic peptide (NPPA) and brain natriuretic peptide (NPPB) processing (PubMed:10880574, PubMed:20489134, PubMed:21288900, PubMed:21763278). Converts through proteolytic cleavage the non-functiona
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01392	Fz	139 → 248	Fz domain	Domain
  PF00057	Ldl_recept_a	268 → 304	Low-density lipoprotein receptor domain class A	Repeat
  PF00057	Ldl_recept_a	305 → 340	Low-density lipoprotein receptor domain class A	Repeat
  PF00057	Ldl_recept_a	341 → 377	Low-density lipoprotein receptor domain class A	Repeat
  PF00057	Ldl_recept_a	378 → 414	Low-density lipoprotein receptor domain class A	Repeat
  PF01392	Fz	455 → 565	Fz domain	Domain
  PF00057	Ldl_recept_a	578 → 614	Low-density lipoprotein receptor domain class A	Repeat
  PF00057	Ldl_recept_a	653 → 689	Low-density lipoprotein receptor domain class A	Repeat
  PF15494	SRCR_2	698 → 794	Scavenger receptor cysteine-rich domain	Domain
  PF00089	Trypsin	802 → 1030	Trypsin	Domain

• Sequence:

  MKQSPALAPEERCRRAGSPKPVLRADDNNMGNGCSQKLATANLLRFLLLVLIPCICALVL
  LLVILLSYVGTLQKVYFKSNGSEPLVTDGEIQGSDVILTNTIYNQSTVVSTAHPDQHVPA
  WTTDASLPGDQSHRNTSACMNITHSQCQMLPYHATLTPLLSVVRNMEMEKFLKFFTYLHR
  LSCYQHIMLFGCTLAFPECIIDGDDSHGLLPCRSFCEAAKEGCESVLGMVNYSWPDFLRC
  SQFRNQTESSNVSRICFSPQQENGKQLLCGRGENFLCASGICIPGKLQCNGYNDCDDWSD
  EAHCNCSENLFHCHTGKCLNYSLVCDGYDDCGDLSDEQNCDCNPTTEHRCGDGRCIAMEW
  VCDGDHDCVDKSDEVNCSCHSQGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTS
  CQEGDQRCLYNPCLDSCGGSSLCDPNNSLNNCSQCEPITLELCMNLPYNSTSYPNYFGHR
  TQKEASISWESSLFPALVQTNCYKYLMFFSCTILVPKCDVNTGEHIPPCRALCEHSKERC
  ESVLGIVGLQWPEDTDCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASRRCD
  GQADCDDDSDEENCGCKERDLWECPSNKQCLKHTVICDGFPDCPDYMDEKNCSFCQDDEL
  ECANHACVSRDLWCDGEADCSDSSDEWDCVTLSINVNSSSFLMVHRAATEHHVCADGWQE
  ILSQLACKQMGLGEPSVTKLIQEQEKEPRWLTLHSNWESLNGTTLHELLVNGQSCESRSK
  ISLLCTKQDCGRRPAARMNKRILGGRTSRPGRWPWQCSLQSEPSGHICGCVLIAKKWVLT
  VAHCFEGRENAAVWKVVLGINNLDHPSVFMQTRFVKTIILHPRYSRAVVDYDISIVELSE
  DISETGYVRPVCLPNPEQWLEPDTYCYITGWGHMGNKMPFKLQEGEVRIISLEHCQSYFD
  MKTITTRMICAGYESGTVDSCMGDSGGPLVCEKPGGRWTLFGLTSWGSVCFSKVLGPGVY
  SNVSYFVEWIKRQIYIQTFLLN

• Sequence length: 1042

Pathways

Reactome:

Physiological factors

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Diabetes mellitus	Diabetes Mellitus, Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs4402960, rs1362648752, rs3745368, rs3792267, rs3842570, rs5030952, rs2975760, rs119489103, rs7903146, rs12255372, rs11196205, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs137852740, rs137852786, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs80356663, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356666, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs387906779, rs141804752, rs182349376, rs184917682, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs61736969, rs587783673, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs797045623, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs1553638903, rs1553638909, rs948820149, rs371977235, rs1553784995, rs76474829, rs200998587, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs776793516, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261
Hypertension	Hypertensive disease	rs13306026, rs13333226
Kidney disease	Chronic Kidney Diseases	rs74315342, rs749740335, rs757649673, rs112417755, rs35138315
Preeclampsia/eclampsia	PREECLAMPSIA/ECLAMPSIA 5	rs1341667, rs387906894, rs387906895	22437503

Unknown
Disease name	Disease term	dbSNP ID	References
Dyssomnia	Dyssomnias
Eclampsia	Eclampsia
Polycystic ovary syndrome	Polycystic Ovary Syndrome
Preeclampsia	Preeclampsia	rs1553354646, rs1555628672
Sleep disorders	Sleep Disorders