IGF2BP2 (insulin like growth factor 2 mRNA binding protein 2)

Gene

• Entrez ID: 10644
• Gene name: Insulin like growth factor 2 mRNA binding protein 2
• Gene symbol: IGF2BP2
• Synonyms: IMP-2, IMP2, VICKZ2
• Chromosome: 3
• Chromosome location: 3q27.2
• Summary: This gene encodes a protein that binds the 5` UTR of insulin-like growth factor 2 (IGF2) mRNA and regulates its translation. It plays an important role in metabolism and variation in this gene is associated with susceptibility to diabetes. Alternative spl

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs4402960	G>T	Risk-factor	Intron variant, genic upstream transcript variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT000792	hsa-miR-18a-5p	Microarray, Northern blot	16331254
MIRT005241	hsa-let-7b-5p	pSILAC	18668040
MIRT018969	hsa-miR-335-5p	Microarray	18185580
MIRT027853	hsa-miR-98-5p	Microarray	19088304
MIRT005241	hsa-let-7b-5p	Proteomics;Other	18668040
MIRT043535	hsa-miR-331-3p	CLASH	23622248
MIRT043535	hsa-miR-331-3p	CLASH	23622248
MIRT038642	hsa-miR-125a-3p	CLASH	23622248
MIRT037361	hsa-miR-877-5p	CLASH	23622248
MIRT005241	hsa-let-7b-5p	Immunohistochemistry, Luciferase reporter assay, QRTPCR, Western blot	23482325
MIRT674545	hsa-miR-589-3p	HITS-CLIP	23824327
MIRT674544	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT674545	hsa-miR-589-3p	HITS-CLIP	23824327
MIRT674544	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT005241	hsa-let-7b-5p	Luciferase reporter assay, Western blotting, qRT-PCR, Immunoprecipitaion (IP)	38443392
MIRT1061981	hsa-miR-1256	CLIP-seq
MIRT1061982	hsa-miR-204	CLIP-seq
MIRT1061983	hsa-miR-211	CLIP-seq
MIRT1061984	hsa-miR-323-5p	CLIP-seq
MIRT1061985	hsa-miR-329	CLIP-seq
MIRT1061986	hsa-miR-362-3p	CLIP-seq
MIRT1061987	hsa-miR-3941	CLIP-seq
MIRT1061988	hsa-miR-4263	CLIP-seq
MIRT1061989	hsa-miR-4299	CLIP-seq
MIRT1061990	hsa-miR-4456	CLIP-seq
MIRT1061991	hsa-miR-4496	CLIP-seq
MIRT1061992	hsa-miR-4517	CLIP-seq
MIRT1061993	hsa-miR-4643	CLIP-seq
MIRT1061994	hsa-miR-4720-5p	CLIP-seq
MIRT1061995	hsa-miR-4738-3p	CLIP-seq
MIRT1061996	hsa-miR-4755-5p	CLIP-seq
MIRT1061997	hsa-miR-4799-3p	CLIP-seq
MIRT1061998	hsa-miR-548c-3p	CLIP-seq
MIRT1061999	hsa-miR-548q	CLIP-seq
MIRT1062000	hsa-miR-576-5p	CLIP-seq
MIRT1062001	hsa-miR-603	CLIP-seq
MIRT1062002	hsa-miR-622	CLIP-seq
MIRT1062003	hsa-miR-623	CLIP-seq
MIRT1062004	hsa-miR-876-3p	CLIP-seq
MIRT1921358	hsa-miR-2116	CLIP-seq
MIRT1921359	hsa-miR-3659	CLIP-seq
MIRT1921360	hsa-miR-3667-3p	CLIP-seq
MIRT1921361	hsa-miR-4273	CLIP-seq
MIRT1921362	hsa-miR-4446-5p	CLIP-seq
MIRT1921363	hsa-miR-4522	CLIP-seq
MIRT1921364	hsa-miR-4658	CLIP-seq
MIRT1921365	hsa-miR-4677-5p	CLIP-seq
MIRT1061996	hsa-miR-4755-5p	CLIP-seq
MIRT1921366	hsa-miR-574-5p	CLIP-seq
MIRT1921367	hsa-miR-642a	CLIP-seq
MIRT2014650	hsa-miR-4698	CLIP-seq
MIRT2014651	hsa-miR-548aa	CLIP-seq
MIRT2437723	hsa-miR-4672	CLIP-seq
MIRT2437724	hsa-miR-552	CLIP-seq
MIRT2437725	hsa-miR-640	CLIP-seq
MIRT2550464	hsa-miR-1206	CLIP-seq
MIRT1061981	hsa-miR-1256	CLIP-seq
MIRT2550465	hsa-miR-1262	CLIP-seq
MIRT2550466	hsa-miR-135a	CLIP-seq
MIRT2550467	hsa-miR-135b	CLIP-seq
MIRT1061984	hsa-miR-323-5p	CLIP-seq
MIRT2550468	hsa-miR-326	CLIP-seq
MIRT2550469	hsa-miR-330-5p	CLIP-seq
MIRT2550470	hsa-miR-34a	CLIP-seq
MIRT2550471	hsa-miR-34c-5p	CLIP-seq
MIRT1921359	hsa-miR-3659	CLIP-seq
MIRT1921360	hsa-miR-3667-3p	CLIP-seq
MIRT2550472	hsa-miR-3925-3p	CLIP-seq
MIRT1061989	hsa-miR-4299	CLIP-seq
MIRT1921362	hsa-miR-4446-5p	CLIP-seq
MIRT1061990	hsa-miR-4456	CLIP-seq
MIRT2550473	hsa-miR-449a	CLIP-seq
MIRT2550474	hsa-miR-449b	CLIP-seq
MIRT2550475	hsa-miR-4634	CLIP-seq
MIRT2550476	hsa-miR-4645-5p	CLIP-seq
MIRT1921364	hsa-miR-4658	CLIP-seq
MIRT2550477	hsa-miR-4666-5p	CLIP-seq
MIRT2437723	hsa-miR-4672	CLIP-seq
MIRT2550478	hsa-miR-4673	CLIP-seq
MIRT2550479	hsa-miR-4701-3p	CLIP-seq
MIRT2550480	hsa-miR-4712-5p	CLIP-seq
MIRT1061996	hsa-miR-4755-5p	CLIP-seq
MIRT2550481	hsa-miR-4793-5p	CLIP-seq
MIRT2550482	hsa-miR-501-5p	CLIP-seq
MIRT2550483	hsa-miR-515-5p	CLIP-seq
MIRT1061999	hsa-miR-548q	CLIP-seq
MIRT2437724	hsa-miR-552	CLIP-seq
MIRT1921366	hsa-miR-574-5p	CLIP-seq
MIRT1062002	hsa-miR-622	CLIP-seq
MIRT2437725	hsa-miR-640	CLIP-seq
MIRT1921367	hsa-miR-642a	CLIP-seq
MIRT2550484	hsa-miR-652	CLIP-seq
MIRT2550485	hsa-miR-766	CLIP-seq
MIRT2550486	hsa-miR-770-5p	CLIP-seq
MIRT1062004	hsa-miR-876-3p	CLIP-seq
MIRT2550464	hsa-miR-1206	CLIP-seq
MIRT2682649	hsa-miR-1238	CLIP-seq
MIRT1061981	hsa-miR-1256	CLIP-seq
MIRT2550465	hsa-miR-1262	CLIP-seq
MIRT2550466	hsa-miR-135a	CLIP-seq
MIRT2550467	hsa-miR-135b	CLIP-seq
MIRT2682650	hsa-miR-147b	CLIP-seq
MIRT2682651	hsa-miR-150	CLIP-seq
MIRT2682652	hsa-miR-210	CLIP-seq
MIRT2682653	hsa-miR-2113	CLIP-seq
MIRT1921358	hsa-miR-2116	CLIP-seq
MIRT2682654	hsa-miR-3183	CLIP-seq
MIRT1061984	hsa-miR-323-5p	CLIP-seq
MIRT2550468	hsa-miR-326	CLIP-seq
MIRT2682655	hsa-miR-330-3p	CLIP-seq
MIRT2550469	hsa-miR-330-5p	CLIP-seq
MIRT2550470	hsa-miR-34a	CLIP-seq
MIRT2550471	hsa-miR-34c-5p	CLIP-seq
MIRT2682656	hsa-miR-3621	CLIP-seq
MIRT2682657	hsa-miR-3656	CLIP-seq
MIRT1921359	hsa-miR-3659	CLIP-seq
MIRT1921360	hsa-miR-3667-3p	CLIP-seq
MIRT2550472	hsa-miR-3925-3p	CLIP-seq
MIRT2682658	hsa-miR-4268	CLIP-seq
MIRT1921361	hsa-miR-4273	CLIP-seq
MIRT1061989	hsa-miR-4299	CLIP-seq
MIRT2682659	hsa-miR-4428	CLIP-seq
MIRT1921362	hsa-miR-4446-5p	CLIP-seq
MIRT1061990	hsa-miR-4456	CLIP-seq
MIRT2682660	hsa-miR-4477a	CLIP-seq
MIRT2550473	hsa-miR-449a	CLIP-seq
MIRT2550474	hsa-miR-449b	CLIP-seq
MIRT1921363	hsa-miR-4522	CLIP-seq
MIRT2550475	hsa-miR-4634	CLIP-seq
MIRT2550476	hsa-miR-4645-5p	CLIP-seq
MIRT1921364	hsa-miR-4658	CLIP-seq
MIRT2550477	hsa-miR-4666-5p	CLIP-seq
MIRT2437723	hsa-miR-4672	CLIP-seq
MIRT2550478	hsa-miR-4673	CLIP-seq
MIRT1921365	hsa-miR-4677-5p	CLIP-seq
MIRT2682661	hsa-miR-4684-5p	CLIP-seq
MIRT2550479	hsa-miR-4701-3p	CLIP-seq
MIRT2550480	hsa-miR-4712-5p	CLIP-seq
MIRT2682662	hsa-miR-4723-3p	CLIP-seq
MIRT1061996	hsa-miR-4755-5p	CLIP-seq
MIRT2682663	hsa-miR-4757-5p	CLIP-seq
MIRT2682664	hsa-miR-4786-5p	CLIP-seq
MIRT2550481	hsa-miR-4793-5p	CLIP-seq
MIRT2682665	hsa-miR-4797-5p	CLIP-seq
MIRT2550482	hsa-miR-501-5p	CLIP-seq
MIRT2550483	hsa-miR-515-5p	CLIP-seq
MIRT1061999	hsa-miR-548q	CLIP-seq
MIRT2682666	hsa-miR-548u	CLIP-seq
MIRT2437724	hsa-miR-552	CLIP-seq
MIRT1921366	hsa-miR-574-5p	CLIP-seq
MIRT1062002	hsa-miR-622	CLIP-seq
MIRT2437725	hsa-miR-640	CLIP-seq
MIRT1921367	hsa-miR-642a	CLIP-seq
MIRT2550484	hsa-miR-652	CLIP-seq
MIRT2550485	hsa-miR-766	CLIP-seq
MIRT2682667	hsa-miR-769-5p	CLIP-seq
MIRT2550486	hsa-miR-770-5p	CLIP-seq
MIRT1062004	hsa-miR-876-3p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
HMGA2	Unknown	17426251;22513850
NFKB1	Unknown	17426251
RELA	Unknown	17426251

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001817	Process	Regulation of cytokine production	IC	9891060
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003729	Function	MRNA binding	IBA	21873635
GO:0003730	Function	MRNA 3'-UTR binding	IBA	21873635
GO:0003730	Function	MRNA 3'-UTR binding	IDA	20080952
GO:0005515	Function	Protein binding	IPI	12674497, 17289661, 32814053
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005634	Component	Nucleus	IDA	15618018
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	IDA	15618018
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IDA	15618018
GO:0007399	Process	Nervous system development	IBA	21873635
GO:0009653	Process	Anatomical structure morphogenesis	TAS	9891060
GO:0010468	Process	Regulation of gene expression	IBA	21873635
GO:0017148	Process	Negative regulation of translation	ISS	9891060
GO:0043488	Process	Regulation of mRNA stability	TAS
GO:0045182	Function	Translation regulator activity	ISS	9891060
GO:0048027	Function	MRNA 5'-UTR binding	IDA	9891060
GO:0051028	Process	MRNA transport	IEA
GO:0051252	Process	Regulation of RNA metabolic process	IBA	21873635

Other IDs

• MIM: 608289
• HGNC: 28867
• e!Ensembl: ENSG00000073792

Protein

• UniProt ID: Q9Y6M1
• Protein name: Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2 mRNA-binding protein 2) (IMP-2) (Hepatocellular carcinoma autoantigen p62) (IGF-II mRNA-binding protein 2) (VICKZ family member 2)
• Protein function: RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcript
• PDB: 2CQH, 6ROL, 7Q98, 7Q99
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00076	RRM_1	5 → 69	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
  PF00076	RRM_1	84 → 151	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
  PF00013	KH_1	195 → 260	KH domain	Domain
  PF00013	KH_1	276 → 343	KH domain	Domain
  PF00013	KH_1	429 → 494	KH domain	Domain
  PF00013	KH_1	511 → 577	KH domain	Domain

• Sequence:

  MMNKLYIGNLSPAVTADDLRQLFGDRKLPLAGQVLLKSGYAFVDYPDQNWAIRAIETLSG
  KVELHGKIMEVDYSVSKKLRSRKIQIRNIPPHLQWEVLDGLLAQYGTVENVEQVNTDTET
  AVVNVTYATREEAKIAMEKLSGHQFENYSFKISYIPDEEVSSPSPPQRAQRGDHSSREQG
  HAPGGTSQARQIDFPLRILVPTQFVGAIIGKEGLTIKNITKQTQSRVDIHRKENSGAAEK
  PVTIHATPEGTSEACRMILEIMQKEADETKLAEEIPLKILAHNGLVGRLIGKEGRNLKKI
  EHETGTKITISSLQDLSIYNPERTITVKGTVEACASAEIEIMKKLREAFENDMLAVNQQA
  NLIPGLNLSALGIFSTGLSVLSPPAGPRGAPPAAPYHPFTTHSGYFSSLYPHHQFGPFPH
  HHSYPEQEIVNLFIPTQAVGAIIGKKGAHIKQLARFAGASIKIAPAEGPDVSERMVIITG
  PPEAQFKAQGRIFGKLKEENFFNPKEEVKLEAHIRVPSSTAGRVIGKGGKTVNELQNLTS
  AEVIVPRDQTPDENEEVIVRIIGHFFASQTAQRKIREIVQQVKQQEQKYPQGVASQRSK

• Sequence length: 599

Pathways

Reactome:

Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Diabetes mellitus	Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs4402960, rs1362648752, rs3745368, rs3792267, rs3842570, rs5030952, rs2975760, rs119489103, rs7903146, rs12255372, rs11196205, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs137852740, rs137852786, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs80356663, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356666, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs387906779, rs141804752, rs182349376, rs184917682, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs61736969, rs587783673, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs797045623, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs1553638903, rs1553638909, rs948820149, rs371977235, rs1553784995, rs76474829, rs200998587, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs776793516, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	20581827, 19401414, 17463248, 22325160, 22693455, 21874001, 30595370, 18711366, 30718926, 21573907, 24509480, 18372903, 26818947, 23945395, 17463249, 30054458, 22885922, 27189021, 22158537, 29358691, 17463246, 31118516, 28869590, 20818381, 23300278, 21647700, 26961502
Schizophrenia	Schizophrenia, Chronic schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	23656854

Unknown
Disease name	Disease term	dbSNP ID	References
Coronary heart disease	Coronary heart disease	rs9289231, rs281864746	21347282