GediPNet logo

IGF2BP3 (insulin like growth factor 2 mRNA binding protein 3)
Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10643
Gene nameGene Name - the full gene name approved by the HGNC.
Insulin like growth factor 2 mRNA binding protein 3
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
IGF2BP3
SynonymsGene synonyms aliases
CT98, IMP-3, IMP3, KOC, KOC1, VICKZ3
ChromosomeChromosome number
7
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
7p15.3
SummarySummary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5` UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded prot
miRNAmiRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
miRTarBase ID miRNA Experiments Reference
MIRT025416 hsa-miR-34a-5p Proteomics 21566225
MIRT025416 hsa-miR-34a-5p Proteomics 21566225
MIRT025416 hsa-miR-34a-5p Proteomics 21566225
MIRT026059 hsa-miR-196a-5p Sequencing 20371350
MIRT032130 hsa-let-7d-5p Sequencing 20371350
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
GO ID Ontology Definition Evidence Reference
GO:0001817 Process Regulation of cytokine production IC 9891060
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0003729 Function MRNA binding IBA 21873635
GO:0003730 Function MRNA 3'-UTR binding IBA 21873635
GO:0003730 Function MRNA 3'-UTR binding IDA 20080952
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM
HGNC
e!Ensembl
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID O00425
Protein name Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2 mRNA-binding protein 3) (IMP-3) (IGF-II mRNA-binding protein 3) (KH domain-containing protein overexpressed in cancer) (hKOC) (VICKZ family member 3)
Protein function RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcr
PDB 2E44 , 6FQ1 , 6FQR , 6GQE , 6GX6
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00076 RRM_1
4 → 69
RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
 Domain
PF00076 RRM_1
83 → 150
RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
 Domain
PF00013 KH_1
197 → 262
KH domain
 Domain
PF00013 KH_1
278 → 345
KH domain
 Domain
PF00013 KH_1
407 → 472
KH domain
 Domain
PF00013 KH_1
489 → 555
KH domain
 Domain
Sequence
Sequence length 579
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
 
Reactome
    Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA
Associated diseases
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Unknown
Disease name Disease term dbSNP ID References
Liver carcinoma Liver carcinoma 28284560
Malignant mesothelioma Malignant mesothelioma 23621518
Peritoneal neoplasms Peritoneal Neoplasms 23621518
Peritoneal carcinomatosis Carcinomatosis of peritoneal cavity 23621518

| © 2021, Biomedical Informatics Centre, NIRRH |
ICMR-National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400012
Tel: +91-22-24192104, Fax No: +91-22-24139412