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IGF2BP1 (insulin like growth factor 2 mRNA binding protein 1)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10642
Gene nameGene Name - the full gene name approved by the HGNC.
Insulin like growth factor 2 mRNA binding protein 1
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
IGF2BP1
SynonymsGene synonyms aliases
CRD-BP, CRDBP, IMP-1, IMP1, VICKZ1, ZBP1
ChromosomeChromosome number
17
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17q21.32
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT003831 hsa-let-7g-5p Western blot 18413726
MIRT003831 hsa-let-7g-5p Western blot 18413726
MIRT003831 hsa-let-7g-5p Western blot 18413726
MIRT003831 hsa-let-7g-5p Western blot 18413726
MIRT003831 hsa-let-7g-5p Western blot 18413726
Transcription factors
Transcription factor Regulation Reference
MYC Activation 21252116
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001817 Process Regulation of cytokine production IC 9891060
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0003729 Function MRNA binding IBA 21873635
GO:0003729 Function MRNA binding IDA 17101699, 17289661
GO:0003730 Function MRNA 3'-UTR binding IBA 21873635
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID Q9NZI8
Protein name Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2 mRNA-binding protein 1) (IMP-1) (IMP1) (Coding region determinant-binding protein) (CRD-BP) (IGF-II mRNA-binding protein 1) (VICKZ family member 1) (Zipcode-binding protein 1) (ZBP-1)
Protein function RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcript
PDB 3KRM , 6QEY
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00076 RRM_1
4 69
RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Domain
PF00076 RRM_1
83 150
RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Domain
PF00013 KH_1
197 262
KH domain
Domain
PF00013 KH_1
278 345
KH domain
Domain
PF00013 KH_1
407 472
KH domain
Domain
PF00013 KH_1
489 555
KH domain
Domain
Sequence
Sequence length 577
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
Reactome
  MicroRNAs in cancer   Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA
MAPK6/MAPK4 signaling
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Coronary artery disease Coronary Artery Disease rs137852988, rs121918313, rs121918529, rs121918531, rs137852340, rs405509, rs1555800701, rs1215189537 28714975
Unknown
Disease name Disease term dbSNP ID References
Liver carcinoma Liver carcinoma 28284560

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