GeDiPNet: Comprehensive Gene Data - OMIM, HGNC, Ensembl, UniProt, GO, Transcription Factors & miRNA

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PDPN (podoplanin)

Gene

10630

Podoplanin

PDPN

AGGRUS, D2-40, GP36, GP40, Gp38, HT1A-1, OTS8, PA2.26, T1A, T1A-2, T1A2, TI1A

1p36.21

This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a di

Show/Hide all(157)

miRTarBase ID	miRNA	Experiments	Reference
MIRT007320	hsa-miR-363-3p	Luciferase reporter assay	23246488
MIRT007320	hsa-miR-363-3p	Luciferase reporter assay	23246488
MIRT007320	hsa-miR-363-3p	Luciferase reporter assay	23246488
MIRT667012	hsa-miR-302f	HITS-CLIP	23706177
MIRT667009	hsa-miR-4695-5p	HITS-CLIP	23706177
MIRT667008	hsa-miR-6808-5p	HITS-CLIP	23706177
MIRT667007	hsa-miR-6893-5p	HITS-CLIP	23706177
MIRT667006	hsa-miR-940	HITS-CLIP	23706177
MIRT667005	hsa-miR-3929	HITS-CLIP	23706177
MIRT667004	hsa-miR-4419b	HITS-CLIP	23706177
MIRT667003	hsa-miR-4478	HITS-CLIP	23706177
MIRT667001	hsa-miR-4768-3p	HITS-CLIP	23706177
MIRT667000	hsa-miR-4459	HITS-CLIP	23706177
MIRT666997	hsa-miR-4649-3p	HITS-CLIP	23706177
MIRT666996	hsa-miR-219b-3p	HITS-CLIP	23706177
MIRT666994	hsa-miR-1827	HITS-CLIP	23706177
MIRT666993	hsa-miR-485-5p	HITS-CLIP	23706177
MIRT666992	hsa-miR-6884-5p	HITS-CLIP	23706177
MIRT666991	hsa-miR-4722-5p	HITS-CLIP	23706177
MIRT666990	hsa-miR-7160-5p	HITS-CLIP	23706177
MIRT666989	hsa-miR-3140-3p	HITS-CLIP	23706177
MIRT666987	hsa-miR-514a-3p	HITS-CLIP	23706177
MIRT666986	hsa-miR-514b-3p	HITS-CLIP	23706177
MIRT666985	hsa-miR-665	HITS-CLIP	23706177
MIRT667012	hsa-miR-302f	HITS-CLIP	23824327
MIRT667011	hsa-miR-512-5p	HITS-CLIP	23824327
MIRT667010	hsa-miR-510-5p	HITS-CLIP	23824327
MIRT667009	hsa-miR-4695-5p	HITS-CLIP	23824327
MIRT667008	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT667007	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT667006	hsa-miR-940	HITS-CLIP	23824327
MIRT667005	hsa-miR-3929	HITS-CLIP	23824327
MIRT667004	hsa-miR-4419b	HITS-CLIP	23824327
MIRT667003	hsa-miR-4478	HITS-CLIP	23824327
MIRT667002	hsa-miR-5690	HITS-CLIP	23824327
MIRT667001	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT667000	hsa-miR-4459	HITS-CLIP	23824327
MIRT666999	hsa-miR-4433a-3p	HITS-CLIP	23824327
MIRT666998	hsa-miR-3664-3p	HITS-CLIP	23824327
MIRT666997	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT666996	hsa-miR-219b-3p	HITS-CLIP	23824327
MIRT666995	hsa-miR-3913-3p	HITS-CLIP	23824327
MIRT666994	hsa-miR-1827	HITS-CLIP	23824327
MIRT666993	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT666992	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT666991	hsa-miR-4722-5p	HITS-CLIP	23824327
MIRT666990	hsa-miR-7160-5p	HITS-CLIP	23824327
MIRT666989	hsa-miR-3140-3p	HITS-CLIP	23824327
MIRT666988	hsa-miR-489-3p	HITS-CLIP	23824327
MIRT666987	hsa-miR-514a-3p	HITS-CLIP	23824327
MIRT666986	hsa-miR-514b-3p	HITS-CLIP	23824327
MIRT666985	hsa-miR-665	HITS-CLIP	23824327
MIRT667012	hsa-miR-302f	HITS-CLIP	23706177
MIRT667009	hsa-miR-4695-5p	HITS-CLIP	23706177
MIRT667008	hsa-miR-6808-5p	HITS-CLIP	23706177
MIRT667007	hsa-miR-6893-5p	HITS-CLIP	23706177
MIRT667006	hsa-miR-940	HITS-CLIP	23706177
MIRT667005	hsa-miR-3929	HITS-CLIP	23706177
MIRT667004	hsa-miR-4419b	HITS-CLIP	23706177
MIRT667003	hsa-miR-4478	HITS-CLIP	23706177
MIRT667001	hsa-miR-4768-3p	HITS-CLIP	23706177
MIRT667000	hsa-miR-4459	HITS-CLIP	23706177
MIRT666997	hsa-miR-4649-3p	HITS-CLIP	23706177
MIRT666996	hsa-miR-219b-3p	HITS-CLIP	23706177
MIRT666994	hsa-miR-1827	HITS-CLIP	23706177
MIRT666993	hsa-miR-485-5p	HITS-CLIP	23706177
MIRT666992	hsa-miR-6884-5p	HITS-CLIP	23706177
MIRT666991	hsa-miR-4722-5p	HITS-CLIP	23706177
MIRT666990	hsa-miR-7160-5p	HITS-CLIP	23706177
MIRT666989	hsa-miR-3140-3p	HITS-CLIP	23706177
MIRT666987	hsa-miR-514a-3p	HITS-CLIP	23706177
MIRT666986	hsa-miR-514b-3p	HITS-CLIP	23706177
MIRT666985	hsa-miR-665	HITS-CLIP	23706177
MIRT667012	hsa-miR-302f	HITS-CLIP	23824327
MIRT667011	hsa-miR-512-5p	HITS-CLIP	23824327
MIRT667010	hsa-miR-510-5p	HITS-CLIP	23824327
MIRT667009	hsa-miR-4695-5p	HITS-CLIP	23824327
MIRT667008	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT667007	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT667006	hsa-miR-940	HITS-CLIP	23824327
MIRT667005	hsa-miR-3929	HITS-CLIP	23824327
MIRT667004	hsa-miR-4419b	HITS-CLIP	23824327
MIRT667003	hsa-miR-4478	HITS-CLIP	23824327
MIRT667002	hsa-miR-5690	HITS-CLIP	23824327
MIRT667001	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT667000	hsa-miR-4459	HITS-CLIP	23824327
MIRT666999	hsa-miR-4433a-3p	HITS-CLIP	23824327
MIRT666998	hsa-miR-3664-3p	HITS-CLIP	23824327
MIRT666997	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT666996	hsa-miR-219b-3p	HITS-CLIP	23824327
MIRT666995	hsa-miR-3913-3p	HITS-CLIP	23824327
MIRT666994	hsa-miR-1827	HITS-CLIP	23824327
MIRT666993	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT666992	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT666991	hsa-miR-4722-5p	HITS-CLIP	23824327
MIRT666990	hsa-miR-7160-5p	HITS-CLIP	23824327
MIRT666989	hsa-miR-3140-3p	HITS-CLIP	23824327
MIRT666988	hsa-miR-489-3p	HITS-CLIP	23824327
MIRT666987	hsa-miR-514a-3p	HITS-CLIP	23824327
MIRT666986	hsa-miR-514b-3p	HITS-CLIP	23824327
MIRT666985	hsa-miR-665	HITS-CLIP	23824327
MIRT755622	hsa-miR-532-3p	Luciferase reporter assay, Western blotting, qRT-PCR	34939978
MIRT1222839	hsa-miR-1185	CLIP-seq
MIRT1222840	hsa-miR-1252	CLIP-seq
MIRT1222841	hsa-miR-1265	CLIP-seq
MIRT1222842	hsa-miR-197	CLIP-seq
MIRT1222843	hsa-miR-25	CLIP-seq
MIRT1222844	hsa-miR-2682	CLIP-seq
MIRT1222845	hsa-miR-2964a-3p	CLIP-seq
MIRT1222846	hsa-miR-32	CLIP-seq
MIRT1222847	hsa-miR-330-3p	CLIP-seq
MIRT1222848	hsa-miR-3611	CLIP-seq
MIRT1222849	hsa-miR-3613-3p	CLIP-seq
MIRT1222850	hsa-miR-363	CLIP-seq
MIRT1222851	hsa-miR-367	CLIP-seq
MIRT1222852	hsa-miR-3675-3p	CLIP-seq
MIRT1222853	hsa-miR-3679-5p	CLIP-seq
MIRT1222854	hsa-miR-3691-3p	CLIP-seq
MIRT1222855	hsa-miR-3714	CLIP-seq
MIRT1222856	hsa-miR-377	CLIP-seq
MIRT1222857	hsa-miR-4484	CLIP-seq
MIRT1222858	hsa-miR-449c	CLIP-seq
MIRT1222859	hsa-miR-4509	CLIP-seq
MIRT1222860	hsa-miR-4684-5p	CLIP-seq
MIRT1222861	hsa-miR-4694-3p	CLIP-seq
MIRT1222862	hsa-miR-4731-3p	CLIP-seq
MIRT1222863	hsa-miR-4743	CLIP-seq
MIRT1222864	hsa-miR-4801	CLIP-seq
MIRT1222865	hsa-miR-548an	CLIP-seq
MIRT1222866	hsa-miR-548c-3p	CLIP-seq
MIRT1222867	hsa-miR-579	CLIP-seq
MIRT1222868	hsa-miR-92a	CLIP-seq
MIRT1222869	hsa-miR-92b	CLIP-seq
MIRT2064683	hsa-miR-150	CLIP-seq
MIRT2064684	hsa-miR-4456	CLIP-seq
MIRT2064685	hsa-miR-4713-5p	CLIP-seq
MIRT755622	hsa-miR-532-3p	CLIP-seq
MIRT2064686	hsa-miR-942	CLIP-seq
MIRT2064687	hsa-miR-4257	CLIP-seq
MIRT2292839	hsa-miR-514	CLIP-seq
MIRT2292840	hsa-miR-873	CLIP-seq
MIRT2064686	hsa-miR-942	CLIP-seq
MIRT2456159	hsa-miR-3122	CLIP-seq
MIRT1222852	hsa-miR-3675-3p	CLIP-seq
MIRT2456160	hsa-miR-3689a-3p	CLIP-seq
MIRT2456161	hsa-miR-3689c	CLIP-seq
MIRT2456162	hsa-miR-3913-5p	CLIP-seq
MIRT2456163	hsa-miR-4455	CLIP-seq
MIRT1222860	hsa-miR-4684-5p	CLIP-seq
MIRT2456164	hsa-miR-4728-5p	CLIP-seq
MIRT1222863	hsa-miR-4743	CLIP-seq
MIRT1222866	hsa-miR-548c-3p	CLIP-seq
MIRT1222852	hsa-miR-3675-3p	CLIP-seq
MIRT2456163	hsa-miR-4455	CLIP-seq
MIRT1222860	hsa-miR-4684-5p	CLIP-seq
MIRT1222863	hsa-miR-4743	CLIP-seq
MIRT1222866	hsa-miR-548c-3p	CLIP-seq

Show/Hide all(76)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000902	Process	Cell morphogenesis	IBA	21873635
GO:0000902	Process	Cell morphogenesis	ISS
GO:0001726	Component	Ruffle	ISS
GO:0001946	Process	Lymphangiogenesis	ISS
GO:0003333	Process	Amino acid transmembrane transport	IEA
GO:0005102	Function	Signaling receptor binding	IBA	21873635
GO:0005102	Function	Signaling receptor binding	IDA	18215137
GO:0005372	Function	Water transmembrane transporter activity	ISS
GO:0005515	Function	Protein binding	IPI	17046996, 17616532, 18215137, 18541721, 19268462, 20962267, 25458834, 32296183
GO:0005739	Component	Mitochondrion	IDA
GO:0005829	Component	Cytosol	IDA	24275092
GO:0005886	Component	Plasma membrane	IDA	17046996, 18215137, 20962267
GO:0005886	Component	Plasma membrane	ISS
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	TAS	10393083
GO:0006833	Process	Water transport	ISS
GO:0006865	Process	Amino acid transport	ISS
GO:0007266	Process	Rho protein signal transduction	IBA	21873635
GO:0007266	Process	Rho protein signal transduction	IMP	25486435
GO:0008285	Process	Negative regulation of cell population proliferation	ISS
GO:0008360	Process	Regulation of cell shape	IEA
GO:0008517	Function	Folic acid transmembrane transporter activity	ISS
GO:0010718	Process	Positive regulation of epithelial to mesenchymal transition	IBA	21873635
GO:0010718	Process	Positive regulation of epithelial to mesenchymal transition	IMP	17046996, 21376833
GO:0015171	Function	Amino acid transmembrane transporter activity	ISS
GO:0015250	Function	Water channel activity	ISS
GO:0015884	Process	Folic acid transport	ISS
GO:0016020	Component	Membrane	IDA	24275092
GO:0016323	Component	Basolateral plasma membrane	IBA	21873635
GO:0016323	Component	Basolateral plasma membrane	IDA	14978162
GO:0016324	Component	Apical plasma membrane	IBA	21873635
GO:0016324	Component	Apical plasma membrane	IDA	20962267
GO:0019956	Function	Chemokine binding	IBA	21873635
GO:0019956	Function	Chemokine binding	IPI	14978162
GO:0030027	Component	Lamellipodium	IBA	21873635
GO:0030027	Component	Lamellipodium	ISS
GO:0030054	Component	Cell junction	IDA
GO:0030168	Process	Platelet activation	TAS	18215137
GO:0030175	Component	Filopodium	IBA	21873635
GO:0030175	Component	Filopodium	ISS
GO:0030324	Process	Lung development	IBA	21873635
GO:0030324	Process	Lung development	ISS
GO:0030335	Process	Positive regulation of cell migration	IBA	21873635
GO:0030335	Process	Positive regulation of cell migration	IMP	21376833
GO:0031258	Component	Lamellipodium membrane	IDA	20962267
GO:0031410	Component	Cytoplasmic vesicle	IDA	17046996
GO:0031527	Component	Filopodium membrane	IDA	17046996
GO:0031528	Component	Microvillus membrane	IDA	17046996
GO:0032587	Component	Ruffle membrane	IDA	17046996
GO:0035239	Process	Tube morphogenesis	IBA	21873635
GO:0042995	Component	Cell projection	IDA	20962267
GO:0043066	Process	Negative regulation of apoptotic process	ISS
GO:0044319	Process	Wound healing, spreading of cells	IMP	20962267
GO:0045121	Component	Membrane raft	IDA	21376833
GO:0048535	Process	Lymph node development	ISS
GO:0051087	Function	Chaperone binding	IBA	21873635
GO:0051087	Function	Chaperone binding	IPI	23541579
GO:0051272	Process	Positive regulation of cellular component movement	ISS
GO:0055093	Process	Response to hyperoxia	IBA	21873635
GO:0060838	Process	Lymphatic endothelial cell fate commitment	ISS
GO:0061851	Component	Leading edge of lamellipodium	IDA	17046996
GO:0070252	Process	Actin-mediated cell contraction	IBA	21873635
GO:0070252	Process	Actin-mediated cell contraction	ISS
GO:0090091	Process	Positive regulation of extracellular matrix disassembly	IBA	21873635
GO:0090091	Process	Positive regulation of extracellular matrix disassembly	IDA	25486435
GO:0097197	Component	Tetraspanin-enriched microdomain	IDA	18541721
GO:0098609	Process	Cell-cell adhesion	IBA	21873635
GO:1900024	Process	Regulation of substrate adhesion-dependent cell spreading	IBA	21873635
GO:1900024	Process	Regulation of substrate adhesion-dependent cell spreading	ISS
GO:1901731	Process	Positive regulation of platelet aggregation	IBA	21873635
GO:1901731	Process	Positive regulation of platelet aggregation	IDA	17222411, 20110424
GO:1901731	Process	Positive regulation of platelet aggregation	IMP	17616532, 18541721
GO:1904328	Process	Regulation of myofibroblast contraction	IBA	21873635
GO:1904328	Process	Regulation of myofibroblast contraction	ISS
GO:2000392	Process	Regulation of lamellipodium morphogenesis	IBA	21873635
GO:2000392	Process	Regulation of lamellipodium morphogenesis	IMP	20962267

MIM	HGNC	e!Ensembl
608863	29602	ENSG00000162493

Protein

UniProt ID

Q86YL7

Protein name

Podoplanin (Aggrus) (Glycoprotein 36) (Gp36) (PA2.26 antigen) (T1-alpha) (T1A) [Cleaved into: 29kDa cytosolic podoplanin intracellular domain (PICD)]

Protein function

Mediates effects on cell migration and adhesion through its different partners. During development plays a role in blood and lymphatic vessels separation by binding CLEC1B, triggering CLEC1B activation in platelets and leading to platelet activa

PDB

3WSR , 4YO0 , 5XCV , 7C94 , 7CQC , 7CQD

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05808	Podoplanin	28 → 161		Family

Sequence

MWKVSALLFVLGSASLWVLAEGASTGQPEDDTETTGLEGGVAMPGAEDDVVTPGTSEDRY
KSGLTTLVATSVNSVTGIRIEDLPTSESTVHAQEQSPSATASNVATSHSTEKVDGDTQTT
VEKDGLSTVTLVGIIVGVLLAIGFIGAIIVVVMRKMSGRYSP

Sequence length

162

Interactions

View interactions

	Reactome
			GPVI-mediated activation cascade

Associated diseases

Show/Hide Unknown Diseases (3)

Unknown
Disease name	Disease term	dbSNP ID	References
Malignant mesothelioma	Malignant mesothelioma		22784439
Peritoneal neoplasms	Peritoneal Neoplasms		22784439
Peritoneal carcinomatosis	Carcinomatosis of peritoneal cavity		22784439

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