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TXNIP (thioredoxin interacting protein)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10628
Gene nameGene Name - the full gene name approved by the HGNC.
Thioredoxin interacting protein
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
TXNIP
SynonymsGene synonyms aliases
ARRDC6, EST01027, HHCPA78, THIF, VDUP1
ChromosomeChromosome number
1
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1q21.1
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a thioredoxin-binding protein that is a member of the alpha arrestin protein family. Thioredoxin is a thiol-oxidoreductase that is a major regulator of cellular redox signaling which protects cells from oxidative stress. This protein inh
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT005561 hsa-miR-373-3p Luciferase reporter assay, qRT-PCR, Western blot 21271679
MIRT019486 hsa-miR-148b-3p Microarray 17612493
MIRT022063 hsa-miR-128-3p Microarray 17612493
MIRT025014 hsa-miR-183-5p Sequencing 20371350
MIRT025554 hsa-miR-34a-5p Sequencing 20371350
Transcription factors
Transcription factor Regulation Reference
FOXO1 Repression 23803610
FOXO3 Activation 20656682
HDAC1 Repression 19351825
HDAC10 Repression 20680488
KLF6 Unknown 19808645
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IEA
GO:0004857 Function Enzyme inhibitor activity IEA
GO:0005515 Function Protein binding IPI 10814541, 14632196, 17260951, 23880345, 26919541, 28514442, 32296183
GO:0005634 Component Nucleus IEA
GO:0005737 Component Cytoplasm IBA 21873635
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID Q9H3M7
Protein name Thioredoxin-interacting protein (Thioredoxin-binding protein 2) (Vitamin D3 up-regulated protein 1)
Protein function May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability (PubMed:17603038). Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translo
PDB 4GEI , 4GEJ , 4GFX , 4LL1 , 4LL4 , 4ROF , 4ROJ , 5CQ2 , 5DF6 , 5DWS , 5DZD
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00339 Arrestin_N
10 152
Arrestin (or S-antigen), N-terminal domain
Domain
PF02752 Arrestin_C
174 300
Arrestin (or S-antigen), C-terminal domain
Domain
Sequence
Sequence length 391
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
Reactome
  NOD-like receptor signaling pathway   The NLRP3 inflammasome
Purinergic signaling in leishmaniasis infection
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Diffuse lymphoma Diffuse Large B-Cell Lymphoma rs121912651, rs121913289, rs121913293, rs878854402, rs869025340, rs1349928568, rs1569115687, rs121913291 16081686
Rheumatoid arthritis Rheumatoid Arthritis rs3766379, rs3792876, rs2071592, rs3087456, rs587776843, rs1566328963, rs2240340, rs1557787212 19192274
Unknown
Disease name Disease term dbSNP ID References
Diabetic nephropathy Diabetic Nephropathy 17582205
Endometrioma Endometrioma 21063030
Endometriosis Endometriosis rs1800629, rs1143634 21063030
Glomerulosclerosis Nodular glomerulosclerosis 17582205

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