IVNS1ABP (influenza virus NS1A binding protein)

Gene

• Entrez ID: 10625
• Gene name: Influenza virus NS1A binding protein
• Gene symbol: IVNS1ABP
• Synonyms: ARA3, FLARA3, HSPC068, IMD70, KLHL39, ND1, NS-1, NS1-BP, NS1BP
• Chromosome: 1
• Chromosome location: 1q25.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT026996	hsa-miR-103a-3p	Sequencing	20371350
MIRT029013	hsa-miR-26b-5p	Microarray	19088304
MIRT030741	hsa-miR-21-5p	Microarray	18591254
MIRT031511	hsa-miR-16-5p	Sequencing	20371350
MIRT044680	hsa-miR-320a	CLASH	23622248
MIRT475068	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT475067	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT031511	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT475066	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT475065	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT475064	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT475063	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT475061	hsa-miR-3201	PAR-CLIP	20371350
MIRT475062	hsa-miR-4791	PAR-CLIP	20371350
MIRT268897	hsa-miR-3177-5p	PAR-CLIP	20371350
MIRT475060	hsa-miR-1261	PAR-CLIP	20371350
MIRT061079	hsa-let-7c-3p	PAR-CLIP	20371350
MIRT475059	hsa-miR-605-5p	PAR-CLIP	20371350
MIRT556873	hsa-miR-3189-5p	PAR-CLIP	21572407
MIRT556872	hsa-miR-874-5p	PAR-CLIP	21572407
MIRT556871	hsa-miR-3650	PAR-CLIP	21572407
MIRT556870	hsa-miR-6800-5p	PAR-CLIP	21572407
MIRT556869	hsa-miR-6802-5p	PAR-CLIP	21572407
MIRT556868	hsa-miR-328-3p	PAR-CLIP	21572407
MIRT475068	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT475067	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT031511	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT475066	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT475065	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT475064	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT475063	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT475061	hsa-miR-3201	PAR-CLIP	21572407
MIRT475062	hsa-miR-4791	PAR-CLIP	21572407
MIRT268897	hsa-miR-3177-5p	PAR-CLIP	21572407
MIRT475060	hsa-miR-1261	PAR-CLIP	21572407
MIRT061079	hsa-let-7c-3p	PAR-CLIP	21572407
MIRT475059	hsa-miR-605-5p	PAR-CLIP	21572407
MIRT485463	hsa-miR-145-5p	PAR-CLIP	23592263
MIRT485462	hsa-miR-5195-3p	PAR-CLIP	23592263
MIRT485461	hsa-miR-5586-3p	PAR-CLIP	23592263
MIRT485460	hsa-miR-7160-3p	PAR-CLIP	23592263
MIRT485459	hsa-miR-4255	PAR-CLIP	23592263
MIRT485458	hsa-miR-3976	PAR-CLIP	23592263
MIRT485457	hsa-miR-362-5p	PAR-CLIP	23592263
MIRT485456	hsa-miR-500b-5p	PAR-CLIP	23592263
MIRT485455	hsa-miR-501-5p	PAR-CLIP	23592263
MIRT485454	hsa-miR-3121-5p	PAR-CLIP	23592263
MIRT485453	hsa-miR-3659	PAR-CLIP	23592263
MIRT485452	hsa-miR-938	PAR-CLIP	23592263
MIRT485451	hsa-miR-6851-3p	PAR-CLIP	23592263
MIRT475068	hsa-miR-15a-5p	PAR-CLIP	23592263
MIRT475067	hsa-miR-15b-5p	PAR-CLIP	23592263
MIRT031511	hsa-miR-16-5p	PAR-CLIP	23592263
MIRT475066	hsa-miR-195-5p	PAR-CLIP	23592263
MIRT475065	hsa-miR-424-5p	PAR-CLIP	23592263
MIRT475064	hsa-miR-497-5p	PAR-CLIP	23592263
MIRT475063	hsa-miR-6838-5p	PAR-CLIP	23592263
MIRT475061	hsa-miR-3201	PAR-CLIP	23592263
MIRT475062	hsa-miR-4791	PAR-CLIP	23592263
MIRT268897	hsa-miR-3177-5p	PAR-CLIP	23592263
MIRT475060	hsa-miR-1261	PAR-CLIP	23592263
MIRT061079	hsa-let-7c-3p	PAR-CLIP	23592263
MIRT475059	hsa-miR-605-5p	PAR-CLIP	23592263
MIRT475068	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT475067	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT031511	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT475066	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT475065	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT475064	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT475063	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT475061	hsa-miR-3201	PAR-CLIP	20371350
MIRT475062	hsa-miR-4791	PAR-CLIP	20371350
MIRT268897	hsa-miR-3177-5p	PAR-CLIP	20371350
MIRT475060	hsa-miR-1261	PAR-CLIP	20371350
MIRT061079	hsa-let-7c-3p	PAR-CLIP	20371350
MIRT475059	hsa-miR-605-5p	PAR-CLIP	20371350
MIRT556873	hsa-miR-3189-5p	PAR-CLIP	21572407
MIRT556872	hsa-miR-874-5p	PAR-CLIP	21572407
MIRT556871	hsa-miR-3650	PAR-CLIP	21572407
MIRT556870	hsa-miR-6800-5p	PAR-CLIP	21572407
MIRT556869	hsa-miR-6802-5p	PAR-CLIP	21572407
MIRT556868	hsa-miR-328-3p	PAR-CLIP	21572407
MIRT475068	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT475067	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT031511	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT475066	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT475065	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT475064	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT475063	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT475061	hsa-miR-3201	PAR-CLIP	21572407
MIRT475062	hsa-miR-4791	PAR-CLIP	21572407
MIRT268897	hsa-miR-3177-5p	PAR-CLIP	21572407
MIRT475060	hsa-miR-1261	PAR-CLIP	21572407
MIRT061079	hsa-let-7c-3p	PAR-CLIP	21572407
MIRT475059	hsa-miR-605-5p	PAR-CLIP	21572407
MIRT485463	hsa-miR-145-5p	PAR-CLIP	23592263
MIRT485462	hsa-miR-5195-3p	PAR-CLIP	23592263
MIRT485461	hsa-miR-5586-3p	PAR-CLIP	23592263
MIRT485460	hsa-miR-7160-3p	PAR-CLIP	23592263
MIRT485459	hsa-miR-4255	PAR-CLIP	23592263
MIRT485458	hsa-miR-3976	PAR-CLIP	23592263
MIRT485457	hsa-miR-362-5p	PAR-CLIP	23592263
MIRT485456	hsa-miR-500b-5p	PAR-CLIP	23592263
MIRT485455	hsa-miR-501-5p	PAR-CLIP	23592263
MIRT485454	hsa-miR-3121-5p	PAR-CLIP	23592263
MIRT485453	hsa-miR-3659	PAR-CLIP	23592263
MIRT485452	hsa-miR-938	PAR-CLIP	23592263
MIRT485451	hsa-miR-6851-3p	PAR-CLIP	23592263
MIRT475068	hsa-miR-15a-5p	PAR-CLIP	23592263
MIRT475067	hsa-miR-15b-5p	PAR-CLIP	23592263
MIRT031511	hsa-miR-16-5p	PAR-CLIP	23592263
MIRT475066	hsa-miR-195-5p	PAR-CLIP	23592263
MIRT475065	hsa-miR-424-5p	PAR-CLIP	23592263
MIRT475064	hsa-miR-497-5p	PAR-CLIP	23592263
MIRT475063	hsa-miR-6838-5p	PAR-CLIP	23592263
MIRT475061	hsa-miR-3201	PAR-CLIP	23592263
MIRT475062	hsa-miR-4791	PAR-CLIP	23592263
MIRT268897	hsa-miR-3177-5p	PAR-CLIP	23592263
MIRT475060	hsa-miR-1261	PAR-CLIP	23592263
MIRT061079	hsa-let-7c-3p	PAR-CLIP	23592263
MIRT475059	hsa-miR-605-5p	PAR-CLIP	23592263
MIRT1075686	hsa-miR-1182	CLIP-seq
MIRT1075687	hsa-miR-1304	CLIP-seq
MIRT1075688	hsa-miR-182	CLIP-seq
MIRT1075689	hsa-miR-193a-5p	CLIP-seq
MIRT1075690	hsa-miR-19a	CLIP-seq
MIRT1075691	hsa-miR-19b	CLIP-seq
MIRT1075692	hsa-miR-203	CLIP-seq
MIRT1075693	hsa-miR-205	CLIP-seq
MIRT1075694	hsa-miR-3120-3p	CLIP-seq
MIRT1075695	hsa-miR-3126-5p	CLIP-seq
MIRT1075696	hsa-miR-3150b-3p	CLIP-seq
MIRT1075697	hsa-miR-33a	CLIP-seq
MIRT1075698	hsa-miR-33b	CLIP-seq
MIRT1075699	hsa-miR-4419a	CLIP-seq
MIRT1075700	hsa-miR-4470	CLIP-seq
MIRT1075701	hsa-miR-4491	CLIP-seq
MIRT1075702	hsa-miR-4510	CLIP-seq
MIRT1075703	hsa-miR-4635	CLIP-seq
MIRT1075704	hsa-miR-4643	CLIP-seq
MIRT1075705	hsa-miR-4652-5p	CLIP-seq
MIRT1075706	hsa-miR-4657	CLIP-seq
MIRT1075707	hsa-miR-466	CLIP-seq
MIRT1075708	hsa-miR-4729	CLIP-seq
MIRT1075709	hsa-miR-4784	CLIP-seq
MIRT1075710	hsa-miR-4789-3p	CLIP-seq
MIRT1075711	hsa-miR-513a-3p	CLIP-seq
MIRT1075712	hsa-miR-526b	CLIP-seq
MIRT1075713	hsa-miR-548l	CLIP-seq
MIRT1075714	hsa-miR-548n	CLIP-seq
MIRT1075715	hsa-miR-633	CLIP-seq
MIRT1075716	hsa-miR-765	CLIP-seq
MIRT2018815	hsa-miR-145	CLIP-seq
MIRT1075692	hsa-miR-203	CLIP-seq
MIRT1075694	hsa-miR-3120-3p	CLIP-seq
MIRT1075696	hsa-miR-3150b-3p	CLIP-seq
MIRT2018816	hsa-miR-3168	CLIP-seq
MIRT1075697	hsa-miR-33a	CLIP-seq
MIRT1075698	hsa-miR-33b	CLIP-seq
MIRT1075703	hsa-miR-4635	CLIP-seq
MIRT1075705	hsa-miR-4652-5p	CLIP-seq
MIRT2018817	hsa-miR-4714-5p	CLIP-seq
MIRT2018818	hsa-miR-4762-3p	CLIP-seq
MIRT1075709	hsa-miR-4784	CLIP-seq
MIRT2018819	hsa-miR-513b	CLIP-seq
MIRT1075712	hsa-miR-526b	CLIP-seq
MIRT2018820	hsa-miR-548aa	CLIP-seq
MIRT2018821	hsa-miR-548ae	CLIP-seq
MIRT2018822	hsa-miR-548aj	CLIP-seq
MIRT2018823	hsa-miR-548am	CLIP-seq
MIRT1075713	hsa-miR-548l	CLIP-seq
MIRT1075714	hsa-miR-548n	CLIP-seq
MIRT2018824	hsa-miR-548x	CLIP-seq
MIRT1075716	hsa-miR-765	CLIP-seq
MIRT2250676	hsa-miR-1264	CLIP-seq
MIRT2250677	hsa-miR-1279	CLIP-seq
MIRT1075687	hsa-miR-1304	CLIP-seq
MIRT2250678	hsa-miR-132	CLIP-seq
MIRT2250679	hsa-miR-15a	CLIP-seq
MIRT2250680	hsa-miR-15b	CLIP-seq
MIRT2250681	hsa-miR-16	CLIP-seq
MIRT1075688	hsa-miR-182	CLIP-seq
MIRT2250682	hsa-miR-195	CLIP-seq
MIRT1075690	hsa-miR-19a	CLIP-seq
MIRT1075691	hsa-miR-19b	CLIP-seq
MIRT1075692	hsa-miR-203	CLIP-seq
MIRT1075693	hsa-miR-205	CLIP-seq
MIRT2250683	hsa-miR-212	CLIP-seq
MIRT2250684	hsa-miR-3064-3p	CLIP-seq
MIRT1075694	hsa-miR-3120-3p	CLIP-seq
MIRT1075695	hsa-miR-3126-5p	CLIP-seq
MIRT2250685	hsa-miR-3163	CLIP-seq
MIRT1075697	hsa-miR-33a	CLIP-seq
MIRT1075698	hsa-miR-33b	CLIP-seq
MIRT2250686	hsa-miR-3682-5p	CLIP-seq
MIRT2250687	hsa-miR-424	CLIP-seq
MIRT2250688	hsa-miR-4251	CLIP-seq
MIRT1075699	hsa-miR-4419a	CLIP-seq
MIRT2250689	hsa-miR-4422	CLIP-seq
MIRT1075700	hsa-miR-4470	CLIP-seq
MIRT1075701	hsa-miR-4491	CLIP-seq
MIRT1075702	hsa-miR-4510	CLIP-seq
MIRT2250690	hsa-miR-455-5p	CLIP-seq
MIRT1075703	hsa-miR-4635	CLIP-seq
MIRT1075704	hsa-miR-4643	CLIP-seq
MIRT1075705	hsa-miR-4652-5p	CLIP-seq
MIRT1075706	hsa-miR-4657	CLIP-seq
MIRT2250691	hsa-miR-4658	CLIP-seq
MIRT1075707	hsa-miR-466	CLIP-seq
MIRT2250692	hsa-miR-4663	CLIP-seq
MIRT2250693	hsa-miR-4722-3p	CLIP-seq
MIRT1075708	hsa-miR-4729	CLIP-seq
MIRT2250694	hsa-miR-4731-3p	CLIP-seq
MIRT2250695	hsa-miR-4763-5p	CLIP-seq
MIRT1075710	hsa-miR-4789-3p	CLIP-seq
MIRT2250696	hsa-miR-4801	CLIP-seq
MIRT2250697	hsa-miR-497	CLIP-seq
MIRT1075712	hsa-miR-526b	CLIP-seq
MIRT2250698	hsa-miR-548k	CLIP-seq
MIRT1075713	hsa-miR-548l	CLIP-seq
MIRT1075714	hsa-miR-548n	CLIP-seq
MIRT2250699	hsa-miR-548t	CLIP-seq
MIRT2250700	hsa-miR-574-5p	CLIP-seq
MIRT2250701	hsa-miR-580	CLIP-seq
MIRT2250684	hsa-miR-3064-3p	CLIP-seq
MIRT2250685	hsa-miR-3163	CLIP-seq
MIRT2554186	hsa-miR-340	CLIP-seq
MIRT2250686	hsa-miR-3682-5p	CLIP-seq
MIRT2554187	hsa-miR-3977	CLIP-seq
MIRT2250688	hsa-miR-4251	CLIP-seq
MIRT2554188	hsa-miR-4252	CLIP-seq
MIRT2250689	hsa-miR-4422	CLIP-seq
MIRT2250692	hsa-miR-4663	CLIP-seq
MIRT2250693	hsa-miR-4722-3p	CLIP-seq
MIRT2250695	hsa-miR-4763-5p	CLIP-seq
MIRT2554189	hsa-miR-4764-3p	CLIP-seq
MIRT2554190	hsa-miR-508-5p	CLIP-seq
MIRT2554191	hsa-miR-516a-3p	CLIP-seq
MIRT2554192	hsa-miR-548an	CLIP-seq
MIRT2250701	hsa-miR-580	CLIP-seq
MIRT2554193	hsa-miR-596	CLIP-seq
MIRT2554194	hsa-miR-766	CLIP-seq
MIRT2250684	hsa-miR-3064-3p	CLIP-seq
MIRT2250685	hsa-miR-3163	CLIP-seq
MIRT2554186	hsa-miR-340	CLIP-seq
MIRT2250686	hsa-miR-3682-5p	CLIP-seq
MIRT2554187	hsa-miR-3977	CLIP-seq
MIRT2250688	hsa-miR-4251	CLIP-seq
MIRT2554188	hsa-miR-4252	CLIP-seq
MIRT2250689	hsa-miR-4422	CLIP-seq
MIRT2250692	hsa-miR-4663	CLIP-seq
MIRT2250693	hsa-miR-4722-3p	CLIP-seq
MIRT2250695	hsa-miR-4763-5p	CLIP-seq
MIRT2554189	hsa-miR-4764-3p	CLIP-seq
MIRT2554190	hsa-miR-508-5p	CLIP-seq
MIRT2554192	hsa-miR-548an	CLIP-seq
MIRT2250701	hsa-miR-580	CLIP-seq
MIRT2554193	hsa-miR-596	CLIP-seq
MIRT2554194	hsa-miR-766	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	23825951, 25619834
GO:0005654	Component	Nucleoplasm	IEA
GO:0005667	Component	Transcription regulator complex	TAS	9696811
GO:0005681	Component	Spliceosomal complex	TAS	9696811
GO:0005829	Component	Cytosol	IDA
GO:0005856	Component	Cytoskeleton	IEA
GO:0006383	Process	Transcription by RNA polymerase III	TAS	9696811
GO:0008380	Process	RNA splicing	IMP	23825951
GO:0009615	Process	Response to virus	IMP	23825951
GO:0016032	Process	Viral process	IEA
GO:0031397	Process	Negative regulation of protein ubiquitination	IMP	25619834
GO:2001243	Process	Negative regulation of intrinsic apoptotic signaling pathway	IEA

Other IDs

• MIM: 609209
• HGNC: 16951
• e!Ensembl: ENSG00000116679

Protein

• UniProt ID: Q9Y6Y0
• Protein name: Influenza virus NS1A-binding protein (NS1-BP) (NS1-binding protein) (Aryl hydrocarbon receptor-associated protein 3) (Kelch-like protein 39)
• Protein function: Involved in many cell functions, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization and protein ubiquitination. Plays a role in the dynamic organization of the actin skeleton as a stabilizer of actin f
• PDB: 5YY8, 6N34, 6N3H
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00651	BTB	22 → 128	BTB/POZ domain	Domain
  PF07707	BACK	134 → 228	BTB And C-terminal Kelch	Domain
  PF01344	Kelch_1	357 → 402	Kelch motif	Repeat
  PF01344	Kelch_1	404 → 450	Kelch motif	Repeat
  PF01344	Kelch_1	452 → 499	Kelch motif	Repeat
  PF01344	Kelch_1	501 → 546	Kelch motif	Repeat
  PF01344	Kelch_1	548 → 593	Kelch motif	Repeat
  PF01344	Kelch_1	595 → 638	Kelch motif	Repeat

• Sequence:

  MIPNGYLMFEDENFIESSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEI
  FNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQV
  CGDYLLSRMDVTSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKLEV
  MLEDNVCLPSNGKLYTKVINWVQRSIWENGDSLEELMEEVQTLYYSADHKLLDGNLLDGQ
  AEVFGSDDDHIQFVQKKPPRENGHKQISSSSTGCLSSPNATVQSPKHEWKIVASEKTSNN
  TYLCLAVLDGIFCVIFLHGRNSPQSSPTSTPKLSKSLSFEMQQDELIEKPMSPMQYARSG
  LGTAEMNGKLIAAGGYNREECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVLMGQLYVV
  GGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLK
  NCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVERYNPENNTWT
  LIAPMNVARRGAGVAVLNGKLFVCGGFDGSHAISCVEMYDPTRNEWKMMGNMTSPRSNAG
  IATVGNTIYAVGGFDGNEFLNTVEVYNLESNEWSPYTKIFQF

• Sequence length: 642

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	19208208

Unknown
Disease name	Disease term	dbSNP ID	References
Prostatic neoplasms	Prostatic Neoplasms		19208208