CENPA (centromere protein A)

Gene

• Entrez ID: 1058
• Gene name: Centromere protein A
• Gene symbol: CENPA
• Synonyms: CENP-A, CenH3
• Chromosome: 2
• Chromosome location: 2p23.3
• Summary: Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. This gene encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. Centr

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT024281	hsa-miR-215-5p	Microarray	19074876
MIRT026545	hsa-miR-192-5p	Microarray	19074876
MIRT509494	hsa-miR-411-5p	PAR-CLIP	21572407
MIRT509493	hsa-miR-187-3p	PAR-CLIP	21572407
MIRT529763	hsa-miR-6507-3p	PAR-CLIP	22012620
MIRT529762	hsa-miR-6750-3p	PAR-CLIP	22012620
MIRT529761	hsa-miR-6813-3p	PAR-CLIP	22012620
MIRT529760	hsa-miR-4714-3p	PAR-CLIP	22012620
MIRT529759	hsa-miR-4719	PAR-CLIP	22012620
MIRT529758	hsa-miR-432-5p	PAR-CLIP	22012620
MIRT529757	hsa-miR-1289	PAR-CLIP	22012620
MIRT529756	hsa-miR-4294	PAR-CLIP	22012620
MIRT529755	hsa-miR-3198	PAR-CLIP	22012620
MIRT529754	hsa-miR-4309	PAR-CLIP	22012620
MIRT243088	hsa-miR-1276	PAR-CLIP	22012620
MIRT243089	hsa-miR-5692a	PAR-CLIP	22012620
MIRT529753	hsa-miR-376c-3p	PAR-CLIP	22012620
MIRT529752	hsa-miR-6504-3p	PAR-CLIP	22012620
MIRT243087	hsa-miR-610	PAR-CLIP	22012620
MIRT509494	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT509493	hsa-miR-187-3p	PAR-CLIP	23446348
MIRT509492	hsa-miR-4668-5p	PAR-CLIP	23446348
MIRT509494	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT509493	hsa-miR-187-3p	PAR-CLIP	23446348
MIRT509492	hsa-miR-4668-5p	PAR-CLIP	23446348
MIRT509491	hsa-miR-3153	PAR-CLIP	23446348
MIRT509490	hsa-miR-6733-5p	PAR-CLIP	23446348
MIRT509489	hsa-miR-6739-5p	PAR-CLIP	23446348
MIRT509494	hsa-miR-411-5p	PAR-CLIP	21572407
MIRT509493	hsa-miR-187-3p	PAR-CLIP	21572407
MIRT529763	hsa-miR-6507-3p	PAR-CLIP	22012620
MIRT529762	hsa-miR-6750-3p	PAR-CLIP	22012620
MIRT529761	hsa-miR-6813-3p	PAR-CLIP	22012620
MIRT529760	hsa-miR-4714-3p	PAR-CLIP	22012620
MIRT529759	hsa-miR-4719	PAR-CLIP	22012620
MIRT529758	hsa-miR-432-5p	PAR-CLIP	22012620
MIRT529757	hsa-miR-1289	PAR-CLIP	22012620
MIRT529756	hsa-miR-4294	PAR-CLIP	22012620
MIRT529755	hsa-miR-3198	PAR-CLIP	22012620
MIRT529754	hsa-miR-4309	PAR-CLIP	22012620
MIRT243088	hsa-miR-1276	PAR-CLIP	22012620
MIRT243089	hsa-miR-5692a	PAR-CLIP	22012620
MIRT529753	hsa-miR-376c-3p	PAR-CLIP	22012620
MIRT529752	hsa-miR-6504-3p	PAR-CLIP	22012620
MIRT243087	hsa-miR-610	PAR-CLIP	22012620
MIRT509494	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT509493	hsa-miR-187-3p	PAR-CLIP	23446348
MIRT509492	hsa-miR-4668-5p	PAR-CLIP	23446348
MIRT509494	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT509493	hsa-miR-187-3p	PAR-CLIP	23446348
MIRT509492	hsa-miR-4668-5p	PAR-CLIP	23446348
MIRT509491	hsa-miR-3153	PAR-CLIP	23446348
MIRT509490	hsa-miR-6733-5p	PAR-CLIP	23446348
MIRT509489	hsa-miR-6739-5p	PAR-CLIP	23446348
MIRT884618	hsa-miR-1272	CLIP-seq
MIRT884619	hsa-miR-1322	CLIP-seq
MIRT884620	hsa-miR-219-5p	CLIP-seq
MIRT884621	hsa-miR-2467-3p	CLIP-seq
MIRT884622	hsa-miR-3125	CLIP-seq
MIRT884623	hsa-miR-3134	CLIP-seq
MIRT884624	hsa-miR-3545-5p	CLIP-seq
MIRT884625	hsa-miR-3614-3p	CLIP-seq
MIRT884626	hsa-miR-365	CLIP-seq
MIRT884627	hsa-miR-3688-3p	CLIP-seq
MIRT884628	hsa-miR-3916	CLIP-seq
MIRT884629	hsa-miR-3973	CLIP-seq
MIRT884630	hsa-miR-4257	CLIP-seq
MIRT884631	hsa-miR-4279	CLIP-seq
MIRT884632	hsa-miR-4297	CLIP-seq
MIRT884633	hsa-miR-4445	CLIP-seq
MIRT884634	hsa-miR-4534	CLIP-seq
MIRT884635	hsa-miR-4645-5p	CLIP-seq
MIRT884636	hsa-miR-4673	CLIP-seq
MIRT884637	hsa-miR-4742-5p	CLIP-seq
MIRT884638	hsa-miR-4777-3p	CLIP-seq
MIRT884639	hsa-miR-4782-3p	CLIP-seq
MIRT884640	hsa-miR-4796-3p	CLIP-seq
MIRT884641	hsa-miR-4796-5p	CLIP-seq
MIRT884642	hsa-miR-4797-5p	CLIP-seq
MIRT884643	hsa-miR-508-3p	CLIP-seq
MIRT884644	hsa-miR-520g	CLIP-seq
MIRT884645	hsa-miR-520h	CLIP-seq
MIRT884646	hsa-miR-556-3p	CLIP-seq
MIRT884647	hsa-miR-656	CLIP-seq
MIRT884648	hsa-miR-767-3p	CLIP-seq
MIRT884649	hsa-miR-942	CLIP-seq
MIRT884650	hsa-miR-4717-3p	CLIP-seq
MIRT884618	hsa-miR-1272	CLIP-seq
MIRT1962347	hsa-miR-1305	CLIP-seq
MIRT884619	hsa-miR-1322	CLIP-seq
MIRT1962348	hsa-miR-1324	CLIP-seq
MIRT1962349	hsa-miR-198	CLIP-seq
MIRT884621	hsa-miR-2467-3p	CLIP-seq
MIRT1962350	hsa-miR-2467-5p	CLIP-seq
MIRT1962351	hsa-miR-3120-3p	CLIP-seq
MIRT884623	hsa-miR-3134	CLIP-seq
MIRT1962352	hsa-miR-3179	CLIP-seq
MIRT1962353	hsa-miR-3188	CLIP-seq
MIRT884624	hsa-miR-3545-5p	CLIP-seq
MIRT884625	hsa-miR-3614-3p	CLIP-seq
MIRT884626	hsa-miR-365	CLIP-seq
MIRT1962354	hsa-miR-3664-5p	CLIP-seq
MIRT1962355	hsa-miR-3671	CLIP-seq
MIRT884627	hsa-miR-3688-3p	CLIP-seq
MIRT1962356	hsa-miR-3919	CLIP-seq
MIRT884629	hsa-miR-3973	CLIP-seq
MIRT1962357	hsa-miR-3975	CLIP-seq
MIRT1962358	hsa-miR-4252	CLIP-seq
MIRT884630	hsa-miR-4257	CLIP-seq
MIRT884632	hsa-miR-4297	CLIP-seq
MIRT1962359	hsa-miR-4307	CLIP-seq
MIRT1962360	hsa-miR-4316	CLIP-seq
MIRT1962361	hsa-miR-4436b-3p	CLIP-seq
MIRT884634	hsa-miR-4534	CLIP-seq
MIRT884635	hsa-miR-4645-5p	CLIP-seq
MIRT1962362	hsa-miR-4668-3p	CLIP-seq
MIRT884636	hsa-miR-4673	CLIP-seq
MIRT1962363	hsa-miR-4698	CLIP-seq
MIRT1962364	hsa-miR-4710	CLIP-seq
MIRT1962365	hsa-miR-4714-5p	CLIP-seq
MIRT884637	hsa-miR-4742-5p	CLIP-seq
MIRT1962366	hsa-miR-4756-3p	CLIP-seq
MIRT1962367	hsa-miR-4792	CLIP-seq
MIRT884640	hsa-miR-4796-3p	CLIP-seq
MIRT884641	hsa-miR-4796-5p	CLIP-seq
MIRT1962368	hsa-miR-485-5p	CLIP-seq
MIRT884644	hsa-miR-520g	CLIP-seq
MIRT884645	hsa-miR-520h	CLIP-seq
MIRT1962369	hsa-miR-545	CLIP-seq
MIRT1962370	hsa-miR-607	CLIP-seq
MIRT884648	hsa-miR-767-3p	CLIP-seq
MIRT2198769	hsa-miR-3064-5p	CLIP-seq
MIRT884626	hsa-miR-365	CLIP-seq
MIRT2198770	hsa-miR-4468	CLIP-seq
MIRT2198771	hsa-miR-4663	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000132	Process	Establishment of mitotic spindle orientation	IMP	19468067
GO:0000281	Process	Mitotic cytokinesis	IMP	27499292
GO:0000775	Component	Chromosome, centromeric region	IDA	11084331, 27499292
GO:0000778	Component	Condensed nuclear chromosome kinetochore	IDA	18195732
GO:0000779	Component	Condensed chromosome, centromeric region	IDA	11682612
GO:0000786	Component	Nucleosome	IDA	27499292
GO:0000939	Component	Condensed chromosome inner kinetochore	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003682	Function	Chromatin binding	TAS	7962047
GO:0005515	Function	Protein binding	IPI	19410544, 19410545, 19503796, 19533040, 20080577, 21478274, 26167883, 26496610, 32814053
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005634	Component	Nucleus	IDA	27499292
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005721	Component	Pericentric heterochromatin	IEA
GO:0005829	Component	Cytosol	TAS
GO:0016032	Process	Viral process	IEA
GO:0034080	Process	CENP-A containing nucleosome assembly	TAS
GO:0046982	Function	Protein heterodimerization activity	IEA
GO:0051382	Process	Kinetochore assembly	IDA	11682612
GO:0071459	Process	Protein localization to chromosome, centromeric region	IDA	11682612

Other IDs

• MIM: 117139
• HGNC: 1851
• e!Ensembl: ENSG00000115163

Protein

• UniProt ID: P49450
• Protein name: Histone H3-like centromeric protein A (Centromere autoantigen A) (Centromere protein A) (CENP-A)
• Protein function: Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes (PubMed:11756469, PubMed:14667408, PubMed:15282608, PubMed:15475964, PubMed:15702419, PubMed:17651496, PubMed:19114591, PubMed:20739937, PubMed:27499292, P
• PDB: 3AN2, 3NQJ, 3NQU, 3R45, 3WTP, 5CVD, 5Z23, 6BUZ, 6C0W, 6E0C, 6E0P, 6KDQ, 6KDS, 6L49, 6MUO, 6MUP, 6O1D, 6SE0, 6SE6, 6SEE, 6SEF, 6SEG, 6TEM, 7D20, 7PII, 7R5R, 7U46, 7U47, 7U4D, 7YWX, 7YYH, 9GXA
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00125	Histone	2 → 133	Core histone H2A/H2B/H3/H4	Domain

• Sequence:

  MGPRRRSRKPEAPRRRSPSPTPTPGPSRRGPSLGASSHQHSRRRQGWLKEIRKLQKSTHL
  LIRKLPFSRLAREICVKFTRGVDFNWQAQALLALQEAAEAFLVHLFEDAYLLTLHAGRVT
  LFPKDVQLARRIRGLEEGLG

• Sequence length: 140

Pathways

Reactome:

Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Deposition of new CENPA-containing nucleosomes at the centromere
Mitotic Prometaphase
EML4 and NUDC in mitotic spindle formation

Associated diseases

Unknown
Disease name	Disease term	dbSNP ID	References
Liver carcinoma	Liver carcinoma		28284560