HTATIP2 (HIV-1 Tat interactive protein 2)

Gene

• Entrez ID: 10553
• Gene name: HIV-1 Tat interactive protein 2
• Gene symbol: HTATIP2
• Synonyms: CC3, SDR44U1, TIP30
• Chromosome: 11
• Chromosome location: 11p15.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT002630	hsa-miR-124-3p	Microarray	15685193
MIRT002630	hsa-miR-124-3p	Microarray	15685193
MIRT002630	hsa-miR-124-3p	Microarray	18668037
MIRT437374	hsa-miR-10b-5p	Luciferase reporter assay, qRT-PCR, Western blot	24096486
MIRT437374	hsa-miR-10b-5p	Luciferase reporter assay, qRT-PCR, Western blot	24096486
MIRT1057092	hsa-miR-1245	CLIP-seq
MIRT1057093	hsa-miR-125a-5p	CLIP-seq
MIRT1057094	hsa-miR-125b	CLIP-seq
MIRT1057095	hsa-miR-3158-3p	CLIP-seq
MIRT1057096	hsa-miR-3924	CLIP-seq
MIRT1057097	hsa-miR-4319	CLIP-seq
MIRT1057098	hsa-miR-4446-3p	CLIP-seq
MIRT1057099	hsa-miR-4656	CLIP-seq
MIRT1057100	hsa-miR-4732-3p	CLIP-seq
MIRT1057101	hsa-miR-4762-5p	CLIP-seq
MIRT1057102	hsa-miR-4765	CLIP-seq
MIRT1057103	hsa-miR-568	CLIP-seq
MIRT1057104	hsa-miR-670	CLIP-seq
MIRT1057105	hsa-miR-1184	CLIP-seq
MIRT1057106	hsa-miR-1205	CLIP-seq
MIRT1057107	hsa-miR-142-3p	CLIP-seq
MIRT1057108	hsa-miR-3065-5p	CLIP-seq
MIRT1057109	hsa-miR-3158-5p	CLIP-seq
MIRT1057110	hsa-miR-3166	CLIP-seq
MIRT1057111	hsa-miR-330-3p	CLIP-seq
MIRT1057112	hsa-miR-3606	CLIP-seq
MIRT1057113	hsa-miR-3919	CLIP-seq
MIRT1057114	hsa-miR-4275	CLIP-seq
MIRT1057115	hsa-miR-4522	CLIP-seq
MIRT1057116	hsa-miR-4666-5p	CLIP-seq
MIRT1057117	hsa-miR-4731-3p	CLIP-seq
MIRT1057118	hsa-miR-4756-3p	CLIP-seq
MIRT1057119	hsa-miR-4771	CLIP-seq
MIRT1057120	hsa-miR-4801	CLIP-seq
MIRT1057121	hsa-miR-505	CLIP-seq
MIRT1057122	hsa-miR-590-3p	CLIP-seq
MIRT1057123	hsa-miR-607	CLIP-seq
MIRT1057124	hsa-miR-2467-3p	CLIP-seq
MIRT1057125	hsa-miR-3155	CLIP-seq
MIRT1057126	hsa-miR-3155b	CLIP-seq
MIRT1057127	hsa-miR-3678-3p	CLIP-seq
MIRT1057128	hsa-miR-4539	CLIP-seq
MIRT1057129	hsa-miR-484	CLIP-seq
MIRT1057130	hsa-miR-760	CLIP-seq
MIRT2013036	hsa-miR-124	CLIP-seq
MIRT1057092	hsa-miR-1245	CLIP-seq
MIRT1057093	hsa-miR-125a-5p	CLIP-seq
MIRT1057094	hsa-miR-125b	CLIP-seq
MIRT1057107	hsa-miR-142-3p	CLIP-seq
MIRT1057112	hsa-miR-3606	CLIP-seq
MIRT1057096	hsa-miR-3924	CLIP-seq
MIRT2013037	hsa-miR-3941	CLIP-seq
MIRT1057114	hsa-miR-4275	CLIP-seq
MIRT1057097	hsa-miR-4319	CLIP-seq
MIRT2013038	hsa-miR-4484	CLIP-seq
MIRT2013039	hsa-miR-466	CLIP-seq
MIRT1057116	hsa-miR-4666-5p	CLIP-seq
MIRT2013040	hsa-miR-4672	CLIP-seq
MIRT1057117	hsa-miR-4731-3p	CLIP-seq
MIRT1057100	hsa-miR-4732-3p	CLIP-seq
MIRT1057102	hsa-miR-4765	CLIP-seq
MIRT1057120	hsa-miR-4801	CLIP-seq
MIRT2013041	hsa-miR-506	CLIP-seq
MIRT2013042	hsa-miR-548an	CLIP-seq
MIRT1057104	hsa-miR-670	CLIP-seq
MIRT2548536	hsa-miR-1	CLIP-seq
MIRT1057105	hsa-miR-1184	CLIP-seq
MIRT2548537	hsa-miR-1185	CLIP-seq
MIRT1057106	hsa-miR-1205	CLIP-seq
MIRT1057092	hsa-miR-1245	CLIP-seq
MIRT1057093	hsa-miR-125a-5p	CLIP-seq
MIRT1057094	hsa-miR-125b	CLIP-seq
MIRT2548538	hsa-miR-1303	CLIP-seq
MIRT2548539	hsa-miR-134	CLIP-seq
MIRT1057107	hsa-miR-142-3p	CLIP-seq
MIRT2548540	hsa-miR-206	CLIP-seq
MIRT2548541	hsa-miR-2278	CLIP-seq
MIRT1057124	hsa-miR-2467-3p	CLIP-seq
MIRT2548542	hsa-miR-29a	CLIP-seq
MIRT2548543	hsa-miR-29b	CLIP-seq
MIRT2548544	hsa-miR-29c	CLIP-seq
MIRT1057108	hsa-miR-3065-5p	CLIP-seq
MIRT2548545	hsa-miR-3118	CLIP-seq
MIRT1057125	hsa-miR-3155	CLIP-seq
MIRT1057126	hsa-miR-3155b	CLIP-seq
MIRT1057109	hsa-miR-3158-5p	CLIP-seq
MIRT2548546	hsa-miR-3164	CLIP-seq
MIRT1057110	hsa-miR-3166	CLIP-seq
MIRT2548547	hsa-miR-3177-3p	CLIP-seq
MIRT1057111	hsa-miR-330-3p	CLIP-seq
MIRT2548548	hsa-miR-3605-5p	CLIP-seq
MIRT1057112	hsa-miR-3606	CLIP-seq
MIRT2548549	hsa-miR-361-3p	CLIP-seq
MIRT2548550	hsa-miR-3663-3p	CLIP-seq
MIRT2548551	hsa-miR-3670	CLIP-seq
MIRT2548552	hsa-miR-3673	CLIP-seq
MIRT1057127	hsa-miR-3678-3p	CLIP-seq
MIRT2548553	hsa-miR-3679-5p	CLIP-seq
MIRT2548554	hsa-miR-3684	CLIP-seq
MIRT1057113	hsa-miR-3919	CLIP-seq
MIRT1057096	hsa-miR-3924	CLIP-seq
MIRT2013037	hsa-miR-3941	CLIP-seq
MIRT2548555	hsa-miR-4271	CLIP-seq
MIRT1057114	hsa-miR-4275	CLIP-seq
MIRT1057097	hsa-miR-4319	CLIP-seq
MIRT2548556	hsa-miR-4468	CLIP-seq
MIRT1057115	hsa-miR-4522	CLIP-seq
MIRT1057128	hsa-miR-4539	CLIP-seq
MIRT2548557	hsa-miR-4642	CLIP-seq
MIRT2013039	hsa-miR-466	CLIP-seq
MIRT1057116	hsa-miR-4666-5p	CLIP-seq
MIRT2013040	hsa-miR-4672	CLIP-seq
MIRT2548558	hsa-miR-4676-5p	CLIP-seq
MIRT2548559	hsa-miR-4690-5p	CLIP-seq
MIRT2548560	hsa-miR-4711-5p	CLIP-seq
MIRT2548561	hsa-miR-4725-3p	CLIP-seq
MIRT2548562	hsa-miR-4725-5p	CLIP-seq
MIRT2548563	hsa-miR-4728-3p	CLIP-seq
MIRT1057117	hsa-miR-4731-3p	CLIP-seq
MIRT1057100	hsa-miR-4732-3p	CLIP-seq
MIRT1057118	hsa-miR-4756-3p	CLIP-seq
MIRT1057101	hsa-miR-4762-5p	CLIP-seq
MIRT1057102	hsa-miR-4765	CLIP-seq
MIRT1057119	hsa-miR-4771	CLIP-seq
MIRT1057120	hsa-miR-4801	CLIP-seq
MIRT1057129	hsa-miR-484	CLIP-seq
MIRT2548564	hsa-miR-504	CLIP-seq
MIRT1057121	hsa-miR-505	CLIP-seq
MIRT2548565	hsa-miR-507	CLIP-seq
MIRT2548566	hsa-miR-509-3p	CLIP-seq
MIRT2548567	hsa-miR-526b	CLIP-seq
MIRT2548568	hsa-miR-544b	CLIP-seq
MIRT2548569	hsa-miR-557	CLIP-seq
MIRT1057103	hsa-miR-568	CLIP-seq
MIRT2548570	hsa-miR-575	CLIP-seq
MIRT2548571	hsa-miR-578	CLIP-seq
MIRT2548572	hsa-miR-579	CLIP-seq
MIRT1057122	hsa-miR-590-3p	CLIP-seq
MIRT2548573	hsa-miR-604	CLIP-seq
MIRT1057123	hsa-miR-607	CLIP-seq
MIRT2548574	hsa-miR-613	CLIP-seq
MIRT2548575	hsa-miR-628-5p	CLIP-seq
MIRT2548576	hsa-miR-647	CLIP-seq
MIRT1057104	hsa-miR-670	CLIP-seq
MIRT1057130	hsa-miR-760	CLIP-seq
MIRT2548577	hsa-miR-767-5p	CLIP-seq
MIRT1057115	hsa-miR-4522	CLIP-seq
MIRT2548536	hsa-miR-1	CLIP-seq
MIRT1057105	hsa-miR-1184	CLIP-seq
MIRT2548537	hsa-miR-1185	CLIP-seq
MIRT1057106	hsa-miR-1205	CLIP-seq
MIRT1057092	hsa-miR-1245	CLIP-seq
MIRT1057093	hsa-miR-125a-5p	CLIP-seq
MIRT1057094	hsa-miR-125b	CLIP-seq
MIRT2548538	hsa-miR-1303	CLIP-seq
MIRT1057107	hsa-miR-142-3p	CLIP-seq
MIRT2548540	hsa-miR-206	CLIP-seq
MIRT2548541	hsa-miR-2278	CLIP-seq
MIRT1057124	hsa-miR-2467-3p	CLIP-seq
MIRT2548542	hsa-miR-29a	CLIP-seq
MIRT2548543	hsa-miR-29b	CLIP-seq
MIRT2548544	hsa-miR-29c	CLIP-seq
MIRT1057108	hsa-miR-3065-5p	CLIP-seq
MIRT1057125	hsa-miR-3155	CLIP-seq
MIRT1057126	hsa-miR-3155b	CLIP-seq
MIRT1057109	hsa-miR-3158-5p	CLIP-seq
MIRT1057110	hsa-miR-3166	CLIP-seq
MIRT2548547	hsa-miR-3177-3p	CLIP-seq
MIRT1057111	hsa-miR-330-3p	CLIP-seq
MIRT2548548	hsa-miR-3605-5p	CLIP-seq
MIRT1057112	hsa-miR-3606	CLIP-seq
MIRT2548549	hsa-miR-361-3p	CLIP-seq
MIRT2548550	hsa-miR-3663-3p	CLIP-seq
MIRT2548551	hsa-miR-3670	CLIP-seq
MIRT2548552	hsa-miR-3673	CLIP-seq
MIRT1057127	hsa-miR-3678-3p	CLIP-seq
MIRT2548553	hsa-miR-3679-5p	CLIP-seq
MIRT1057113	hsa-miR-3919	CLIP-seq
MIRT1057096	hsa-miR-3924	CLIP-seq
MIRT2013037	hsa-miR-3941	CLIP-seq
MIRT2548555	hsa-miR-4271	CLIP-seq
MIRT1057114	hsa-miR-4275	CLIP-seq
MIRT1057097	hsa-miR-4319	CLIP-seq
MIRT2548556	hsa-miR-4468	CLIP-seq
MIRT1057115	hsa-miR-4522	CLIP-seq
MIRT1057128	hsa-miR-4539	CLIP-seq
MIRT2548557	hsa-miR-4642	CLIP-seq
MIRT2013039	hsa-miR-466	CLIP-seq
MIRT1057116	hsa-miR-4666-5p	CLIP-seq
MIRT2013040	hsa-miR-4672	CLIP-seq
MIRT2548558	hsa-miR-4676-5p	CLIP-seq
MIRT2548559	hsa-miR-4690-5p	CLIP-seq
MIRT2548560	hsa-miR-4711-5p	CLIP-seq
MIRT2548561	hsa-miR-4725-3p	CLIP-seq
MIRT1057117	hsa-miR-4731-3p	CLIP-seq
MIRT1057100	hsa-miR-4732-3p	CLIP-seq
MIRT1057118	hsa-miR-4756-3p	CLIP-seq
MIRT1057101	hsa-miR-4762-5p	CLIP-seq
MIRT1057102	hsa-miR-4765	CLIP-seq
MIRT1057119	hsa-miR-4771	CLIP-seq
MIRT1057120	hsa-miR-4801	CLIP-seq
MIRT1057129	hsa-miR-484	CLIP-seq
MIRT1057121	hsa-miR-505	CLIP-seq
MIRT2548565	hsa-miR-507	CLIP-seq
MIRT2548566	hsa-miR-509-3p	CLIP-seq
MIRT2548567	hsa-miR-526b	CLIP-seq
MIRT2548568	hsa-miR-544b	CLIP-seq
MIRT2548569	hsa-miR-557	CLIP-seq
MIRT1057103	hsa-miR-568	CLIP-seq
MIRT2548570	hsa-miR-575	CLIP-seq
MIRT2548571	hsa-miR-578	CLIP-seq
MIRT2548572	hsa-miR-579	CLIP-seq
MIRT1057122	hsa-miR-590-3p	CLIP-seq
MIRT1057123	hsa-miR-607	CLIP-seq
MIRT2548574	hsa-miR-613	CLIP-seq
MIRT1057104	hsa-miR-670	CLIP-seq
MIRT1057130	hsa-miR-760	CLIP-seq
MIRT2548577	hsa-miR-767-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001525	Process	Angiogenesis	IEA
GO:0003713	Function	Transcription coactivator activity	TAS	9482853
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	10698937
GO:0005515	Function	Protein binding	IPI	15282309, 30614533
GO:0005634	Component	Nucleus	TAS	9482853
GO:0005635	Component	Nuclear envelope	IDA	15282309
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	IDA	15282309
GO:0005829	Component	Cytosol	IDA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	TAS	9482853
GO:0006915	Process	Apoptotic process	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016032	Process	Viral process	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0043066	Process	Negative regulation of apoptotic process	TAS	10611237
GO:0043068	Process	Positive regulation of programmed cell death	IDA	10698937
GO:0045765	Process	Regulation of angiogenesis	IDA	11313954
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	10698937
GO:0046777	Process	Protein autophosphorylation	IDA	10698937
GO:0051170	Process	Import into nucleus	IBA	21873635
GO:0051170	Process	Import into nucleus	IDA	15282309

Other IDs

• MIM: 605628
• HGNC: 16637
• e!Ensembl: ENSG00000109854

Protein

• UniProt ID: Q9BUP3
• Protein name: Protein HTATIP2 (30 kDa HIV-1 TAT-interacting protein) (HIV-1 TAT-interactive protein 2)
• Protein function: Represses translation by preventing reactivation of elongation factor eEF1A (By similarity). May also inhibit nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors (PubMed:15282309). Ha
• PDB: 2BKA
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13460	NAD_binding_10	25 → 214	NAD(P)H-binding	Domain

• Sequence:

  MAETEALSKLREDFRMQNKSVFILGASGETGRVLLKEILEQGLFSKVTLIGRRKLTFDEE
  AYKNVNQEVVDFEKLDDYASAFQGHDVGFCCLGTTRGKAGAEGFVRVDRDYVLKSAELAK
  AGGCKHFNLLSSKGADKSSNFLYLQVKGEVEAKVEELKFDRYSVFRPGVLLCDRQESRPG
  EWLVRKFFGSLPDSWASGHSVPVVTVVRAMLNNVVRPRDKQMELLENKAIHDLGKAHGSL
  KP

• Sequence length: 242

Associated diseases

Unknown
Disease name	Disease term	dbSNP ID	References
Liver carcinoma	Liver carcinoma		16799960