PROCR (protein C receptor)

Gene

• Entrez ID: 10544
• Gene name: Protein C receptor
• Gene symbol: PROCR
• Synonyms: CCCA, CCD41, EPCR
• Chromosome: 20
• Chromosome location: 20q11.22
• Summary: The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT019919	hsa-miR-375	Microarray	20215506
MIRT023818	hsa-miR-1-3p	Proteomics	18668040
MIRT037191	hsa-miR-877-3p	CLASH	23622248
MIRT1265035	hsa-miR-181a	CLIP-seq
MIRT1265036	hsa-miR-181b	CLIP-seq
MIRT1265037	hsa-miR-181c	CLIP-seq
MIRT1265038	hsa-miR-181d	CLIP-seq
MIRT1265039	hsa-miR-361-5p	CLIP-seq
MIRT1265040	hsa-miR-4262	CLIP-seq
MIRT1265041	hsa-miR-4477a	CLIP-seq
MIRT1265042	hsa-miR-4494	CLIP-seq
MIRT1265043	hsa-miR-499a-5p	CLIP-seq
MIRT1265044	hsa-miR-543	CLIP-seq
MIRT1265045	hsa-miR-577	CLIP-seq
MIRT1265046	hsa-miR-656	CLIP-seq
MIRT1265047	hsa-miR-889	CLIP-seq
MIRT1556847	hsa-miR-3692	CLIP-seq
MIRT2077894	hsa-miR-1228	CLIP-seq
MIRT2077895	hsa-miR-1237	CLIP-seq
MIRT2077896	hsa-miR-1255a	CLIP-seq
MIRT2077897	hsa-miR-1255b	CLIP-seq
MIRT2077898	hsa-miR-219-5p	CLIP-seq
MIRT2077899	hsa-miR-329	CLIP-seq
MIRT2077900	hsa-miR-330-3p	CLIP-seq
MIRT2077901	hsa-miR-3613-5p	CLIP-seq
MIRT2077902	hsa-miR-362-3p	CLIP-seq
MIRT2077903	hsa-miR-3691-5p	CLIP-seq
MIRT2077904	hsa-miR-409-3p	CLIP-seq
MIRT2077905	hsa-miR-4291	CLIP-seq
MIRT2077906	hsa-miR-4422	CLIP-seq
MIRT2077907	hsa-miR-4445	CLIP-seq
MIRT2077908	hsa-miR-4752	CLIP-seq
MIRT2077909	hsa-miR-4760-3p	CLIP-seq
MIRT2077910	hsa-miR-4782-3p	CLIP-seq
MIRT2077911	hsa-miR-508-3p	CLIP-seq
MIRT2077912	hsa-miR-545	CLIP-seq
MIRT2077913	hsa-miR-619	CLIP-seq
MIRT2077914	hsa-miR-642b	CLIP-seq
MIRT2601300	hsa-miR-1202	CLIP-seq
MIRT2077894	hsa-miR-1228	CLIP-seq
MIRT2077895	hsa-miR-1237	CLIP-seq
MIRT2077896	hsa-miR-1255a	CLIP-seq
MIRT2077897	hsa-miR-1255b	CLIP-seq
MIRT2601301	hsa-miR-125a-3p	CLIP-seq
MIRT2601302	hsa-miR-128	CLIP-seq
MIRT2601303	hsa-miR-136	CLIP-seq
MIRT2601304	hsa-miR-149	CLIP-seq
MIRT2601305	hsa-miR-1913	CLIP-seq
MIRT2601306	hsa-miR-204	CLIP-seq
MIRT2601307	hsa-miR-211	CLIP-seq
MIRT2601308	hsa-miR-2110	CLIP-seq
MIRT2077898	hsa-miR-219-5p	CLIP-seq
MIRT2601309	hsa-miR-2392	CLIP-seq
MIRT2601310	hsa-miR-27a	CLIP-seq
MIRT2601311	hsa-miR-27b	CLIP-seq
MIRT2601312	hsa-miR-3064-5p	CLIP-seq
MIRT2601313	hsa-miR-3074-5p	CLIP-seq
MIRT2601314	hsa-miR-3120-5p	CLIP-seq
MIRT2601315	hsa-miR-3145-5p	CLIP-seq
MIRT2601316	hsa-miR-3150a-3p	CLIP-seq
MIRT2601317	hsa-miR-3175	CLIP-seq
MIRT2601318	hsa-miR-3189-5p	CLIP-seq
MIRT2601319	hsa-miR-3194-5p	CLIP-seq
MIRT2601320	hsa-miR-324-3p	CLIP-seq
MIRT2077899	hsa-miR-329	CLIP-seq
MIRT2601321	hsa-miR-3605-5p	CLIP-seq
MIRT2077901	hsa-miR-3613-5p	CLIP-seq
MIRT2077902	hsa-miR-362-3p	CLIP-seq
MIRT2077903	hsa-miR-3691-5p	CLIP-seq
MIRT1556847	hsa-miR-3692	CLIP-seq
MIRT2601322	hsa-miR-3934	CLIP-seq
MIRT2601323	hsa-miR-3972	CLIP-seq
MIRT2077904	hsa-miR-409-3p	CLIP-seq
MIRT2601324	hsa-miR-4259	CLIP-seq
MIRT2601325	hsa-miR-4294	CLIP-seq
MIRT2601326	hsa-miR-4299	CLIP-seq
MIRT2601327	hsa-miR-4443	CLIP-seq
MIRT2077907	hsa-miR-4445	CLIP-seq
MIRT2601328	hsa-miR-4446-5p	CLIP-seq
MIRT2601329	hsa-miR-4456	CLIP-seq
MIRT2601330	hsa-miR-4640-5p	CLIP-seq
MIRT2601331	hsa-miR-4694-5p	CLIP-seq
MIRT2601332	hsa-miR-4722-3p	CLIP-seq
MIRT2601333	hsa-miR-4726-5p	CLIP-seq
MIRT2601334	hsa-miR-4738-3p	CLIP-seq
MIRT2077908	hsa-miR-4752	CLIP-seq
MIRT2601335	hsa-miR-4755-5p	CLIP-seq
MIRT2601336	hsa-miR-4758-3p	CLIP-seq
MIRT2601337	hsa-miR-4778-5p	CLIP-seq
MIRT2601338	hsa-miR-4780	CLIP-seq
MIRT2077910	hsa-miR-4782-3p	CLIP-seq
MIRT2601339	hsa-miR-4794	CLIP-seq
MIRT2601340	hsa-miR-483-3p	CLIP-seq
MIRT2077911	hsa-miR-508-3p	CLIP-seq
MIRT2601341	hsa-miR-511	CLIP-seq
MIRT2601342	hsa-miR-513a-5p	CLIP-seq
MIRT2601343	hsa-miR-516a-3p	CLIP-seq
MIRT2601344	hsa-miR-548q	CLIP-seq
MIRT2601345	hsa-miR-614	CLIP-seq
MIRT2077913	hsa-miR-619	CLIP-seq
MIRT2601346	hsa-miR-623	CLIP-seq
MIRT2077914	hsa-miR-642b	CLIP-seq
MIRT2601347	hsa-miR-659	CLIP-seq
MIRT2601348	hsa-miR-668	CLIP-seq
MIRT2601349	hsa-miR-764	CLIP-seq
MIRT2601350	hsa-miR-765	CLIP-seq
MIRT2601351	hsa-miR-885-5p	CLIP-seq
MIRT2601352	hsa-miR-887	CLIP-seq
MIRT2601353	hsa-miR-9	CLIP-seq
MIRT2601354	hsa-miR-939	CLIP-seq
MIRT2601300	hsa-miR-1202	CLIP-seq
MIRT2077894	hsa-miR-1228	CLIP-seq
MIRT2077895	hsa-miR-1237	CLIP-seq
MIRT2077896	hsa-miR-1255a	CLIP-seq
MIRT2077897	hsa-miR-1255b	CLIP-seq
MIRT2601301	hsa-miR-125a-3p	CLIP-seq
MIRT2601302	hsa-miR-128	CLIP-seq
MIRT2688654	hsa-miR-1290	CLIP-seq
MIRT2601303	hsa-miR-136	CLIP-seq
MIRT2601304	hsa-miR-149	CLIP-seq
MIRT2601305	hsa-miR-1913	CLIP-seq
MIRT2601306	hsa-miR-204	CLIP-seq
MIRT2601307	hsa-miR-211	CLIP-seq
MIRT2601308	hsa-miR-2110	CLIP-seq
MIRT2077898	hsa-miR-219-5p	CLIP-seq
MIRT2601309	hsa-miR-2392	CLIP-seq
MIRT2601310	hsa-miR-27a	CLIP-seq
MIRT2601311	hsa-miR-27b	CLIP-seq
MIRT2601312	hsa-miR-3064-5p	CLIP-seq
MIRT2688655	hsa-miR-3074-3p	CLIP-seq
MIRT2601313	hsa-miR-3074-5p	CLIP-seq
MIRT2601314	hsa-miR-3120-5p	CLIP-seq
MIRT2688656	hsa-miR-3127-3p	CLIP-seq
MIRT2601315	hsa-miR-3145-5p	CLIP-seq
MIRT2601316	hsa-miR-3150a-3p	CLIP-seq
MIRT2688657	hsa-miR-3160-3p	CLIP-seq
MIRT2688658	hsa-miR-3167	CLIP-seq
MIRT2601317	hsa-miR-3175	CLIP-seq
MIRT2688659	hsa-miR-3184	CLIP-seq
MIRT2601318	hsa-miR-3189-5p	CLIP-seq
MIRT2601319	hsa-miR-3194-5p	CLIP-seq
MIRT2601320	hsa-miR-324-3p	CLIP-seq
MIRT2077899	hsa-miR-329	CLIP-seq
MIRT2601321	hsa-miR-3605-5p	CLIP-seq
MIRT2077901	hsa-miR-3613-5p	CLIP-seq
MIRT2077902	hsa-miR-362-3p	CLIP-seq
MIRT2688660	hsa-miR-3676	CLIP-seq
MIRT2688661	hsa-miR-3682-5p	CLIP-seq
MIRT2077903	hsa-miR-3691-5p	CLIP-seq
MIRT1556847	hsa-miR-3692	CLIP-seq
MIRT2601322	hsa-miR-3934	CLIP-seq
MIRT2601323	hsa-miR-3972	CLIP-seq
MIRT2077904	hsa-miR-409-3p	CLIP-seq
MIRT2688662	hsa-miR-423-5p	CLIP-seq
MIRT2601324	hsa-miR-4259	CLIP-seq
MIRT2601325	hsa-miR-4294	CLIP-seq
MIRT2601326	hsa-miR-4299	CLIP-seq
MIRT2688663	hsa-miR-4303	CLIP-seq
MIRT2601327	hsa-miR-4443	CLIP-seq
MIRT2077907	hsa-miR-4445	CLIP-seq
MIRT2601328	hsa-miR-4446-5p	CLIP-seq
MIRT2601329	hsa-miR-4456	CLIP-seq
MIRT2688664	hsa-miR-4487	CLIP-seq
MIRT2601330	hsa-miR-4640-5p	CLIP-seq
MIRT2688665	hsa-miR-4649-3p	CLIP-seq
MIRT2688666	hsa-miR-4662a-3p	CLIP-seq
MIRT2601331	hsa-miR-4694-5p	CLIP-seq
MIRT2601332	hsa-miR-4722-3p	CLIP-seq
MIRT2601333	hsa-miR-4726-5p	CLIP-seq
MIRT2601334	hsa-miR-4738-3p	CLIP-seq
MIRT2077908	hsa-miR-4752	CLIP-seq
MIRT2601335	hsa-miR-4755-5p	CLIP-seq
MIRT2601336	hsa-miR-4758-3p	CLIP-seq
MIRT2688667	hsa-miR-4778-3p	CLIP-seq
MIRT2601337	hsa-miR-4778-5p	CLIP-seq
MIRT2601338	hsa-miR-4780	CLIP-seq
MIRT2077910	hsa-miR-4782-3p	CLIP-seq
MIRT2601339	hsa-miR-4794	CLIP-seq
MIRT2601340	hsa-miR-483-3p	CLIP-seq
MIRT2077911	hsa-miR-508-3p	CLIP-seq
MIRT2601341	hsa-miR-511	CLIP-seq
MIRT2601342	hsa-miR-513a-5p	CLIP-seq
MIRT2601343	hsa-miR-516a-3p	CLIP-seq
MIRT2601344	hsa-miR-548q	CLIP-seq
MIRT2688668	hsa-miR-558	CLIP-seq
MIRT2601345	hsa-miR-614	CLIP-seq
MIRT2077913	hsa-miR-619	CLIP-seq
MIRT2601346	hsa-miR-623	CLIP-seq
MIRT2077914	hsa-miR-642b	CLIP-seq
MIRT2601347	hsa-miR-659	CLIP-seq
MIRT2601348	hsa-miR-668	CLIP-seq
MIRT2601349	hsa-miR-764	CLIP-seq
MIRT2601350	hsa-miR-765	CLIP-seq
MIRT2688669	hsa-miR-876-5p	CLIP-seq
MIRT2601351	hsa-miR-885-5p	CLIP-seq
MIRT2601352	hsa-miR-887	CLIP-seq
MIRT2688670	hsa-miR-890	CLIP-seq
MIRT2601353	hsa-miR-9	CLIP-seq
MIRT2601354	hsa-miR-939	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	17299037, 20826780
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0005813	Component	Centrosome	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	TAS	7929370
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0007596	Process	Blood coagulation	TAS
GO:0009986	Component	Cell surface	HDA	19581412
GO:0038023	Function	Signaling receptor activity	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0050819	Process	Negative regulation of coagulation	IBA	21873635
GO:0050819	Process	Negative regulation of coagulation	IMP	19696402
GO:0070062	Component	Extracellular exosome	HDA	23533145

Other IDs

• MIM: 600646
• HGNC: 9452
• e!Ensembl: ENSG00000101000

Protein

• UniProt ID: Q9UNN8
• Protein name: Endothelial protein C receptor (Activated protein C receptor) (APC receptor) (Endothelial cell protein C receptor) (CD antigen CD201)
• Protein function: Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation.
• PDB: 1L8J, 1LQV, 3JTC, 4V3D, 4V3E, 6SNY, 7OKS, 7OKT, 7OKU, 7OKV, 7Q5D, 8C44
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF16497	MHC_I_3	1 → 199	MHC-I family domain	Domain

• Sequence:

  MLTTLLPILLLSGWAFCSQDASDGLQRLHMLQISYFRDPYHVWYQGNASLGGHLTHVLEG
  PDTNTTIIQLQPLQEPESWARTQSGLQSYLLQFHGLVRLVHQERTLAFPLTIRCFLGCEL
  PPEGSRAHVFFEVAVNGSSFVSFRPERALWQADTQVTSGVVTFTLQQLNAYNRTRYELRE
  FLEDTCVQYVQKHISAENTKGSQTSRSYTSLVLGVLVGSFIIAGVAVGIFLCTGGRRC

• Sequence length: 238

Pathways

KEGG:

Complement and coagulation cascades

Reactome:

Common Pathway of Fibrin Clot Formation
Cell surface interactions at the vascular wall

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Coronary artery disease	Coronary Artery Disease	rs137852988, rs121918313, rs121918529, rs121918531, rs137852340, rs405509, rs1555800701, rs1215189537	29212778, 28530674, 23202125

Unknown
Disease name	Disease term	dbSNP ID	References
Coronary arteriosclerosis	Coronary Arteriosclerosis		28530674
Coronary heart disease	Coronary heart disease	rs9289231, rs281864746	21966275
Ischemic stroke	Ischemic stroke	rs6025, rs1799963, rs1799983	26908601
Non rare thrombophilia	NON RARE IN EUROPE: Non rare thrombophilia
Stroke	Cerebrovascular accident		26908601
Thrombosis	Deep Vein Thrombosis		26908601
Ulcerative colitis	Ulcerative Colitis		26192919, 23128233