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CEBPD (CCAAT enhancer binding protein delta)

Gene

1052

CCAAT enhancer binding protein delta

CEBPD

C/EBP-delta, CELF, CRP3, NF-IL6-beta

8q11.21

The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulati

Show/Hide all(215)

miRTarBase ID	miRNA	Experiments	Reference
MIRT027592	hsa-miR-98-5p	Microarray	19088304
MIRT713044	hsa-miR-4999-3p	HITS-CLIP	19536157
MIRT713043	hsa-miR-455-3p	HITS-CLIP	19536157
MIRT713042	hsa-miR-6516-5p	HITS-CLIP	19536157
MIRT713044	hsa-miR-4999-3p	HITS-CLIP	19536157
MIRT713043	hsa-miR-455-3p	HITS-CLIP	19536157
MIRT713042	hsa-miR-6516-5p	HITS-CLIP	19536157
MIRT643978	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT453703	hsa-miR-203b-5p	PAR-CLIP	23592263
MIRT453702	hsa-miR-6718-5p	PAR-CLIP	23592263
MIRT453701	hsa-miR-140-5p	PAR-CLIP	23592263
MIRT453700	hsa-miR-4645-5p	PAR-CLIP	23592263
MIRT453699	hsa-miR-4673	PAR-CLIP	23592263
MIRT453698	hsa-miR-6814-3p	PAR-CLIP	23592263
MIRT453697	hsa-miR-6872-5p	PAR-CLIP	23592263
MIRT453696	hsa-miR-3137	PAR-CLIP	23592263
MIRT453695	hsa-miR-103a-2-5p	PAR-CLIP	23592263
MIRT453694	hsa-miR-323a-5p	PAR-CLIP	23592263
MIRT453693	hsa-miR-876-3p	PAR-CLIP	23592263
MIRT453692	hsa-miR-4727-3p	PAR-CLIP	23592263
MIRT453691	hsa-miR-4460	PAR-CLIP	23592263
MIRT453690	hsa-miR-3591-5p	PAR-CLIP	23592263
MIRT453689	hsa-miR-4426	PAR-CLIP	23592263
MIRT453688	hsa-miR-4647	PAR-CLIP	23592263
MIRT453687	hsa-miR-4662b	PAR-CLIP	23592263
MIRT453686	hsa-miR-3668	PAR-CLIP	23592263
MIRT453684	hsa-miR-4709-5p	PAR-CLIP	23592263
MIRT453685	hsa-miR-4433a-3p	PAR-CLIP	23592263
MIRT453683	hsa-miR-421	PAR-CLIP	23592263
MIRT054423	hsa-miR-95-3p	qRT-PCR, Western blot, Luciferase reporter assay	26165303
MIRT713044	hsa-miR-4999-3p	HITS-CLIP	19536157
MIRT713043	hsa-miR-455-3p	HITS-CLIP	19536157
MIRT713042	hsa-miR-6516-5p	HITS-CLIP	19536157
MIRT713044	hsa-miR-4999-3p	HITS-CLIP	19536157
MIRT713043	hsa-miR-455-3p	HITS-CLIP	19536157
MIRT713042	hsa-miR-6516-5p	HITS-CLIP	19536157
MIRT643978	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT453703	hsa-miR-203b-5p	PAR-CLIP	23592263
MIRT453702	hsa-miR-6718-5p	PAR-CLIP	23592263
MIRT453701	hsa-miR-140-5p	PAR-CLIP	23592263
MIRT453700	hsa-miR-4645-5p	PAR-CLIP	23592263
MIRT453699	hsa-miR-4673	PAR-CLIP	23592263
MIRT453698	hsa-miR-6814-3p	PAR-CLIP	23592263
MIRT453697	hsa-miR-6872-5p	PAR-CLIP	23592263
MIRT453696	hsa-miR-3137	PAR-CLIP	23592263
MIRT453695	hsa-miR-103a-2-5p	PAR-CLIP	23592263
MIRT453694	hsa-miR-323a-5p	PAR-CLIP	23592263
MIRT453693	hsa-miR-876-3p	PAR-CLIP	23592263
MIRT453692	hsa-miR-4727-3p	PAR-CLIP	23592263
MIRT453691	hsa-miR-4460	PAR-CLIP	23592263
MIRT453690	hsa-miR-3591-5p	PAR-CLIP	23592263
MIRT453689	hsa-miR-4426	PAR-CLIP	23592263
MIRT453688	hsa-miR-4647	PAR-CLIP	23592263
MIRT453687	hsa-miR-4662b	PAR-CLIP	23592263
MIRT453686	hsa-miR-3668	PAR-CLIP	23592263
MIRT453684	hsa-miR-4709-5p	PAR-CLIP	23592263
MIRT453685	hsa-miR-4433a-3p	PAR-CLIP	23592263
MIRT453683	hsa-miR-421	PAR-CLIP	23592263
MIRT883307	hsa-let-7a	CLIP-seq
MIRT883308	hsa-let-7b	CLIP-seq
MIRT883309	hsa-let-7c	CLIP-seq
MIRT883310	hsa-let-7d	CLIP-seq
MIRT883311	hsa-let-7e	CLIP-seq
MIRT883312	hsa-let-7f	CLIP-seq
MIRT883313	hsa-let-7g	CLIP-seq
MIRT883314	hsa-let-7i	CLIP-seq
MIRT883315	hsa-miR-1184	CLIP-seq
MIRT883316	hsa-miR-1207-5p	CLIP-seq
MIRT883317	hsa-miR-1231	CLIP-seq
MIRT883318	hsa-miR-1238	CLIP-seq
MIRT883319	hsa-miR-1283	CLIP-seq
MIRT883320	hsa-miR-149	CLIP-seq
MIRT883321	hsa-miR-202	CLIP-seq
MIRT883322	hsa-miR-22	CLIP-seq
MIRT883323	hsa-miR-3064-5p	CLIP-seq
MIRT883324	hsa-miR-3115	CLIP-seq
MIRT883325	hsa-miR-3178	CLIP-seq
MIRT883326	hsa-miR-323-5p	CLIP-seq
MIRT883327	hsa-miR-338-5p	CLIP-seq
MIRT883328	hsa-miR-3545-5p	CLIP-seq
MIRT883329	hsa-miR-3615	CLIP-seq
MIRT883330	hsa-miR-4264	CLIP-seq
MIRT883331	hsa-miR-4288	CLIP-seq
MIRT883332	hsa-miR-4418	CLIP-seq
MIRT883333	hsa-miR-4436b-3p	CLIP-seq
MIRT883334	hsa-miR-4458	CLIP-seq
MIRT883335	hsa-miR-4500	CLIP-seq
MIRT883336	hsa-miR-4649-3p	CLIP-seq
MIRT883337	hsa-miR-4663	CLIP-seq
MIRT883338	hsa-miR-4685-5p	CLIP-seq
MIRT883339	hsa-miR-4711-5p	CLIP-seq
MIRT883340	hsa-miR-4738-3p	CLIP-seq
MIRT883341	hsa-miR-4763-3p	CLIP-seq
MIRT883342	hsa-miR-4766-5p	CLIP-seq
MIRT883343	hsa-miR-4768-5p	CLIP-seq
MIRT883344	hsa-miR-4794	CLIP-seq
MIRT883345	hsa-miR-509-3-5p	CLIP-seq
MIRT883346	hsa-miR-509-5p	CLIP-seq
MIRT883347	hsa-miR-520d-5p	CLIP-seq
MIRT883348	hsa-miR-524-5p	CLIP-seq
MIRT883349	hsa-miR-572	CLIP-seq
MIRT883350	hsa-miR-604	CLIP-seq
MIRT883351	hsa-miR-622	CLIP-seq
MIRT883352	hsa-miR-627	CLIP-seq
MIRT883353	hsa-miR-628-5p	CLIP-seq
MIRT883354	hsa-miR-632	CLIP-seq
MIRT883355	hsa-miR-647	CLIP-seq
MIRT883356	hsa-miR-760	CLIP-seq
MIRT883357	hsa-miR-924	CLIP-seq
MIRT883358	hsa-miR-941	CLIP-seq
MIRT883359	hsa-miR-942	CLIP-seq
MIRT883360	hsa-miR-98	CLIP-seq
MIRT883326	hsa-miR-323-5p	CLIP-seq
MIRT883328	hsa-miR-3545-5p	CLIP-seq
MIRT883329	hsa-miR-3615	CLIP-seq
MIRT883343	hsa-miR-4768-5p	CLIP-seq
MIRT883347	hsa-miR-520d-5p	CLIP-seq
MIRT883348	hsa-miR-524-5p	CLIP-seq
MIRT883359	hsa-miR-942	CLIP-seq
MIRT1961896	hsa-miR-105	CLIP-seq
MIRT883315	hsa-miR-1184	CLIP-seq
MIRT883316	hsa-miR-1207-5p	CLIP-seq
MIRT883317	hsa-miR-1231	CLIP-seq
MIRT883318	hsa-miR-1238	CLIP-seq
MIRT883319	hsa-miR-1283	CLIP-seq
MIRT883320	hsa-miR-149	CLIP-seq
MIRT883323	hsa-miR-3064-5p	CLIP-seq
MIRT883325	hsa-miR-3178	CLIP-seq
MIRT883327	hsa-miR-338-5p	CLIP-seq
MIRT1961897	hsa-miR-3671	CLIP-seq
MIRT883330	hsa-miR-4264	CLIP-seq
MIRT883331	hsa-miR-4288	CLIP-seq
MIRT883332	hsa-miR-4418	CLIP-seq
MIRT883333	hsa-miR-4436b-3p	CLIP-seq
MIRT883338	hsa-miR-4685-5p	CLIP-seq
MIRT883340	hsa-miR-4738-3p	CLIP-seq
MIRT883341	hsa-miR-4763-3p	CLIP-seq
MIRT883342	hsa-miR-4766-5p	CLIP-seq
MIRT883344	hsa-miR-4794	CLIP-seq
MIRT883345	hsa-miR-509-3-5p	CLIP-seq
MIRT883346	hsa-miR-509-5p	CLIP-seq
MIRT883347	hsa-miR-520d-5p	CLIP-seq
MIRT883348	hsa-miR-524-5p	CLIP-seq
MIRT883349	hsa-miR-572	CLIP-seq
MIRT1961898	hsa-miR-600	CLIP-seq
MIRT883350	hsa-miR-604	CLIP-seq
MIRT1961899	hsa-miR-607	CLIP-seq
MIRT883351	hsa-miR-622	CLIP-seq
MIRT883354	hsa-miR-632	CLIP-seq
MIRT883355	hsa-miR-647	CLIP-seq
MIRT883356	hsa-miR-760	CLIP-seq
MIRT883358	hsa-miR-941	CLIP-seq
MIRT883307	hsa-let-7a	CLIP-seq
MIRT883308	hsa-let-7b	CLIP-seq
MIRT883309	hsa-let-7c	CLIP-seq
MIRT883310	hsa-let-7d	CLIP-seq
MIRT883311	hsa-let-7e	CLIP-seq
MIRT883312	hsa-let-7f	CLIP-seq
MIRT883313	hsa-let-7g	CLIP-seq
MIRT883314	hsa-let-7i	CLIP-seq
MIRT883316	hsa-miR-1207-5p	CLIP-seq
MIRT883321	hsa-miR-202	CLIP-seq
MIRT883322	hsa-miR-22	CLIP-seq
MIRT883324	hsa-miR-3115	CLIP-seq
MIRT883325	hsa-miR-3178	CLIP-seq
MIRT883326	hsa-miR-323-5p	CLIP-seq
MIRT883328	hsa-miR-3545-5p	CLIP-seq
MIRT883329	hsa-miR-3615	CLIP-seq
MIRT883333	hsa-miR-4436b-3p	CLIP-seq
MIRT883334	hsa-miR-4458	CLIP-seq
MIRT883335	hsa-miR-4500	CLIP-seq
MIRT883336	hsa-miR-4649-3p	CLIP-seq
MIRT883338	hsa-miR-4685-5p	CLIP-seq
MIRT883339	hsa-miR-4711-5p	CLIP-seq
MIRT883341	hsa-miR-4763-3p	CLIP-seq
MIRT883343	hsa-miR-4768-5p	CLIP-seq
MIRT883359	hsa-miR-942	CLIP-seq
MIRT883360	hsa-miR-98	CLIP-seq
MIRT2427303	hsa-miR-1183	CLIP-seq
MIRT883317	hsa-miR-1231	CLIP-seq
MIRT883318	hsa-miR-1238	CLIP-seq
MIRT883319	hsa-miR-1283	CLIP-seq
MIRT2427304	hsa-miR-200b	CLIP-seq
MIRT2427305	hsa-miR-200c	CLIP-seq
MIRT883322	hsa-miR-22	CLIP-seq
MIRT2427306	hsa-miR-3163	CLIP-seq
MIRT883327	hsa-miR-338-5p	CLIP-seq
MIRT2427307	hsa-miR-3607-3p	CLIP-seq
MIRT2427308	hsa-miR-3609	CLIP-seq
MIRT883330	hsa-miR-4264	CLIP-seq
MIRT883331	hsa-miR-4288	CLIP-seq
MIRT2427309	hsa-miR-429	CLIP-seq
MIRT2427310	hsa-miR-4433	CLIP-seq
MIRT883339	hsa-miR-4711-5p	CLIP-seq
MIRT883342	hsa-miR-4766-5p	CLIP-seq
MIRT883347	hsa-miR-520d-5p	CLIP-seq
MIRT883348	hsa-miR-524-5p	CLIP-seq
MIRT2427311	hsa-miR-548ah	CLIP-seq
MIRT2427312	hsa-miR-548c-3p	CLIP-seq
MIRT2427313	hsa-miR-548t	CLIP-seq
MIRT883351	hsa-miR-622	CLIP-seq
MIRT883354	hsa-miR-632	CLIP-seq
MIRT2427314	hsa-miR-889	CLIP-seq
MIRT883315	hsa-miR-1184	CLIP-seq
MIRT883320	hsa-miR-149	CLIP-seq
MIRT883323	hsa-miR-3064-5p	CLIP-seq
MIRT883332	hsa-miR-4418	CLIP-seq
MIRT883340	hsa-miR-4738-3p	CLIP-seq
MIRT883344	hsa-miR-4794	CLIP-seq
MIRT883345	hsa-miR-509-3-5p	CLIP-seq
MIRT883346	hsa-miR-509-5p	CLIP-seq
MIRT883350	hsa-miR-604	CLIP-seq
MIRT883355	hsa-miR-647	CLIP-seq
MIRT883356	hsa-miR-760	CLIP-seq
MIRT883358	hsa-miR-941	CLIP-seq

Show/Hide all(13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IEA
GO:0005515	Function	Protein binding	IPI	20102225, 20805509
GO:0005654	Component	Nucleoplasm	TAS
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0006366	Process	Transcription by RNA polymerase II	TAS	8314590
GO:0019221	Process	Cytokine-mediated signaling pathway	TAS
GO:0045595	Process	Regulation of cell differentiation	IBA	21873635
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

MIM	HGNC	e!Ensembl
116898	1835	ENSG00000221869

Protein

UniProt ID

P49716

Protein name

CCAAT/enhancer-binding protein delta (C/EBP delta) (Nuclear factor NF-IL6-beta) (NF-IL6-beta)

Protein function

Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers (PubMed:16397300). Important transcription factor regulating the expression of

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07716	bZIP_2	190 → 243	Basic region leucine zipper	Coiled-coil

Sequence

MSAALFSLDGPARGAPWPAEPAPFYEPGRAGKPGRGAEPGALGEPGAAAPAMYDDESAID
FSAYIDSMAAVPTLELCHDELFADLFNSNHKAGGAGPLELLPGGPARPLGPGPAAPRLLK
REPDWGDGDAPGSLLPAQVAACAQTVVSLAAAGQPTPPTSPEPPRSSPRQTPAPGPAREK
SAGKRGPDRGSPEYRQRRERNNIAVRKSRDKAKRRNQEMQQKLVELSAENEKLHQRVEQL
TRDLAGLRQFFKQLPSPPFLPAAGTADCR

Sequence length

269

Interactions

View interactions

	Reactome
			Interleukin-4 and Interleukin-13 signaling HCMV Late Events

Associated diseases

Show/Hide Causal Diseases (1)

Causal
Disease name	Disease term	dbSNP ID	References
Leukemia	Leukemia, Myelocytic, Acute, Acute Myeloid Leukemia (AML-M2)	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297, rs11978267, rs4132601	17234736

Show/Hide Unknown Diseases (6)

Unknown
Disease name	Disease term	dbSNP ID	References
Liver carcinoma	Liver carcinoma		14563831
Macroprolactinoma	Macroprolactinoma		21980073
Microprolactinoma	Microprolactinoma		21980073
Myeloid leukemia	Acute Myeloid Leukemia, M1		17234736
Myocardial ischemia	Myocardial Ischemia		16214533
Prolactinoma	Prolactinoma		21980073

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