MYBBP1A (MYB binding protein 1a)

Gene

• Entrez ID: 10514
• Gene name: MYB binding protein 1a
• Gene symbol: MYBBP1A
• Synonyms: P160, PAP2, Pol5
• Chromosome: 17
• Chromosome location: 17p13.2
• Summary: This gene encodes a nucleolar transcriptional regulator that was first identified by its ability to bind specifically to the Myb proto-oncogene protein. The encoded protein is thought to play a role in many cellular processes including response to nucleol

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT027438	hsa-miR-98-5p	Microarray	19088304
MIRT029101	hsa-miR-26b-5p	Microarray	19088304
MIRT049640	hsa-miR-92a-3p	CLASH	23622248
MIRT047122	hsa-miR-183-5p	CLASH	23622248
MIRT043518	hsa-miR-331-3p	CLASH	23622248
MIRT041453	hsa-miR-193b-3p	CLASH	23622248
MIRT041453	hsa-miR-193b-3p	CLASH	23622248
MIRT038652	hsa-miR-30b-3p	CLASH	23622248
MIRT496504	hsa-miR-3186-5p	PAR-CLIP	22291592
MIRT496504	hsa-miR-3186-5p	PAR-CLIP	22291592
MIRT1167466	hsa-miR-1184	CLIP-seq
MIRT1167467	hsa-miR-1228	CLIP-seq
MIRT1167468	hsa-miR-1291	CLIP-seq
MIRT1167469	hsa-miR-3130-3p	CLIP-seq
MIRT1167470	hsa-miR-3150a-3p	CLIP-seq
MIRT1167471	hsa-miR-3175	CLIP-seq
MIRT1167472	hsa-miR-3620	CLIP-seq
MIRT1167473	hsa-miR-3649	CLIP-seq
MIRT1167474	hsa-miR-4254	CLIP-seq
MIRT1167475	hsa-miR-4292	CLIP-seq
MIRT1167476	hsa-miR-4308	CLIP-seq
MIRT1167477	hsa-miR-4651	CLIP-seq
MIRT1167478	hsa-miR-4655-5p	CLIP-seq
MIRT1167479	hsa-miR-4690-3p	CLIP-seq
MIRT1167480	hsa-miR-4763-5p	CLIP-seq
MIRT1167481	hsa-miR-4787-5p	CLIP-seq
MIRT1167482	hsa-miR-4793-3p	CLIP-seq
MIRT1167483	hsa-miR-491-5p	CLIP-seq
MIRT1167484	hsa-miR-593	CLIP-seq
MIRT1167485	hsa-miR-608	CLIP-seq
MIRT1167486	hsa-miR-885-3p	CLIP-seq
MIRT1167487	hsa-miR-939	CLIP-seq
MIRT1167468	hsa-miR-1291	CLIP-seq
MIRT2048360	hsa-miR-328	CLIP-seq
MIRT1167474	hsa-miR-4254	CLIP-seq
MIRT1167476	hsa-miR-4308	CLIP-seq
MIRT1167469	hsa-miR-3130-3p	CLIP-seq
MIRT2277212	hsa-miR-4714-3p	CLIP-seq
MIRT2277213	hsa-miR-767-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001649	Process	Osteoblast differentiation	HDA	16210410
GO:0003714	Function	Transcription corepressor activity	IBA	21873635
GO:0003714	Function	Transcription corepressor activity	ISS
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0005634	Component	Nucleus	IDA	21471221
GO:0005634	Component	Nucleus	ISS
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IBA	21873635
GO:0005730	Component	Nucleolus	IDA	21471221
GO:0005730	Component	Nucleolus	ISS
GO:0005737	Component	Cytoplasm	ISS
GO:0006355	Process	Regulation of transcription, DNA-templated	TAS	10644447
GO:0008134	Function	Transcription factor binding	IEA
GO:0016020	Component	Membrane	HDA	16210410, 19946888
GO:0022904	Process	Respiratory electron transport chain	IEA
GO:0032922	Process	Circadian regulation of gene expression	ISS
GO:0042149	Process	Cellular response to glucose starvation	IDA	21471221
GO:0042254	Process	Ribosome biogenesis	IEA
GO:0042564	Component	NLS-dependent protein nuclear import complex	ISS
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA
GO:0043565	Function	Sequence-specific DNA binding	IBA	21873635
GO:0045815	Process	Positive regulation of gene expression, epigenetic	TAS
GO:0045892	Process	Negative regulation of transcription, DNA-templated	ISS
GO:0070888	Function	E-box binding	IEA
GO:0071158	Process	Positive regulation of cell cycle arrest	IMP	21471221
GO:0072332	Process	Intrinsic apoptotic signaling pathway by p53 class mediator	IMP	21471221
GO:2000210	Process	Positive regulation of anoikis	IMP	23388179

Other IDs

• MIM: 604885
• HGNC: 7546
• e!Ensembl: ENSG00000132382

Protein

• UniProt ID: Q9BQG0
• Protein name: Myb-binding protein 1A
• Protein function: May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity). Acts as a corepresso
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF04931	DNA_pol_phi	72 → 836	DNA polymerase phi	Family

• Sequence:

  MESRDPAQPMSPGEATQSGARPADRYGLLKHSREFLDFFWDIAKPEQETRLAATEKLLEY
  LRGRPKGSEMKYALKRLITGLGVGRETARPCYSLALAQLLQSFEDLPLCSILQQIQEKYD
  LHQVKKAMLRPALFANLFGVLALFQSGRLVKDQEALMKSVKLLQALAQYQNHLQEQPRKA
  LVDILSEVSKATLQEILPEVLKADLNIILSSPEQLELFLLAQQKVPSKLKKLVGSVNLFS
  DENVPRLVNVLKMAASSVKKDRKLPAIALDLLRLALKEDKFPRFWKEVVEQGLLKMQFWP
  ASYLCFRLLGAALPLLTKEQLHLVMQGDVIRHYGEHVCTAKLPKQFKFAPEMDDYVGTFL
  EGCQDDPERQLAVLVAFSSVTNQGLPVTPTFWRVVRFLSPPALQGYVAWLRAMFLQPDLD
  SLVDFSTNNQKKAQDSSLHMPERAVFRLRKWIIFRLVSIVDSLHLEMEEALTEQVARFCL
  FHSFFVTKKPTSQIPETKHPFSFPLENQAREAVSSAFFSLLQTLSTQFKQAPGQTQGGQP
  WTYHLVQFADLLLNHSHNVTTVTPFTAQQRQAWDRMLQTLKELEAHSAEARAAAFQHLLL
  LVGIHLLKSPAESCDLLGDIQTCIRKSLGEKPRRSRTKTIDPQEPPWVEVLVEILLALLA
  QPSHLMRQVARSVFGHICSHLTPRALQLILDVLNPETSEDENDRVVVTDDSDERRLKGAE
  DKSEEGEDNRSSESEEESEGEESEEEERDGDVDQGFREQLMTVLQAGKALGGEDSENEEE
  LGDEAMMALDQSLASLFAEQKLRIQARRDEKNKLQKEKALRRDFQIRVLDLVEVLVTKQP
  ENALVLELLEPLLSIIRRSLRSSSSKQEQDLLHKTARIFTHHLCRARRYCHDLGERAGAL
  HAQVERLVQQAGRQPDSPTALYHFNASLYLLRVLKGNTAEGCVHETQEKQKAGTDPSHMP
  TGPQAASCLDLNLVTRVYSTALSSFLTKRNSPLTVPMFLSLFSRHPVLCQSLLPILVQHI
  TGPVRPRHQACLLLQKTLSMREVRSCFEDPEWKQLMGQVLAKVTENLRVLGEAQTKAQHQ
  QALSSLELLNVLFRTCKHEKLTLDLTVLLGVLQGQQQSLQQGAHSTGSSRLHDLYWQAMK
  TLGVQRPKLEKKDAKEIPSATQSPISKKRKKKGFLPETKKRKKRKSEDGTPAEDGTPAAT
  GGSQPPSMGRKKRNRTKAKVPAQANGTPTTKSPAPGAPTRSPSTPAKSPKLQKKNQKPSQ
  VNGAPGSPTEPAGQKQHQKALPKKGVLGKSPLSALARKKARLSLVIRSPSLLQSGAKKKA
  QVRKAGKP

• Sequence length: 1328

Pathways

Reactome:

B-WICH complex positively regulates rRNA expression

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	29610475

Unknown
Disease name	Disease term	dbSNP ID	References
Prostatic neoplasms	Prostatic Neoplasms		29610475