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CEBPB (CCAAT enhancer binding protein beta)

Gene

1051

CCAAT enhancer binding protein beta

CEBPB

C/EBP-beta, IL6DBP, NF-IL6, TCF5

20q13.13

This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain. The encoded protein functions as a homodimer but can also form heterodimers with CCAAT/enhancer-binding proteins alpha, delta, and gamma. Activity of t

Show/Hide all(258)

miRTarBase ID	miRNA	Experiments	Reference
MIRT001560	hsa-miR-155-5p	Luciferase reporter assay	18367535
MIRT001560	hsa-miR-155-5p	Review	20029422
MIRT001560	hsa-miR-155-5p	Luciferase reporter assay, qRT-PCR, Western blot	20427544
MIRT001560	hsa-miR-155-5p	pSILAC	18668040
MIRT001560	hsa-miR-155-5p	Microarray, qRT-PCR, Western blot	19193853
MIRT005723	hsa-miR-34a-5p	Luciferase reporter assay	20598588
MIRT006090	hsa-miR-663a	Microarray, qRT-PCR	21378144
MIRT006133	kshv-miR-K12-11-3p	Luciferase reporter assay, qRT-PCR	21813606
MIRT006133	kshv-miR-K12-11-3p	Luciferase reporter assay, qRT-PCR	21813606
MIRT001560	hsa-miR-155-5p	Luciferase reporter assay, qRT-PCR	21813606
MIRT001560	hsa-miR-155-5p	Luciferase reporter assay, qRT-PCR	21813606
MIRT006090	hsa-miR-663a	Microarray, qRT-PCR	21378144
MIRT006133	kshv-miR-K12-11-3p	Luciferase reporter assay, qRT-PCR	21813606
MIRT006133	kshv-miR-K12-11-3p	Luciferase reporter assay, qRT-PCR	21813606
MIRT001560	hsa-miR-155-5p	Luciferase reporter assay, qRT-PCR	21813606
MIRT001560	hsa-miR-155-5p	Luciferase reporter assay, qRT-PCR	21813606
MIRT001560	hsa-miR-155-5p	Luciferase reporter assay	19596814
MIRT001560	hsa-miR-155-5p	ELISA, Immunoblot, Immunocytochemistry, Immunofluorescence, Luciferase reporter assay, qRT-PCR	19887047
MIRT006090	hsa-miR-663a	Microarray, qRT-PCR	21378144
MIRT006133	kshv-miR-K12-11-3p	Luciferase reporter assay, qRT-PCR	21813606
MIRT006133	kshv-miR-K12-11-3p	Luciferase reporter assay, qRT-PCR	21813606
MIRT001560	hsa-miR-155-5p	Luciferase reporter assay, qRT-PCR	21813606
MIRT001560	hsa-miR-155-5p	Luciferase reporter assay, qRT-PCR	21813606
MIRT001560	hsa-miR-155-5p	Luciferase reporter assay	19596814
MIRT001560	hsa-miR-155-5p	ELISA, Immunoblot, Immunocytochemistry, Immunofluorescence, Luciferase reporter assay, qRT-PCR	19887047
MIRT016122	hsa-miR-421	Sequencing	20371350
MIRT001560	hsa-miR-155-5p	Proteomics	18668040
MIRT005723	hsa-miR-34a-5p	Reporter assay	20598588
MIRT038165	hsa-miR-423-5p	CLASH	23622248
MIRT001560	hsa-miR-155-5p	Western blot	23749759
MIRT001560	hsa-miR-155-5p	Chip, ELISA, Luciferase reporter assay, QRTPCR, Western blot	23612310
MIRT437806	hsa-let-7c-5p	Luciferase reporter assay	23667114
MIRT296299	hsa-miR-374a-5p	Luciferase reporter assay	23468252
MIRT154313	hsa-miR-191-5p	Luciferase reporter assay, qRT-PCR, Western blot	25094047
MIRT154313	hsa-miR-191-5p	Luciferase reporter assay, qRT-PCR, Western blot	25094047
MIRT202310	hsa-miR-548n	PAR-CLIP	20371350
MIRT202317	hsa-miR-548az-5p	PAR-CLIP	20371350
MIRT202311	hsa-miR-548t-5p	PAR-CLIP	20371350
MIRT202308	hsa-miR-561-3p	PAR-CLIP	20371350
MIRT235776	hsa-miR-4255	PAR-CLIP	20371350
MIRT202313	hsa-miR-3613-3p	PAR-CLIP	20371350
MIRT564030	hsa-miR-371b-5p	PAR-CLIP	20371350
MIRT564029	hsa-miR-373-5p	PAR-CLIP	20371350
MIRT564028	hsa-miR-616-5p	PAR-CLIP	20371350
MIRT564027	hsa-miR-371a-5p	PAR-CLIP	20371350
MIRT564026	hsa-miR-372-5p	PAR-CLIP	20371350
MIRT154323	hsa-miR-2116-5p	PAR-CLIP	20371350
MIRT564025	hsa-miR-22-5p	PAR-CLIP	20371350
MIRT564024	hsa-miR-4477a	PAR-CLIP	20371350
MIRT564023	hsa-miR-513c-5p	PAR-CLIP	20371350
MIRT564022	hsa-miR-514b-5p	PAR-CLIP	20371350
MIRT407003	hsa-miR-4677-5p	PAR-CLIP	20371350
MIRT001560	hsa-miR-155-5p	HITS-CLIP	22473208
MIRT001560	hsa-miR-155-5p	HITS-CLIP	22473208
MIRT154313	hsa-miR-191-5p	Luciferase reporter assay, qRT-PCR, Western blot	25784653
MIRT038165	hsa-miR-423-5p	PAR-CLIP	26701625
MIRT038165	hsa-miR-423-5p	PAR-CLIP	26701625
MIRT038165	hsa-miR-423-5p	PAR-CLIP	26701625
MIRT736781	hsa-miR-155-3p	qRT-PCR	32366887
MIRT736781	hsa-miR-155-3p	Western blotting, qRT-PCR	32481686
MIRT202310	hsa-miR-548n	PAR-CLIP	20371350
MIRT202317	hsa-miR-548az-5p	PAR-CLIP	20371350
MIRT202311	hsa-miR-548t-5p	PAR-CLIP	20371350
MIRT202308	hsa-miR-561-3p	PAR-CLIP	20371350
MIRT235776	hsa-miR-4255	PAR-CLIP	20371350
MIRT202313	hsa-miR-3613-3p	PAR-CLIP	20371350
MIRT564030	hsa-miR-371b-5p	PAR-CLIP	20371350
MIRT564029	hsa-miR-373-5p	PAR-CLIP	20371350
MIRT564028	hsa-miR-616-5p	PAR-CLIP	20371350
MIRT564027	hsa-miR-371a-5p	PAR-CLIP	20371350
MIRT564026	hsa-miR-372-5p	PAR-CLIP	20371350
MIRT154323	hsa-miR-2116-5p	PAR-CLIP	20371350
MIRT564025	hsa-miR-22-5p	PAR-CLIP	20371350
MIRT564024	hsa-miR-4477a	PAR-CLIP	20371350
MIRT564023	hsa-miR-513c-5p	PAR-CLIP	20371350
MIRT564022	hsa-miR-514b-5p	PAR-CLIP	20371350
MIRT407003	hsa-miR-4677-5p	PAR-CLIP	20371350
MIRT001560	hsa-miR-155-5p	Western blotting, qRT-PCR	37505742
MIRT883257	hsa-miR-1207-5p	CLIP-seq
MIRT883258	hsa-miR-1225-3p	CLIP-seq
MIRT883259	hsa-miR-1273e	CLIP-seq
MIRT883260	hsa-miR-147b	CLIP-seq
MIRT883261	hsa-miR-1537	CLIP-seq
MIRT883262	hsa-miR-155	CLIP-seq
MIRT883263	hsa-miR-185	CLIP-seq
MIRT883264	hsa-miR-1909	CLIP-seq
MIRT883265	hsa-miR-191	CLIP-seq
MIRT883266	hsa-miR-1910	CLIP-seq
MIRT883267	hsa-miR-2116	CLIP-seq
MIRT883268	hsa-miR-2277-5p	CLIP-seq
MIRT883269	hsa-miR-3121-3p	CLIP-seq
MIRT883270	hsa-miR-3157-5p	CLIP-seq
MIRT883271	hsa-miR-3177-5p	CLIP-seq
MIRT883272	hsa-miR-3184	CLIP-seq
MIRT883273	hsa-miR-3189-5p	CLIP-seq
MIRT883274	hsa-miR-3191	CLIP-seq
MIRT883275	hsa-miR-329	CLIP-seq
MIRT883276	hsa-miR-3591-3p	CLIP-seq
MIRT883277	hsa-miR-362-3p	CLIP-seq
MIRT883278	hsa-miR-369-3p	CLIP-seq
MIRT883279	hsa-miR-374a	CLIP-seq
MIRT883280	hsa-miR-374b	CLIP-seq
MIRT883281	hsa-miR-374c	CLIP-seq
MIRT883282	hsa-miR-376a	CLIP-seq
MIRT883283	hsa-miR-376b	CLIP-seq
MIRT883284	hsa-miR-376c	CLIP-seq
MIRT883285	hsa-miR-3941	CLIP-seq
MIRT883286	hsa-miR-4282	CLIP-seq
MIRT883287	hsa-miR-4323	CLIP-seq
MIRT883288	hsa-miR-4480	CLIP-seq
MIRT883289	hsa-miR-4520a-3p	CLIP-seq
MIRT883290	hsa-miR-4520b-3p	CLIP-seq
MIRT883291	hsa-miR-4529-3p	CLIP-seq
MIRT883292	hsa-miR-455-3p	CLIP-seq
MIRT883293	hsa-miR-4643	CLIP-seq
MIRT883294	hsa-miR-4659a-3p	CLIP-seq
MIRT883295	hsa-miR-4659b-3p	CLIP-seq
MIRT883296	hsa-miR-466	CLIP-seq
MIRT883297	hsa-miR-4691-3p	CLIP-seq
MIRT883298	hsa-miR-4707-3p	CLIP-seq
MIRT883299	hsa-miR-4711-5p	CLIP-seq
MIRT883300	hsa-miR-4716-3p	CLIP-seq
MIRT883301	hsa-miR-4716-5p	CLIP-seq
MIRT883302	hsa-miR-4763-3p	CLIP-seq
MIRT883303	hsa-miR-4778-3p	CLIP-seq
MIRT883304	hsa-miR-4789-3p	CLIP-seq
MIRT883305	hsa-miR-603	CLIP-seq
MIRT883306	hsa-miR-655	CLIP-seq
MIRT883276	hsa-miR-3591-3p	CLIP-seq
MIRT883294	hsa-miR-4659a-3p	CLIP-seq
MIRT883295	hsa-miR-4659b-3p	CLIP-seq
MIRT883303	hsa-miR-4778-3p	CLIP-seq
MIRT883258	hsa-miR-1225-3p	CLIP-seq
MIRT883260	hsa-miR-147b	CLIP-seq
MIRT883262	hsa-miR-155	CLIP-seq
MIRT883263	hsa-miR-185	CLIP-seq
MIRT883272	hsa-miR-3184	CLIP-seq
MIRT883273	hsa-miR-3189-5p	CLIP-seq
MIRT883276	hsa-miR-3591-3p	CLIP-seq
MIRT883284	hsa-miR-376c	CLIP-seq
MIRT883287	hsa-miR-4323	CLIP-seq
MIRT883289	hsa-miR-4520a-3p	CLIP-seq
MIRT883290	hsa-miR-4520b-3p	CLIP-seq
MIRT883291	hsa-miR-4529-3p	CLIP-seq
MIRT883293	hsa-miR-4643	CLIP-seq
MIRT883294	hsa-miR-4659a-3p	CLIP-seq
MIRT883295	hsa-miR-4659b-3p	CLIP-seq
MIRT883296	hsa-miR-466	CLIP-seq
MIRT883298	hsa-miR-4707-3p	CLIP-seq
MIRT883303	hsa-miR-4778-3p	CLIP-seq
MIRT883304	hsa-miR-4789-3p	CLIP-seq
MIRT1961895	hsa-miR-561	CLIP-seq
MIRT883258	hsa-miR-1225-3p	CLIP-seq
MIRT2198457	hsa-miR-1266	CLIP-seq
MIRT883260	hsa-miR-147b	CLIP-seq
MIRT2198458	hsa-miR-1538	CLIP-seq
MIRT883263	hsa-miR-185	CLIP-seq
MIRT883266	hsa-miR-1910	CLIP-seq
MIRT883267	hsa-miR-2116	CLIP-seq
MIRT883268	hsa-miR-2277-5p	CLIP-seq
MIRT2198459	hsa-miR-3120-3p	CLIP-seq
MIRT2198460	hsa-miR-3127-5p	CLIP-seq
MIRT883270	hsa-miR-3157-5p	CLIP-seq
MIRT883271	hsa-miR-3177-5p	CLIP-seq
MIRT2198461	hsa-miR-3178	CLIP-seq
MIRT883272	hsa-miR-3184	CLIP-seq
MIRT883273	hsa-miR-3189-5p	CLIP-seq
MIRT883275	hsa-miR-329	CLIP-seq
MIRT883276	hsa-miR-3591-3p	CLIP-seq
MIRT883277	hsa-miR-362-3p	CLIP-seq
MIRT2198462	hsa-miR-3660	CLIP-seq
MIRT883284	hsa-miR-376c	CLIP-seq
MIRT2198463	hsa-miR-3914	CLIP-seq
MIRT2198464	hsa-miR-3918	CLIP-seq
MIRT2198465	hsa-miR-3940-5p	CLIP-seq
MIRT883285	hsa-miR-3941	CLIP-seq
MIRT883287	hsa-miR-4323	CLIP-seq
MIRT2198466	hsa-miR-4503	CLIP-seq
MIRT2198467	hsa-miR-4507	CLIP-seq
MIRT2198468	hsa-miR-4518	CLIP-seq
MIRT883289	hsa-miR-4520a-3p	CLIP-seq
MIRT883290	hsa-miR-4520b-3p	CLIP-seq
MIRT2198469	hsa-miR-4526	CLIP-seq
MIRT883291	hsa-miR-4529-3p	CLIP-seq
MIRT883292	hsa-miR-455-3p	CLIP-seq
MIRT883293	hsa-miR-4643	CLIP-seq
MIRT2198470	hsa-miR-4645-3p	CLIP-seq
MIRT883294	hsa-miR-4659a-3p	CLIP-seq
MIRT883295	hsa-miR-4659b-3p	CLIP-seq
MIRT883296	hsa-miR-466	CLIP-seq
MIRT883297	hsa-miR-4691-3p	CLIP-seq
MIRT883298	hsa-miR-4707-3p	CLIP-seq
MIRT2198471	hsa-miR-4709-5p	CLIP-seq
MIRT883301	hsa-miR-4716-5p	CLIP-seq
MIRT2198472	hsa-miR-4745-3p	CLIP-seq
MIRT2198473	hsa-miR-4767	CLIP-seq
MIRT883303	hsa-miR-4778-3p	CLIP-seq
MIRT883304	hsa-miR-4789-3p	CLIP-seq
MIRT2198474	hsa-miR-510	CLIP-seq
MIRT2198475	hsa-miR-512-5p	CLIP-seq
MIRT2198476	hsa-miR-548t	CLIP-seq
MIRT1961895	hsa-miR-561	CLIP-seq
MIRT883305	hsa-miR-603	CLIP-seq
MIRT2198477	hsa-miR-935	CLIP-seq
MIRT883263	hsa-miR-185	CLIP-seq
MIRT883266	hsa-miR-1910	CLIP-seq
MIRT883271	hsa-miR-3177-5p	CLIP-seq
MIRT883272	hsa-miR-3184	CLIP-seq
MIRT883275	hsa-miR-329	CLIP-seq
MIRT883277	hsa-miR-362-3p	CLIP-seq
MIRT2198462	hsa-miR-3660	CLIP-seq
MIRT883285	hsa-miR-3941	CLIP-seq
MIRT2198469	hsa-miR-4526	CLIP-seq
MIRT883292	hsa-miR-455-3p	CLIP-seq
MIRT2198470	hsa-miR-4645-3p	CLIP-seq
MIRT883298	hsa-miR-4707-3p	CLIP-seq
MIRT883305	hsa-miR-603	CLIP-seq
MIRT2198477	hsa-miR-935	CLIP-seq
MIRT883269	hsa-miR-3121-3p	CLIP-seq
MIRT883282	hsa-miR-376a	CLIP-seq
MIRT883283	hsa-miR-376b	CLIP-seq
MIRT883261	hsa-miR-1537	CLIP-seq
MIRT883263	hsa-miR-185	CLIP-seq
MIRT883270	hsa-miR-3157-5p	CLIP-seq
MIRT883271	hsa-miR-3177-5p	CLIP-seq
MIRT883272	hsa-miR-3184	CLIP-seq
MIRT883275	hsa-miR-329	CLIP-seq
MIRT883277	hsa-miR-362-3p	CLIP-seq
MIRT883284	hsa-miR-376c	CLIP-seq
MIRT883285	hsa-miR-3941	CLIP-seq
MIRT883293	hsa-miR-4643	CLIP-seq
MIRT883294	hsa-miR-4659a-3p	CLIP-seq
MIRT883295	hsa-miR-4659b-3p	CLIP-seq
MIRT883296	hsa-miR-466	CLIP-seq
MIRT883297	hsa-miR-4691-3p	CLIP-seq
MIRT883298	hsa-miR-4707-3p	CLIP-seq
MIRT883299	hsa-miR-4711-5p	CLIP-seq
MIRT883301	hsa-miR-4716-5p	CLIP-seq
MIRT883303	hsa-miR-4778-3p	CLIP-seq
MIRT883304	hsa-miR-4789-3p	CLIP-seq
MIRT883305	hsa-miR-603	CLIP-seq
MIRT883266	hsa-miR-1910	CLIP-seq
MIRT2198465	hsa-miR-3940-5p	CLIP-seq
MIRT2198467	hsa-miR-4507	CLIP-seq
MIRT883292	hsa-miR-455-3p	CLIP-seq
MIRT2198470	hsa-miR-4645-3p	CLIP-seq
MIRT2198477	hsa-miR-935	CLIP-seq
MIRT2198459	hsa-miR-3120-3p	CLIP-seq
MIRT883269	hsa-miR-3121-3p	CLIP-seq
MIRT883278	hsa-miR-369-3p	CLIP-seq
MIRT883279	hsa-miR-374a	CLIP-seq
MIRT883280	hsa-miR-374b	CLIP-seq
MIRT883281	hsa-miR-374c	CLIP-seq
MIRT883282	hsa-miR-376a	CLIP-seq
MIRT883283	hsa-miR-376b	CLIP-seq
MIRT2198463	hsa-miR-3914	CLIP-seq
MIRT2198471	hsa-miR-4709-5p	CLIP-seq
MIRT883306	hsa-miR-655	CLIP-seq

Transcription factors

Show/Hide all(2)

Transcription factor	Regulation	Reference
ATF4	Activation	16026328
ESR1	Unknown	19652226

Show/Hide all(71)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	ISS	15308669
GO:0000779	Component	Condensed chromosome, centromeric region	IEA
GO:0000785	Component	Chromatin	ISA
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA	7959007
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	21873635
GO:0000979	Function	RNA polymerase II core promoter sequence-specific DNA binding	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISS
GO:0001227	Function	DNA-binding transcription repressor activity, RNA polymerase II-specific	ISS	15308669
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IEA
GO:0001541	Process	Ovarian follicle development	ISS
GO:0001892	Process	Embryonic placenta development	IEA
GO:0003677	Function	DNA binding	TAS	10821850
GO:0003682	Function	Chromatin binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	NAS	10821850
GO:0005515	Function	Protein binding	IPI	7651415, 12692227, 16227626, 17724128, 18820298, 20102225, 20111005, 20829347, 24043631, 31527615
GO:0005634	Component	Nucleus	IDA	20829347
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IEA
GO:0006355	Process	Regulation of transcription, DNA-templated	IDA	20829347
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0006357	Process	Regulation of transcription by RNA polymerase II	ISS
GO:0006953	Process	Acute-phase response	TAS	2112087
GO:0006954	Process	Inflammatory response	TAS	2112087
GO:0006955	Process	Immune response	TAS	2112087
GO:0007613	Process	Memory	IEA
GO:0016363	Component	Nuclear matrix	IEA
GO:0019900	Function	Kinase binding	IEA
GO:0030182	Process	Neuron differentiation	IEA
GO:0032675	Process	Regulation of interleukin-6 production	IEA
GO:0032753	Process	Positive regulation of interleukin-4 production	ISS
GO:0033598	Process	Mammary gland epithelial cell proliferation	IEA
GO:0034976	Process	Response to endoplasmic reticulum stress	IDA	20829347
GO:0035035	Function	Histone acetyltransferase binding	IEA
GO:0035259	Function	Glucocorticoid receptor binding	IEA
GO:0036488	Component	CHOP-C/EBP complex	NAS	15775988
GO:0042130	Process	Negative regulation of T cell proliferation	ISS
GO:0042742	Process	Defense response to bacterium	ISS
GO:0042803	Function	Protein homodimerization activity	ISS
GO:0042826	Function	Histone deacetylase binding	IEA
GO:0043524	Process	Negative regulation of neuron apoptotic process	IEA
GO:0044389	Function	Ubiquitin-like protein ligase binding	IEA
GO:0045595	Process	Regulation of cell differentiation	IBA	21873635
GO:0045600	Process	Positive regulation of fat cell differentiation	ISS
GO:0045669	Process	Positive regulation of osteoblast differentiation	IEA
GO:0045670	Process	Regulation of osteoclast differentiation	ISS
GO:0045893	Process	Positive regulation of transcription, DNA-templated	IDA	27812542
GO:0045893	Process	Positive regulation of transcription, DNA-templated	IMP	27812542
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	7959007
GO:0046982	Function	Protein heterodimerization activity	IEA
GO:0050729	Process	Positive regulation of inflammatory response	IEA
GO:0050873	Process	Brown fat cell differentiation	IEA
GO:0060644	Process	Mammary gland epithelial cell differentiation	IEA
GO:0070059	Process	Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	TAS	14685163
GO:0070169	Process	Positive regulation of biomineral tissue development	IDA	27812542
GO:0070169	Process	Positive regulation of biomineral tissue development	IMP	27812542
GO:0071222	Process	Cellular response to lipopolysaccharide	IEA
GO:0071230	Process	Cellular response to amino acid stimulus	IEA
GO:0071347	Process	Cellular response to interleukin-1	IEA
GO:0071407	Process	Cellular response to organic cyclic compound	IEA
GO:0072574	Process	Hepatocyte proliferation	ISS
GO:0097421	Process	Liver regeneration	ISS
GO:0120162	Process	Positive regulation of cold-induced thermogenesis	ISS	15762841
GO:1901329	Process	Regulation of odontoblast differentiation	ISS	15308669
GO:1990440	Process	Positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	IDA	15775988
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536
GO:2000120	Process	Positive regulation of sodium-dependent phosphate transport	IDA	27812542
GO:2000120	Process	Positive regulation of sodium-dependent phosphate transport	IMP	27812542
GO:2001198	Process	Regulation of dendritic cell differentiation	IEA

MIM	HGNC	e!Ensembl
189965	1834	ENSG00000172216

Protein

UniProt ID

P17676

Protein name

CCAAT/enhancer-binding protein beta (C/EBP beta) (Liver activator protein) (LAP) (Liver-enriched inhibitory protein) (LIP) (Nuclear factor NF-IL6) (Transcription factor 5) (TCF-5)

Protein function

Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:12048245, PubMed:1741402, PubMed:18647749, PubMed:9374525). Also plays a significant role in adipogenesis, as well as in the

PDB

1GTW , 1GU4 , 1GU5 , 1H88 , 1H89 , 1H8A , 1HJB , 1IO4 , 2E42 , 2E43 , 6MG1 , 6MG2 , 6MG3 , 7L4V , 7UPZ , 8K8D

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07716	bZIP_2	270 → 323	Basic region leucine zipper	Coiled-coil

Sequence

MQRLVAWDPACLPLPPPPPAFKSMEVANFYYEADCLAAAYGGKAAPAAPPAARPGPRPPA
GELGSIGDHERAIDFSPYLEPLGAPQAPAPATATDTFEAAPPAPAPAPASSGQHHDFLSD
LFSDDYGGKNCKKPAEYGYVSLGRLGAAKGALHPGCFAPLHPPPPPPPPPAELKAEPGFE
PADCKRKEEAGAPGGGAGMAAGFPYALRAYLGYQAVPSGSSGSLSTSSSSSPPGTPSPAD
AKAPPTACYAGAAPAPSQVKSKAKKTVDKHSDEYKIRRERNNIAVRKSRDKAKMRNLETQ
HKVLELTAENERLQKKVEQLSRELSTLRNLFKQLPEPLLASSGHC

Sequence length

345

Interactions

View interactions

	KEGG		Reactome
	Efferocytosis IL-17 signaling pathway TNF signaling pathway Tuberculosis Transcriptional misregulation in cancer		Senescence-Associated Secretory Phenotype (SASP) Transcriptional regulation of white adipocyte differentiation Transcriptional Regulation by VENTX Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency

Associated diseases

Show/Hide Causal Diseases (1)

Causal
Disease name	Disease term	dbSNP ID	References
Pulmonary fibrosis	Pulmonary Fibrosis	rs121918666, rs199422300, rs121917737, rs121917834, rs199422294, rs201159197, rs199422297, rs199422305, rs751381953, rs876661305, rs878853260, rs863223336, rs786205702, rs1555811762, rs1060502990, rs1555903332, rs1554038539, rs1554042899, rs938938578	17177178

Show/Hide Unknown Diseases (5)

Unknown
Disease name	Disease term	dbSNP ID	References
Alveolitis	Alveolitis, Fibrosing		17177178
Cerebral ischemia	Brain Ischemia		17394460
Fatty liver	Fatty Liver, Steatohepatitis		24469900
Liver carcinoma	Liver carcinoma		14563831
Subfertility	Subfertility, Female		21177758

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