ENOX2 (ecto-NOX disulfide-thiol exchanger 2)

Gene

• Entrez ID: 10495
• Gene name: Ecto-NOX disulfide-thiol exchanger 2
• Gene symbol: ENOX2
• Synonyms: APK1, COVA1, tNOX
• Chromosome: X
• Chromosome location: Xq26.1
• Summary: This gene is a tumor-specific member of the ECTO-NOX family of genes that encode cell surface NADH oxidases. The encoded protein has two enzymatic activities: catalysis of hydroquinone or NADH oxidation, and protein disulfide interchange. The protein also

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016542	hsa-miR-193b-3p	Microarray	20304954
MIRT550777	hsa-miR-376c-3p	PAR-CLIP	20371350
MIRT550776	hsa-miR-1265	PAR-CLIP	20371350
MIRT550775	hsa-miR-4464	PAR-CLIP	20371350
MIRT550774	hsa-miR-4748	PAR-CLIP	20371350
MIRT550773	hsa-miR-873-5p	PAR-CLIP	20371350
MIRT550772	hsa-miR-1286	PAR-CLIP	20371350
MIRT550771	hsa-miR-4722-5p	PAR-CLIP	20371350
MIRT550770	hsa-miR-3665	PAR-CLIP	20371350
MIRT550769	hsa-miR-657	PAR-CLIP	20371350
MIRT550768	hsa-miR-4764-5p	PAR-CLIP	20371350
MIRT550767	hsa-miR-5087	PAR-CLIP	20371350
MIRT550766	hsa-miR-3944-5p	PAR-CLIP	20371350
MIRT550765	hsa-miR-143-5p	PAR-CLIP	20371350
MIRT550764	hsa-miR-8068	PAR-CLIP	20371350
MIRT550763	hsa-miR-4666a-5p	PAR-CLIP	20371350
MIRT550777	hsa-miR-376c-3p	PAR-CLIP	21572407
MIRT550776	hsa-miR-1265	PAR-CLIP	21572407
MIRT550775	hsa-miR-4464	PAR-CLIP	21572407
MIRT550774	hsa-miR-4748	PAR-CLIP	21572407
MIRT550773	hsa-miR-873-5p	PAR-CLIP	21572407
MIRT550772	hsa-miR-1286	PAR-CLIP	21572407
MIRT550771	hsa-miR-4722-5p	PAR-CLIP	21572407
MIRT550770	hsa-miR-3665	PAR-CLIP	21572407
MIRT550769	hsa-miR-657	PAR-CLIP	21572407
MIRT550768	hsa-miR-4764-5p	PAR-CLIP	21572407
MIRT550767	hsa-miR-5087	PAR-CLIP	21572407
MIRT550766	hsa-miR-3944-5p	PAR-CLIP	21572407
MIRT550765	hsa-miR-143-5p	PAR-CLIP	21572407
MIRT550764	hsa-miR-8068	PAR-CLIP	21572407
MIRT550763	hsa-miR-4666a-5p	PAR-CLIP	21572407
MIRT550777	hsa-miR-376c-3p	PAR-CLIP	20371350
MIRT550776	hsa-miR-1265	PAR-CLIP	20371350
MIRT550775	hsa-miR-4464	PAR-CLIP	20371350
MIRT550774	hsa-miR-4748	PAR-CLIP	20371350
MIRT550773	hsa-miR-873-5p	PAR-CLIP	20371350
MIRT550772	hsa-miR-1286	PAR-CLIP	20371350
MIRT550771	hsa-miR-4722-5p	PAR-CLIP	20371350
MIRT550770	hsa-miR-3665	PAR-CLIP	20371350
MIRT550769	hsa-miR-657	PAR-CLIP	20371350
MIRT550768	hsa-miR-4764-5p	PAR-CLIP	20371350
MIRT550767	hsa-miR-5087	PAR-CLIP	20371350
MIRT550766	hsa-miR-3944-5p	PAR-CLIP	20371350
MIRT550765	hsa-miR-143-5p	PAR-CLIP	20371350
MIRT550764	hsa-miR-8068	PAR-CLIP	20371350
MIRT550763	hsa-miR-4666a-5p	PAR-CLIP	20371350
MIRT550777	hsa-miR-376c-3p	PAR-CLIP	21572407
MIRT550776	hsa-miR-1265	PAR-CLIP	21572407
MIRT550775	hsa-miR-4464	PAR-CLIP	21572407
MIRT550774	hsa-miR-4748	PAR-CLIP	21572407
MIRT550773	hsa-miR-873-5p	PAR-CLIP	21572407
MIRT550772	hsa-miR-1286	PAR-CLIP	21572407
MIRT550771	hsa-miR-4722-5p	PAR-CLIP	21572407
MIRT550770	hsa-miR-3665	PAR-CLIP	21572407
MIRT550769	hsa-miR-657	PAR-CLIP	21572407
MIRT550768	hsa-miR-4764-5p	PAR-CLIP	21572407
MIRT550767	hsa-miR-5087	PAR-CLIP	21572407
MIRT550766	hsa-miR-3944-5p	PAR-CLIP	21572407
MIRT550765	hsa-miR-143-5p	PAR-CLIP	21572407
MIRT550764	hsa-miR-8068	PAR-CLIP	21572407
MIRT550763	hsa-miR-4666a-5p	PAR-CLIP	21572407
MIRT963836	hsa-miR-3685	CLIP-seq
MIRT963837	hsa-miR-384	CLIP-seq
MIRT963838	hsa-miR-4777-5p	CLIP-seq
MIRT963839	hsa-miR-576-3p	CLIP-seq
MIRT963840	hsa-miR-586	CLIP-seq
MIRT963841	hsa-miR-1227	CLIP-seq
MIRT963842	hsa-miR-1276	CLIP-seq
MIRT963843	hsa-miR-1303	CLIP-seq
MIRT963844	hsa-miR-1321	CLIP-seq
MIRT963845	hsa-miR-138	CLIP-seq
MIRT963846	hsa-miR-140-3p	CLIP-seq
MIRT963847	hsa-miR-190	CLIP-seq
MIRT963848	hsa-miR-190b	CLIP-seq
MIRT963849	hsa-miR-3064-3p	CLIP-seq
MIRT963850	hsa-miR-3074-5p	CLIP-seq
MIRT963851	hsa-miR-3123	CLIP-seq
MIRT963852	hsa-miR-3152-3p	CLIP-seq
MIRT963853	hsa-miR-33a	CLIP-seq
MIRT963854	hsa-miR-33b	CLIP-seq
MIRT963855	hsa-miR-3653	CLIP-seq
MIRT963856	hsa-miR-3672	CLIP-seq
MIRT963857	hsa-miR-3689a-5p	CLIP-seq
MIRT963858	hsa-miR-3689b	CLIP-seq
MIRT963859	hsa-miR-3689e	CLIP-seq
MIRT963860	hsa-miR-3689f	CLIP-seq
MIRT963861	hsa-miR-370	CLIP-seq
MIRT963862	hsa-miR-3925-5p	CLIP-seq
MIRT963863	hsa-miR-4269	CLIP-seq
MIRT963864	hsa-miR-4311	CLIP-seq
MIRT963865	hsa-miR-4327	CLIP-seq
MIRT963866	hsa-miR-4461	CLIP-seq
MIRT963867	hsa-miR-4493	CLIP-seq
MIRT963868	hsa-miR-4494	CLIP-seq
MIRT963869	hsa-miR-4495	CLIP-seq
MIRT963870	hsa-miR-4497	CLIP-seq
MIRT963871	hsa-miR-4666-5p	CLIP-seq
MIRT963872	hsa-miR-4699-3p	CLIP-seq
MIRT963873	hsa-miR-4728-5p	CLIP-seq
MIRT963874	hsa-miR-4739	CLIP-seq
MIRT963875	hsa-miR-4753-5p	CLIP-seq
MIRT963876	hsa-miR-4756-5p	CLIP-seq
MIRT963838	hsa-miR-4777-5p	CLIP-seq
MIRT963877	hsa-miR-4795-3p	CLIP-seq
MIRT963878	hsa-miR-516a-3p	CLIP-seq
MIRT963879	hsa-miR-518d-5p	CLIP-seq
MIRT963880	hsa-miR-519b-5p	CLIP-seq
MIRT963881	hsa-miR-519c-5p	CLIP-seq
MIRT963882	hsa-miR-520c-5p	CLIP-seq
MIRT963883	hsa-miR-526a	CLIP-seq
MIRT963884	hsa-miR-548q	CLIP-seq
MIRT963885	hsa-miR-583	CLIP-seq
MIRT963841	hsa-miR-1227	CLIP-seq
MIRT963845	hsa-miR-138	CLIP-seq
MIRT963849	hsa-miR-3064-3p	CLIP-seq
MIRT963850	hsa-miR-3074-5p	CLIP-seq
MIRT1985683	hsa-miR-330-3p	CLIP-seq
MIRT1985684	hsa-miR-3614-3p	CLIP-seq
MIRT963861	hsa-miR-370	CLIP-seq
MIRT1985685	hsa-miR-376c	CLIP-seq
MIRT1985686	hsa-miR-4297	CLIP-seq
MIRT1985687	hsa-miR-4436b-5p	CLIP-seq
MIRT1985688	hsa-miR-450b-5p	CLIP-seq
MIRT1985689	hsa-miR-4717-3p	CLIP-seq
MIRT1985690	hsa-miR-4769-3p	CLIP-seq
MIRT1985691	hsa-miR-4790-3p	CLIP-seq
MIRT963878	hsa-miR-516a-3p	CLIP-seq
MIRT963884	hsa-miR-548q	CLIP-seq
MIRT2220110	hsa-miR-30a	CLIP-seq
MIRT2220111	hsa-miR-30b	CLIP-seq
MIRT2220112	hsa-miR-30c	CLIP-seq
MIRT2220113	hsa-miR-30d	CLIP-seq
MIRT2220114	hsa-miR-30e	CLIP-seq
MIRT2220115	hsa-miR-3120-3p	CLIP-seq
MIRT963872	hsa-miR-4699-3p	CLIP-seq
MIRT963841	hsa-miR-1227	CLIP-seq
MIRT963845	hsa-miR-138	CLIP-seq
MIRT963849	hsa-miR-3064-3p	CLIP-seq
MIRT963850	hsa-miR-3074-5p	CLIP-seq
MIRT2220115	hsa-miR-3120-3p	CLIP-seq
MIRT963861	hsa-miR-370	CLIP-seq
MIRT963878	hsa-miR-516a-3p	CLIP-seq
MIRT963884	hsa-miR-548q	CLIP-seq
MIRT1985688	hsa-miR-450b-5p	CLIP-seq
MIRT2523996	hsa-miR-1237	CLIP-seq
MIRT2523997	hsa-miR-147b	CLIP-seq
MIRT2523998	hsa-miR-186	CLIP-seq
MIRT2523999	hsa-miR-188-5p	CLIP-seq
MIRT2524000	hsa-miR-200b	CLIP-seq
MIRT2524001	hsa-miR-200c	CLIP-seq
MIRT2524002	hsa-miR-210	CLIP-seq
MIRT2524003	hsa-miR-2113	CLIP-seq
MIRT2524004	hsa-miR-3145-5p	CLIP-seq
MIRT2524005	hsa-miR-3153	CLIP-seq
MIRT963855	hsa-miR-3653	CLIP-seq
MIRT2524006	hsa-miR-4252	CLIP-seq
MIRT2524007	hsa-miR-429	CLIP-seq
MIRT2524008	hsa-miR-4436a	CLIP-seq
MIRT2524009	hsa-miR-4475	CLIP-seq
MIRT963867	hsa-miR-4493	CLIP-seq
MIRT963868	hsa-miR-4494	CLIP-seq
MIRT2524010	hsa-miR-452	CLIP-seq
MIRT2524011	hsa-miR-4643	CLIP-seq
MIRT2524012	hsa-miR-4676-3p	CLIP-seq
MIRT2524013	hsa-miR-4711-5p	CLIP-seq
MIRT2524014	hsa-miR-4727-5p	CLIP-seq
MIRT963875	hsa-miR-4753-5p	CLIP-seq
MIRT1985690	hsa-miR-4769-3p	CLIP-seq
MIRT2524015	hsa-miR-549	CLIP-seq
MIRT2524016	hsa-miR-570	CLIP-seq
MIRT2524017	hsa-miR-605	CLIP-seq
MIRT2524018	hsa-miR-889	CLIP-seq
MIRT2524019	hsa-miR-892a	CLIP-seq
MIRT2523997	hsa-miR-147b	CLIP-seq
MIRT2524002	hsa-miR-210	CLIP-seq
MIRT2524003	hsa-miR-2113	CLIP-seq
MIRT2680061	hsa-miR-27a	CLIP-seq
MIRT2680062	hsa-miR-27b	CLIP-seq
MIRT2524006	hsa-miR-4252	CLIP-seq
MIRT2680063	hsa-miR-4290	CLIP-seq
MIRT2524011	hsa-miR-4643	CLIP-seq
MIRT2680064	hsa-miR-4667-3p	CLIP-seq
MIRT2680065	hsa-miR-4724-5p	CLIP-seq
MIRT2680066	hsa-miR-4760-3p	CLIP-seq
MIRT2680067	hsa-miR-513a-5p	CLIP-seq
MIRT2524019	hsa-miR-892a	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003676	Function	Nucleic acid binding	IEA
GO:0005615	Component	Extracellular space	IEA
GO:0005829	Component	Cytosol	TAS	8150545
GO:0007624	Process	Ultradian rhythm	IDA	12356293
GO:0009897	Component	External side of plasma membrane	IDA	11488599
GO:0015035	Function	Protein disulfide oxidoreductase activity	IDA	1888291
GO:0040008	Process	Regulation of growth	IEA

Other IDs

• MIM: 300282
• HGNC: 2259
• e!Ensembl: ENSG00000165675

Protein

• UniProt ID: Q16206
• Protein name: Ecto-NOX disulfide-thiol exchanger 2 (APK1 antigen) (Cytosolic ovarian carcinoma antigen 1) (Tumor-associated hydroquinone oxidase) (tNOX) [Includes: Hydroquinone [NADH] oxidase (EC 1.-.-.-); Protein disulfide-thiol oxidoreductase (EC 1.-.-.-)]
• Protein function: May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol i
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00076	RRM_1	130 → 189	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain

• Sequence:

  MQRDFRWLWVYEIGYAADNSRTLNVDSTAMTLPMSDPTAWATAMNNLGMAPLGIAGQPIL
  PDFDPALGMMTGIPPITPMMPGLGIVPPPIPPDMPVVKEIIHCKSCTLFPPNPNLPPPAT
  RERPPGCKTVFVGGLPENGTEQIIVEVFEQCGEIIAIRKSKKNFCHIRFAEEYMVDKALY
  LSGYRIRLGSSTDKKDTGRLHVDFAQARDDLYEWECKQRMLAREERHRRRMEEERLRPPS
  PPPVVHYSDHECSIVAEKLKDDSKFSEAVQTLLTWIERGEVNRRSANNFYSMIQSANSHV
  RRLVNEKAAHEKDMEEAKEKFKQALSGILIQFEQIVAVYHSASKQKAWDHFTKAQRKNIS
  VWCKQAEEIRNIHNDELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEALKEENDS
  LRWQLDAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEA
  ELEKLKDDKLQVEKMLENLKEKESCASRLCASNQDSEYPLEKTMNSSPIKSEREALLVGI
  ISTFLHVHPFGASIEYICSYLHRLDNKICTSDVECLMGRLQHTFKQEMTGVGASLEKRWK
  FCGFEGLKLT

• Sequence length: 610

Associated diseases

Unknown
Disease name	Disease term	dbSNP ID	References
Benign neoplasm	Benign Neoplasm		20518072
Malignant mesothelioma	Malignant mesothelioma		26807072
Malignant neoplasm	Malignant Neoplasms		20518072
Neoplasms	Neoplasms		20518072