STK25 (serine/threonine kinase 25)

Gene

• Entrez ID: 10494
• Gene name: Serine/threonine kinase 25
• Gene symbol: STK25
• Synonyms: SOK1, YSK1
• Chromosome: 2
• Chromosome location: 2q37.3
• Summary: This gene encodes a member of the germinal centre kinase III (GCK III) subfamily of the sterile 20 superfamily of kinases. The encoded enzyme plays a role in serine-threonine liver kinase B1 (LKB1) signaling pathway to regulate neuronal polarization and m

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT049469	hsa-miR-92a-3p	CLASH	23622248
MIRT044928	hsa-miR-186-5p	CLASH	23622248
MIRT723640	hsa-miR-4681	HITS-CLIP	19536157
MIRT723639	hsa-miR-1179	HITS-CLIP	19536157
MIRT723638	hsa-miR-4310	HITS-CLIP	19536157
MIRT723637	hsa-miR-7157-5p	HITS-CLIP	19536157
MIRT723636	hsa-miR-338-3p	HITS-CLIP	19536157
MIRT723635	hsa-miR-6734-3p	HITS-CLIP	19536157
MIRT723634	hsa-miR-3667-3p	HITS-CLIP	19536157
MIRT723633	hsa-miR-6868-3p	HITS-CLIP	19536157
MIRT629769	hsa-miR-1245a	HITS-CLIP	23824327
MIRT629768	hsa-miR-8079	HITS-CLIP	23824327
MIRT629767	hsa-miR-7151-5p	HITS-CLIP	23824327
MIRT629766	hsa-miR-6513-3p	HITS-CLIP	23824327
MIRT629765	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT629764	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT629763	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT629762	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT629761	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT629760	hsa-miR-640	HITS-CLIP	23824327
MIRT723640	hsa-miR-4681	HITS-CLIP	19536157
MIRT723639	hsa-miR-1179	HITS-CLIP	19536157
MIRT723638	hsa-miR-4310	HITS-CLIP	19536157
MIRT723637	hsa-miR-7157-5p	HITS-CLIP	19536157
MIRT723636	hsa-miR-338-3p	HITS-CLIP	19536157
MIRT723635	hsa-miR-6734-3p	HITS-CLIP	19536157
MIRT723634	hsa-miR-3667-3p	HITS-CLIP	19536157
MIRT723633	hsa-miR-6868-3p	HITS-CLIP	19536157
MIRT629769	hsa-miR-1245a	HITS-CLIP	23824327
MIRT629768	hsa-miR-8079	HITS-CLIP	23824327
MIRT629767	hsa-miR-7151-5p	HITS-CLIP	23824327
MIRT629766	hsa-miR-6513-3p	HITS-CLIP	23824327
MIRT629765	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT629764	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT629763	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT629762	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT629761	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT629760	hsa-miR-640	HITS-CLIP	23824327
MIRT1397605	hsa-miR-101	CLIP-seq
MIRT1397606	hsa-miR-1197	CLIP-seq
MIRT1397607	hsa-miR-2681	CLIP-seq
MIRT1397608	hsa-miR-296-5p	CLIP-seq
MIRT1397609	hsa-miR-3166	CLIP-seq
MIRT1397610	hsa-miR-3187-3p	CLIP-seq
MIRT1397611	hsa-miR-3200-5p	CLIP-seq
MIRT1397612	hsa-miR-326	CLIP-seq
MIRT1397613	hsa-miR-330-5p	CLIP-seq
MIRT1397614	hsa-miR-3591-3p	CLIP-seq
MIRT1397615	hsa-miR-4436a	CLIP-seq
MIRT1397616	hsa-miR-4457	CLIP-seq
MIRT1397617	hsa-miR-4488	CLIP-seq
MIRT1397618	hsa-miR-4519	CLIP-seq
MIRT1397619	hsa-miR-4529-5p	CLIP-seq
MIRT1397620	hsa-miR-4539	CLIP-seq
MIRT1397621	hsa-miR-4667-5p	CLIP-seq
MIRT1397622	hsa-miR-4697-5p	CLIP-seq
MIRT1397623	hsa-miR-4700-5p	CLIP-seq
MIRT1397624	hsa-miR-4762-5p	CLIP-seq
MIRT1397625	hsa-miR-483-3p	CLIP-seq
MIRT1397626	hsa-miR-495	CLIP-seq
MIRT1397627	hsa-miR-637	CLIP-seq
MIRT2119036	hsa-miR-1255a	CLIP-seq
MIRT2119037	hsa-miR-1255b	CLIP-seq
MIRT2119038	hsa-miR-1299	CLIP-seq
MIRT2119039	hsa-miR-2116	CLIP-seq
MIRT2119040	hsa-miR-3065-3p	CLIP-seq
MIRT2119041	hsa-miR-3123	CLIP-seq
MIRT2119042	hsa-miR-3190	CLIP-seq
MIRT2119043	hsa-miR-3202	CLIP-seq
MIRT2119044	hsa-miR-3607-5p	CLIP-seq
MIRT2119045	hsa-miR-3622b-5p	CLIP-seq
MIRT2119046	hsa-miR-3661	CLIP-seq
MIRT2119047	hsa-miR-3691-3p	CLIP-seq
MIRT2119048	hsa-miR-3925-5p	CLIP-seq
MIRT2119049	hsa-miR-425	CLIP-seq
MIRT2119050	hsa-miR-4277	CLIP-seq
MIRT2119051	hsa-miR-4299	CLIP-seq
MIRT2119052	hsa-miR-4428	CLIP-seq
MIRT2119053	hsa-miR-4533	CLIP-seq
MIRT2119054	hsa-miR-4651	CLIP-seq
MIRT2119055	hsa-miR-4720-5p	CLIP-seq
MIRT2119056	hsa-miR-4731-3p	CLIP-seq
MIRT2119057	hsa-miR-4773	CLIP-seq
MIRT2119058	hsa-miR-4782-5p	CLIP-seq
MIRT2119059	hsa-miR-4799-3p	CLIP-seq
MIRT2119060	hsa-miR-4801	CLIP-seq
MIRT2119061	hsa-miR-516b	CLIP-seq
MIRT2119062	hsa-miR-543	CLIP-seq
MIRT2119063	hsa-miR-608	CLIP-seq
MIRT2119064	hsa-miR-631	CLIP-seq
MIRT2119065	hsa-miR-642b	CLIP-seq
MIRT2119066	hsa-miR-765	CLIP-seq
MIRT1397605	hsa-miR-101	CLIP-seq
MIRT2341359	hsa-miR-1205	CLIP-seq
MIRT1397607	hsa-miR-2681	CLIP-seq
MIRT1397609	hsa-miR-3166	CLIP-seq
MIRT1397610	hsa-miR-3187-3p	CLIP-seq
MIRT1397614	hsa-miR-3591-3p	CLIP-seq
MIRT1397616	hsa-miR-4457	CLIP-seq
MIRT2341360	hsa-miR-4468	CLIP-seq
MIRT1397619	hsa-miR-4529-5p	CLIP-seq
MIRT1397624	hsa-miR-4762-5p	CLIP-seq
MIRT2341361	hsa-miR-556-5p	CLIP-seq
MIRT1397605	hsa-miR-101	CLIP-seq
MIRT1397606	hsa-miR-1197	CLIP-seq
MIRT2635339	hsa-miR-1224-3p	CLIP-seq
MIRT2635340	hsa-miR-146b-3p	CLIP-seq
MIRT2635341	hsa-miR-2277-3p	CLIP-seq
MIRT1397607	hsa-miR-2681	CLIP-seq
MIRT1397608	hsa-miR-296-5p	CLIP-seq
MIRT2635342	hsa-miR-3152-5p	CLIP-seq
MIRT1397609	hsa-miR-3166	CLIP-seq
MIRT2635343	hsa-miR-3173-5p	CLIP-seq
MIRT1397610	hsa-miR-3187-3p	CLIP-seq
MIRT1397612	hsa-miR-326	CLIP-seq
MIRT1397613	hsa-miR-330-5p	CLIP-seq
MIRT1397614	hsa-miR-3591-3p	CLIP-seq
MIRT2635344	hsa-miR-4286	CLIP-seq
MIRT2635345	hsa-miR-4423-5p	CLIP-seq
MIRT1397615	hsa-miR-4436a	CLIP-seq
MIRT1397616	hsa-miR-4457	CLIP-seq
MIRT2341360	hsa-miR-4468	CLIP-seq
MIRT1397617	hsa-miR-4488	CLIP-seq
MIRT1397619	hsa-miR-4529-5p	CLIP-seq
MIRT1397621	hsa-miR-4667-5p	CLIP-seq
MIRT1397622	hsa-miR-4697-5p	CLIP-seq
MIRT1397623	hsa-miR-4700-5p	CLIP-seq
MIRT2119056	hsa-miR-4731-3p	CLIP-seq
MIRT1397624	hsa-miR-4762-5p	CLIP-seq
MIRT2119060	hsa-miR-4801	CLIP-seq
MIRT1397625	hsa-miR-483-3p	CLIP-seq
MIRT2341361	hsa-miR-556-5p	CLIP-seq
MIRT1397627	hsa-miR-637	CLIP-seq
MIRT2119065	hsa-miR-642b	CLIP-seq
MIRT2635346	hsa-miR-874	CLIP-seq
MIRT1397605	hsa-miR-101	CLIP-seq
MIRT2635341	hsa-miR-2277-3p	CLIP-seq
MIRT1397607	hsa-miR-2681	CLIP-seq
MIRT1397608	hsa-miR-296-5p	CLIP-seq
MIRT1397609	hsa-miR-3166	CLIP-seq
MIRT1397610	hsa-miR-3187-3p	CLIP-seq
MIRT1397614	hsa-miR-3591-3p	CLIP-seq
MIRT1397616	hsa-miR-4457	CLIP-seq
MIRT2341360	hsa-miR-4468	CLIP-seq
MIRT1397619	hsa-miR-4529-5p	CLIP-seq
MIRT2119056	hsa-miR-4731-3p	CLIP-seq
MIRT1397624	hsa-miR-4762-5p	CLIP-seq
MIRT2119060	hsa-miR-4801	CLIP-seq
MIRT2341361	hsa-miR-556-5p	CLIP-seq
MIRT2119065	hsa-miR-642b	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0004672	Function	Protein kinase activity	TAS	9160885
GO:0005515	Function	Protein binding	IPI	15037601, 16189514, 17657516, 18782753, 20332113, 21423148, 21516116, 21561863, 22652780, 23455922, 23665169, 25416956, 26871637, 27107012, 28514442, 31515488, 32296183
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IDA	22652780
GO:0005794	Component	Golgi apparatus	IDA	22652780
GO:0006468	Process	Protein phosphorylation	IDA	17657516
GO:0006979	Process	Response to oxidative stress	TAS	8887545
GO:0007163	Process	Establishment or maintenance of cell polarity	IEA
GO:0007165	Process	Signal transduction	TAS	8887545
GO:0032874	Process	Positive regulation of stress-activated MAPK cascade	IDA	22652780
GO:0036481	Process	Intrinsic apoptotic signaling pathway in response to hydrogen peroxide	IGI	22652780
GO:0042542	Process	Response to hydrogen peroxide	IDA	22291017
GO:0042803	Function	Protein homodimerization activity	IDA	15037601
GO:0046777	Process	Protein autophosphorylation	IDA	17657516
GO:0046872	Function	Metal ion binding	IEA
GO:0050772	Process	Positive regulation of axonogenesis	IEA
GO:0051645	Process	Golgi localization	IDA	15037601
GO:0051683	Process	Establishment of Golgi localization	IMP	20332113
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:0090168	Process	Golgi reassembly	IMP	20332113
GO:0106310	Function	Protein serine kinase activity	IEA
GO:0106311	Function	Protein threonine kinase activity	IEA

Other IDs

• MIM: 602255
• HGNC: 11404
• e!Ensembl: ENSG00000115694

Protein

• UniProt ID: O00506
• Protein name: Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Ste20-like kinase) (Sterile 20/oxidant stress-response kinase 1) (SOK-1) (Ste20/oxidant stress response kinase 1)
• Protein function: Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important
• PDB: 2XIK, 3W8H, 4NZW, 7Z4V
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00069	Pkinase	20 → 270	Protein kinase domain	Domain

• Sequence:

  MAHLRGFANQHSRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEI
  EDIQQEITVLSQCDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLKPGPLEETYIATI
  LREILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPF
  WMAPEVIKQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQHS
  KPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYKRWKSEGHGEESS
  SEDSDIDGEAEDGEQGPIWTFPPTIRPSPHSKLHKGTALHSSQKPAEPVKRQPRSQCLST
  LVRPVFGELKEKHKQSGGSVGALEELENAFSLAEESCPGISDKLMVHLVERVQRFSHNRN
  HLTSTR

• Sequence length: 426

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Hypothyroidism	Hypothyroidism	rs869320723, rs121908862, rs121908863, rs121908865, rs121908866, rs121908867, rs121908870, rs121908871, rs121908872, rs2140110277, rs121908881, rs121908884, rs121908885, rs786205080, rs1586182912, rs121917847, rs104893655, rs104893657, rs104893658, rs104893659, rs104893660, rs104893656, rs121917719, rs786204790, rs189261858, rs879255608, rs868197660, rs879255609, rs1586744173, rs1586182837, rs771222349, rs1587618417, rs1601844140, rs760832986, rs780982673, rs1603336347, rs1691155605	30595370