TACC3 (transforming acidic coiled-coil containing protein 3)

Gene

• Entrez ID: 10460
• Gene name: Transforming acidic coiled-coil containing protein 3
• Gene symbol: TACC3
• Synonyms: ERIC-1, ERIC1, Tacc4, maskin
• Chromosome: 4
• Chromosome location: 4p16.3
• Summary: This gene encodes a member of the transforming acidic colied-coil protein family. The encoded protein is a motor spindle protein that may play a role in stabilization of the mitotic spindle. This protein may also play a role in growth a differentiation of

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016566	hsa-miR-193b-3p	Microarray	20304954
MIRT045607	hsa-miR-149-5p	CLASH	23622248
MIRT043259	hsa-miR-324-5p	CLASH	23622248
MIRT042910	hsa-miR-324-3p	CLASH	23622248
MIRT016566	hsa-miR-193b-3p	CLASH	23622248
MIRT040904	hsa-miR-18a-3p	CLASH	23622248
MIRT039103	hsa-miR-769-3p	CLASH	23622248
MIRT037681	hsa-miR-744-5p	CLASH	23622248
MIRT438423	hsa-miR-425-5p	Luciferase reporter assay, Microarray, qRT-PCR, Western blot	23174883
MIRT438422	hsa-miR-152-3p	Luciferase reporter assay, Microarray, qRT-PCR, Western blot	23174883
MIRT438421	hsa-miR-24-3p	Luciferase reporter assay, Microarray, qRT-PCR, Western blot	23174883
MIRT438423	hsa-miR-425-5p	Luciferase reporter assay, Microarray, qRT-PCR, Western blot	23174883
MIRT438422	hsa-miR-152-3p	Luciferase reporter assay, Microarray, qRT-PCR, Western blot	23174883
MIRT438421	hsa-miR-24-3p	Luciferase reporter assay, Microarray, qRT-PCR, Western blot	23174883
MIRT489756	hsa-miR-6798-5p	PAR-CLIP	23592263
MIRT489755	hsa-miR-4706	PAR-CLIP	23592263
MIRT489754	hsa-miR-4749-5p	PAR-CLIP	23592263
MIRT489753	hsa-miR-1908-5p	PAR-CLIP	23592263
MIRT489752	hsa-miR-663a	PAR-CLIP	23592263
MIRT489750	hsa-miR-6787-5p	PAR-CLIP	23592263
MIRT489751	hsa-miR-3180	PAR-CLIP	23592263
MIRT489749	hsa-miR-3180-3p	PAR-CLIP	23592263
MIRT489748	hsa-miR-3196	PAR-CLIP	23592263
MIRT489747	hsa-miR-6816-5p	PAR-CLIP	23592263
MIRT489746	hsa-miR-1237-5p	PAR-CLIP	23592263
MIRT489745	hsa-miR-4488	PAR-CLIP	23592263
MIRT489744	hsa-miR-4697-5p	PAR-CLIP	23592263
MIRT489743	hsa-miR-328-5p	PAR-CLIP	23592263
MIRT489742	hsa-miR-6885-5p	PAR-CLIP	23592263
MIRT489756	hsa-miR-6798-5p	PAR-CLIP	23592263
MIRT489755	hsa-miR-4706	PAR-CLIP	23592263
MIRT489754	hsa-miR-4749-5p	PAR-CLIP	23592263
MIRT489753	hsa-miR-1908-5p	PAR-CLIP	23592263
MIRT489752	hsa-miR-663a	PAR-CLIP	23592263
MIRT489750	hsa-miR-6787-5p	PAR-CLIP	23592263
MIRT489751	hsa-miR-3180	PAR-CLIP	23592263
MIRT489749	hsa-miR-3180-3p	PAR-CLIP	23592263
MIRT489748	hsa-miR-3196	PAR-CLIP	23592263
MIRT489747	hsa-miR-6816-5p	PAR-CLIP	23592263
MIRT489746	hsa-miR-1237-5p	PAR-CLIP	23592263
MIRT489745	hsa-miR-4488	PAR-CLIP	23592263
MIRT489744	hsa-miR-4697-5p	PAR-CLIP	23592263
MIRT489743	hsa-miR-328-5p	PAR-CLIP	23592263
MIRT489742	hsa-miR-6885-5p	PAR-CLIP	23592263
MIRT1408451	hsa-miR-1305	CLIP-seq
MIRT1408452	hsa-miR-1324	CLIP-seq
MIRT1408453	hsa-miR-1908	CLIP-seq
MIRT1408454	hsa-miR-1909	CLIP-seq
MIRT1408455	hsa-miR-2277-3p	CLIP-seq
MIRT1408456	hsa-miR-3123	CLIP-seq
MIRT1408457	hsa-miR-330-3p	CLIP-seq
MIRT1408458	hsa-miR-3605-3p	CLIP-seq
MIRT1408459	hsa-miR-4307	CLIP-seq
MIRT1408460	hsa-miR-4436a	CLIP-seq
MIRT1408461	hsa-miR-4461	CLIP-seq
MIRT1408462	hsa-miR-4496	CLIP-seq
MIRT1408463	hsa-miR-4700-3p	CLIP-seq
MIRT1408464	hsa-miR-483-5p	CLIP-seq
MIRT1408465	hsa-miR-488	CLIP-seq
MIRT1408466	hsa-miR-607	CLIP-seq
MIRT1408467	hsa-miR-627	CLIP-seq
MIRT1408468	hsa-miR-663	CLIP-seq
MIRT1408452	hsa-miR-1324	CLIP-seq
MIRT1408453	hsa-miR-1908	CLIP-seq
MIRT1408454	hsa-miR-1909	CLIP-seq
MIRT1408455	hsa-miR-2277-3p	CLIP-seq
MIRT1408456	hsa-miR-3123	CLIP-seq
MIRT1408458	hsa-miR-3605-3p	CLIP-seq
MIRT1408460	hsa-miR-4436a	CLIP-seq
MIRT1408463	hsa-miR-4700-3p	CLIP-seq
MIRT1408464	hsa-miR-483-5p	CLIP-seq
MIRT1408468	hsa-miR-663	CLIP-seq
MIRT1408452	hsa-miR-1324	CLIP-seq
MIRT1408455	hsa-miR-2277-3p	CLIP-seq
MIRT1408456	hsa-miR-3123	CLIP-seq
MIRT1408460	hsa-miR-4436a	CLIP-seq
MIRT1408463	hsa-miR-4700-3p	CLIP-seq
MIRT1408464	hsa-miR-483-5p	CLIP-seq
MIRT1408452	hsa-miR-1324	CLIP-seq
MIRT1408455	hsa-miR-2277-3p	CLIP-seq
MIRT1408456	hsa-miR-3123	CLIP-seq
MIRT1408458	hsa-miR-3605-3p	CLIP-seq
MIRT1408460	hsa-miR-4436a	CLIP-seq
MIRT1408463	hsa-miR-4700-3p	CLIP-seq
MIRT1408464	hsa-miR-483-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000226	Process	Microtubule cytoskeleton organization	IBA	21873635
GO:0000922	Component	Spindle pole	IEA
GO:0005515	Function	Protein binding	IPI	20360068, 21297582, 25416956, 26496610, 29892012, 32296183
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005829	Component	Cytosol	IDA
GO:0007052	Process	Mitotic spindle organization	IEA
GO:0007091	Process	Metaphase/anaphase transition of mitotic cell cycle	IMP	23532825
GO:0008283	Process	Cell population proliferation	IBA	21873635
GO:0021987	Process	Cerebral cortex development	IBA	21873635
GO:0034451	Component	Centriolar satellite	IDA
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA
GO:0051301	Process	Cell division	IEA
GO:0060236	Process	Regulation of mitotic spindle organization	IMP	21297582
GO:0072686	Component	Mitotic spindle	IDA
GO:1902850	Process	Microtubule cytoskeleton organization involved in mitosis	IMP	23532825

Other IDs

• MIM: 605303
• HGNC: 11524
• e!Ensembl: ENSG00000013810

Protein

• UniProt ID: Q9Y6A5
• Protein name: Transforming acidic coiled-coil-containing protein 3 (ERIC-1)
• Protein function: Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as a component of
• PDB: 5LXN, 5LXO, 5ODS, 5ODT
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05010	TACC_C	639 → 832	Transforming acidic coiled-coil-containing protein (TACC), C-terminal	Coiled-coil

• Sequence:

  MSLQVLNDKNVSNEKNTENCDFLFSPPEVTGRSSVLRVSQKENVPPKNLAKAMKVTFQTP
  LRDPQTHRILSPSMASKLEAPFTQDDTLGLENSHPVWTQKENQQLIKEVDAKTTHGILQK
  PVEADTDLLGDASPAFGSGSSSESGPGALADLDCSSSSQSPGSSENQMVSPGKVSGSPEQ
  AVEENLSSYSLDRRVTPASETLEDPCRTESQHKAETPHGAEEECKAETPHGAEEECRHGG
  VCAPAAVATSPPGAIPKEACGGAPLQGLPGEALGCPAGVGTPVPADGTQTLTCAHTSAPE
  STAPTNHLVAGRAMTLSPQEEVAAGQMASSSRSGPVKLEFDVSDGATSKRAPPPRRLGER
  SGLKPPLRKAAVRQQKAPQEVEEDDGRSGAGEDPPMPASRGSYHLDWDKMDDPNFIPFGG
  DTKSGCSEAQPPESPETRLGQPAAEQLHAGPATEEPGPCLSQQLHSASAEDTPVVQLAAE
  TPTAESKERALNSASTSLPTSCPGSEPVPTHQQGQPALELKEESFRDPAEVLGTGAEVDY
  LEQFGTSSFKESALRKQSLYLKFDPLLRDSPGRPVPVATETSSMHGANETPSGRPREAKL
  VEFDFLGALDIPVPGPPPGVPAPGGPPLSTGPIVDLLQYSQKDLDAVVKATQEENRELRS
  RCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQKELSKAEIQKVLKEKDQLTTDLNSMEK
  SFSDLFKRFEKQKEVIEGYRKNEESLKKCVEDYLARITQEGQRYQALKAHAEEKLQLANE
  EIAQVRSKAQAEALALQASLRKEQMRIQSLEKTVEQKTKENEELTRICDDLISKMEKI

• Sequence length: 838

Associated diseases

Unknown
Disease name	Disease term	dbSNP ID	References
Urinary bladder cancer	Malignant neoplasm of urinary bladder		24121792, 24163127, 20348956, 20972438
Bladder neoplasm	Bladder Neoplasm		24121792
Bladder carcinoma	Carcinoma of bladder		20348956, 24163127, 20972438
Giant cell glioblastoma	Giant Cell Glioblastoma		22837387
Gliosarcoma	gliosarcoma		22837387
Liver carcinoma	Liver carcinoma		28284560
Osteoarthritis of hip	Osteoarthritis of hip		30664745